Glaucoma-induced degeneration of retinal ganglion cells prevented by hypoxic preconditioning: A model of glaucoma tolerance

Molecular Medicine

Volumn 18, Issue 4, 2012, Pages 697-706

  Zhu, Yanli ^a   Zhang, Lihong ^a   Schmidt, Jimena F ^a   Gidday, Jeffrey M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; APOPTOSIS; ARTICLE; C57BL MOUSE; CELL HYPOXIA; DISEASE MODEL; GLAUCOMA; INTRAOCULAR PRESSURE; MALE; METABOLISM; MOUSE; NERVE FIBER; PATHOLOGY; RETINA GANGLION CELL;

ANIMALS; APOPTOSIS; AXONS; CELL HYPOXIA; DISEASE MODELS, ANIMAL; GLAUCOMA; INTRAOCULAR PRESSURE; MALE; MICE; MICE, INBRED C57BL; RETINAL GANGLION CELLS;

EID: 84871955173     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2012.00050     Document Type: Article

References (41)

1. Quigley HA, Broman AT. (2006) The number of people with glaucoma worldwide in 2010 and 2020. Br. J. Ophthalmol. 90:262-7.
2. Peeters A, et al. (2010) Quantifying the effect of intraocular pressure reduction on the occurrence of glaucoma. Acta Ophthalmol. 88:5-11.
3. Cheung W, Guo L, Cordeiro MF. (2008) Neuroprotection in glaucoma: drug-based approaches. Optom. Vis. Sci. 85:406-16.
4. Levin LA, Peeples P. (2008) History of neuroprotection and rationale as a therapy for glaucoma. Am. J. Manag. Care. 14:11-4.
5. Zhu Y, Zhang Y, Ojwang BA, Brantley MA Jr, Gidday JM. (2007) Long-term tolerance to retinal ischemia by repetitive hypoxic preconditioning: role of HIF-1alpha and heme oxygenase-1. Invest. Ophthalmol. Vis. Sci. 48:1735-1743.
6. Zhu Y, Zhang L, Gidday JM. (2008) Deferroxamine preconditioning promotes long-lasting retinal ischemic tolerance. J. Ocul. Pharmacol. Ther. 24:527-35.
7. Wang WH, Millar JC, Pang IH, Wax MB, Clark AF. (2005) Noninvasive measurement of rodent intraocular pressure with a rebound tonometer. Invest. Ophthalmol. Vis. Sci. 46:4617-21.
8. Leahy KM, et al. (2004) Quantitative ex vivo detection of rodent retinal ganglion cells by immunolabeling Brn-3b. Exp. Eye Res. 79:131-40.
9. Zhong L, et al. (2007) Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice. Invest. Ophthalmol. Vis. Sci. 48:1212-8.
10. Dieterich DC, et al. (2002) Partial regeneration and long-term survival of rat retinal ganglion cells after optic nerve crush is accompanied by altered expression, phosphorylation and distribution of cytoskeletal proteins. Eur J. Neurosci. 15:1433-43.
11. Jakobs TC, Libby RT, Ben Y, John SWM, Masland RH. (2005) Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J. Cell Biol. 171:313-25.
12. Raymond ID, Pool AL, Vila A, Brecha NC. (2009) A Thy1-CFP DBA/2J mouse line with cyan fluorescent protein expression in retinal ganglion cells. Vis. Neurosci. 26:453-65.
13. Drager UC, Hofbauer A. (1984) Antibodies to heavy neurofilament subunit detect a subpopulation of damaged ganglion cells in retina. Nature. 309:624-6.
14. Libby RT, et al. (2005) Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet. 1:17-26.
15. Nickells RW, Semaan SJ, Schlamp CL. (2008) Involvement of the Bcl2 gene family in the signaling and control of retinal ganglion cell death. Prog. Brain Res. 173:423-35.
16. McKinnon SJ, Schlamp CL, Nickells RW. (2009) Mouse models of retinal ganglion cell death and glaucoma. Exp. Eye Res. 88:816-24.
17. Crish SD, Calkins DJ. (2011) Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms. Neuroscience. 176:1-11.
18. Howell GR, et al. (2007) Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J. Cell Biol. 179:1523-37.
19. Soto I, et al. (2008) Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model. J. Neurosci. 28:548-61.
20. Vohra BPS, et al. (2010) Amyloid precursor protein cleavage-dependent and-independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway. J. Neurosci. 30:13729-38.
21. Ji J, et al. (2005) Effects of elevated intraocular pressure on mouse retinal ganglion cells. Vision Res. 45:169-79.
22. Nakazawa T, et al. (2006) Tumor necrosis factoralpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma. J. Neurosci. 26:12633-41.
23. Ruiz-Ederra J, Verkman AS. (2006) Mouse model of sustained elevation in intraocular pressure produced by episcleral vein occlusion. Exp. Eye Res. 82:879-84.
24. Sappington RM, Carlson BJ, Crish SD, Calkins DJ. (2010) The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice. Invest. Ophthalmol. Vis. Sci. 51:207-16.
25. Mittag TW, et al. (2000) Retinal damage after 3 to 4 months of elevated intraocular pressure in a rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 41:3451-9.
26. McKinnon SJ, et al. (2002) Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest. Ophthalmol. Vis. Sci. 43:1077-87.
27. Yu S, Tanabe T, Yoshimura N. (2006) A rat model of glaucoma induced by episcleral vein ligation. Exp. Eye Res. 83:758-70.
28. Quigley HA, et al. (1995) Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest. Ophthalmol. Vis. Sci. 36:774-86.
29. Kerrigan LA, Zack DJ, Quigley HA, Smith SD, Pease ME. (1997) TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch. Ophthalmol. 115:1031-5.
30. Huang W, et al. (2005) Transcriptional upregulation and activation of initiating caspases in experimental glaucoma. Am. J. Pathol. 167:673-81.
31. Chierzi S, et al. (1998) Protection of retinal ganglion cells and preservation of function after optic nerve lesion in bcl-2 transgenic mice. Vision Res. 38:1537-43.
32. Lingor P, Koeberle P, Kugler S, Bahr M. (2005) Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo. Brain. 128:550-8.
33. Mabuchi F, Aihara M, Mackey MR, Lindsey JD, Weinreb RN. (2003) Optic nerve damage in experimental mouse ocular hypertension. Invest. Ophthalmol. Vis. Sci. 44:4321-30.
34. Balaratnasingam C, Morgan WH, Bass L, Cringle SJ, Yu D-Y. (2008) Time-dependent effects of elevated intraocular pressure on optic nerve head axonal transport and cytoskeleton proteins. Invest. Ophthalmol. Vis. Sci. 49:986-99.
35. Sun D, Lye-Barthel M, Masland RH, Jakobs TC. (2009) The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse. J. Comp. Neurol. 516:1-19.
36. Mabuchi F, Aihara M, Mackey MR, Lindsey JD, Weinreb RN. (2004) Regional optic nerve damage in experimental mouse glaucoma. Invest. Ophthalmol. Vis. Sci. 45:4352-8.
37. Hernandez MR, Miao H, Lukas T. (2008) Astrocytes in glaucomatous optic neuropathy. Prog. Brain Res. 173:353-73.
38. Johnson EC, Morrison JC. (2009) Friend or foe? Resolving the impact of glial responses in glaucoma. J. Glaucoma. 18:341-53.
39. Inman DM, Horner PJ. (2007) Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia. 55:942-53.
40. Son JL, et al. (2010) Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss. Glia. 58:780-9.
41. Gidday JM. (2006) Cerebral preconditioning and ischaemic tolerance. Nat. Rev. Neurosci. 7:437-48.