메뉴 건너뛰기




Volumn 33, Issue SUPPL. 1, 2013, Pages 3-13

Optimal treatment with telaprevir for chronic HCV infection

Author keywords

Direct acting antivirals; Hepatitis C virus; Telaprevir

Indexed keywords

ANTIANEMIC AGENT; ATAZANAVIR; EFAVIRENZ; EMTRICITABINE; ERYTHROPOIETIN; HEMOGLOBIN; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4A; PEGINTERFERON; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PLACEBO; PROTEINASE INHIBITOR; RIBAVIRIN; RITONAVIR; TELAPREVIR; TENOFOVIR;

EID: 84872022455     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12079     Document Type: Review
Times cited : (10)

References (30)
  • 1
    • 30044432484 scopus 로고    scopus 로고
    • American Gastroenterological Association technical review on the management of hepatitis C
    • Dienstag JL, McHutchison JG, et al. American Gastroenterological Association technical review on the management of hepatitis C. Gastroenterology 2006; 130: 231-64.
    • (2006) Gastroenterology , vol.130 , pp. 231-264
    • Dienstag, J.L.1    McHutchison, J.G.2
  • 2
    • 0004016899 scopus 로고    scopus 로고
    • World Health Organization. World Health Organization, Geneva, Switzerland 2000 October. Available at Accessed: August 15, 2012.
    • World Health Organization. Hepatitis C. World Health Organization, Geneva, Switzerland 2000 October. Available at http:www.who.int/mediacentre/factsheets/fs165/en. Accessed: August 15, 2012.
    • Hepatitis C
  • 3
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of heaptocellular carcinoma in the United States
    • El-Serag HB, Mason AC, et al. Rising incidence of heaptocellular carcinoma in the United States. New Eng J Med 1999; 340: 745-50.
    • (1999) New Eng J Med , vol.340 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 4
    • 0036828784 scopus 로고    scopus 로고
    • The burden of Hepatitis C in the United States
    • Kim WR. The burden of Hepatitis C in the United States. Hepatology 2002; 36(Suppl): S30-4.
    • (2002) Hepatology , vol.36 , Issue.SUPPL
    • Kim, W.R.1
  • 5
    • 65449136656 scopus 로고    scopus 로고
    • AASLD Practice Guidelines: diagnosis, management, and treatment of hepatitis C: an update
    • Ghany MG, Strader DB, Thomas DL, et al. AASLD Practice Guidelines: diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009; 49: 1335-75.
    • (2009) Hepatology , vol.49 , pp. 1335-1375
    • Ghany, M.G.1    Strader, D.B.2    Thomas, D.L.3
  • 6
    • 69249101721 scopus 로고    scopus 로고
    • Treatment options for patients with chronic hepatitis C not responding to antiviral therapy
    • Jacobson IM. Treatment options for patients with chronic hepatitis C not responding to antiviral therapy. Clin Gastroenterol Hepatol 2009; 7: 921-30.
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 921-930
    • Jacobson, I.M.1
  • 7
    • 0345188811 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    • Lohmann V, Körner F, Koch J, et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999; 285: 110-3.
    • (1999) Science , vol.285 , pp. 110-113
    • Lohmann, V.1    Körner, F.2    Koch, J.3
  • 8
    • 23044437222 scopus 로고    scopus 로고
    • Complete replication of hepatitis C virus in cell culture
    • Lindenbach BD, Evans MJ, Syder AJ, et al. Complete replication of hepatitis C virus in cell culture. Science 2005; 309: 623-6.
    • (2005) Science , vol.309 , pp. 623-626
    • Lindenbach, B.D.1    Evans, M.J.2    Syder, A.J.3
  • 9
    • 34247895578 scopus 로고    scopus 로고
    • The hepatitis C viral life cycle as a target for new antiviral therapies
    • Pawlotsky JM. The hepatitis C viral life cycle as a target for new antiviral therapies. Gastroenterology 2007; 132: 1979-98.
    • (2007) Gastroenterology , vol.132 , pp. 1979-1998
    • Pawlotsky, J.M.1
  • 10
    • 33749360242 scopus 로고    scopus 로고
    • Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase 1b, placebo-controlled, randomized study
    • Reesink HW. Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase 1b, placebo-controlled, randomized study. Gastroenterology 2006; 131: 997-1002.
    • (2006) Gastroenterology , vol.131 , pp. 997-1002
    • Reesink, H.W.1
  • 11
    • 34548758435 scopus 로고    scopus 로고
    • Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis c virus replication in patients
    • Kieffer TL, Sarrazin C, Miller JS, et al. Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis c virus replication in patients. Hepatology 2007; 46: 631-9.
    • (2007) Hepatology , vol.46 , pp. 631-639
    • Kieffer, T.L.1    Sarrazin, C.2    Miller, J.S.3
  • 12
    • 34247565001 scopus 로고    scopus 로고
    • Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C
    • Forestier N, Reesink HW, Weegink CJ, et al. Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C. Hepatology 2007; 46: 640-7.
    • (2007) Hepatology , vol.46 , pp. 640-647
    • Forestier, N.1    Reesink, H.W.2    Weegink, C.J.3
  • 13
    • 46149127335 scopus 로고    scopus 로고
    • Antiviral effects and safety of telaprevir, peginterferon alfa-2a, and ribavirin for 28 days in hepatitis C patients
    • Lawitz E, Rodriguez-Torres M, Muir AJ, et al. Antiviral effects and safety of telaprevir, peginterferon alfa-2a, and ribavirin for 28 days in hepatitis C patients. J Hepatol 2008; 49: 163-9.
    • (2008) J Hepatol , vol.49 , pp. 163-169
    • Lawitz, E.1    Rodriguez-Torres, M.2    Muir, A.J.3
  • 14
    • 65449152185 scopus 로고    scopus 로고
    • Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
    • McHutchinson JG, Everson GT, Gordon SC, et al. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. New Eng J Med 2009; 360: 1827-38.
    • (2009) New Eng J Med , vol.360 , pp. 1827-1838
    • McHutchinson, J.G.1    Everson, G.T.2    Gordon, S.C.3
  • 15
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • Hezode C, Forestier N, Dusheiko G, et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. New Eng J Med 2009; 360: 1839-50.
    • (2009) New Eng J Med , vol.360 , pp. 1839-1850
    • Hezode, C.1    Forestier, N.2    Dusheiko, G.3
  • 16
    • 77950817619 scopus 로고    scopus 로고
    • Telaprevir for previously treated chronic HCV infection
    • McHutchinson JG, Manns MP, Muir AJ, et al. Telaprevir for previously treated chronic HCV infection. New Eng J Med 2010; 14: 1292-303.
    • (2010) New Eng J Med , vol.14 , pp. 1292-1303
    • McHutchinson, J.G.1    Manns, M.P.2    Muir, A.J.3
  • 17
    • 79959438789 scopus 로고    scopus 로고
    • Telaprevir for previously untreated chronic hepatitis C virus infection
    • Jacobson IM, McHutchison JG, Dusheiko G, et al. Telaprevir for previously untreated chronic hepatitis C virus infection. New Eng J Med 2011; 364: 2405-16.
    • (2011) New Eng J Med , vol.364 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 18
    • 85172064539 scopus 로고    scopus 로고
    • Clinical Virology Results from Telaprevir Phase 3 Study ADVANCE. Hepatology
    • Kieffer TL, Bartels G, Sullivan J., et al. Clinical Virology Results from Telaprevir Phase 3 Study ADVANCE. Hepatology 2010; 52(Suppl.): 223A.
    • (2010) , vol.52 , Issue.SUPPL.
    • Kieffer, T.L.1    Bartels, G.2    Sullivan, J.3
  • 19
    • 78751626981 scopus 로고    scopus 로고
    • Telaprevir in combination with peginterferon alfa2a and ribavirin for 24 or 48 weeks in treatment-naïve genotype 1 HCV patients who achieved an extended rapid viral response: final results of phase 3 ILLUMINATE study. Hepatology
    • Sherman KE, Flamm SL, Afdhal NH, et al. Telaprevir in combination with peginterferon alfa2a and ribavirin for 24 or 48 weeks in treatment-naïve genotype 1 HCV patients who achieved an extended rapid viral response: final results of phase 3 ILLUMINATE study. Hepatology 2010; 52(Suppl.): 401A.
    • (2010) , vol.52 , Issue.SUPPL.
    • Sherman, K.E.1    Flamm, S.L.2    Afdhal, N.H.3
  • 20
    • 79959381354 scopus 로고    scopus 로고
    • Telaprevir for retreatment of HCV infection
    • Zeuzem S, Andreone P, Pol S, et al. Telaprevir for retreatment of HCV infection. New Eng J Med 2011; 364: 2417-28.
    • (2011) New Eng J Med , vol.364 , pp. 2417-2428
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 21
    • 79960729857 scopus 로고    scopus 로고
    • Subanalyses of the telaprevir lead-in arm in the REALIZE study: response at week 4 is not a substitute for prior null response categorization
    • Foster GR, Zeuzem S, Andreone P, et al. Subanalyses of the telaprevir lead-in arm in the REALIZE study: response at week 4 is not a substitute for prior null response categorization. J Hepatol 2011; 54(Suppl. 1): S3-4.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL 1
    • Foster, G.R.1    Zeuzem, S.2    Andreone, P.3
  • 22
    • 79951630741 scopus 로고    scopus 로고
    • Long-term Follow-up of Patients with Chronic Hepatitis C Treated with Telaprevir in Combination with Peginterferon Alfa-2a and Ribavirin: Interim Analysis of the EXTEND Study. 61st Annual Meeting of the American Association for the Study of Liver Diseases. Hepatology
    • Zeuzem S, Sulkowski MS, Zoulim F, et al. Long-term Follow-up of Patients with Chronic Hepatitis C Treated with Telaprevir in Combination with Peginterferon Alfa-2a and Ribavirin: Interim Analysis of the EXTEND Study. 61st Annual Meeting of the American Association for the Study of Liver Diseases. Hepatology 2010; 52(Suppl.): 436A.
    • (2010) , vol.52 , Issue.SUPPL.
    • Zeuzem, S.1    Sulkowski, M.S.2    Zoulim, F.3
  • 23
    • 80055062466 scopus 로고    scopus 로고
    • Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response
    • Muir AJ, Poordad FF, McHutchison JG, et al. Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response. Hepatology 2011; 54: 1538-46.
    • (2011) Hepatology , vol.54 , pp. 1538-1546
    • Muir, A.J.1    Poordad, F.F.2    McHutchison, J.G.3
  • 24
    • 84863529543 scopus 로고    scopus 로고
    • Ribavirin dose modification in treatment-naïve and previously treated patients who received telaprevir combination treatment: no impact on sustained virologic response in phase 3 studies
    • Sulkowski MS, Roberts S, Afdhal NH, et al. Ribavirin dose modification in treatment-naïve and previously treated patients who received telaprevir combination treatment: no impact on sustained virologic response in phase 3 studies. J Hepatol 2012; 56(Suppl.): S459-60.
    • (2012) J Hepatol , vol.56 , Issue.SUPPL.
    • Sulkowski, M.S.1    Roberts, S.2    Afdhal, N.H.3
  • 25
    • 84863519517 scopus 로고    scopus 로고
    • Safety of telaprevir or boceprevir in combination with peginterferon alfa/ribavirin, in cirrhotic nonresponders. First results of the French early access program (ANRS CO20-CUPIC)
    • Hezode C, Dorival C, Zoulim F, Poynard T, et al. Safety of telaprevir or boceprevir in combination with peginterferon alfa/ribavirin, in cirrhotic nonresponders. First results of the French early access program (ANRS CO20-CUPIC). J Hepatol 2012; 56(Suppl.): S4.
    • (2012) J Hepatol , vol.56 , Issue.SUPPL.
    • Hezode, C.1    Dorival, C.2    Zoulim, F.3    Poynard, T.4
  • 26
    • 79251554986 scopus 로고    scopus 로고
    • Telaprevir is effective given every 8 or 12 hours with ribavirin and peginterferon alfa-2a or -2b to patients with chronic hepatitis C
    • Marcellin P, Forns X, Goeser T, et al. Telaprevir is effective given every 8 or 12 hours with ribavirin and peginterferon alfa-2a or -2b to patients with chronic hepatitis C. Gastroenterology 2011; 140: 459-68.
    • (2011) Gastroenterology , vol.140 , pp. 459-468
    • Marcellin, P.1    Forns, X.2    Goeser, T.3
  • 27
    • 85172066296 scopus 로고    scopus 로고
    • Telaprevir in combination with pegylated interferon-alfa-2a 1 ribavirin in HCV/HIV-coinfected patients: a 24-week treatment interim analysis. Presented at the 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012). Available at
    • Dieterich D, Soriano V, Sherman K, et al. Telaprevir in combination with pegylated interferon-alfa-2a 1 ribavirin in HCV/HIV-coinfected patients: a 24-week treatment interim analysis. Presented at the 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012). 2012. Available at http://retroconference.org/2012b/Abstracts/42969.htm.
    • (2012)
    • Dieterich, D.1    Soriano, V.2    Sherman, K.3
  • 28
    • 80052116134 scopus 로고    scopus 로고
    • Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections
    • Foster GR, Hézode C, Bronowicki JP, et al. Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections. Gastroenterology 2011; 141: 881-9.
    • (2011) Gastroenterology , vol.141 , pp. 881-889
    • Foster, G.R.1    Hézode, C.2    Bronowicki, J.P.3
  • 29
    • 80052869823 scopus 로고    scopus 로고
    • Cambridge, Mass: Vertex Pharmaceuticals, Available at Accessed November 12, 2012.
    • Incivek (package insert). Cambridge, Mass: Vertex Pharmaceuticals, 2011. Available at http://www.incivek.com/. Accessed November 12, 2012.
    • (2011) Incivek (package insert)
  • 30
    • 84867100342 scopus 로고    scopus 로고
    • Futility rules in telaprevir combination treatment
    • Jacobson IM, Bartels DJ, Gritz L, et al. Futility rules in telaprevir combination treatment. J Hepatol 2012; 56(Suppl.): S24.
    • (2012) J Hepatol , vol.56 , Issue.SUPPL.
    • Jacobson, I.M.1    Bartels, D.J.2    Gritz, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.