Functionally redundant protein phosphatase genes PTP2 and MSG5 co-regulate the calcium signaling pathway in Saccharomyces cerevisiae upon exposure to high extracellular calcium concentration

Journal of Bioscience and Bioengineering

Volumn 115, Issue 2, 2013, Pages 138-146

  Laviña, Walter A ^a   Hermansyah, ^b   Sugiyama, Minetaka ^a   Kaneko, Yoshinobu ^a   Harashima, Satoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b SRIWIJAYA UNIVERSITY   (Indonesia)

Author keywords

Calcium sensitivity; MSG5; PTP2; Saccharomyces cerevisiae; Stress response

Indexed keywords

CALCINEURIN; CALCINEURIN INHIBITORS; CALCIUM CONCENTRATION; CALCIUM SIGNALING; CELLULAR PROCESS; EXTRACELLULAR; FUNCTIONAL REDUNDANCY; MSG5; PARALLEL CONTROL; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN PHOSPHATASE; PTP2; REGULATORY SUBUNITS; REVERSIBLE PHOSPHORYLATION; SIGNAL CASCADES; SIGNALING CASCADES; SIGNALING PATHWAYS; STRESS RESPONSE;

ENZYME ACTIVITY; GENES; PHOSPHATASES; PHOSPHORYLATION; PROTEINS; YEAST;

CALCIUM;

CALCINEURIN; CALCIUM; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2; PHOSPHOTRANSFERASE; PROTEIN PHOSPHATASE MSG5; TACROLIMUS; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; ENZYME INACTIVATION; EXTRACELLULAR CALCIUM; GENE DISRUPTION; NONHUMAN; PHENOTYPE; SACCHAROMYCES CEREVISIAE;

CALCINEURIN; CALCIUM; CALCIUM SIGNALING; GENES, FUNGAL; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TYROSINE PHOSPHATASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 84871932882     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2012.08.022     Document Type: Article

References (31)

1. Gustin M.C., Albertyn J., Alexander M., Davenport K. MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 1998, 62:1264-1300.
2. Cyert M.S. Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress. Biochem. Biophys. Res. Commun. 2003, 311:1143-1150.
3. 2+ transport in Saccharomyces cerevisiae. J. Exp. Biol. 1994, 196:157-166.
4. Davis T.N. Calcium in Saccharomyces cerevisiae. Adv. Second Messenger Phosphoprotein Res. 1995, 30:339-358.
5. 2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase. Mol. Cell. Biol. 1995, 15:4103-4114.
6. 2+ ATPase family. Cell 1989, 58:133-145.
7. 2+ influx systems by pheromone signaling in Saccharomyces cerevisiae. Genetics 2001, 159:1527-1538.
8. Stark M.J.R. Yeast protein serine/threonine phosphatases: multiple roles and diverse regulation. Yeast 1996, 12:1647-1675.
9. Miyakawa T., Mizunuma M. Physiological roles of calcineurin in Saccharomyces cerevisiae with special emphasis on its roles in G2/M cell-cycle regulation. Biosci. Biotecnol. Biochem. 2007, 71:633-645.
10. Sakumoto N., Matsuoka I., Mukai Y., Ogawa N., Kaneko Y., Harashima S. A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis. Yeast 2002, 19:587-599.
11. Hermansyah, Sugiyama M., Kaneko Y., Harashima S. Yeast protein phosphatase Ptp2p and Msg5p are involved in G1-S transition, CLN2 transcription, and vacuole morphogenesis. Arch. Microbiol. 2009, 191:721-733.
12. Hermansyah, Laviña W.A., Sugiyama M., Kaneko Y., Harashima S. Identification of protein kinase disruptions as suppressors of the calcium sensitivity of S. cerevisiae Δptp2Δmsg5 protein phosphatase double disruptant. Arch. Microbiol. 2010, 192:157-165.
13. Martin H., Flandez M., Nombela C., Molina M. Protein phosphatases in MAPK signalling: we keep learning from yeast. Mol. Microbiol. 2005, 58:6-16.
14. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning: a laboratory manual 1989, Cold Spring Harbor, New York. 2nd ed.
15. Gerami-Nejad M., Berman J., Gale C.A. Cassettes for PCR-mediated construction of green, yellow and cyan fluorescent protein fusions in Candida albicans. Yeast 2001, 18:859-864.
16. Gietz R.D., Schiestl R.H. High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat. Protoc. 2007, 2:31-34.
17. Spellman P.T., Sherlock G., Zhang M.Q., Iyer V.R., Anders K., Eisen M.B., Brown P.O., Botstein D., Futcher B. Comprehensive identification of cell-cycle regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol. Biol. Cell 1998, 9:3273-3297.
18. Yoshimoto H., Saltsman K., Gasch A.P., Li H.X., Ogawa N., Botstein D., Brown P.O., Cyert M.S. Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae. J. Biol. Chem. 2002, 277:31079-31088.
19. Stathopoulos-Genontides A., Guo J.J., Cyert M.S. Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation. Genes Dev. 1999, 13:798-803.
20. Watanabe Y., Irie K., Matsumoto K. Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol. Cell. Biol. 1995, 15:5740-5749.
21. Levin D.E. Cell wall integrity signaling in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 2005, 69:262-291.
22. Jung U.S., Levin D.E. Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway. Mol. Microbiol. 1999, 34:1049-1057.
23. Hahn J.S., Thiele D.J. Regulation of the Saccharomyces cerevisiae Slt2 kinase pathway by the stress-inducible Sdp1 dual specificity phosphatase. J. Biol. Chem. 2002, 277:21278-21284.
24. Klis F.M., Boorsma A., De Groot P.W.J. Cell construction in Saccharomyces cerevisiae. Yeast 2006, 23:185-202.
25. Zhao X., Mehrabi R., Xu J.-R. Mitogen-activated protein kinase pathways and fungal pathogenesis. Eukaryot. Cell 2007, 6:1701-1714.
26. Nakamura T., Ohmoto T., Hirata D., Tsuchiya E., Miyakawa T. Genetic evidence for the functional redundancy of the calcineurin and Mpkl-mediated pathways in the regulation of cellular events important for growth in Saccharomyces cerevisiae. Mol. Gen. Genet. 1996, 251:211-219.
27. Mazur P., Morin N., Baginsky W., el-Sherbeini M., Clemas J.A., Nielsen J.B., Foor F. Differential expression and function of two homologous subunits of yeast 1,3-beta-d-glucan synthase. Mol. Cell. Biol. 1995, 15:5671-5681.
28. Zhao C., Jung U.S., Garrett-Engele P., Roe T., Cyert M.S., Levin D.E. Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin. Mol. Cell. Biol. 1998, 18:1013-1022.
29. Mattison C.P., Spencer S.S., Kresge K.A., Lee J., Ota I.M. Differential regulation of the cell wall integrity mitogen-activated protein kinase pathway in budding yeast by the protein tyrosine phosphatases Ptp2 and Ptp3. Mol. Cell. Biol. 1999, 19:7651-7660.
30. Martin H., Rodriguez-Pachon J.M., Ruiz C., Nombela C., Molina M. Regulatory mechanisms for modulation of signaling through the cell integrity Slt2-mediated pathway in Saccharomyces cerevisiae. J. Biol. Chem. 2000, 275:1511-1519.
31. Collister M., Didmon M.P., MacIsaac F., Stark M.J., MacDonald N.Q., Keyse S.M. YIL113W encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiae. FEBS Lett. 2002, 527:186-192.