Thymohexin exhibits cytoprotective effect in experimental gastric lesions in rats both through the inhibition of inducible nitric oxide synthase and reduction of oxidative mucosal damage

Regulatory Peptides

Volumn 180, Issue 1, 2013, Pages 50-57

  Nasadyuk, C ^a   Sklyarov, A ^a  

^a DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY   (Ukraine)

Author keywords

Aminoguanidine; Gastric lesions; L Arginine; Lipoperoxidation processes; Nitric oxide synthase; Short peptides

Indexed keywords

AMINOGUANIDINE; ARGININE; CATALASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; THYMOHEXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIULCER ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME INHIBITION; LIPID PEROXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH ULCER;

ANIMALS; GASTRIC MUCOSA; MALE; NITRIC OXIDE SYNTHASE TYPE II; OLIGOPEPTIDES; OXIDATIVE STRESS; RATS; STOMACH ULCER;

RATTUS;

EID: 84871927484     PISSN: 01670115     EISSN: 18731686     Source Type: Journal    
DOI: 10.1016/j.regpep.2012.11.004     Document Type: Article

References (26)

1. Balenovic D., Bencic M.L., Udovicic M., et al. Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system. Regul Pept 2009, 156:83-89.
2. Falalyeyeva T.M., Samonina G.E., Beregovaya T.V., Andreeva L.A., Dvorshchenko E.V. Effect of glyprolines on homeostasis of gastric mucosa in rats with stress ulcers. Bull Exp Biol Med 2010, 149:26-28.
3. Ilic S., Brcic I., Mester M., Filipovic M., Sever M., Klicek R., et al. Over-dose insulin and stable gastric pentadecapeptide BPC 157 attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats. J Physiol Pharmacol 2009, 60:107-114.
4. Fleishman M.Y., Zhivotova E.Y., Lebedko O.A., Deigin V.I., Timoshin S.S. Protective effect of dermorphin analogue sedatin on indomethacin-induced injury to the gastric mucosa. Bull Exp Biol Med 2009, 148:60-63.
5. Cibrián D., Berlanga J., Guevara L., et al. Cardiac and extracardiac cytoprotective effects of GHRP6. Biotecnol Apl 2008, 25:279-281.
6. Zhivotova E.Y., Fleishman M.Y., Sazonova E.N., Lebed'ko O.A., Timoshin S.S. Gastroprotective effect of dalargin in gastropathy due to treatment with nonsteroid antiinflammatory drugs. Bull Exp Biol Med 2009, 147:441-443.
7. Sikiric P. The pharmacological properties of the novel peptide BPC 157 (PL-10). Inflammopharmacology 1999, 7:1-14.
8. Peskar B.M. Neuronal aspects of prostaglandin involvement in gastric mucosal defense. J Physiol Pharmacol 2001, 52:555-568.
9. Pisarev V.M., Tutel'ian A.V., Danilina A.V., Kremlev S.G., Tkacheva T.D., Lebedeve V.V., Pevnitski L.A. Mechanisms of inhibiting production of tumor necrosis factor alpha by the synthetic hexapeptide-immunophane. Vopr Med Khim 1995, 41:5-11.
10. Konturek P.C., Konturek S.J., Celinski K., Slomka M., Cichoz-Lach H., Bielanski W., Reiter R.J. Role of melatonin in mucosal gastroprotection against aspirin-induced gastric lesions in humans. J Pineal Res 2010, 48:318-323.
11. Zhuroms'ky V.S., Skliarov O.Ia. Effect of vitamin C on the condition of NO-synthase system in experimental stomach ulcer. Fiziol Zh 2011, 57:90-98.
12. Kato S., Ohkawa F., Ito Y., Amagase K., Takeuchi K. Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced damage in adjuvant arthritic rats. J Physiol Pharmacol 2009, 60:147-155.
13. Sklyarov A.Y., Panasyuk N.B., Fomenko I.S. Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis. J Physiol Pharmacol 2011, 62:65-73.
14. Green L.C., David A.W. Analysis of nitrate, nitrite and nitrate in biological fluids. Anal Biochem 1982, 126:131-138.
15. Brzozowski T., Konturek P.C., Pajdo R., et al. Physiological mediators in nonsteroidal anti-inflammatory drugs (NSAIDs)-induced impairment of gastric mucosal defense and adaptation. Focus on nitric oxide and lipoxins. J Physiol Pharmacol 2008, 59:89-102.
16. Naito Y., Yoshikawa T., Yoshida N., Kondo M. Role of oxygen radical and lipid peroxidation in indomethacin induced gastric mucosal injury. Dig Dis Sci 1998, 43:30-34.
17. Kattab M., Gad M., Abdallah D. Protective role of nitric oxide in indomethacin-induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res 2001, 43:463-467.
18. Guo J., Cho C., Wang J., Koo M. Differential effects of selective and non-selective inhibition of nitric oxide synthase on the expression and activity of cyclooxygenase-2 during gastric ulcer healing. Eur J Pharmacol 2006, 536:301-308.
19. Wallace J., Miller M. Nitric oxide in mucosal defense: a little goes a long way. Gastroenterology 2000, 119:512-520.
20. Wallace J.L., Ma L. Inflammatory mediators in gastrointestinal defense and injury. Exp Biol Med 2001, 226:1003-1015.
21. Ohta Y., Nishida K. l-Arginine protects against stress-induced gastric mucosal lesions by preserving gastric mucus. Clin Exp Pharmacol Physiol 2002, 29:32-38.
22. Nagai N., Fukuhata T., Ito Y., Usui S., Hirano K. Preventive effect of co-administration of water containing magnesium ion on indomethacin induced lesions of gastric mucosa in adjuvant-induced arthritis rat. Biol Pharm Bull 2009, 32:116-120.
23. Kwiecień S., Brzozowski T., Konturek S.J. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J Physiol Pharmacol 2002, 53:39-50.
24. Kwiecien S., Pawlik M.W., Brzozowski T., Konturek P.C., Sliwowski Z., Pawlik W.W., Konturek S.J. Nitric oxide (NO)-releasing aspirin and (NO) donors in protection of gastric mucosa against stress. J Physiol Pharmacol 2008, 59:103-115.
25. Onasanwo S.A., Singh N., Olaleye S.B., Mishra V., Palit G. Anti-ulcer and antioxidant activities of Hedranthera barteri (Hook F.) Pichon with possible involvement of H+, K+ ATPase inhibitory activity. Indian J Med Res 2010, 132:442-449.
26. Takagi T., Naito Y., Yoshikawa T. The expression of heme oxygenase-1 induced by lansoprazole. J Clin Biochem Nutr 2009, 45:9-13.