Severe stroke induces long-lasting alterations of high-mobility group Box 1

Stroke

Volumn 44, Issue 1, 2013, Pages 246-248

  Schulze, Juliane ^a   Zierath, Dannielle ^b   Tanzi, Patricia ^b   Cain, Kevin ^b   Shibata, Dean ^b   Dressel, Alexander ^a   Becker, Kyra ^b  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

alarmin; DAMP; HMGB1; inflammation; monocytes; stroke

Indexed keywords

BRAIN ANTIGEN; HIGH MOBILITY GROUP B1 PROTEIN; MYELIN BASIC PROTEIN;

ADAPTIVE IMMUNITY; ARTICLE; BRAIN ISCHEMIA; DISEASE SEVERITY; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; LEUKOCYTE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

BIOLOGICAL MARKERS; HMGB1 PROTEIN; HUMANS; LEUKOCYTES; SEVERITY OF ILLNESS INDEX; STROKE; TIME FACTORS;

EID: 84872068621     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.112.676072     Document Type: Article

References (13)

1. Buck BH, Liebeskind DS, Saver JL, Bang OY, Yun SW, Starkman S, et al. Early neutrophilia is associated with volume of ischemic tissue in acute stroke. Stroke. 2008;39:355-360.
2. Audebert HJ, Rott MM, Eck T, Haberl RL. Systemic inflammatory response depends on initial stroke severity but is attenuated by successful thrombolysis. Stroke. 2004;35:2128-2133.
3. Prass K, Meisel C, Höflich C, Braun J, Halle E, Wolf T, et al. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med. 2003;198:725-736.
4. Hug A, Dalpke A, Wieczorek N, Giese T, Lorenz A, Auffarth G, et al. Infarct volume is a major determiner of post-stroke immune cell function and susceptibility to infection. Stroke. 2009;40:3226-3232.
5. Becker KJ, Kalil AJ, Tanzi P, Zierath DK, Savos AV, Gee JM, et al. Autoimmune responses to the brain after stroke are associated with worse outcome. Stroke. 2011;42:2763-2769.
6. Oppenheim JJ, Tewary P, de la Rosa G, Yang D. Alarmins initiate host defense. Adv Exp Med Biol. 2007;601:185-194.
7. Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol. 2005;5:331-342.
8. Liu K, Mori S, Takahashi HK, Tomono Y, Wake H, Kanke T, et al. Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats. FASEB J. 2007;21:3904-3916.
9. Muhammad S, Barakat W, Stoyanov S, Murikinati S, Yang H, Tracey KJ, et al. The HMGB1 receptor RAGE mediates ischemic brain damage. J Neurosci. 2008;28:12023-12031.
10. Sims JR, Gharai LR, Schaefer PW, Vangel M, Rosenthal ES, Lev MH, et al. ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes. Neurology. 2009;72:2104-2110.
11. Qiu J, Nishimura M, Wang Y, Sims JR, Qiu S, Savitz SI, et al. Early release of HMGB-1 from neurons after the onset of brain ischemia. J Cereb Blood Flow Metab. 2008;28:927-938.
12. Kim JB, Sig Choi J, Yu YM, Nam K, Piao CS, Kim SW, et al. HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. J Neurosci. 2006;26:6413-6421.
13. Vogelgesang A, May VE, Grunwald U, Bakkeboe M, Langner S, Wallaschofski H, et al. Functional status of peripheral blood T-cells in ischemic stroke patients. PLoS ONE. 2010;5:e8718.