Bile acids and coagulation factors: Paradoxical association in children with chronic liver disease

European Journal of Gastroenterology and Hepatology

Volumn 25, Issue 2, 2013, Pages 152-158

  Magnusson, Maria ^a   Fischler, Björn ^a   Svensson, Jan ^b   Petrini, Pia ^a   Schulman, Sam ^c   Németh, Antal ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b DANDERYD HOSPITAL   (Sweden)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Bile acids; Blood coagulation factors; Cholestasis; Factor VII; Hepatology; International normalized ratio; Liver transplantation; Pediatrics; Prognosis; Severity of illness index

Indexed keywords

ALBUMIN; BILE ACID; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 7; PHYTOMENADIONE; PROTHROMBIN; VITAMIN K GROUP;

ALBUMIN BLOOD LEVEL; ARTICLE; BILE ACID BLOOD LEVEL; CHILD; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; ECHOGRAPHY; END STAGE LIVER DISEASE; EPISTAXIS; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; IN VITRO STUDY; INFANT; INTERNATIONAL NORMALIZED RATIO; MALE; OBSERVATIONAL STUDY; PORTAL VEIN THROMBOSIS; PRESCHOOL CHILD; PRESCRIPTION; PRIORITY JOURNAL; PROGNOSIS; PROTHROMBIN TIME; SCORING SYSTEM; TERTIARY HEALTH CARE;

ADOLESCENT; BILE ACIDS AND SALTS; BIOLOGICAL MARKERS; BLOOD COAGULATION FACTORS; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INFANT; INTERNATIONAL NORMALIZED RATIO; LIVER DISEASES; MALE; SERUM ALBUMIN;

EID: 84872086640     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0b013e32835a86f3     Document Type: Article

References (27)

1. Lisman T, Leebeek FW. Hemostatic alterations in liver disease: A review on pathophysiology, clinical consequences, and treatment. Dig Surg 2007; 24:250-258 (Pubitemid 47174040)
2. Bismuth H, Samuel D, Castaing D, Adam R, Saliba F, Johann M, et al. Orthotopic liver transplantation in fulminant and subfulminant hepatitis. The Paul Brousse experience. Ann Surg 1995; 222:109-119
3. Dymock IW, Tucker JS,Woolf IL, Poller L, Thomson JM. Coagulation studies as a prognostic index in acute liver failure. Br J Haematol 1975; 29: 385-395
4. O'Grady JG, Schalm SW, Williams R. Acute liver failure: Redefining the syndromes. Lancet 1993; 342:273-275 (Pubitemid 23224421)
5. McDiarmid SV, Anand R, Lindblad AS. Development of a pediatric end-stage liver disease score to predict poor outcome in children awaiting liver transplantation. Transplantation 2002; 74:173-181 (Pubitemid 34810283)
6. HRSA/OPTN. Policies: 3.6 organ distribution: Allocation of livers, 11 September 2010. Available at :http://optn.transplant.hrsa.gov [Accessed 1 August 2012
7. McDiarmid SV, Merion RM, Dykstra DM, Harper AM. Selection of pediatric candidates under the PELD system. Liver Transpl 2004; 10:S23-S30 (Pubitemid 39406098)
8. Lindahl TL, Egberg N, Hillarp A, Odegaard OR, Edlund B, Svensson J, et al. INR calibration of Owren-Type prothrombin time based on the relationship between PT% and INR utilizing normal plasma samples. Thromb Haemost 2004; 91:1223-1231 (Pubitemid 38821281)
9. Cederblad G, Korsan-Bengtsen K, Olsson R. Observations of increased levels of blood coagulation factors and other plasma proteins in cholestatic liver disease. Scand J Gastroenterol 1976; 11:391-396
10. Segal H, Cottam S, Potter D, Hunt BJ. Coagulation and fibrinolysis in primary biliary cirrhosis compared with other liver disease and during orthotopic liver transplantation. Hepatology 1997; 25:683-688 (Pubitemid 27106454)
11. Ritter DM, Owen CA Jr, Bowie EJ, Rettke SR, Cole TL, Taswell HF, et al. Evaluation of preoperative hematology-coagulation screening in liver transplantation. Mayo Clin Proc 1989; 64:216-223 (Pubitemid 19080938)
12. Soulier JP, Gozin D, Lefrere JJ. Assay of des-gamma-carboxyprothrombin using staphylocoagulase. Application to the diagnosis of cellular hepatocarcinoma. Haematologia (Budap) 1986; 19:3-12
13. Seligsohn U, Osterud B, Rapaport SI. Coupled amidolytic assay for factor VII: Its use with a clotting assay to determine the activity state of factor VII. Blood 1978; 52:978-988 (Pubitemid 9112690)
14. Bergstrom K, Egberg N. Determination of vitamin K sensitive coagulation factors in plasma: Studies on three methods using synthetic chromogenic substrates. Thromb Res 1978; 12:531-547 (Pubitemid 8303600)
15. Talalay P. Enzymatic mechanisms in steroid biochemistry. Annu Rev Biochem 1965; 34:347-380
16. Bajwa SS, Hanahan DJ. Interaction of short chain and long chain fatty acid phosphoglycerides and bile salts with prothrombin. Biochim Biophys Acta 1976; 444:118-130
17. Andrew MPB, Johnston M. Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol 1990; 12:95-104 (Pubitemid 20132100)
18. Arnell H, Papadogiannakis N, Zemack H, Knisely AS, Nemeth A, Fischler B. Follow-up in children with progressive familial intrahepatic cholestasis after partial external biliary diversion. J Pediatr Gastroenterol Nutr 2010; 51:494-499
19. Pennington CR, McKenzie H, Main J, Parratt D. Bowel rest and nutritional support in the management of Crohn's disease. Gut 1989; 30:422-423
20. Crosignani A, Setchell KD, Invernizzi P, Larghi A, Rodrigues CM, Podda M. Clinical pharmacokinetics of therapeutic bile acids. Clin Pharmacokinet 1996; 30:333-358 (Pubitemid 26177180)
21. Ben-Ari Z, Panagou M, Patch D, Bates S, Osman E, Pasi J, et al. Hypercoagulability in patients with primary biliary cirrhosis and primary sclerosing cholangitis evaluated by thrombelastography. J Hepatol 1997; 26:554-559 (Pubitemid 27112720)
22. Semeraro N, Montemurro P, Chetta G, Altomare DF, Giordano D, Colucci M. Increased procoagulant activity of peripheral blood monocytes in human and experimental obstructive jaundice. Gastroenterology 1989; 96:892-898 (Pubitemid 19057616)
23. Van Thiel DH, George M, Mindikoglu AL, Baluch MH, Dhillon S. Coagulation and fibrinolysis in individuals with advanced liver disease. Turk J Gastroenterol 2004; 15:67-72 (Pubitemid 39050089)
24. Papadopoulos VFD, Manolis E, Mimidis K. Haemostasis impairment in patients with obstructive jaundice. J Gastrointestin Liver Dis 2007; 16: 177-186 (Pubitemid 47011913)
25. Dalmon J, Laurent M, Courtois G. The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1-Dependent interleukin-6-responsive element. Mol Cell Biol 1993; 13:1183-1193 (Pubitemid 23040285)
26. Anisfeld AM, Kast-Woelbern HR, Lee H, Zhang Y, Lee FY, Edwards PA. Activation of the nuclear receptor FXR induces fibrinogen expression: A new role for bile acid signaling. J Lipid Res 2005; 46:458-468 (Pubitemid 43109782)
27. Lundborg H, Hamberger A. Amino acid incorporation into liver proteins during extrahepatic cholestasis in the rat. Eur Surg Res 1974; 6:95-109