Site-specific identification of an Aβ fibril-heparin interaction site by using solid-state NMR spectroscopy

Angewandte Chemie - International Edition

Volumn 51, Issue 52, 2012, Pages 13140-13143

  Madine, Jillian ^a   Pandya, Maya J ^b   Hicks, Matthew R ^c   Rodger, Alison ^c   Yates, Edwin A ^a   Radford, Sheena E ^b   Middleton, David A ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Alzheimer's disease; Amyloid peptides; Heparin; Linear dichroism; NMR spectroscopy

Indexed keywords

ALZHEIMER'S DISEASE; AMYLOID DEPOSITS; CLOSE PROXIMITY; COLOCALIZE; HEPARIN; IN-VIVO; INTERACTION SITE; LINEAR DICHROISM; MOLECULAR INSIGHTS; N-TERMINALS; PACKING GEOMETRY; PROTEIN SEQUENCES; RECOGNITION SITE; SITE-SPECIFIC; SOLID-STATE NMR SPECTROSCOPY; STRUCTURAL STUDIES;

GLYCOPROTEINS; MORPHOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

POLYSACCHARIDES;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; CARBON; HEPARIN; PEPTIDE FRAGMENT;

ARTICLE; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

AMYLOID BETA-PEPTIDES; BINDING SITES; CARBON ISOTOPES; HEPARIN; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84871953993     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201204459     Document Type: Article

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