Design of a novel bilayered gastric mucoadhesive system for localized and unidirectional release of lamotrigine

Saudi Pharmaceutical Journal

Volumn 21, Issue 1, 2013, Pages 45-52

  Mohana Raghava Srivalli, K ^a,b   Lakshmi, P K ^a   Balasubramaniam, J ^b  

^a OSMANIA UNIVERSITY   (India)

^b RA Chem Pharma Limited   (India)

Author keywords

23 full factorial design; Bilayered gastric mucoadhesive tablets; Lamotrigine; Methacrylic polymers; Modified basket dissolution model; Unidirectional drug release; Zero order release

Indexed keywords

CARBOMER; EUDRAGIT; LAMOTRIGINE; MAGNESIUM STEARATE; POLYMER; POLYOXIN B; TALC;

ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; DRUG SOLUBILITY; EX VIVO STUDY; GOAT; MUCOADHESION; NONHUMAN; STOMACH MUCOSA; TABLET; TABLET FORMULATION; TABLET FRIABILITY; TABLET HARDNESS; TABLET THICKNESS;

EID: 84871958346     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsps.2012.01.004     Document Type: Article

References (22)

1. Bardonnet P.L., Faivre V., Pugh W.J., Piffaretti J.C., Falson F. Gastroretentive dosage forms: overview and special case of Helicobacter pylori. J. Control Release 2006, 111:1-18.
2. Brodie M.J. Lamotrigine. Lancet 1992, 339:1397-1400.
3. Chanda R., Roy A., Bahadur S., Saha S., Das S., Choudhury A. Floating drug delivery: a potential alternative to conventional therapy. Int. J. Pharm. Tech. Res. 2010, 2(1):49-59.
4. Cheng C.L., Chou C.H., Hu O.Y. Determination of lamotrigine in small volumes of plasma by high-performance liquid chromatography. J. Chromatogr. B 2005, 817(2):199-206.
5. Costa P., Jose M.S.L. Modeling and comparison of dissolution profiles. Eur. J. Pharm. Sci. 2001, 13:123-133.
6. Costa P. An alternative method to the evaluation of similarity factor in dissolution testing. Int. J. Pharm. 2001, 220:77-83.
7. Gupta A., Garg S., Khar R.K. Measurement of bioadhesive strength of muco-adhesive buccal tablets: design of an in vitro assembly. Indian Drugs 1992, 30:152-155.
8. Han R.Y., Fang J.Y., Sung K.C., Hu O.Y.P. Mucoadhesive buccal disks for novel nalbuphine prodrug controlled delivery: effect of formulation variables on drug release and mucoadhesive performance. Int. J. Pharm. 1999, 177:201-209.
9. He X., Secreast P.J., Amidon G.E. Mechanistic study of the effect of roller compaction and lubricant on tablet mechanical strength. J. Pharm. Sci. 2007, 96:1342-1355.
10. Joao F.P. Site-specific drug delivery systems within the gastro-intestinal tract: from the mouth to the colon. Int. J. Pharm. 2010, 395:44-52.
11. Mockel J.E., Lippold B.C. Zero order release from hydrocolloid matrices. Pharm. Res. 1993, 10:1066-1070.
12. Narendra C., Srinath M.S., Rao B.P. Development of three layered buccal compact containing metoprolol tartrate by statistical optimization technique. Int. J. Pharm. 2005, 304:102-114.
13. Park H., Robinson J.R. Mechanisms of bioadhesion of poly (acrylic acid) hydrogels. Pharm. Res. 1987, 4:457-464.
14. Patel V.M., Prajapati B.G., Patel M.M. Formulation, evaluation, and comparison of bilayered and multilayered mucoadhesive buccal devices of propranolol hydrochloride. AAPS PharmSciTech 2007, 8(1):E1-E8. (Article 22).
15. Peppas N.A. Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta Helv. 1985, 60:110-111.
16. Ponchel G., Touchard F., Duchene D., Peppas N.A. Bioadhesive analysis of controlled release systems. I. Fracture and interpenetration analysis in poly(acrylic-acid) containing systems. J. Control Release 1987, 5:129-141.
17. Raval J.A., Patel M.M. Formulation and characterization of gastroretentive discs containing famotidine. Braz. Arch. Biol. Technol. 2011, 54(2):293-300.
18. Rowe, R.C., Sheskey, P.J., Quinn, M.E., 2009. Handbook of Pharmaceutical Excipients, sixth ed. Pharmaceutical Press, London, UK, American Pharmacists Association, Chicago, USA, pp. 110-114.
19. Ruben M.M., Patrico M.C., Teodoo S.K. A new principal component analysis-based approach for testing "similarity" of drug dissolution profiles. Eur. J. Pharm. Sci. 2008, 34:66-77.
20. Sivakumar R., Vaithiyalingam Vilayat, Sayeed A. Critical factors in manufacturing multi-layer tablets - assessing material attributes, in-process controls, manufacturing process and product performance. Int. J. Pharm. 2010, 398:9-13.
21. Thomas O.H., Adrian D., Jackie D., John D. A review of methods used to compare dissolution profile data. Pharm. Sci. Technol. Today 1998, 1(5):214-223.
22. Date: 2/1/2010, time: 7:08:36 AM. FDA approves GlaxoSmithKline (GSK)'s once-a-day Lamictal(R)XR(TM) as add-on epilepsy therapy for primary generalized tonic-clonic seizures. http://www.biospace.com/.