메뉴 건너뛰기




Volumn 33, Issue SUPPL. 1, 2013, Pages 157-163

Why do I treat HBeAg-negative chronic hepatitis B patients with pegylated interferon?

Author keywords

Chronic hepatitis B; HBeAg negative; HBsAg levels; HBV DNA; IL28B polymorphism; PEG IFN ; Sustained response

Indexed keywords

ENTECAVIR; HEPATITIS B(E) ANTIGEN; INTERLEUKIN 28B; LAMIVUDINE; PEGINTERFERON; PEGINTERFERON ALPHA2A; RIBAVIRIN; TENOFOVIR; VIRUS DNA;

EID: 84872039847     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12064     Document Type: Review
Times cited : (16)

References (35)
  • 1
    • 84862664371 scopus 로고    scopus 로고
    • Management of chronic hepatitis B virus infection
    • EASL Clinical Practice Guidelines.
    • EASL Clinical Practice Guidelines. Management of chronic hepatitis B virus infection. J Hepatol 2012; 57: 167-85.
    • (2012) J Hepatol , vol.57 , pp. 167-185
  • 2
    • 33847701354 scopus 로고    scopus 로고
    • Chronic hepatitis B
    • Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology 2007; 45: 507-39.
    • (2007) Hepatology , vol.45 , pp. 507-539
    • Lok, A.S.1    McMahon, B.J.2
  • 3
    • 20444363583 scopus 로고    scopus 로고
    • Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2005 update
    • Liaw YF, Leung N, Guan R, et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2005 update. Liver Int 2005; 25: 472-89.
    • (2005) Liver Int , vol.25 , pp. 472-489
    • Liaw, Y.F.1    Leung, N.2    Guan, R.3
  • 4
    • 18444405565 scopus 로고    scopus 로고
    • Pharmacokinetics of pegylated interferons: what is misleading?
    • Caliceti P. Pharmacokinetics of pegylated interferons: what is misleading? Dig Liver Dis 2004; 36: S334-9.
    • (2004) Dig Liver Dis , vol.36
    • Caliceti, P.1
  • 5
    • 17844380498 scopus 로고    scopus 로고
    • Pegylation: a novel process for modifying pharmacokinetics
    • Harris JM, Martin NE, Modi M. Pegylation: a novel process for modifying pharmacokinetics. Clin Pharmacokinet 2011; 40: 539-51.
    • (2011) Clin Pharmacokinet , vol.40 , pp. 539-551
    • Harris, J.M.1    Martin, N.E.2    Modi, M.3
  • 6
    • 0037381649 scopus 로고    scopus 로고
    • Long-term suppression of hepatitis B e antigen-negative chronic hepatitis B by 24-month interferon therapy
    • Lampertico P, Del Ninno E, Viganò M, et al. Long-term suppression of hepatitis B e antigen-negative chronic hepatitis B by 24-month interferon therapy. Hepatology 2003; 37: 756-63.
    • (2003) Hepatology , vol.37 , pp. 756-763
    • Lampertico, P.1    Del Ninno, E.2    Viganò, M.3
  • 7
    • 66449106670 scopus 로고    scopus 로고
    • Efficacy and impact on disease progression of IFN treatment in patients with HBeAg-negative chronic hepatitis B: a long term Italian multicenter A.I.S.F. cohort study
    • Oliveri F, Puoti M, Santantonio T, et al. Efficacy and impact on disease progression of IFN treatment in patients with HBeAg-negative chronic hepatitis B: a long term Italian multicenter A.I.S.F. cohort study. Hepatology 2005; 42: 577A.
    • (2005) Hepatology , vol.42
    • Oliveri, F.1    Puoti, M.2    Santantonio, T.3
  • 8
    • 0037325438 scopus 로고    scopus 로고
    • Natural history and prognosis of hepatitis B
    • Fattovich G. Natural history and prognosis of hepatitis B. Semin Liver Dis 2003; 23: 47-58.
    • (2003) Semin Liver Dis , vol.23 , pp. 47-58
    • Fattovich, G.1
  • 9
    • 38049044476 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors
    • Fattovich G, Bortolotti F, Donato F. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol 2008; 48: 335-52.
    • (2008) J Hepatol , vol.48 , pp. 335-352
    • Fattovich, G.1    Bortolotti, F.2    Donato, F.3
  • 10
    • 2942596233 scopus 로고    scopus 로고
    • The natural history of chronic hepatitis B virus infection
    • McMahon BJ. The natural history of chronic hepatitis B virus infection. Semin Liver Dis 2004; 24: S17-21.
    • (2004) Semin Liver Dis , vol.24
    • McMahon, B.J.1
  • 11
    • 0035110693 scopus 로고    scopus 로고
    • The long-term outcome of interferon-alpha treated and untreated patients with HBeAg-negative chronic hepatitis B
    • Papatheodoridis GV, Manesis E, Hadziyannis SJ. The long-term outcome of interferon-alpha treated and untreated patients with HBeAg-negative chronic hepatitis B. J Hepatol 2001; 34: 306-13.
    • (2001) J Hepatol , vol.34 , pp. 306-313
    • Papatheodoridis, G.V.1    Manesis, E.2    Hadziyannis, S.J.3
  • 12
    • 0036168816 scopus 로고    scopus 로고
    • Outcome of anti-HBe positive chronic hepatitis B in alpha interferon treated and untreated patients: a long term cohort study
    • Brunetto MR, Oliveri F, Coco B, et al. Outcome of anti-HBe positive chronic hepatitis B in alpha interferon treated and untreated patients: a long term cohort study. J Hepatol 2002; 36: 263-70.
    • (2002) J Hepatol , vol.36 , pp. 263-270
    • Brunetto, M.R.1    Oliveri, F.2    Coco, B.3
  • 13
    • 0033002176 scopus 로고    scopus 로고
    • The long term course of chronic hepatitis B
    • Di Marco V, Lo Iacono O, Cammà C, et al. The long term course of chronic hepatitis B. Hepatology 1999; 30: 257-64.
    • (1999) Hepatology , vol.30 , pp. 257-264
    • Di Marco, V.1    Lo Iacono, O.2    Cammà, C.3
  • 14
    • 4544239807 scopus 로고    scopus 로고
    • Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B
    • Marcellin P, Lau GK, Bonino F, et al. Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2004; 351: 1206-17.
    • (2004) N Engl J Med , vol.351 , pp. 1206-1217
    • Marcellin, P.1    Lau, G.K.2    Bonino, F.3
  • 15
    • 66449121130 scopus 로고    scopus 로고
    • Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a
    • Marcellin P, Bonino F, Lau GK, et al. Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a. Gastroenterology 2009; 136: 2169-79.
    • (2009) Gastroenterology , vol.136 , pp. 2169-2179
    • Marcellin, P.1    Bonino, F.2    Lau, G.K.3
  • 16
    • 84872020257 scopus 로고    scopus 로고
    • Sustained immune control 1 year post-treatment with Peginterferon Alfa-2a [40KD] (PEGASYS) is durable up to 5 years post-treatment and is associated with a high rate of HBsAg clearance in HBeAg-negative chronic hepatitis B. 20th Conference of the Asian Pacific Association for the Study of the Liver (APASL), 25-28 March, Beijing, China.
    • Piratvisuth T, Marcellin P, Brunetto M, et al. Sustained immune control 1 year post-treatment with Peginterferon Alfa-2a [40KD] (PEGASYS) is durable up to 5 years post-treatment and is associated with a high rate of HBsAg clearance in HBeAg-negative chronic hepatitis B. 20th Conference of the Asian Pacific Association for the Study of the Liver (APASL), 25-28 March 2010, Beijing, China.
    • (2010)
    • Piratvisuth, T.1    Marcellin, P.2    Brunetto, M.3
  • 17
    • 34247538953 scopus 로고    scopus 로고
    • Predicting response to peginterferon alpha-2a, lamivudine and the two combined for HBeAg-negative chronic hepatitis B
    • Bonino F, Marcellin P, Lau GK, et al. Predicting response to peginterferon alpha-2a, lamivudine and the two combined for HBeAg-negative chronic hepatitis B. Gut 2007; 56: 699-705.
    • (2007) Gut , vol.56 , pp. 699-705
    • Bonino, F.1    Marcellin, P.2    Lau, G.K.3
  • 18
    • 84874471701 scopus 로고    scopus 로고
    • IL28B polymorphisms predict interferon-related HBsAg seroclearance in genotype D HBeAg negative patients with chronic hepatitis B
    • doi: 10.1002/hep.25749.
    • Lampertico P, Viganò M, Cheroni C, et al. IL28B polymorphisms predict interferon-related HBsAg seroclearance in genotype D HBeAg negative patients with chronic hepatitis B. Hepatology 2012. doi: 10.1002/hep.25749.
    • (2012) Hepatology
    • Lampertico, P.1    Viganò, M.2    Cheroni, C.3
  • 19
    • 84874491566 scopus 로고    scopus 로고
    • Studies of IL28B genotype and response to peginterferon in chronic hepatitis B Should be stratified by HBV genotype
    • doi: 10.1002/hep.25882. [Epub ahead of print]
    • Lampertico P, Galmozzi E, Colombo M. Studies of IL28B genotype and response to peginterferon in chronic hepatitis B Should be stratified by HBV genotype. Hepatology 2012. doi: 10.1002/hep.25882. [Epub ahead of print]
    • (2012) Hepatology
    • Lampertico, P.1    Galmozzi, E.2    Colombo, M.3
  • 20
    • 73449142131 scopus 로고    scopus 로고
    • A randomized controlled trial of pegylated interferon-alpha2a plus adefovir dipivoxil for hepatitis B e antigen negative chronic hepatitis B
    • Piccolo P, Lenci I, Demelia L, et al. A randomized controlled trial of pegylated interferon-alpha2a plus adefovir dipivoxil for hepatitis B e antigen negative chronic hepatitis B. Antivir Ther 2009; 14: 1165-74.
    • (2009) Antivir Ther , vol.14 , pp. 1165-1174
    • Piccolo, P.1    Lenci, I.2    Demelia, L.3
  • 21
    • 79960678798 scopus 로고    scopus 로고
    • Sequential therapy with adefovir dipivoxil and pegylated interferon alfa-2a for HBeAg-negative patients
    • Moucari R, Boyer N, Ripault MP, et al. Sequential therapy with adefovir dipivoxil and pegylated interferon alfa-2a for HBeAg-negative patients. J Viral Hepat 2011; 18: 580-6.
    • (2011) J Viral Hepat , vol.18 , pp. 580-586
    • Moucari, R.1    Boyer, N.2    Ripault, M.P.3
  • 22
    • 77955383602 scopus 로고    scopus 로고
    • A randomized trial of peginterferon alpha-2a with or without ribavirin for HBeAg-negative chronic hepatitis B
    • Rijckborst V, Ter Borg MJ, Cakaloglu Y, et al. A randomized trial of peginterferon alpha-2a with or without ribavirin for HBeAg-negative chronic hepatitis B. Am J Gastroenterol 2010; 105: 1762-9.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1762-1769
    • Rijckborst, V.1    Ter Borg, M.J.2    Cakaloglu, Y.3
  • 23
    • 0030724692 scopus 로고    scopus 로고
    • A randomized, controlled trial of a 24-month course of interferon alfa 2b in patients with chronic hepatitis B who had hepatitis virus DNA without hepatitits B e antigen in serum
    • Lampertico P, Del Ninno E, Manzin A, et al. A randomized, controlled trial of a 24-month course of interferon alfa 2b in patients with chronic hepatitis B who had hepatitis virus DNA without hepatitits B e antigen in serum. Hepatology 1997; 26: 1621-5.
    • (1997) Hepatology , vol.26 , pp. 1621-1625
    • Lampertico, P.1    Del Ninno, E.2    Manzin, A.3
  • 24
    • 35948931362 scopus 로고    scopus 로고
    • A pilot study of extended duration peginterferon alfa-2a for patients with hepatitis B e antigen-negative chronic hepatitis B
    • Gish RG, Lau DT, Schmid P, Perrillo R. A pilot study of extended duration peginterferon alfa-2a for patients with hepatitis B e antigen-negative chronic hepatitis B. Am J Gastroenterol 2007; 102: 2718-23.
    • (2007) Am J Gastroenterol , vol.102 , pp. 2718-2723
    • Gish, R.G.1    Lau, D.T.2    Schmid, P.3    Perrillo, R.4
  • 25
    • 84872069582 scopus 로고    scopus 로고
    • Randomised study comparing 48 and 96 weeks peginterferon α-2a therapy in genotype D HBeAg-negative chronic hepatitis B
    • PMID: 22859496.
    • Lampertico P, Viganò M, Di Costanzo GG, et al. Randomised study comparing 48 and 96 weeks peginterferon α-2a therapy in genotype D HBeAg-negative chronic hepatitis B. Gut 2012; PMID: 22859496.
    • (2012) Gut
    • Lampertico, P.1    Viganò, M.2    Di Costanzo, G.G.3
  • 26
    • 40949158076 scopus 로고    scopus 로고
    • Comparing the safety, tolerability and quality of life in patients with chronic hepatitis B vs chronic hepatitis C treated with peginterferon alpha-2a
    • Marcellin P, Lau GK, Zeuzem S, et al. Comparing the safety, tolerability and quality of life in patients with chronic hepatitis B vs chronic hepatitis C treated with peginterferon alpha-2a. Liver Int 2008; 28: 477-85.
    • (2008) Liver Int , vol.28 , pp. 477-485
    • Marcellin, P.1    Lau, G.K.2    Zeuzem, S.3
  • 27
    • 65449123444 scopus 로고    scopus 로고
    • Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients
    • Moucari R, Mackiewicz V, Lada O, et al. Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients. Hepatology 2009; 49: 1151-7.
    • (2009) Hepatology , vol.49 , pp. 1151-1157
    • Moucari, R.1    Mackiewicz, V.2    Lada, O.3
  • 28
    • 79957533576 scopus 로고    scopus 로고
    • On-treatment decline in serum HBsAg levels predicts sustained immune control 1 year posttreatment, subsequent HBsAg clearance in HBeAg-negative hepatitis B virus-infected patients treated with peginterferon alfa-2a
    • Marcellin P, Piratvisuth T, Brunetto M, et al. On-treatment decline in serum HBsAg levels predicts sustained immune control 1 year posttreatment, subsequent HBsAg clearance in HBeAg-negative hepatitis B virus-infected patients treated with peginterferon alfa-2a. Hepatol Int 2010; 4: 151.
    • (2010) Hepatol Int , vol.4 , pp. 151
    • Marcellin, P.1    Piratvisuth, T.2    Brunetto, M.3
  • 29
    • 84858955374 scopus 로고    scopus 로고
    • PegBeLiver study: HBsAg decline at week 24 of extended peginterferon alfa-2a (Peg-IFNα-2a) therapy is significantly associated with post-treatment response in HBeAg-negative genotype D patients
    • Lampertico P, Viganò M, Galeota Lanza A, et al. PegBeLiver study: HBsAg decline at week 24 of extended peginterferon alfa-2a (Peg-IFNα-2a) therapy is significantly associated with post-treatment response in HBeAg-negative genotype D patients. J Hepatol 2011; 54: S293.
    • (2011) J Hepatol , vol.54
    • Lampertico, P.1    Viganò, M.2    Galeota Lanza, A.3
  • 30
    • 58649123220 scopus 로고    scopus 로고
    • In patients with HBeAg-negative chronic hepatitis B HBsAg serum levels early during treatment with peginterferon alfa-2a predict HBsAg clearance 4 years post-treatment
    • Marcellin P, Brunetto M, Bonino F, et al. In patients with HBeAg-negative chronic hepatitis B HBsAg serum levels early during treatment with peginterferon alfa-2a predict HBsAg clearance 4 years post-treatment. Hepatology 2008; 48: 718A.
    • (2008) Hepatology , vol.48
    • Marcellin, P.1    Brunetto, M.2    Bonino, F.3
  • 31
    • 65449117946 scopus 로고    scopus 로고
    • Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B
    • Brunetto MR, Moriconi F, Bonino F, et al. Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B. Hepatology 2009; 49: 1141-50.
    • (2009) Hepatology , vol.49 , pp. 1141-1150
    • Brunetto, M.R.1    Moriconi, F.2    Bonino, F.3
  • 32
    • 77955703978 scopus 로고    scopus 로고
    • Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B using HBsAg and HBV DNA levels
    • Rijckborst V, Hansen BE, Cakaloglu Y, et al. Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B using HBsAg and HBV DNA levels. Hepatology 2010; 52: 454-61.
    • (2010) Hepatology , vol.52 , pp. 454-461
    • Rijckborst, V.1    Hansen, B.E.2    Cakaloglu, Y.3
  • 33
    • 84859734382 scopus 로고    scopus 로고
    • Validation of a stopping rule at week 12 using HBsAg and HBV DNA for HBeAg-negative patients treated with peginterferon alfa-2a
    • Rijckborst V, Hansen BE, Ferenci P, et al. Validation of a stopping rule at week 12 using HBsAg and HBV DNA for HBeAg-negative patients treated with peginterferon alfa-2a. J Hepatol 2012; 56: 1006-11.
    • (2012) J Hepatol , vol.56 , pp. 1006-1011
    • Rijckborst, V.1    Hansen, B.E.2    Ferenci, P.3
  • 34
    • 84861865262 scopus 로고    scopus 로고
    • Adding pegylated interferon to a current nucleos(t)ide therapy leads to HBsAg seroconversion in a subgroup of patients with chronic hepatitis B
    • Kittner JM, Sprinzl MF, Grambihler A, et al. Adding pegylated interferon to a current nucleos(t)ide therapy leads to HBsAg seroconversion in a subgroup of patients with chronic hepatitis B. J Clin Virol 2012; 54: 93-5.
    • (2012) J Clin Virol , vol.54 , pp. 93-95
    • Kittner, J.M.1    Sprinzl, M.F.2    Grambihler, A.3
  • 35
    • 84872049814 scopus 로고    scopus 로고
    • Add-on Peg-IFN improves HBsAg kinetics in patients long-term fully suppressed by nucleos(t)ide analogs
    • Lampertico P, Invernizzi F, Soffredini R, et al. Add-on Peg-IFN improves HBsAg kinetics in patients long-term fully suppressed by nucleos(t)ide analogs. J Hepatol 2012; 56S: S207.
    • (2012) J Hepatol , vol.56
    • Lampertico, P.1    Invernizzi, F.2    Soffredini, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.