Engineering of magnetic DNA nanoparticles for tumor-targeted therapy

Journal of Nanoparticle Research

Volumn 15, Issue 1, 2013, Pages

  Hosseinkhani, Hossein ^a   Chen, Yi Ru ^b   He, Wenjie ^a   Hong, Po Da ^a   Yu, Dah Shyong ^c   Domb, Abraham J ^d  

^a NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Dextran; Magnetic; Nanoparticles; Plasmid DNA; Tumor targeting

Indexed keywords

BIOMOLECULES; CHEMICAL BONDS; DEXTRAN; EFFICIENCY; GENE THERAPY; GENE TRANSFER; LIGHT SCATTERING; MAGNETIC NANOPARTICLES; MAGNETISM; METAL NANOPARTICLES; NANOPARTICLES; TRANSMISSION ELECTRON MICROSCOPY; TUMORS;

DYNAMIC LIGHT SCATTERING MEASUREMENT; ELECTROPHORETIC LIGHT SCATTERING; EXTERNAL MAGNETIC FIELD; MAGNETIC; NON-VIRAL GENE DELIVERY; PLASMID DNA; TARGETED DELIVERY SYSTEMS; TUMOR TARGETING;

DNA;

DEXTRAN; DNA NANOPARTICLE; IRON; MAGNETIC NANOPARTICLE; PLASMID DNA; SPERMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INVASION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG TARGETING; ELECTROPHORETIC LIGHT SCATTERING; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84872043651     PISSN: 13880764     EISSN: 1572896X     Source Type: Journal    
DOI: 10.1007/s11051-012-1345-z     Document Type: Article

References (33)

1. Abdullah S, Yeo Y, Hosseinkhani H, Hosseinkhani M, Masrawa E, Ramasamy R, Rosli R, Rahman SA, Domb AJ (2010) Gene transfer into the lung by nanoparticles dextran-spermine/plasmid DNA complexes. J Biomed Biotechnol 2010:1-10
2. Abedini F, Ismail M, Hosseinkhani H, Azmi TI, Omar AR, Chong PP et al (2010) Toxicity evaluation of dextran-spermine polycation as a tool for gene therapy in vitro. J Cell Anim Biol 4:170-176
3. Abedini F, Hosseinkhani H, Ismail M, Omar AR, Chong PP, Domb AJ (2011a) In vitro intracellular trafficking of biodegradable nanoparticles of dextran-spermine in cancer cell lines. Int J Nanotechnol 8:712-723
4. Abedini F, Ismail M, Hosseinkhani H, Azmi TI, Omar AR, Pei Pei C, Bejo MH, Domb AJ (2011b) Effects of CXCR4 siRNAs/dextran-spermine nanoparticles on CXCR4 expression and serum LDH levels in a mouse model of colorectal cancer metastasis to the liver. Cancer Manag Res 3:301-309
5. Azzam T, Eliyahu H, Shapira L, Linial M, Barenholz Y, Domb AJ (2002) Polysaccharide-oligo amine based conjugates for gene delivery. J Med Chem 45:1817-1823 (Pubitemid 34415377)
6. Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353-364 (Pubitemid 26272076)
7. Harris JM, Chess RB (2003) Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov 2:214-221 (Pubitemid 37361666)
8. Holmgren L, O'Reilly MS, Folkman J (1995) Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1:149-153
9. Hosseinkhani H (2006) DNA nanoparticles for gene delivery to cells and tissue. Int J Nanotechnol 3:416-461 (Pubitemid 46003822)
10. Hosseinkhani H, Hosseinkhani M (2009) Biodegradable polymer-metal complexes for gene and drug delivery. Curr Drug Saf 4:79-83
11. Hosseinkhani H, Tabata Y (2005) Ultrasound enhances in vivo tumor expression of plasmid DNA by PEG-introduced cationized dextran. J Control Release 108:540-556 (Pubitemid 41608682)
12. Hosseinkhani H, Aoyama T, Ogawa O, Tabata Y (2002) Liver targeting of plasmid DNA by pullulan conjugation based on metal coordination. J Control Release 83:286-301 (Pubitemid 35279472)
13. Hosseinkhani H, Aoyama T, Ogawa O, Tabata Y (2003) Tumor targeting of gene expression by dextran conjugation based on metal coordination. J Control Release 88:297-312 (Pubitemid 36287346)
14. Hosseinkhani H, Azzam T, Tabata Y, Domb AJ (2004) Dextran-spermine polycation: an efficient nonviral vector for in vitro and in vivo gene transfection. Gene Ther 11:194-203 (Pubitemid 38159692)
15. Hosseinkhani H, Azzam T, Kobayashi H, Hiraoka Y, Shimokawa H, Domb AJ, Tabata Y (2006a) Combination of 3-D tissue engineered scaffold and non-viral gene enhance in vitro DNA expression of mesenchymal stem cells. Biomaterials 27:269-4278
16. Hosseinkhani H, Kushibiki T, Matsumoto K, Nakamura T, Tabata Y (2006b) Enhanced suppression of tumor growth using a combination of NK4 plasmid DNA-PEG engrafted cationized dextran complex and ultrasound. Cancer Gene Ther 13:479-489
17. Hosseinkhani H, Hosseinkhani M, Khademhosseini (2006c) A Emerging applications of hydrogels and microscale technologies in drug discovery. Drug Discov 1:32-34
18. Hosseinkhani M, Hosseinkhani H, Chen YR, Subramani K (2011a) In vitro physicochemical evaluation of DNA nanoparticles. Int J Nanotechnol 8:736-748
19. Hosseinkhani H, Hosseinkhani M, Chen YR, Subramani K, Domb AJ (2011b) Innovative technology of engineering magnetic DNA nanoparticles for gene therapy. Int J Nanotechnol 8:724-735
20. Kircheis R, Wightman L, Schreiber A, Robitza B, Rossler V, Kursa M, Wagner (2001) Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application. Gene Ther 8:28-40 (Pubitemid 32162413)
21. Kuba K, Matsumoto K, Ohnishi K, Shiratsuchi T, Tanaka M, Nakamura T (2000a) Kringle 1-4 of hepatocyte growth factor inhibits proliferation and migration of human microvascular endothelial cells. Biochem Biophys Res Commun 279:846-852 (Pubitemid 32042865)
22. Kuba K, Matsumoto K, Date K, Shimura H, Tanaka M, Nakamura T (2000b) HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice. Cancer Res 60:6737-6743
23. Kushibiki T, Matsumoto K, Nakamura T, Tabata Y (2004) Suppression of tumor metastasis by NK4 plasmid DNA released from cationized gelatin. Gene Ther 11:1205-1214 (Pubitemid 39136784)
24. Langer R, Tirrell DA (2004) Designing materials for biology and medicine. Nature 428:487-492 (Pubitemid 38480528)
25. Maemondo M, Narumi K, Saijo Y et al (2002) Targeting angiogenesis and HGF function using an adenoviral vector expressing the HGF antagonist NK4 for cancer therapy. Mol Ther 5:177-185 (Pubitemid 34144834)
26. Mahmoudi M, Hosseinkhani H, Hosseinkhani M, Boutry S, Simchi A, Journeay WS et al (2011) Magnetic resonance imaging tracking of stem cells in vivo using iron oxide nanoparticles as a tool for the advancement of clinical regenerative medicine. Chem Rev 111:253-280
27. Molineux G (2003) Pegylation: engineering improved biopharmaceuticals for oncology. Pharmacotherapy 23:3S-8S (Pubitemid 36904012)
28. O'Reilly MS, Holmgren L, Chen C, Folkman J (1996) Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 2:689-692 (Pubitemid 26191958)
29. Peppas NA, Langer R (1994) New challenges in biomaterials. Science 263:1715-1720 (Pubitemid 24131582)
30. Roberts MJ, Bentley MD, Harris JM (2002) Chemistry for peptide and protein PEGylation. Adv Drug Deliv Rev 54:459-476 (Pubitemid 34615543)
31. Saimura M, Nagai E, Mizumoto K et al (2002) Intraperitoneal injection of adenovirus-mediated NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice. Cancer Gene Ther 9:799-806
32. Sato N, Kobayashi H, Saga T, Nakamoto Y, Ishimori T, Togashi K et al (2001) Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice. Clin Cancer Res 7:3606-3612 (Pubitemid 33070001)
33. Sim BK, MacDonald NJ, Gubish ER (2000) Angiostatin and endostatin: endogenous inhibitors of tumor growth. Cancer Metastasis Rev 19:181-190 (Pubitemid 32004708)