End point determination of blending process for trimebutine tablets using principle component analysis (PCA) and partial least squares (PLS) regression

Archives of Pharmacal Research

Volumn 35, Issue 9, 2012, Pages 1599-1607

  Lee, Sun Hee ^a   Lee, Jun Ho ^a   Cho, Soohwa ^a   Do, Sung Ho ^b   Woo, Young Ah ^a,c  

^a Korea United Pharm Inc   (South Korea)

^b Korea University   (South Korea)

^c ChongKunDang Pharm ^*  (South Korea)

Author keywords

Blending; Near infrared (NIR) spectroscopy; Partial least squares (PLS); Principal component analysis (PCA); Raman spectroscopy; Trimebutine tablets

Indexed keywords

MAGNESIUM STEARATE; SILICON; SILICON OXIDE; STEARIC ACID; TALC; TRIMEBUTINE; UNCLASSIFIED DRUG;

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NEAR INFRARED SPECTROSCOPY; PARTIAL LEAST SQUARES REGRESSION; PRINCIPAL COMPONENT ANALYSIS; RAMAN SPECTROMETRY; TABLET;

ARTIFICIAL INTELLIGENCE; CALIBRATION; CHEMISTRY, PHARMACEUTICAL; ENDPOINT DETERMINATION; FEASIBILITY STUDIES; LEAST-SQUARES ANALYSIS; PARASYMPATHOLYTICS; PRINCIPAL COMPONENT ANALYSIS; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; REPUBLIC OF KOREA; SPECTROSCOPY, NEAR-INFRARED; SPECTRUM ANALYSIS, RAMAN; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TRIMEBUTINE;

EID: 84872110830     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0911-3     Document Type: Article

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