Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1

PLoS Pathogens

Volumn 8, Issue 12, 2012, Pages

  Tellam, Judy T ^a   Lekieffre, Lea ^a   Zhong, Jie ^a   Lynn, David J ^b   Khanna, Rajiv ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b TEAGASC   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYTOKINE; EPSTEIN BARR VIRUS ANTIGEN 1; GLYCINE; MESSENGER RNA; SERINE;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; CONFOCAL MICROSCOPY; DENSITOMETRY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; FRAMESHIFT MUTATION; GAMMAHERPESVIRINAE; GENE CONSTRUCT; GENE DELETION; HERPES VIRUS; HUMAN; HUMAN CELL; LYMPHOCRYPTOVIRUS; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; BASE SEQUENCE; CELL LINE; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; FRAMESHIFT MUTATION; GENES, MHC CLASS I; HEK293 CELLS; HUMANS; IMMUNE EVASION; MOLECULAR SEQUENCE DATA; REPETITIVE SEQUENCES, AMINO ACID; RNA, MESSENGER; SEQUENCE ALIGNMENT; T-LYMPHOCYTES, CYTOTOXIC;

HUMAN HERPESVIRUS 4; LYMPHOCRYPTOVIRUS;

EID: 84872038873     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003112     Document Type: Article

References (42)

1. Blake N, (2010) Immune evasion by gammaherpesvirus genome maintenance proteins. J Gen Virol 91: 829-846.
2. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM, (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 332: 1186-1191.
3. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, et al. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266: 1865-1869.
4. Rickinson AB, and Kieff E. (1996) Epstein-Barr Virus; In: Fields BN, Knipe DM, and Howley PM, eds. Philadelphia: Lippincott, Williams and Wilkins. pp. 2397-2446.
5. Feeney KM, Parish JL, (2009) Targeting mitotic chromosomes: a conserved mechanism to ensure viral genome persistence. Proc Biol Sci 276: 1535-1544.
6. Stevenson PG, (2004) Immune evasion by gamma-herpesviruses. Curr Opin Immunol 16: 456-462.
7. Hansen TH, Bouvier M, (2009) MHC class I antigen presentation: learning from viral evasion strategies. Nat Rev Immunol 9: 503-513.
8. Lindner SE, Sugden B, (2007) The plasmid replicon of Epstein-Barr virus: mechanistic insights into efficient, licensed, extrachromosomal replication in human cells. Plasmid 58: 1-12.
9. Zaldumbide A, Ossevoort M, Wiertz EJ, Hoeben RC, (2006) In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus. Mol Immunol 44: 1352-1360.
10. Yin Y, Manoury B, Fahraeus R, (2003) Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1. Science 301: 1371-1374.
11. Tellam J, Fogg MH, Rist M, Connolly G, Tscharke D, et al. (2007) Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes. J Exp Med 204: 525-532.
12. Tellam J, Smith C, Rist M, Webb N, Cooper L, et al. (2008) Regulation of protein translation through mRNA structure influences MHC class I loading and T cell recognition. Proc Natl Acad Sci U S A 105: 9319-9324.
13. Lee SP, Brooks JM, Al Jarrah H, Thomas WA, Haigh TA, et al. (2004) CD8 T cell recognition of endogenously expressed epstein-barr virus nuclear antigen 1. The Journal of Experimental Medicine 199: 1409-1420.
14. Voo KS, Fu T, Wang HY, Tellam J, Heslop HE, et al. (2004) Evidence for the presentation of major histocompatibility complex class I-restricted Epstein-Barr virus nuclear antigen 1 peptides to CD8+ T lymphocytes. Journal of Experimental Medicine 199: 459-470.
15. Ossevoort M, Zaldumbide A, te Velthuis AJ, Melchers M, Ressing ME, et al. (2007) The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis. Mol Immunol 44: 3588-3596.
16. Kwun HJ, da Silva SR, Shah IM, Blake N, Moore PS, et al. (2007) Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing. J Virol 81: 8225-8235.
17. Frappier L (2003) The Biology of Plasmids. Washington DC: ASM Press.
18. Kieff E, Rickinson AB (2001) Epstein-Barr virus and its replication. In: Knipe DM, Howley, PM., editor. Field's Virology. Philadelphia: Lippincott Williams and Wilkins. pp. 2511-2573.
19. Apcher S, Komarova A, Daskalogianni C, Yin Y, Malbert-Colas L, et al. (2009) mRNA translation regulation by the Gly-Ala repeat of Epstein-Barr virus nuclear antigen 1. J Virol 83: 1289-1298.
20. Tellam J, Connolly G, Green KJ, Miles JJ, Moss DJ, et al. (2004) Endogenous presentation of CD8+ T cell epitopes from Epstein-Barr virus-encoded nuclear antigen 1. J Exp Med 199: 1421-1431.
21. Levitskaya J, Coram M, Levitsky V, Imreh S, Steigerwald-Mullen PM, et al. (1995) Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature 375: 685-688.
22. Cardinaud S, Starck SR, Chandra P, Shastri N, (2010) The synthesis of truncated polypeptides for immune surveillance and viral evasion. PLoS One 5: e8692.
23. Bennett NJ, May JS, Stevenson PG, (2005) Gamma-herpesvirus latency requires T cell evasion during episome maintenance. PLoS Biol 3: e120.
24. Gao J, Coulson JM, Whitehouse A, Blake N, (2009) Reduction in RNA levels rather than retardation of translation is responsible for the inhibition of major histocompatibility complex class I antigen presentation by the glutamic acid-rich repeat of herpesvirus saimiri open reading frame 73. J Virol 83: 273-282.
25. Davison AJ, Eberle R, Ehlers B, Hayward GS, McGeoch DJ, et al. (2009) The order Herpesvirales. Arch Virol 154: 171-177.
26. Wang F, Rivailler P, Rao P, Cho Y, (2001) Simian homologues of Epstein-Barr virus. Philos Trans R Soc Lond B Biol Sci 356: 489-497.
27. Kieff E, Rickinson AB (2007) Epstein-Barr virus and its replication. In: Knipe DM, Howley, PM., editor. Field's Virology. Philadelphia: Lippincott Williams and Wilkins. pp. 2603-2654.
28. Yates JL, Camiolo SM, Ali S, Ying A, (1996) Comparison of the EBNA1 proteins of Epstein-Barr virus and herpesvirus papio in sequence and function. Virology 222: 1-13.
29. Blake NW, Moghaddam A, Rao P, Kaur A, Glickman R, et al. (1999) Inhibition of antigen presentation by the glycine/alanine repeat domain is not conserved in simian homologues of Epstein-Barr virus nuclear antigen 1. J Virol 73: 7381-7389.
30. Mesri EA, Cesarman E, Arvanitakis L, Rafii S, Moore MA, et al. (1996) Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. J Exp Med 183: 2385-2390.
31. Renne R, Lagunoff M, Zhong W, Ganem D, (1996) The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions. J Virol 70: 8151-8154.
32. Fickenscher H, Fleckenstein B, (2001) Herpesvirus saimiri. Philos Trans R Soc Lond B Biol Sci 356: 545-567.
33. Damania B, Desrosiers RC, (2001) Simian homologues of human herpesvirus 8. Philos Trans R Soc Lond B Biol Sci 356: 535-543.
34. Ensser A, Pflanz R, Fleckenstein B, (1997) Primary structure of the alcelaphine herpesvirus 1 genome. J Virol 71: 6517-6525.
35. Hart J, Ackermann M, Jayawardane G, Russell G, Haig DM, et al. (2007) Complete sequence and analysis of the ovine herpesvirus 2 genome. J Gen Virol 88: 28-39.
36. The National Centre for Biotechnology Information (NCBI). (2012) Available: http://www.ncbi.nlm.nih.gov/ Accessed 29 June 2012.
37. Ovcharenko I, Loots GG, Hardison RC, Miller W, Stubbs L, (2004) zPicture: dynamic alignment and visualization tool for analyzing conservation profiles. Genome Res 14: 472-477.
38. Porgador A, Yewdell JW, Deng Y, Bennink JR, Germain RN, (1997) Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity 6: 715-726.
39. Cristillo AD, Mortimer JR, Barrette IH, Lillicrap TP, Forsdyke DR, (2001) Double-stranded RNA as a not-self alarm signal: to evade, most viruses purine-load their RNAs, but some (HTLV-1, Epstein-Barr) pyrimidine-load. J Theor Biol 208: 475-491.
40. Horsburgh BC, Kollmus H, Hauser H, Coen DM, (1996) Translational recoding induced by G-rich mRNA sequences that form unusual structures. Cell 86: 949-959.
41. Johannsen E, Calderwood M, Kang M.-S, Zhao B, Portal D, and Kieff E (2009) Epstein-Barr virus latent infection nuclear proteins: genome maintenance and regulation of lymphocyte cell growth and survival. In: Damania B, Pipas JM, eds. DNA Tumor Viruses. New York: Springer. pp.317-353.
42. Henikoff S, Henikoff JG, (1992) Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci U S A 89: 10915-10919.