HIV-1 co-receptor expression and epithelial immune cells of the cervix in asymptomatic women attending a genitourinary medicine clinic

HIV Medicine

Volumn 14, Issue 2, 2013, Pages 108-114

  Mcclure, C P ^a   Bowman, C A ^a   Geary, I ^b   Ryan, C ^a   Ball, J K ^a   Eley, A ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Cervical cytology; Chlamydia trachomatis; Genital tract infection; HIV immunology; Immunofluorescence

Indexed keywords

ANTIBODY; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; FLUORESCENT DYE; T6 ANTIGEN;

ADULT; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ARTICLE; CANDIDA; CD4+ T LYMPHOCYTE; CELL FUNCTION; CELL POPULATION; CELL SURFACE; CELL TYPE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LANGERHANS CELL; MACROPHAGE; MONOCYTE; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; UTERINE CERVIX; UTERINE CERVIX CYTOLOGY; UTERINE CERVIX EPITHELIUM; VAGINITIS;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CERVIX UTERI; CHLAMYDIA TRACHOMATIS; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; HIV SEROPOSITIVITY; HIV-1; HUMANS; MACROPHAGES; RECEPTORS, CCR5; RECEPTORS, CXCR4; T-LYMPHOCYTE SUBSETS; VAGINOSIS, BACTERIAL; VIRAL TROPISM; VIRUS REPLICATION; WOMEN'S HEALTH;

EID: 84871933856     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/hiv.12002     Document Type: Article

References (24)

1. UNAIDS. The global AIDS epidemic - key facts. 2012; Available at www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2012/201207_FactSheet_Global_en.pdf (accessed 8 November 2012).
2. HPA. HIV in the United Kingdom: 2011 report. 2011; Available at www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1317131685847 (accessed 8 November 2012).
3. Deng H, Liu R, Ellmeier W etal. Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996; 381: 661-666.
4. Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996; 272: 872-877.
5. Miller CJ, Shattock RJ. Target cells in vaginal HIV transmission. Microbes Infect 2003; 5: 59-67.
6. Hladik F, McElrath MJ. Setting the stage: host invasion by HIV. Nat Rev Immunol 2008; 8: 447-457.
7. Levine WC, Pope V, Bhoomkar A etal. Increase in endocervical CD4 lymphocytes among women with nonulcerative sexually transmitted diseases. J Infect Dis 1998; 177: 167-174.
8. Pudney J, Quayle AJ, Anderson DJ. Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone. Biol Reprod 2005; 73: 1253-1263.
9. Ficarra M, Ibana JS, Poretta C etal. A distinct cellular profile is seen in the human endocervix during Chlamydia trachomatis infection. Am J Reprod Immunol 2008; 60: 415-425.
10. Prakash M, Kapembwa MS, Gotch F, Patterson S. Higher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy women. J Reprod Immunol 2001; 52: 101-111.
11. Patterson BK, Landay A, Andersson J etal. Repertoire of chemokine receptor expression in the female genital tract: implications for human immunodeficiency virus transmission. Am J Pathol 1998; 153: 481-490.
12. McClure CP, Tighe PJ, Robins RA etal. HIV co-receptor and chemokine ligand gene expression in the male urethra and female cervix. AIDS 2005; 19: 1257-1265.
13. Zhang L, He T, Talal A, Wang G, Frankel SS, Ho DD. In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus co-receptors: CXCR4, CCR3, and CCR5. J Virol 1998; 72: 5035-5045.
14. Hladik F, Sakchalathorn P, Ballweber L etal. Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1. Immunity 2007; 26: 257-270.
15. Sheffield JS, Wendel GD Jr, McIntire DD, Norgard MV. Effect of genital ulcer disease on HIV-1 co-receptor expression in the female genital tract. J Infect Dis 2007; 196: 1509-1516.
16. Prakash M, Patterson S, Gotch F, Kapembwa MS. Recruitment of CD4 T lymphocytes and macrophages into the cervical epithelium of women after coitus. Am J Obstet Gynecol 2003; 188: 376-381.
17. Prakash M, Kapembwa MS, Gotch F, Patterson S. Oral contraceptive use induces upregulation of the CCR5 chemokine receptor on CD4(+) T cells in the cervical epithelium of healthy women. J Reprod Immunol 2002; 54: 117-131.
18. Sheffield JS, Wendel GD, Jr, McIntire DD, Norgard MV. The effect of progesterone levels and pregnancy on HIV-1 co-receptor expression. Reprod Sci. 2009; 16: 20-31.
19. Prakash M, Patterson S, Kapembwa MS. Evaluation of the cervical cytobrush sampling technique for the preparation of CD45+ mononuclear cells from the human cervix. J Immunol Methods 2001; 258: 37-46.
20. Shen R, Richter HE, Clements RH etal. Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection. J Virol 2009; 83: 3258-3267.
21. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005; 5: 953-964.
22. Schutt C. Cd14. Int J Biochem Cell Biol 1999; 31: 545-549.
23. Prakash M, Kapembwa MS, Gotch F, Patterson S. Chemokine receptor expression on mucosal dendritic cells from the endocervix of healthy women. J Infect Dis 2004; 190: 246-250.
24. Dejucq N, Simmons G, Clapham PR. Expanded tropism of primary human immunodeficiency virus type 1 R5 strains to CD4(+) T-cell lines determined by the capacity to exploit low concentrations of CCR5. J Virol 1999; 73: 7842-7847.