Application of key events dose response framework to defining the upper intake level of leucine in young men

Journal of Nutrition

Volumn 142, Issue 12, 2012, Pages

  Pencharz, Paul B ^a,b,c   Russell, Robert M ^d,e  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEUCINE;

ARTICLE; DIETARY INTAKE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; INGESTION; INSULIN BLOOD LEVEL; MALE; NORMAL HUMAN; NUTRITIONAL REQUIREMENT; RISK BENEFIT ANALYSIS; TOXICITY;

ADULT; BLOOD GLUCOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD SAFETY; HUMANS; LEUCINE; MALE; NUTRITIONAL REQUIREMENTS; OXIDATION-REDUCTION;

EID: 84872167242     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.112.159079     Document Type: Article

References (4)

1. Food and Nutrition Board, IOM. Dietary Reference Intakes: a risk assessment model for establishing upper intake levels for nutrients. Washington, DC: National Academy Press; 1998.
2. Julien E, Boobis AR, Olin SS, The ILSI Research Foundation Threshold Working Group. The key events dose-response framework: a cross-disciplinary mode- of-action based approach to examining dose-response and thresholds. Crit Rev Food Sci Nutr. 2009;49:682-9.
3. Ross AC, Russell RM, Miller SA, Munro IC, Rodricks JV, Yetley EA, Julien E. Application of a key events dose-response analysis to nutrients: a case study with vitamin A (retinol). Crit Rev Food Sci Nutr. 2009; 49:708-17.
4. Pencharz PB, Elango R, Ball RO. Determination of the tolerable upper intake level of leucine in adult men. J Nutr. 2012;142:2220S-24S.