메뉴 건너뛰기




Volumn 24, Issue 4, 2007, Pages 250-258

Hemostatic alterations in liver disease: A review on pathophysiology, clinical consequences, and treatment

Author keywords

Fibrinolytic system; Hemostasis testing; Hemostatic abnormalities; Hemostatic dysbalance; Primary hemostasis; Secondary hemostasis

Indexed keywords

APROTININ; DESMOPRESSIN; FRESH FROZEN PLASMA; RECOMBINANT BLOOD CLOTTING FACTOR 7A; TRANEXAMIC ACID;

EID: 34547416114     PISSN: 02534886     EISSN: None     Source Type: Journal    
DOI: 10.1159/000103655     Document Type: Conference Paper
Times cited : (147)

References (62)
  • 1
    • 0013912854 scopus 로고
    • Pooling of platelets in the spleen: Role in the pathogenesis of 'hypersplenic' thrombocytopenia
    • Aster RH: Pooling of platelets in the spleen: role in the pathogenesis of 'hypersplenic' thrombocytopenia. J Clin Invest 1966;45:645-657.
    • (1966) J Clin Invest , vol.45 , pp. 645-657
    • Aster, R.H.1
  • 2
    • 0033042073 scopus 로고    scopus 로고
    • Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation
    • Goulis J, Chau TN, Jordan S, Mehta AB, Watkinson A, Rolles K, Burroughs AK: Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation. Gut 1999;44:754-758.
    • (1999) Gut , vol.44 , pp. 754-758
    • Goulis, J.1    Chau, T.N.2    Jordan, S.3    Mehta, A.B.4    Watkinson, A.5    Rolles, K.6    Burroughs, A.K.7
  • 3
    • 0038241772 scopus 로고    scopus 로고
    • A role of auto-antibody-mediated platelet destruction in thrombocytopenia in patients with cirrhosis
    • Kajihara M, Kato S, Okazaki Y, Kawakami Y, Ishii H, Ikeda Y, Kuwana M: A role of auto-antibody-mediated platelet destruction in thrombocytopenia in patients with cirrhosis. Hepatology 2003;37:1267-1276.
    • (2003) Hepatology , vol.37 , pp. 1267-1276
    • Kajihara, M.1    Kato, S.2    Okazaki, Y.3    Kawakami, Y.4    Ishii, H.5    Ikeda, Y.6    Kuwana, M.7
  • 5
    • 0032847122 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation in liver cirrhosis: Fact or fiction?
    • Ben Ari Z, Osman E, Hutton RA, Burroughs AK: Disseminated intravascular coagulation in liver cirrhosis: fact or fiction? Am J Gastroenterol 1999;94:2977-2982.
    • (1999) Am J Gastroenterol , vol.94 , pp. 2977-2982
    • Ben Ari, Z.1    Osman, E.2    Hutton, R.A.3    Burroughs, A.K.4
  • 6
    • 0032766096 scopus 로고    scopus 로고
    • Evaluation of acquired platelet dysfunctions in uremic and cirrhotic patients using the platelet function analyzer (PFA-100): Influence of hematocrit elevation
    • Escolar G, Cases A, Vinas M, Pino M, Calls J, Cirera I, Ordinas A: Evaluation of acquired platelet dysfunctions in uremic and cirrhotic patients using the platelet function analyzer (PFA-100): influence of hematocrit elevation. Haematologica 1999;84:614-619.
    • (1999) Haematologica , vol.84 , pp. 614-619
    • Escolar, G.1    Cases, A.2    Vinas, M.3    Pino, M.4    Calls, J.5    Cirera, I.6    Ordinas, A.7
  • 9
    • 0024216071 scopus 로고
    • Altered platelet function in cirrhosis of the liver: Impairment of inositol lipid and arachidonic acid metabolism in response to agonists
    • Laffi G, Cominelli F, Ruggiero M, Fedi S, Chiarugi VP, La Villa G, Pinzani M, Gentilini P: Altered platelet function in cirrhosis of the liver: impairment of inositol lipid and arachidonic acid metabolism in response to agonists. Hepatology 1988;8:1620-1626.
    • (1988) Hepatology , vol.8 , pp. 1620-1626
    • Laffi, G.1    Cominelli, F.2    Ruggiero, M.3    Fedi, S.4    Chiarugi, V.P.5    La Villa, G.6    Pinzani, M.7    Gentilini, P.8
  • 10
    • 0027953315 scopus 로고
    • Structural changes in platelet glycoprotein IIb/IIIa by plasmin: Determinants and functional consequences
    • Pasche B, Ouimet H, Francis S, Loscalzo J: Structural changes in platelet glycoprotein IIb/IIIa by plasmin: determinants and functional consequences. Blood 1994;83:404-414.
    • (1994) Blood , vol.83 , pp. 404-414
    • Pasche, B.1    Ouimet, H.2    Francis, S.3    Loscalzo, J.4
  • 11
    • 0024510027 scopus 로고
    • Inhibition of platelet aggregation by abnormal high density lipoprotein particles in plasma from patients with hepatic cirrhosis
    • Desai K, Mistry P, Bagget C, Burroughs AK, Bellamy MF, Owen JS: Inhibition of platelet aggregation by abnormal high density lipoprotein particles in plasma from patients with hepatic cirrhosis. Lancet 1989;1:693-695.
    • (1989) Lancet , vol.1 , pp. 693-695
    • Desai, K.1    Mistry, P.2    Bagget, C.3    Burroughs, A.K.4    Bellamy, M.F.5    Owen, J.S.6
  • 12
    • 0016759880 scopus 로고
    • Platelet interaction with subendothelium in a perfusion system: Physical role of red blood cells
    • Turitto VT, Baumgartner HR: Platelet interaction with subendothelium in a perfusion system: physical role of red blood cells. Microvasc Res 1975;9:335-344.
    • (1975) Microvasc Res , vol.9 , pp. 335-344
    • Turitto, V.T.1    Baumgartner, H.R.2
  • 13
    • 0034966875 scopus 로고    scopus 로고
    • Endothelial dysfunction in cirrhosis and portal hypertension
    • Cahill PA, Redmond EM, Sitzmann JV: Endothelial dysfunction in cirrhosis and portal hypertension. Pharmacol Ther 2001;89:273-293.
    • (2001) Pharmacol Ther , vol.89 , pp. 273-293
    • Cahill, P.A.1    Redmond, E.M.2    Sitzmann, J.V.3
  • 14
    • 33747179530 scopus 로고    scopus 로고
    • No evidence for an intrinsic platelet defect in patients with liver cirrhosis - studies under flow conditions
    • Lisman T, Adelmeijer J, de Groot PG, Janssen HL, Leebeek FW: No evidence for an intrinsic platelet defect in patients with liver cirrhosis - studies under flow conditions. J Thromb Haemost 2006;4:2070-2072.
    • (2006) J Thromb Haemost , vol.4 , pp. 2070-2072
    • Lisman, T.1    Adelmeijer, J.2    de Groot, P.G.3    Janssen, H.L.4    Leebeek, F.W.5
  • 16
    • 0029939485 scopus 로고    scopus 로고
    • High plasma levels of von Willebrand factor as a marker of endothelial perturbation in cirrhosis: Relationship to endotoxemia
    • Ferro D, Quintarelli C, Lattuada A, Leo R, Alessandroni M, Mannucci PM, Violi F: High plasma levels of von Willebrand factor as a marker of endothelial perturbation in cirrhosis: relationship to endotoxemia. Hepatology 1996;23:1377-1383.
    • (1996) Hepatology , vol.23 , pp. 1377-1383
    • Ferro, D.1    Quintarelli, C.2    Lattuada, A.3    Leo, R.4    Alessandroni, M.5    Mannucci, P.M.6    Violi, F.7
  • 20
    • 0020622344 scopus 로고
    • The role of sialic acid in the dysfibrinogenemia associated with liver disease: Distribution of sialic acid on the constituent chains
    • Martinez J, MacDonald KA, Palascak JE: The role of sialic acid in the dysfibrinogenemia associated with liver disease: distribution of sialic acid on the constituent chains. Blood 1983;61:1196-1202.
    • (1983) Blood , vol.61 , pp. 1196-1202
    • Martinez, J.1    MacDonald, K.A.2    Palascak, J.E.3
  • 24
    • 0036022849 scopus 로고    scopus 로고
    • Haemostatic abnormalities in patients with liver disease
    • Lisman T, Leebeek FWG, de Groot PG: Haemostatic abnormalities in patients with liver disease. J Hepatol 2002;37:280-287.
    • (2002) J Hepatol , vol.37 , pp. 280-287
    • Lisman, T.1    Leebeek, F.W.G.2    de Groot, P.G.3
  • 25
    • 0025222311 scopus 로고
    • Cultured normal human hepatocytes do not synthesize lipoprotein-associated coagulation inhibitor: Evidence that endothelium is the principal site of its synthesis
    • Bajaj MS, Kuppuswamy MN, Saito H, Spitzer SG, Bajaj SP: Cultured normal human hepatocytes do not synthesize lipoprotein-associated coagulation inhibitor: evidence that endothelium is the principal site of its synthesis. Proc Natl Acad Sci USA 1990;87:8869-8873.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8869-8873
    • Bajaj, M.S.1    Kuppuswamy, M.N.2    Saito, H.3    Spitzer, S.G.4    Bajaj, S.P.5
  • 26
    • 0031053413 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor concentrations in cirrhotic patients with and without portal vein thrombosis
    • Oksuzoglu G, Simsek H, Haznedaroglu IC, Kirazli S: Tissue factor pathway inhibitor concentrations in cirrhotic patients with and without portal vein thrombosis. Am J Gastroenterol 1997;92:303-306.
    • (1997) Am J Gastroenterol , vol.92 , pp. 303-306
    • Oksuzoglu, G.1    Simsek, H.2    Haznedaroglu, I.C.3    Kirazli, S.4
  • 27
    • 0020041246 scopus 로고
    • Kinetic and functional studies of platelets, fibrinogen, and plasminogen in patients with hepatic cirrhosis
    • Stein SF, Harker LA: Kinetic and functional studies of platelets, fibrinogen, and plasminogen in patients with hepatic cirrhosis. J Lab Clin Med 1982;99:217-230.
    • (1982) J Lab Clin Med , vol.99 , pp. 217-230
    • Stein, S.F.1    Harker, L.A.2
  • 29
    • 0018146207 scopus 로고
    • Quantitative estimation of coagulation factors in liver disease. The diagnostic and prognostic value of factor XIII, factor V and plasminogen
    • Biland L, Duckert F, Prisender S, Nyman D: Quantitative estimation of coagulation factors in liver disease. The diagnostic and prognostic value of factor XIII, factor V and plasminogen. Thromb Haemost 1978;39:646-656.
    • (1978) Thromb Haemost , vol.39 , pp. 646-656
    • Biland, L.1    Duckert, F.2    Prisender, S.3    Nyman, D.4
  • 30
    • 0028348758 scopus 로고
    • Tissue plasminogen activator, plasminogen activator inhibitors, and activator-inhibitor complex in liver disease
    • Leiper K, Croll A, Booth NA, Moore NR, Sinclair T, Bennett B: Tissue plasminogen activator, plasminogen activator inhibitors, and activator-inhibitor complex in liver disease. J Clin Pathol 1994;47:214-217.
    • (1994) J Clin Pathol , vol.47 , pp. 214-217
    • Leiper, K.1    Croll, A.2    Booth, N.A.3    Moore, N.R.4    Sinclair, T.5    Bennett, B.6
  • 31
    • 0026080024 scopus 로고
    • A shift in balance between profibrinolytic and antifibrinolytic factors causes enhanced fibrinolysis in cirrhosis
    • Leebeek FWG, Kluft C, Knot EAR, de Maat MPM, Wilson JHP: A shift in balance between profibrinolytic and antifibrinolytic factors causes enhanced fibrinolysis in cirrhosis. Gastroenterology 1991;101:1382-1390.
    • (1991) Gastroenterology , vol.101 , pp. 1382-1390
    • Leebeek, F.W.G.1    Kluft, C.2    Knot, E.A.R.3    de Maat, M.P.M.4    Wilson, J.H.P.5
  • 32
    • 0027438332 scopus 로고
    • Activation of the fibrinolytic system in patients with fulminant liver failure
    • Pernambuco JR, Langley PG, Hughes RD, Izumi S, Williams R: Activation of the fibrinolytic system in patients with fulminant liver failure. Hepatology 1993;18:1350-1356.
    • (1993) Hepatology , vol.18 , pp. 1350-1356
    • Pernambuco, J.R.1    Langley, P.G.2    Hughes, R.D.3    Izumi, S.4    Williams, R.5
  • 33
    • 4243610048 scopus 로고
    • Hyperfibrinolysis in liver cirrhosis
    • Greenwaldt P ed, Boca Raton, CRC Press
    • Leebeek FWG: Hyperfibrinolysis in liver cirrhosis; in Greenwaldt P (ed): Fibrinolysis in Disease. Boca Raton, CRC Press, 1995, pp 194-201.
    • (1995) Fibrinolysis in Disease , pp. 194-201
    • Leebeek, F.W.G.1
  • 34
    • 0027471093 scopus 로고
    • the CALC Group: Hyperfibrinolysis resulting from clotting activation in patients with different degrees of cirrhosis
    • Violi F, Ferro D, Basili S, Quintarelli C, Musca A, Cordova C, Balsano F, the CALC Group: Hyperfibrinolysis resulting from clotting activation in patients with different degrees of cirrhosis. Hepatology 1993;17:78-83.
    • (1993) Hepatology , vol.17 , pp. 78-83
    • Violi, F.1    Ferro, D.2    Basili, S.3    Quintarelli, C.4    Musca, A.5    Cordova, C.6    Balsano, F.7
  • 35
    • 0018691551 scopus 로고
    • Intravascular coagulation in autopsy cases with liver diseases
    • Oka K, Tanaka K: Intravascular coagulation in autopsy cases with liver diseases. Thromb Haemost 1979;42:564-570.
    • (1979) Thromb Haemost , vol.42 , pp. 564-570
    • Oka, K.1    Tanaka, K.2
  • 36
    • 0038798847 scopus 로고    scopus 로고
    • Deficiency of thrombin activatable fibrinolysis inhibitor in cirrhosis is associated with increased plasma fibrinolysis
    • Colucci M, Binetti BM, Branca MG, Clerici C, Morelli A, Semeraro N, Gresele P: Deficiency of thrombin activatable fibrinolysis inhibitor in cirrhosis is associated with increased plasma fibrinolysis. Hepatology 2003;38:230-237.
    • (2003) Hepatology , vol.38 , pp. 230-237
    • Colucci, M.1    Binetti, B.M.2    Branca, M.G.3    Clerici, C.4    Morelli, A.5    Semeraro, N.6    Gresele, P.7
  • 37
    • 0031048424 scopus 로고    scopus 로고
    • Coagulation and fibrinolysis in primary biliary cirrhosis compared with other liver disease and during orthotopic liver transplantation
    • Segal H, Cottam S, Potter D, Hunt BJ: Coagulation and fibrinolysis in primary biliary cirrhosis compared with other liver disease and during orthotopic liver transplantation. Hepatology 1997;25:683-688.
    • (1997) Hepatology , vol.25 , pp. 683-688
    • Segal, H.1    Cottam, S.2    Potter, D.3    Hunt, B.J.4
  • 39
    • 0010692253 scopus 로고    scopus 로고
    • Hemostatic abnormalities in liver and renal disease
    • Colman RW, Hirsh J, Marder VJ, Clowes AE, George JN eds, Philadelphia, Lippincott Williams & Wilkins
    • Joist JH, George JN: Hemostatic abnormalities in liver and renal disease; in Colman RW, Hirsh J, Marder VJ, Clowes AE, George JN (eds): Hemostasis and Thrombosis. Philadelphia, Lippincott Williams & Wilkins, 2001, pp 955-973.
    • (2001) Hemostasis and Thrombosis , pp. 955-973
    • Joist, J.H.1    George, J.N.2
  • 44
    • 33644978158 scopus 로고    scopus 로고
    • Abnormal hemostasis tests and bleeding in chronic liver disease: Are they related?
    • Mannucci PM: Abnormal hemostasis tests and bleeding in chronic liver disease: Are they related? No. J Thromb Haemost 2006;4:721-723.
    • (2006) J Thromb Haemost , vol.4 , pp. 721-723
    • Mannucci, P.M.1
  • 45
    • 33747203468 scopus 로고    scopus 로고
    • Hemostasis in chronic liver disease - Is chronic liver disease associated with a bleeding diathesis?
    • Lisman T, Caldwell SH, Leebeek FWG, Porte RJ: Hemostasis in chronic liver disease - Is chronic liver disease associated with a bleeding diathesis? J Thromb Haemost 2006;4:2059-2060.
    • (2006) J Thromb Haemost , vol.4 , pp. 2059-2060
    • Lisman, T.1    Caldwell, S.H.2    Leebeek, F.W.G.3    Porte, R.J.4
  • 46
    • 0035975323 scopus 로고    scopus 로고
    • Gastroesophageal variceal hemorrhage
    • Sharara AI, Rockey DC: Gastroesophageal variceal hemorrhage. N Engl J Med 2001;345:669-681.
    • (2001) N Engl J Med , vol.345 , pp. 669-681
    • Sharara, A.I.1    Rockey, D.C.2
  • 47
    • 26444613416 scopus 로고    scopus 로고
    • Minimizing blood loss in liver transplantation: Progress through research and evolution of techniques
    • De Boer MT, Molenaar IQ, Hendriks HG, Slooff MJ, Porte RJ: Minimizing blood loss in liver transplantation: progress through research and evolution of techniques. Dig Surg 2005;22:265-275.
    • (2005) Dig Surg , vol.22 , pp. 265-275
    • De Boer, M.T.1    Molenaar, I.Q.2    Hendriks, H.G.3    Slooff, M.J.4    Porte, R.J.5
  • 48
    • 4544300925 scopus 로고    scopus 로고
    • Specific laboratory methodologies achieve higher model for end-stage liver disease (MELD) scores for patients listed for liver transplantation
    • Trotter JF, Brimhall B, Arjal R, Phillips C: Specific laboratory methodologies achieve higher model for end-stage liver disease (MELD) scores for patients listed for liver transplantation. Liver Transpl 2004;10:995-1000.
    • (2004) Liver Transpl , vol.10 , pp. 995-1000
    • Trotter, J.F.1    Brimhall, B.2    Arjal, R.3    Phillips, C.4
  • 49
    • 0029912013 scopus 로고    scopus 로고
    • Prothrombin time in liver failure: Time, ratio, activity percentage, or international normalized ratio?
    • Robert A, Chazouilleres O: Prothrombin time in liver failure: time, ratio, activity percentage, or international normalized ratio? Hepatology 1996;24:1392-1394.
    • (1996) Hepatology , vol.24 , pp. 1392-1394
    • Robert, A.1    Chazouilleres, O.2
  • 51
    • 0038649821 scopus 로고    scopus 로고
    • Role of fresh-frozen plasma infusion in correction of coagulopathy of chronic liver disease: A dual phase study
    • Youssef WI, Salazar F, Dasarathy S, Beddow T, Mullen KD: Role of fresh-frozen plasma infusion in correction of coagulopathy of chronic liver disease: a dual phase study. Am J Gastroenterol 2003;98:1391-1394.
    • (2003) Am J Gastroenterol , vol.98 , pp. 1391-1394
    • Youssef, W.I.1    Salazar, F.2    Dasarathy, S.3    Beddow, T.4    Mullen, K.D.5
  • 55
    • 0037285948 scopus 로고    scopus 로고
    • Desmopressin does not decrease blood loss and transfusion requirements in patients undergoing hepatectomy
    • Wong AY, Irwin MG, Hui TW, Fung SK, Fan ST, Ma ES: Desmopressin does not decrease blood loss and transfusion requirements in patients undergoing hepatectomy. Can J Anaesth 2003;50:14-20.
    • (2003) Can J Anaesth , vol.50 , pp. 14-20
    • Wong, A.Y.1    Irwin, M.G.2    Hui, T.W.3    Fung, S.K.4    Fan, S.T.5    Ma, E.S.6
  • 58
    • 0029861942 scopus 로고    scopus 로고
    • Tranexamic acid reduces blood loss, transfusion requirements, and coagulation factor use in primary orthotopic liver transplantation
    • Boylan JF, Klinck JR, Sandler AN, Arellano R, Greig PD, Nierenberg H, Roger SL, Glynn MF: Tranexamic acid reduces blood loss, transfusion requirements, and coagulation factor use in primary orthotopic liver transplantation. Anesthesiology 1996;85:1043-1048.
    • (1996) Anesthesiology , vol.85 , pp. 1043-1048
    • Boylan, J.F.1    Klinck, J.R.2    Sandler, A.N.3    Arellano, R.4    Greig, P.D.5    Nierenberg, H.6    Roger, S.L.7    Glynn, M.F.8
  • 59
    • 31344467254 scopus 로고    scopus 로고
    • The risk associated with aprotinin in cardiac surgery
    • Mangano DT, Tudor IC, Dietzel C: The risk associated with aprotinin in cardiac surgery. N Engl J Med 2006;354:353-365.
    • (2006) N Engl J Med , vol.354 , pp. 353-365
    • Mangano, D.T.1    Tudor, I.C.2    Dietzel, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.