Neutrophil apoptosis and its induction as a potential treatment for chronic inflammatory disease

Current Opinion in Hematology

Volumn 20, Issue 1, 2013, Pages 10-15

  Hampson, Peter ^a   Hazeldine, Jon ^a   Lord, Janet M ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Apoptosis; CDK inhibitors; Inflammation; Neutrophils

Indexed keywords

CASPASE 8; CASPASE 9; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYTOCHROME C; DEATH RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PROTEIN MCL 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ACUTE RESPIRATORY TRACT DISEASE; APOPTOSIS; CELL CYCLE PROGRESSION; CELL SURVIVAL; CYTOKINE PRODUCTION; ENZYME ACTIVATION; HOMEOSTASIS; HUMAN; INFLAMMATION; LUNG LAVAGE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; REGULATORY T LYMPHOCYTE; REVIEW; RHEUMATOID ARTHRITIS;

ANIMALS; APOPTOSIS; CHRONIC DISEASE; HUMANS; INFLAMMATION; NEUTROPHILS;

EID: 84871968533     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e32835b06be     Document Type: Review

References (33)

1. Athens JW, Haab OP, Raab SO, et al. Leukokinetic studies. IV. The total blood, circulating and marginal granulocyte pools and the granulocyte turnover rate in normal subjects. J Clin Invest 1961; 40:989-995
2. Dancey JT, Deubelbeiss KA, Harker LA, Finch CA. Neutrophil kinetics in man. J Clin Invest 1976; 58:705-715
3. Martin C, Burdon PC, Bridger G, et al. Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence. Immunity 2003; 19:583-593
4. Brach MA, deVos S, Gruss HJ, Herrmann F. Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death. Blood 1992; 80:2920-2924
5. Wang K, Scheel-Toellner D, Wong SH, et al. Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-delta, and NF-kappa B signaling pathways. J Immunol 2003; 171:1035-1041
6. Cross A, Barnes T, Bucknall RC, et al. Neutrophil apoptosis in rheumatoid arthritis is regulated by local oxygen tensions within joints. J Leukoc Biol 2006; 80:521-528
7. Edwards SW, Hallett MB. Seeing the wood for the trees: The forgotten role of neutrophils in rheumatoid arthritis. Immunol Today 1997; 18:320-324
8. Raza K, Scheel-Toellner D, Lee CY, et al. Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis. Arthritis Res Ther 2006; 8:R120
9. Savill J, Dransfield I, Hogg N, Haslett C. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 1990; 343:170- 173
10. Savill JS, Wyllie AH, Henson JE, et al. Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J Clin Invest 1989; 83:865-875
11. Scheel-Toellner D, Wang K, Craddock R, et al. Reactive oxygen species limit neutrophil life span by activating death receptor signaling. Blood 2004; 104:2557-2564
12. Scaffidi C, Fulda S, Srinivasan A, et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J 1998; 17:1675-1687
13. Schulze-Osthoff K, Ferrari D, Los M, et al. Apoptosis signaling by death receptors. Eur J Biochem 1998; 254:439-459
14. Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91:479-489
15. Leuenroth SJ, Grutkoski PS, Ayala A, Simms HH. The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis. J Leukoc Biol 2000; 68:158-166
16. Moulding DA, Quayle JA, Hart CA, Edwards SW. Mcl-1 expression in human neutrophils: Regulation by cytokines and correlation with cell survival. Blood 1998; 92:2495-2502
17. Klausen P, Bjerregaard MD, Borregaard N, Cowland JB. End-stage differentiation of neutrophil granulocytes in vivo is accompanied by up-regulation of p27kip1 and down-regulation of CDK2, CDK4, and CDK6. J Leukoc Biol 2004; 75:569-578
18. Rossi AG, Sawatzky DA, Walker A, et al. Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis. Nat Med 2006; 12:1056-1064
19. Wang K, Hampson P, Hazeldine J, et al. Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis. PLoS One 2012; 7:e30128
20. Leitch AE, Lucas CD, Marwick JA, et al. Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation. Cell Death Differ 2012. [Epub ahead of print]
21. D'Alessio FR, Tsushima K, Aggarwal NR, et al. CD4CD25Foxp3 Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest 2009; 119:2898-2913
22. Lewkowicz P, Lewkowicz N, Sasiak A, Tchorzewski H. Lipopolysaccharideactivated CD4CD25 T regulatory cells inhibit neutrophil function and promote their apoptosis and death. J Immunol 2006; 177:7155-7163
23. Thoren FB, Riise RE, Ousback J, et al. Human NK cells induce neutrophil apoptosis via an NKp46- and Fas-dependent mechanism. J Immunol 2012; 188:1668-1674
24. Bhatnagar N, Hong HS, Krishnaswamy JK, et al. Cytokine-activated NK cells inhibit PMN apoptosis and preserve their functional capacity. Blood 2010; 116:1308-1316
25. Costantini C, Micheletti A, Calzetti F, et al. Neutrophil activation and survival are modulated by interaction with NK cells. Int Immunol 2010; 22:827-838
26. Aldridge AJ. Role of the neutrophil in septic shock and the adult respiratory distress syndrome. Eur J Surg 2002; 168:204-214
27. Ren Y, Xie Y, Jiang G, et al. Apoptotic cells protect mice against lipopolysaccharide- induced shock. J Immunol 2008; 180:4978-4985
28. Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science 1997; 276:111-113
29. Chaudhary PM, EbyM, Jasmin A, et al. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity 1997; 7:821-830
30. Gonzalvez F, Ashkenazi A. New insights into apoptosis signaling by Apo2L/ TRAIL. Oncogene 2010; 29:4752-4765
31. McGrath EE, Marriott HM, Lawrie A, et al. TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation. J Leukoc Biol 2011; 90:855-865
32. Wortinger MA, Foley JW, Larocque P, et al. Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue. Immunology 2003; 110:225-233
33. Sekine C, Sugihara T, Miyake S, et al. Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors. J Immunol 2008; 180:1954-1961.