Antimalarial and hepatoprotective effects of crude ethanolic extract of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W.Curt.:Fr.)P.Karst. (Higher basidiomycetes), in Plasmodium berghei- infected mice

International Journal of Medicinal Mushrooms

Volumn 14, Issue 5, 2012, Pages 459-466

  Oluba, Olarewaju M ^a   Olusola, Augustine O ^b   Fagbohunka, Bamidele S ^a   Chukwu Onyeneke, E ^c  

^a JOSEPH AYOBABALOLA UNIVERSITY   (Nigeria)

^b ADEKUNLE AJASIN UNIVERSITY   (Nigeria)

^c UNIVERSITY OF BENIN   (Nigeria)

Author keywords

Antiplasmodial; Ethanolic extract; Ganoderma lucidum; Hepatoprotection; Lingzhi or Reishi medicinal mushroom; Malaria; Medicinal mushrooms

Indexed keywords

ALKALINE PHOSPHATASE; AMINOTRANSFERASE; CHLOROQUINE; GAMMA GLUTAMYLTRANSFERASE; GANODERMA LUCIDUM EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; FRUITING BODY; GANODERMA LUCIDUM; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PLASMODIUM BERGHEI INFECTION; PROTEIN ANALYSIS;

ANIMALS; ANTIMALARIALS; ETHANOL; FRUITING BODIES, FUNGAL; MALARIA; MICE; PLASMODIUM BERGHEI; REISHI;

ANIMALIA; BASIDIOMYCOTA; GANODERMA LUCIDUM; MUS; PLASMODIUM BERGHEI; RODENTIA;

EID: 84872005717     PISSN: 15219437     EISSN: 19404344     Source Type: Journal    
DOI: 10.1615/IntJMedMushr.v14.i5.30     Document Type: Article

References (35)

1. WHO. WHO Report on Infectious Diseases: Removing Obstacles to Health Development. World Health Organization, Geneva; 1999.
2. Ibezim EC, Odo U. Current trends in malaria chemotherapy. Afr J Biotechnol. 2008;7:349-56.
3. Lytton SD, Mesker B, Libman J, Shanzer A, Cabantchik ZI. Mode of action of iron (III) chelators as antimalarial II: evidence for differential effects on parasite iron-dependent nucleic acid synthesis. Blood. 1994;84:910-15.
4. Klayman DL. Quinghausu (artemisinin): an antimalarial drug from China. Science. 1985;228:1049-55.
5. Nzila A. The past, present and future of antifolates in the treatment of Plasmodium falciparum infection. J Antimicrob Chemother. 2006;57:1043-54.
6. De Wet H, Van Heerden FR, Van Wyk BE, Van Zyl RL. Antiplasmodial activity and cytotoxicity of Albertisia delagoensis. Fitoterapia. 2007;78:420-22.
7. Wasser SP. Medicinal mushroom science: current status, future trends, and unsolved problems. Int J Med Mushr. 2010;12(1):1-16.
8. Adams M, Chriten M, Plitzko I, Zimmermann S, Brun R, Kaiser M, Hamburger M. Antiplasmodial lanostans from the Ganoderma lucidum mushroom. J Nat Prod. 2010;30:2.
9. Ciulei I. Methodology for analysis of vegetal drugs. Bucharest, Romania: Ministry of Chemical Industry, 1982, pp. 1-67.
10. Oloyede OI. Chemical profile of unripe pulp of Carica papaya. Pak J Nutr. 2005;4:379-81.
11. National Research Council. Guides for the Care and Use of Laboratory Animals, National Institutes of Health, Bethesda, MD; 1985.
12. Carvalho LH, Brandao MJI, Santos-Fiho D, Lopes JLC, Krettli AU. Antimalarial activity of crude extracts from Brazilian plant studied in vivo in Plasmodium berghei infected mice and in vitro against Plasmodium falciparum in culture. Braz J Med Biol Res. 1991;24:1113-23.
13. Builders MI, Wannang NN, Ajoku GA, Builders PF, Orisadipe A, Aguiyi JC. Evaluation of the antimalarial potential of Vernonia ambigua Kotschy and Peyr (Asteraceae). Int J Pharmacol. 2011;7(2):238-47.
14. Reitman S, Frankel S. Colorimetric method for the determination of serum glutamic oxaloacetate and glutamic pyruvate transaminases. Am J Clin Pathol. 1957;28:50-62.
15. Bessey AO, Lawry OH, Block MJ. A method for rapid determination of alkaline phosphatase with cubic millimeter of serum. J Biol Chem. 1946;146:321-28.
16. Szaz G. A kinetic photometric method for serum gamma glutamyl transpeptidase. Clin Chem. 1976;15:124-36.
17. Gornall AG, Baradawill CJ, Maxima D. Determination of serum proteins by means of the biuret reaction. Biol Chem. 1949;177:751-66.
18. Philipson JD, Wright CW. Antiprotozoal compounds from plants source. Planta Med. 1990;57:553-59.
19. Milliken W. Malaria and antimalarial plants in Roraima, Braz. Trop Doctor. 1997;27:12-16.
20. Christensen SB, Kharazmi A. Antimalarial natural products: isolation, characterization and biological properties, in bioactive compounds from natural sources. Tringali C, ed. London: Taylor and Francis Ltd.; 2001, pp. 379-32.
21. Kim HW, Kim BK. Biomedical triterpenoids of Ganoderma lucidum (Curt.:Fr.) P. Karst. (Aphyllophoromycetideae). Int J Med Mushr. 1999;1:121-38.
22. Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB. Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice. World J Gastroenterol. 2002;8:728-33.
23. Song CH, Yang BK, Ra KS, Shon DH, Park EJ, Go GI, Kim YH. Hepatoprotective effect of extracellular polymer produced by submerged culture of Ganoderma lucidum WK-003. J Microbiol Biotechnol. 1998;8:277-79.
24. Chen RY, Yu DQ. Studies on the triterpenoid constituents of the spores of Ganoderma lucidum (Curt.:Fr.) P. Karst. (Aphyllophoromycetideae). Int J Med Mushr. 1999;1:147-52.
25. Baheti R, Laddha P, Gehlot RS. Liver involvement in falciparum malaria: a histopathological analysis. J Indian Acad Clin Med. 2003;4:34-38.
26. Premaratna R, Gunatilake AK, De Silva NR, Tilakaratne Y, Fonreka MM, De Silva HJ. Severe hepatic dysfunction associated with falciparum malaria. Southwest Asian J Trop Med Pub Health. 2001;32:70-72.
27. Oluba OM, Onyeneke EC, Ojieh GC, Eidangbe GO. Effect of soy protein on selected enzymes in some tissues of rats fed a cholesterol diet. Int J Med Med Sci. 2009;1:400-6.
28. Maegraith B. Aspects of the pathogenesis of malaria. Southwest Asian J Trop Med Pub Health. 1981;12:251-67.
29. Kochar DK, Saxena V, Singh N, Kochar SV, Das A. Plas modium vivax malaria. EID. 2005;11:132-33.
30. Adeosun OG, Oduola T, Akanji BO, Sunday AM, Udoh SJ, Bello IS. Biochemical alteration in Nigerian children with acute falciparum malaria. Afr J Biotechnol. 2007;67:881-85.
31. WHO. Severe and complicated malaria. Trans R Soc Trop Med Hyg. 1990;84:1-65.
32. Jarikre AE, Emureyan EE, Idogun SE. Pitfalls in the interpretation of liver parenchymal and membranous enzyme results in pre-clinical Plasmodium falciparum malaria in the Nigerian environment. Nig J Clin Pract. 1991;4:19-21.
33. Wright PJ, Plummer DT. The use of urinary enzyme measurement to detect renal damage caused by nephrotoxic compounds. Biochem Pharmacol. 1974;23:65-73.
34. Shieh YH, Liu CF, Huang YK, Yang JY, Wu IL, Lin CH, Li SC. Evaluation of hepatic and renal protective effects of Ganoderma lucidum in mice. Am J Clin Med. 2001;29:501-7.
35. Lin SB, Li CH, Lee SS, Kan LS. Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sci. 2003;72:2381-90.