C-Terminal tensin-like gene functions as an oncogene and promotes cell motility in pancreatic cancer

Pancreas

Volumn 42, Issue 1, 2013, Pages 135-140

  Al Ghamdi, Saleh ^a,b   Cachat, Julien ^a   Albasri, Abdulkader ^a   Ahmed, Mohammed ^a   Jackson, Darryl ^a   Zaitoun, Abed ^a   Guppy, Naomi ^c   Otto, William R ^d   Alison, Malcolm R ^d   Kindle, Karin B ^a   Ilyas, Mohammad ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

cell motility; colony formation; CTEN; oncogene; pancreatic cancer

Indexed keywords

C TERMINAL TENSIN; FOCAL ADHESION KINASE; INTEGRIN LINKED KINASE; TENSIN; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CANCER CELL CULTURE; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CELL STIMULATION; COLONY FORMATION; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ONCOGENE; PANCREAS CANCER; PRIORITY JOURNAL;

CADHERINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FOCAL ADHESION KINASE 1; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; MICROFILAMENT PROTEINS; NEOPLASM INVASIVENESS; ONCOGENE PROTEINS; PANCREATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TISSUE ARRAY ANALYSIS; TRANSFECTION; UP-REGULATION;

EID: 84872070076     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3182557ceb     Document Type: Article

References (24)

1. Lo SH, Lo TB. Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. Cancer Res. 2002;62(15):4217-4221.
2. Lo SH. Tensin. Int J Biochem Cell Biol. 2004;36(1):31-34.
3. Lo SH, Janmey PA, Hartwig JH, et al. Interactions of tensin with actin and identification of its three distinct actin-binding domains. J Cell Biol. 1994;125(5):1067-1075.
4. Albasri A, Seth R, Jackson D, et al. C-terminal tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer. J Pathol. 2009;218(1):57-65.
5. Liao YC, Chen NT, Shih YP, et al. Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer through beta-catenin. Cancer Res. 2009;69(11):4563-4566. E-pub 2009.
6. Albasri A, Aleskandarany M, Benhasouna A, et al. CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma of poor prognosis. Breast Cancer Res Treat. 2011;126(1):47-54.
7. Katz M, Amit I, Citri A, et al. A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. Nat Cell Biol. 2007;9(8):961-969.
8. Sasaki H, Moriyama S, Mizuno K, et al. Cten mRNA expression was correlated with tumor progression in lung cancers. Lung Cancer. 2003;40(2):151-155.
9. Sakashita K, Mimori K, Tanaka F, et al. Prognostic relevance of Tensin4 expression in human gastric cancer. Ann Surg Oncol. 2008;15(9):2606-2613.
10. Sasaki H, Yukiue H, Kobayashi Y, et al. Cten mRNA expression is correlated with tumor progression in thymoma. Tumour Biol. 2003;24(5):271-274.
11. Barbieri I, Pensa S, Pannellini T, et al. Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten. Cancer Res. 2010;70(6):2558-2567. 2010. [Epub ahead of print].
12. Wong HH, Lemoine NR. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Nat Rev Gastroenterol Hepatol. 2009;6(7):412-422. 2009. [Epub ahead of print].
13. David M, Lepage C, Jouve JL, et al. Management and prognosis of pancreatic cancer over a 30-year period. Br J Cancer. 2009;101(2):215-218. 2009. [Epub ahead of print].
14. Morris JPT, Wang SC, Hebrok M. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer. 10:(10):683-695. 2010. [Epub ahead of print].
15. Al-Ghamdi S, Albasri A, Cachat J, et al. Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas. PloS one. 2011;6(6):e20919. 2011. [Epub ahead of print].
16. Aloysius MM, Zaitoun AM, Bates TE, et al. Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia. BMC Cancer. 2009;9:327. 2009. [Epub ahead of print].
17. Albasri A, Al-Ghamdi S, Fadhil W, et al. Cten signals through integrin-linked kinase (ILK) and may promote metastasis in colorectal cancer. Oncogene. 2011;30(26):2997-3002.
18. Elsaba TM, Martinez-Pomares L, Robins AR, et al. The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer. PloS One. 2010;5(5):e10714. 2010. [Epub ahead of print].
19. Ahmed MA, Jackson D, Seth R, et al. CD24 is upregulated in inflammatory bowel disease and stimulates cell motility and colony formation. Inflamm Bowel Dis. 2010;16(5):795-803. 2009. [Epub ahead of print].
20. Kajiwara Y, Panchabhai S, Levin VA. A new preclinical 3-dimensional agarose colony formation assay. Technol Cancer Res Treat. 2008;7(4):329-334. 2008. [Epub ahead of print].
21. Geback T, Schulz MM, Koumoutsakos P, et al. TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques. 2009;46(4):265-274. 2009. [Epub ahead of print].
22. Li A, Omura N, Hong SM, et al. Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels. Cancer Res. 2010;70(13):5226-5237. 2010. [Epub ahead of print].
23. Frisch SM, Screaton RA. Anoikis mechanisms. Curr Opin Cell Biol. 2001;13(5):555-562. 2001. [Epub ahead of print].
24. Ilyas M. Wnt signalling and the mechanistic basis of tumour development. J Pathol. 2005;205(2):130-144. 2005. [Epub ahead of print].