Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury

Shock

Volumn 39, Issue 1, 2013, Pages 11-18

  Rendon, Juan L ^a   Li, Xiaoling ^a   Akhtar, Suhail ^a   Choudhry, Mashkoor A ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

antimicrobial peptides; epithelium; Ethanol; mice; permeability; thermal injury

Indexed keywords

INTERLEUKIN 22;

ALCOHOL INTOXICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERIAL LOAD; BODY SURFACE; BURN; CONTROLLED STUDY; IN VIVO STUDY; INTESTINE EPITHELIUM; INTESTINE MUCOSA PERMEABILITY; MALE; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PROTEIN EXPRESSION;

ADENOSINE MONOPHOSPHATE; ALCOHOLIC INTOXICATION; ANIMALS; ANTIGENS, NEOPLASM; BACTERIAL LOAD; BURNS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; IMMUNITY, MUCOSAL; INTERLEUKINS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINE, SMALL; LECTINS, C-TYPE; MALE; MICE; MICE, INBRED C57BL; PERMEABILITY; PROTEINS; RECOMBINANT PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 84871953886     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3182749f96     Document Type: Article

References (35)

1. Sonnenberg GF, Fouser LA, Artis D: Border patrol: Regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat Immunol 12:383-390, 2011.
2. Kolls JK, McCray PB Jr, Chan YR: Cytokine-mediated regulation of antimicrobial proteins. Nat Rev Immunol 8:829-835, 2008.
3. Zheng Y, Valdez PA, Danilenko DM, Hu Y, Sa SM, Gong Q, Abbas AR, Modrusan Z, Ghilardi N, de Sauvage FJ, et al.: Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med 14:282-289, 2008.
4. Cash HL, Whitham CV, Behrendt CL, Hooper LV: Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313:1126-1130, 2006.
5. American Burn Association. Burn Incidence and Treatment in the US: 2007 Fact Sheet. 2010. Available at: Ameriburn.org
6. Jones JD, Barber B, Engrav L, Heimbach D: Alcohol use and burn injury. J Burn Care Rehabil 12:148-152, 1991.
7. McGill V, Kowal-Vern A, Fisher SG, Kahn S, Gamelli RL: The impact of substance use on mortality and morbidity from thermal injury. J Trauma 38:931-934, 1995.
8. Kelley D, Lynch JB: Burns in alcohol and drug users result in longer treatment times with more complications. J Burn Care Rehabil 13:218-220, 1992.
9. Albright JM, Kovacs EJ, Gamelli RL, Schermer CR: Implications of formal alcohol screening in burn patients. J Burn Care Res 30:62-69, 2009.
10. Silver GM, Albright JM, Schermer CR, Halerz M, Conrad P, Ackerman PD, Lau L, Emanuele MA, Kovacs EJ, Gamelli RL: Adverse clinical outcomes associated with elevated blood alcohol levels at the time of burn injury. J Burn Care Res 29:784-789, 2008.
11. Choudhry MA, Chaudry IH: Alcohol intoxication and post-burn complications. Front Biosci 11:998-1005, 2006.
12. Choudhry MA, Rana SN, Kavanaugh MJ, Kovacs EJ, Gamelli RL, Sayeed MM: Impaired intestinal immunity and barrier function: A cause for enhanced bacterial translocation in alcohol intoxication and burn injury. Alcohol 33: 199-208, 2004.
13. Faunce DE, Gregory MS, Kovacs EJ: Acute ethanol exposure prior to thermal injury results in decreased T-cell responses mediated in part by increased production of IL-6. Shock 10:135-140, 1998.
14. Deitch EA, Rutan R, Waymack JP: Trauma, shock, and gut translocation. New Horiz 4:289-299, 1996.
15. Keshavarzian A, Farhadi A, Forsyth CB, Rangan J, Jakate S, Shaikh M, Banan A, Fields JZ: Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats. J Hepatol 50:538-547, 2009.
16. Li X, Rana SN, Kovacs EJ, Gamelli RL, Chaudry IH, Choudhry MA: Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury. Am J Physiol Regul Integr Comp Physiol 289:R37YR44, 2005.
17. Li X, Chaudry IH, Choudhry MA: ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury. J Immunol 183:3955-3962, 2009.
18. Choudhry MA, Fazal N, Namak SY, Haque F, Ravindranath T, Sayeed MM: PGE2 suppresses intestinal T cell function in thermal injury: A cause of enhanced bacterial translocation. Shock 16:183-188, 2001.
19. Choudhry MA, Fazal N, Goto M, Gamelli RL, Sayeed MM: Gut-associated lymphoid T cell suppression enhances bacterial translocation in alcohol and burn injury. Am J Physiol Gastrointest Liver Physiol 282:G937YG947, 2002.
20. Li X, Schwacha MG, Chaudry IH, Choudhry MA: Acute alcohol intoxication potentiates neutrophil-mediated intestinal tissue damage after burn injury. Shock 29:377-383, 2008.
21. Li X, Akhtar S, Kovacs EJ, Gamelli RL, Choudhry MA: Inflammatory response in multiple organs in a mouse model of acute alcohol intoxication and burn injury. J Burn Care Res 32:489-497, 2011.
22. Walker HL, Mason AD Jr: A standard animal burn. J Trauma 8:1049-1051, 1968.
23. Ki SH, Park O, Zheng M, Morales-Ibanez O, Kolls JK, Bataller R, Gao B: Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3. Hepatology 52:1291-1300, 2010.
24. Lehotzky RE, Partch CL, Mukherjee S, Cash HL, Goldman WE, Gardner KH, Hooper LV: Nolecular basis for peptidoglycan recognition by a bactericidal lectin. Proc Natl Acad Sci U S A 107:7722-7727, 2010.
25. Kavanaugh MJ, Clark C, Goto M, Kovacs EJ, Gamelli RL, Sayeed MM, Choudhry MA: Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function. Burns 31:290-296, 2005.
26. Branski LK, Al-Mousawi A, Rivero H, Jeschke MG, Sanford AP, Herndon DN: Emerging infections in burns. Surg Infect (Larchmt) 10:389-397, 2009.
27. Pruitt BA Jr, McManus AT, Kim SH, Goodwin CW: Burn wound infections: Current status. World J Surg 22:135-145, 1998.
28. Radaeva S, Sun R, Pan HN, Hong F, Gao B: Interleukin 22 (IL-22) plays a protective role in T cellYmediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39:1332-1342, 2004.
29. Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, et al.: IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 14:275-281, 2008.
30. Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi A: IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 118:534-544, 2008.
31. Bingold TM, Ziesche E, Scheller B, Sadik CD, Franck K, Just L, Sartorius S, Wahrmann M, Wissing H, Zwissler B, et al.: Interleukin-22 detected in patients with abdominal sepsis. Shock 34:337-340, 2010.
32. Li X, Akhtar S, Choudhry MA: Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury. Biochim Biophys Acta 1822: 196-203, 2012.
33. Alexander M, Chaudry IH, Schwacha MG: Relationships between burn size, immunosuppression, and macrophage hyperactivity in a murine model of thermal injury. Cell Immunol 220:63-69, 2002.
34. Mlcak RP, Dimick AR, Mlcak G: Pre-hospital management, transportation and emergency care. In: Herndon DN, ed. Total Burn Care. Philadelphia, PA: WB Saunders Company Ltd, 1997, pp 33-43.
35. McGwin G Jr, George RL, Cross JM, Reiff DA, Chaudry IH, Rue LW 3rd: Gender differences in mortality following burn injury. Shock 18: 311-315, 2002.