Could maternal exposure to the antidepressants fluoxetine and St. John's Wort induce long-term reproductive effects on male rats?

Reproductive Toxicology

Volumn 35, Issue 1, 2013, Pages 102-107

  Vieira, Milene Leivas ^a   Hamada, Renata Yumi ^a   Gonzaga, Natalia Ignácio ^a   Bacchi, Andre Demambre ^a   Barbieri, Mainara ^a   Moreira, Estefânia Gastaldello ^a   Mesquita, Suzana de Fátima Paccola ^a   Gerardin, Daniela Cristina Ceccatto ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

Author keywords

Antidepressant; Fluoxetine; Male reproduction; Maternal exposure; St. John's Wort

Indexed keywords

FLUOXETINE; HYPERICUM PERFORATUM EXTRACT; TESTOSTERONE;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOGENITAL DISTANCE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; EPIDIDYMIS; FEMALE; HABITUATION; MALE; NONHUMAN; PROGENY; PROSTATE; REPRODUCTIVE TOXICITY; SEMINAL VESICLE; SEMINIFEROUS TUBULE; SEXUAL BEHAVIOR; SPERMATOZOON; TESTIS; TESTOSTERONE BLOOD LEVEL;

ANIMALS; ANTIDEPRESSIVE AGENTS; FEMALE; FLUOXETINE; HYPERICUM; MALE; MATERNAL-FETAL EXCHANGE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; SEXUAL BEHAVIOR; SEXUAL DEVELOPMENT; SPERMATOGENESIS; TESTIS; TESTOSTERONE;

RATTUS;

EID: 84871926917     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2012.07.006     Document Type: Article

References (49)

1. Freeman M.P. Complementary and alternative medicine for perinatal depression. Journal of Affective Disorders 2009, 112:1-10.
2. Moses-Kolko E.L., Roth E.K. Antepartum and postpartum depression: healthy mom, healthy baby. Journal of the American Medical Women's Association 2004, 59(3):181-191.
3. McElhatton P.R. Drug use in pregnancy. Part 1. Pharmaceutical Journal 2003, 270:270-272.
4. Zeskind P.S., Stephens L.E. Maternal selective serotonin reuptake inhibitor use during pregnancy and newborn neurobehavior. Pediatrics 2004, 113:368-375.
5. Use of psychoactive medication during pregnancy and possible effects on the fetus and newborn. Pediatrics 2000, 105:880-887. American Academy of Pediatrics Committee on Drugs.
6. Einarson A., Koren G. New antidepressants in pregnancy. Canadian Family Physician 2004, 50(227):9.
7. Butterweck V., Böckers T., Korte B., Wittkowski W., Winterhoff H. Long-term effects of St John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. Brain Research 2002, 930:21-29.
8. Brenner R., Azbel V., Madhusoodanan S., Pawlowska M. Comparison of an extract of Hypericum (LI 160) and setraline in the treatment of depression: a double-blind, randomized pilot study. Clinical Therapeutics 2000, 22:411-419.
9. Schrader E. Equivalence of St John's wort extract (Ze 117) and fluxetine: a randomized, controlled study in mild-moderate depression. International Clinical Psychopharmacology 2000, 5:61-68.
10. Volz H.P. Controlled clinical trials of Hypericum extracts in depressed patients: an overview. Pharmacopsychiatry 1997, 30:72-76.
11. Wheatly D. Hypericum extracts - potential in the treatment of depression. CNS Drugs 1998, 9:431-440.
12. Woelk H. Comparison of St. John's wort and imipramine for treating depression: randomized controlled trail. British Medical Journal 2000, 321:536-539.
13. Mischoulon D. Update and critique of natural remedies as antidepressant treatments. Psychiatric Clinics of North America 2007, 30:51-68.
14. Calapai G., Crupi A., Firenzuoli F., Constantino G., Inferrera G., Campo G.M., et al. Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat. Journal of Pharmacy and Pharmacology 1999, 51:723-728.
15. De Vries G.J. Sex differences in neurotransmitters systems. Journal of Neuroendocrinology 1990, 2:1-14.
16. Tobet S.A., Hanna L.K. Ontogeny of sex differences in the mammalian hypothalamus and preoptic area. Cellular and Molecular Neurobiology 1997, 17:561-601.
17. Wilson C.A., Gonzales M.I., Albonetti M.E., Farabollini E. The involvement of neonatal 5-HT receptor mediated effects on sexual dimorphism of adult behavior in the rat. Males, females and behavior 1998, 109-127. Westport, Praeger. L. Ellis, L. Ebertz (Eds.).
18. McCarthy M.M., Auger A.P., Perrot-Sinal T.S. Getting excited about GABA and sex differences in the brain. Trends in Neurosciences 2002, 25:307-312.
19. Murray J.F., Dakin C.L., Siddiqui A., Pellatt L.J., Ahmed S., Ormerod L.J., et al. Neonatal 5HT activity antagonizes the masculinizing effect of testosterone on the luteinizing hormone release response to gonadal steroids and on brain structures in rats. European Journal of Neuroscience 2004, 19:387-395.
20. Lee L.-J., Lee L.J.-H Neonatal fluoxetine exposure alters motor performances of adolescent rats. Development Neurobiology 2011, 28. doi:10.1002/dneu.20942.
21. Favaro P.N., Costa L.C., Moreira E.G. Maternal fluoxetine treatment decreases behavioral response to dopaminergic drugs in female pups. Neurotoxicology and Teratology 2008, 30(6):487-494.
22. Lisboa S.F.S., Oliveira P.E., Costa L.C., Venâncio E.J., Moreira E.G. Behavioral evaluation of male and female mice pups exposed to fluoxetine during pregnancy and lactation. Pharmacology 2007, 80:49-56.
23. Forcelli P.A., Heinrichs S.C. Teratogenic effects of maternal antidepressant exposure on neural substrates of drug-seeking behavior in offspring. Addiction Biology 2007, 13:52-62.
24. Rayburn W.F., Christensen H.D., Gonzalez C.L. Effect of antenatal exposure to Saint John's wort (Hypericum) on neurobehavior of developing mice. American Journal of Obstetrics and Gynecology 2000, 183(5):1225-1231.
25. Rayburn W.F., Gonzalez C.L., Christensen H.D., Harkins T.L., Kupiec T.C. Impact of hypericum (St. John's Wort) given prenatally on cognition of mice offspring. Neurotoxicology and Teratology 2001, 23(6):629-637.
26. Rayburn W.F., Gonzalez C.L., Christensen H.D., Stewart J.D. Effect of prenatal administered hypericum (St. John's wort) on growth and physical maturation of mouse offspring. American Journal of Obstetrics and Gynecology 2001, 184:191-195.
27. Cada A.M., Hansen D.K., LaBorde J.B., Ferguson S.A. Minimal effects from developmental exposure to St. John's Wort (Hypericum perforatum) in Sprague-Dawley rats. Nutritional Neuroscience 2001, 4(2):135-141.
28. Gouvêa T.S., Morimoto H.K., Faria M.J.S.S., Moreira E.G., Gerardin D.C.C. Maternal exposure to the antidepressant fluoxetine impairs sexual motivation in adult male mice. Pharmacology Biochemistry and Behavior 2008, 90:416-419.
29. Gregoretti B., Stebel M., Candussio L., Crivellato E., Fiora B., Decorti G. Toxicity of Hypericum perforatum (St. John's Wort) administered during pregnancy and lactation in rats. Toxicology and Applied Pharmacology 2004, 200:201-205.
30. Broadhurst P.L. Experiments in psychogenetics. Experiments in personality 1960, 31-61. Rutledge and Kegan Paul, London. H.J. Eysenk (Ed.).
31. Moreira E.G., Vassilieff I., Vassilieff V.S. Developmental lead exposure: behavioral alterations in the short and long term. Neurotoxicology and Teratology 2001, 23:489-495.
32. Barros D., Amaral O., Izquierdo I., Geracitano L., Raseira M.C.B., Henriques A.T., Ramirez M.R. Behavioral and genoprotective effects of Vaccinium berries intake in mice. Pharmacology Biochemistry and Behavior 2006, 84:229-234.
33. Robb G.W., Amann R.P., Killian G.J. Daily sperm production and epididymal sperm reserves of pubertal and adult rats. Journal of Reproduction and Fertility 1978, 54(1):103-107.
34. Fernandes G.S., Arena A.C., Fernadez C.D., Mercadante A., Barbisan L.F., Kempinas W.G. Reproductive effects in male exposed to diuron. Reproductive Toxicology 2007, 23(1):106-112.
35. Gerardin D.C.C., Bernardi M.M., Moreira E.G., Pereira O.C.M. Neuroendocrine and reproductive aspects of adult male rats exposed neonatally to an antiestrogen. Pharmacology Biochemistry and Behavior 2006, 83:618-623.
36. Agmo A. Lack of opioid or dopaminergic effects on unconditioned sexual incentive motivation in male rats. Behavioral Neuroscience 2003, 117:55-68.
37. Nojimoto F.D., Piffer R.C., Kiguti L.R.A., Lameu C., Camargo A.C.M., Pereira O.C.M., et al. Multiple effects of sibutramine ejaculation and on vas deferens and seminal vesicle contractility. Toxicology and Applied Pharmacology 2009, 239:233-240.
38. Bellentani F.F., Fernandes G.S.A., Perobelli J.E., Pacini E.S.A., Kiguti L.R.A., Pupo A.S., et al. Acceleration of sperm transit time and reduction of sperm reserves in the epididymis of rats exposed to sibutramine. Journal of Andrology 2011, 32:718-724.
39. Kaleczyc J., Majewski M., Calka J., Lakomy M. Adrenergic innervation of the epididymis, vas deferens, accessory genital glands and urethra in the boar. Folia Histochemica et Cytobiologica 1993, 31:117-123.
40. Ricker D.D. The autonomic innervation of the epididymis: its effects on epididymal function and fertility. Journal of Andrology 1998, 19:1-4.
41. Kempinas W.D.G., Klinefelter G.R. The epididymis as a target for toxicants. Comprehensive toxicology 2010, 149-166. Academic Press, United Kingdom. C.A. McQueen (Ed.).
42. Bataineh H.N., Daradka T. Effects of long-term use of fluoxetine on fertility parameters in adult male rats. Neuroendocrinology Letters 2007, 28(3):321-325.
43. França R.L., Silva J.V.A., Chiarini-Garcia H., Garcia S.K., Debeljuk L. Cell proliferation and hormonal changes during postnatal development of the testis in the pig. Biology of Reproduction 2000, 63:1629-1636.
44. Das T.K., Mazunder R., Biswas N.M. Spermatogenesis in rat: effect of l-tryptophan loading. Andrologia 1982, 14:242-249.
45. Das T.K., Mazunder R., Biswas N.M. Effects of intraventricular injection of 5,6-dihydroxytryptamine on spermatogenesis and plasma testosterone levels in rat. Journal of Endocrinology 1985, 106:395-400.
46. Kalla N.R. Demonstration of direct effect of serotonin on rat Leyding cell. Andrologia 1979, 11:259-262.
47. Das T.K., Mazunder R., Biswas N.M. Further evidence for na inhibitory effect of l-trryptophan loading on testicular functions of rat. Andrologia 1986, 18:618-623.
48. Hedger M.P., Khatab S., Gonzales G., De Krestser D.M. Acute and shot-term action of serotonin administration on the pituitary-testicular axis in the adult rat. Reproduction, Fertility, and Development 1995, 7:1101-1109.
49. Butterweck V., Schmidt M. St. John's Wort: role of active compounds for its mechanism of action and efficacy. Wiener Medizinische Wochenschrift 2007, 157(13):356-361.