Compartmental modeling and simplified quantification of [ 11C]sertraline distribution in human brain

Archives of Pharmacal Research

Volumn 35, Issue 9, 2012, Pages 1591-1597

  Kim, Ji Who ^a   Lee, Jae Sung ^a   Kim, Su Jin ^a   Hoigebazar, Lathika ^a   Shin, Kwang Hee ^a   Yu, Kyung Sang ^a   Ahn, Wonsik ^a   Jeong, Jae Min ^a   Lee, Dong Soo ^a  

^a Seoul National University   (South Korea)

Author keywords

11C sertraline; Kinetic modeling; Microdose; PET; Pharmacokinetics; Serotonin transporters

Indexed keywords

CARBON 11; SERTRALINE;

ADULT; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; BRAIN REGION; BRAIN TISSUE; CEREBELLUM; COMPARTMENT MODEL; DISTRIBUTION VOLUME RATIO; DRUG DISTRIBUTION; DRUG SYNTHESIS; DRUG UPTAKE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PUTAMEN; STANDARD UPTAKE VALUE;

ADULT; ANTIDEPRESSIVE AGENTS; BRAIN; CARBON RADIOISOTOPES; CEREBELLUM; FEASIBILITY STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MODELS, BIOLOGICAL; POSITRON-EMISSION TOMOGRAPHY; PUTAMEN; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; TIME FACTORS; TISSUE DISTRIBUTION; YOUNG ADULT;

EID: 84872111855     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0910-4     Document Type: Article

References (24)

1. Boecker, H., Sprenger, T., Henriksen, G., Toelle, T. R., and Spilker, M. E., Optimal duration of PET studies with 18Ffluoroethyl- diprenorphine. J. Nucl. Med., 46, 2092-2096 (2005).
2. Dahl, A. A., Ravindran, A., Allgulander, C., Kutcher, S. P., Austin, C., and Burt, T., Sertraline in generalized anxiety disorder: efficacy in treating the psychic and somatic anxiety factors. Acta Psychiat. Scand., 111, 429-435 (2005).
3. Dayan, P. and Huys, Q. J., Serotonin, inhibition, and negative mood. PLos. Comput. Biol., 4, e4 (2008).
4. Esposito, E., Serotonin-dopamine interaction as a focus of novel antidepressant drugs. Curr. Drug Targets, 7, 177-185 (2006).
5. Fazaeli, Y., Jalilian, A. R., Amini, M. M., Ardaneh, K., Rahiminejad, A., Bolourinovin, F., Moradkhani, S., and Majdabadi, A., Development of a 68Ga-fluorinated porphyrin complex as a possible PET imaging agent. Nucl. Med. Mol. Imaging, 46, 20-26 (2011)
6. Frankle, W. G., Huang, Y., Hwang, D. R., Talbot, P. S., Slifstein, M., Van Heertum, R., Abi-Dargham, A., and Laruelle, M., Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans. J. Nucl. Med., 45, 682-694 (2004).
7. Huang, T. Y., Hwang, D. R., Narendran, R., Sudo, Y., Chatterjee, R., Bae, S. A., Mawiawi, O., Kegeles, L. S., Wilson, A. A., Kung, H. F., and Laruelle, M., Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM. J. Cereb. Blood Flow Metab., 22, 1377-1398 (2002).
8. Kapur, S. and Remington, G., Serotonin-dopamine interaction and its relevance to schizophrenia. Am. J. Psychiatry, 153, 466-476 (1996).
9. Kim, S. J., Lee, J. S., Im, K. C., Kim, S. Y., Park, S. A., Lee, S. J., Oh, S. J., Lee, D. S., and Moon, D. H., Kinetic modeling of 3'-deoxy-3'-18F- fluorothymidine for quantitative cell proliferation imaging in subcutaneous tumor models in mice. J. Nucl. Med., 49, 2057-2066 (2008a).
10. Kim, S. J., Lee, J. S., Kim, Y. K., Frost, J., Wand, G., McCaul, M. E., and Lee, D. S., Multiple linear analysis methods for the quantification of irreversibly binding radiotracers. J. Cereb. Blood Flow Metab., 28, 1965-1977(2008b)
11. Kim, S. W., Park, S. Y., and Hwang, O., Up-regulation of tryptophan hydroxylase expression and serotonin synthesis by sertraline. Mol. Pharmacol., 61, 778-785 (2002).
12. Lee, J. S., Lee, D. S., Kim, S. J., Kim, Y. K., Kang, E., Kang, H., Kang, K. W., Lee, J. M., Kim, J. J., Park, H. J., Kwon, J. S., Kim, S. I., Yoo, T. W., Chang, K. H., and Lee, M. C., Development of korean standard brain templates. J. Korean Med. Sci., 20, 483-488 (2005).
13. Lee, J. S., Lee, D. S., Ahn, J. Y., Yeo, J. S., Cheon, G. J., Kim, S. K., Park, K. S., Chung, J. K., and Lee, M. C., Generation of parametric image of regional myocardial blood flow using H(2)(15)O dynamic PET and a linear least-squares method. J. Nucl. Med., 46, 1687-1695 (2005).
14. Lim, K. S., Kwon, J. S., Jang, I. J., Jeong, J. M., Lee, J. S., Kim, H. W., Kang, W. J., Kim, J. R., Cho, J. Y., Kim, E., Yoo, S. Y., Shin, S. G., and Yu, K. S., Modeling of brain D2 receptor occupancy-plasma concentration relationships with a novel antipsychotic, YKP1358, using serial PET scans in healthy volunteers. Clin. Pharmacol. Ther., 81, 252-258 (2007).
15. Lopresti, B. J., Klunk, W. E., Mathis, C. A., Hoge, J. A., Ziolko, S. K., Lu, X., Meltzer, C. C., Schimmel, K., Tsopelas, N. D., DeKosky, S. T., and Price, J. C., Simplified quantification of pittsburghcompound amyloid imaging PET studies:a comparative analysis. J. Nucl. Med., 46, 1959-1972 (2005).
16. Ludden, T. M., Beal, S. L., and Sheiner, L. B., Comparison of the akaike information criterion, the schwarz criterion and the F-test as guides to model selection. J. Pharmacokinet. Biopharm., 22, 431-445 (1994).
17. Munhoz, R. P., Serotonin syndrome induced by a combination of bupropion and SSRIs. Clin. Neuropharmacol., 27, 219-222 (2004).
18. Sanacora, G., Mason, G. F., Rothman, D. L., and Krystal, J. H., Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. Am. J. Psychiatry, 159, 663-665 (2002).
19. Shields, A. F. and Price, P., In vivo imaging of cancer therapy: An Overview, In Saleem, A. and Price, P. (Eds.). Positron emission tomography measurement of drugkinetics. Springer, pp. 169-204, (2007).
20. Szabo, Z., Scheffel, U., Mathews, W. B., Ravert, H. T., Szabo, K., Kraut, M., Palmon, S., Ricaurte, G. A., and Dannals, R. F., Kinetic analysis of [11C]McN5652: A serotonin transporter radioligand. J. Cereb. Blood Flow Metab., 19, 967- 981 (1999).
21. Valk, P. E., Bailey, D. L., Townsend, D. W., and Maisey, M. N., Positron emission tomography: An Overview, In Carson, R. E. (Eds.). Tracer kinetic modeling in PET. Springer, pp. 147-179, (2003).
22. Voineskos, A. N., Wilson, A. A., Boovariwala, A., Saqrati, S., Houle, S., Rusjan, P., Sokolove, S., Spencer, E. P., Ginovart, N., and Meyer, J. H., Serotonin transporteroccupancy of high-dose selective serotonin reuptake inhibitors during majordepressive disorder measured with [11C] DASB positron emission tomography. Psychopharmacology, 193, 539-545 (2007).
23. Yamaoka, K., Nakagawa, T., and Uno, T., Application of Akaike's information criterion (AIC) in the evaluationof linear pharmacokinetic equations. J. Pharmacokinet. Biopharm., 6, 165-175 (1978).
24. Zhu, A. and Shim, H., Current Molecular Imaging Positron Emitting Radiotracers in Oncology. Nucl. Med. Mol. Imaging, 45, 1-14 (2011).