New-onset diabetes with a history of dyslipidemia predicts pancreatic cancer

Pancreas

Volumn 42, Issue 1, 2013, Pages 42-48

  Tseng, Chin Hsiao ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

detection bias; dyslipidemia; new onset diabetes; pancreatic cancer; Taiwan

Indexed keywords

ARTICLE; CANCER DIAGNOSIS; CANCER RISK; DIABETES MELLITUS; DIABETIC PATIENT; DYSLIPIDEMIA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; PANCREAS CANCER; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RANDOM SAMPLE; RISK FACTOR;

BIAS (EPIDEMIOLOGY); CHI-SQUARE DISTRIBUTION; DIABETES MELLITUS, TYPE 2; DYSLIPIDEMIAS; FEMALE; HUMANS; INCIDENCE; LONGITUDINAL STUDIES; MALE; MULTIVARIATE ANALYSIS; NATIONAL HEALTH PROGRAMS; PANCREATIC NEOPLASMS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; TAIWAN; TIME FACTORS;

EID: 84872089119     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3182571ba9     Document Type: Article

References (33)

1. Chari ST. Detecting early pancreatic cancer: problems and prospects. Semin Oncol. 2007;34:284-294.
2. Ben Q, Xu M, Ning X, et al. Diabetes mellitus and risk of pancreatic cancer: a meta-analysis of cohort studies. Eur J Cancer. 2011;47:1928-1937.
3. Chen HF, Chen P, Li CY. Risk of malignant neoplasm of the pancreas in relation to diabetes: a population-based study in Taiwan. Diabetes Care. 2011;34:1177-1179.
4. Pezzilli R, Casadei R, Morselli-Labate AM. Is type 2 diabetes a risk factor for pancreatic cancer? JOP. 2009;10:705-706.
5. Rousseau MC, Parent ME, Pollak MN, et al. Diabetes mellitus and cancer risk in a population-based case-control study among men from Montreal, Canada. Int J Cancer. 2006;118:2105-2109.
6. Pannala R, Basu A, Petersen GM, et al. New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer. Lancet Oncol. 2009;10:88-95.
7. Giovannucci E, Michaud D. The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology. 2007;132:2208-2225.
8. Greer JB, Whitcomb DC. Inflammation and pancreatic cancer: an evidence-based review. Curr Opin Pharmacol. 2009;9:411-418.
9. Takasu S Mutoh M Takahashi M et al. Lipoprotein lipase as a Candidate Target For Cancer Preventiontherapy. Biochem Res Int. 2012;2012398697
10. HoriM, Kitahashi T, Imai T, et al. Enhancement of carcinogenesis and fatty infiltration in the pancreas in N-nitrosobis(2-oxopropyl)amine-treated hamsters by high-fat diet. Pancreas. 2011;40:1234-1240.
11. National Health Research Institutes. National Health Insurance Research Database. Available at
12. Kleinbaum DG, Kupper LL, Morgenstern H. Epidemiologic Research: Principles and Quantitative Methods. New York, NY: John Wiley and Sons; 1982:298-302.
13. Grote VA, Rohrmann S, Nieters A, et al. Diabetes mellitus, glycated hemoglobin and C-peptide levels in relation to pancreatic cancer risk: a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Diabetologia. 2011;54:3037-3046.
14. Saruc M, Iki K, Pour PM. Morphometric studies in human pancreatic cancer argues against the etiological role of type 2 diabetes in pancreatic cancer. Histol Histopathol. 2010;25:423-432.
15. Gangi S, Fletcher JG, Nathan MA, et al. Time interval between abnormalities seen on CT and the clinical diagnosis of pancreatic cancer: retrospective review of CT scans obtained before diagnosis. AJR Am J Roentgenol. 2004;182:897-903.
16. Smits MM, van Geenen EJ. The clinical significance of pancreatic steatosis. Nat Rev Gastroenterol Hepatol. 2011;8:169-177.
17. Giacca A, Xiao C, Oprescu AI, et al. Lipid-induced pancreatic A-cell dysfunction: focus on in vivo studies. Am J Physiol Endocrinol Metab. 2011;300:E255-E262.
18. Lowenfels AB, Maisonneuve P. Epidemiology and risk factors for pancreatic cancer. Best Pract Res Clin Gastroenterol. 2006;20:197-209.
19. Aune D, Greenwood DC, Chan DS, et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Ann Oncol. 2012;23(4):843-852.
20. Bracci PM. Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms. Mol Carcinog. 2012;51:53-63.
21. Larsson SC Bergkvist L Wolk A. Consumption of sugar sugar-sweetened foods the risk of pancreatic cancer in a Prospective Study. Am J Clin Nutr. 2006;841171-1176
22. Khurana V, Sheth A, Caldito G, et al. Statins reduce the risk of pancreatic cancer in humans: a case-control study of half a million veterans. Pancreas. 2007;34:260-265.
23. Bao B, Wang Z, Li Y, et al. The complexities of obesity, diabetes, and the development and progression of pancreatic cancer. Biochim Biophys Acta. 2011;1815:135-146.
24. Li D, Yeung SC, Hassan MM, et al. Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology. 2009;137:482-488.
25. Freelove R, Walling AD. Pancreatic cancer: diagnosis and management. Am Fam Physician. 2006;73:485-492.
26. Hassan MM, Bondy ML, Wolff RA, et al. Risk factors for pancreatic cancer: case-control study. Am J Gastroenterol. 2007;102:2696-2707.
27. Thiébaut AC, Jiao L, Silverman DT, et al. Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health study. J Natl Cancer Inst. 2009;101:1001-1011.
28. Anderson LN, Cotterchio M, Gallinger S. Lifestyle, dietary, and medical history factors associated with pancreatic cancer risk in Ontario, Canada. Cancer Causes Control. 2009;20:825-834.
29. Risch HA. Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. J Natl Cancer Inst. 2003;95:948-960.
30. Stolzenberg-Solomon RZ, Sheffler-Collins S, Weinstein S, et al. Vitamin E intake, alpha-tocopherol status, and pancreatic cancer in a cohort of male smokers. Am J Clin Nutr. 2009;89:584-591.
31. Larsson SC, Giovannucci E, Wolk A. Methionine and vitamin B6 intake and risk of pancreatic cancer: a prospective study of Swedish women and men. Gastroenterology. 2007;132:113-118.
32. Larsson SC, Håkansson N, Giovannucci E, et al. Folate intake and pancreatic cancer incidence: a prospective study of Swedish women and men. J Natl Cancer Inst. 2006;98:407-413.
33. Calton BA, Stolzenberg-Solomon RZ, Moore SC, et al. A prospective study of physical activity and the risk of pancreatic cancer among women (United States). BMC Cancer. 2008;8:63.