Is intra-arterial thrombolysis beneficial for M2 occlusions? Subgroup analysis of the PROACT-II trial

Stroke

Volumn 44, Issue 1, 2013, Pages 240-242

  Rahme, Ralph ^a   Abruzzo, Todd A ^a   Martin, Renee Hebert ^c   Tomsick, Thomas A ^b   Ringer, Andrew J ^a   Furlan, Anthony J ^d   Carrozzella, Janice A ^b   Khatri, Pooja ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

acute ischemic stroke; intra arterial thrombolysis; middle cerebral artery; prourokinase

Indexed keywords

HEPARIN; SARUPLASE;

ADULT; AGED; ARTICLE; BRAIN ANGIOGRAPHY; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MECHANICAL THROMBECTOMY; MIDDLE CEREBRAL ARTERY OCCLUSION; OPEN STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REFERENCE DATABASE; REPERFUSION;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; INJECTIONS, INTRA-ARTERIAL; MALE; MIDDLE AGED; RECOMBINANT PROTEINS; THROMBOLYTIC THERAPY; TREATMENT OUTCOME; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84872055493     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.112.671495     Document Type: Article

References (6)

1. IMS Study Investigators. Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke. 2004;35:904-911.
2. Arnold M, Kappeler L, Nedeltchev K, Brekenfeld C, Fischer U, Keserue B, et al. Recanalization and outcome after intra-arterial thrombolysis in middle cerebral artery and internal carotid artery occlusion: does sex matter? Stroke. 2007;38:1281-1285.
3. Tomsick T, Broderick J, Carrozella J, Khatri P, Hill M, Palesch Y, et al. Revascularization results in the Interventional Management of Stroke II trial. AJNR Am J Neuroradiol. 2008;29:582-587.
4. Shi ZS, Loh Y, Walker G, Duckwiler GR; MERCI and Multi-MERCI Investigators. Clinical outcomes in middle cerebral artery trunk occlusions versus secondary division occlusions after mechanical thrombectomy: pooled analysis of the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI trials. Stroke. 2010;41:953-960.
5. Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, et al.Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA. 1999;282:2003-2011.
6. Tomsick TA, Khatri P, Jovin T, Demaerschalk B, Malisch T, Demchuk A, et al. Equipoise among recanalization strategies. Neurology. 2010;74:1069-1076.