Single Cord Blood Combined with HLA-Mismatched Third Party Donor Cells: Comparable Results to Matched Unrelated Donor Transplantation in High-Risk Patients with Hematologic Disorders

Biology of Blood and Marrow Transplantation

Volumn 19, Issue 1, 2013, Pages 143-149

  Kwon, Mi ^a,b   Balsalobre, Pascual ^a,b   Serrano, David ^a,b   Perez Corral A ^b   Buño, Ismael ^a,b   Anguita, Javier ^a,b   Gayoso, Jorge ^a,b   Diez Martin, Jose Luis ^a,b  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

Allogeneic stem cell transplantation; Dual transplant; Haploidentical donor

Indexed keywords

ACICLOVIR; BUSULFAN; CD34 ANTIBODY; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN; ITRACONAZOLE; METHOTREXATE; METHYLPREDNISOLONE; MICAFUNGIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; THIOTEPA; THYMOCYTE ANTIBODY;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ARTICLE; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; ENGRAFTMENT; FEMALE; GRAFT VERSUS HOST REACTION; HEMATOLOGIC DISEASE; HEMORRHAGIC CYSTITIS; HERPES VIRUS INFECTION; HIGH RISK PATIENT; HUMAN; INCIDENCE; LYMPHOPROLIFERATIVE DISEASE; MALE; MORTALITY; MYCOSIS; NEUTROPHIL; NONMYELOABLATIVE STEM CELL TRANSPLANTATION; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PNEUMOCYSTOSIS; RADIATION DOSE; RELAPSE; STEM CELL TRANSPLANTATION; UMBILICAL CORD BLOOD;

ACUTE DISEASE; ADULT; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA ANTIGENS; HUMANS; MALE; MIDDLE AGED; SIBLINGS; SURVIVAL RATE; TIME FACTORS; UNRELATED DONORS;

EID: 84871925561     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2012.08.019     Document Type: Article

References (39)

1. Van Rood J.J., Oudshoorn M. Eleven million donors in Bone Marrow Donors Worldwide! Time for reassessment?. Bone Marrow Transplant 2008, 41:1-9.
2. Sanz G.F., Saavedra S., Planelles D., et al. Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood 2001, 98:2332-2338.
3. Sanz J., Boluda J.C., Martín C., et al. Single-unit umbilical cord blood transplantation from unrelated donors in patients with hematological malignancy using busulfan, thiotepa, fludarabine and ATG as myeloablative conditioning regimen. Bone Marrow Transplant 2012, 47:1287-1293.
4. Rocha V., Labopin M., Sanz G., et al. Transplants of umbilical cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004, 351:2276-2285.
5. Eapen M., Rocha V., Sanz G., et al. Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. Lancet Oncol 2010, 11:653-660.
6. Majhail N.S., Mothukuri J.M., Brunstein C.G., et al. Costs of hematopoietic cell transplantation: comparison of umbilical cord blood and matched related donor transplantation and the impact of posttransplant complications. Biol Blood Marrow Transplant 2009, 15:564-573.
7. Kelly S.S., Sola C.B., De Lima M., et al. Ex vivo expansion of cord blood. Bone Marrow Transplant 2009, 44:673-681.
8. Dahlberg A., Delaney C., Bernstein I.D. Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood 2011, 117:6083-6090.
9. Verneris M.R., Brunstein C.G., Barker J., et al. Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units. Blood 2009, 114:4293-4299.
10. Frassoni F., Gualandi F., Podestà M., et al. Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia: a phase I/II study. Lancet Oncol 2008, 9:831-839.
11. + cells from an HLA-haploidentical donor. Exp Hematol 2003, 31:535-544.
12. Magro E., Regidor C., Cabrera R., et al. Early hematopoietic recovery after single unit unrelated cord blood transplantation in adults supported by co-infusion of mobilized stem cells from a third party donor. Haematologica 2006, 91:640-648.
13. Bautista G., Cabrera R., Regidor C., et al. Cord blood transplants supported by co-infusion of mobilized hematopoietic stem cells from a third-party donor. Bone Marrow Transplant 2009, 43:365-373.
14. Fernández M.N. Improving the outcome of cord blood transplantation: use of mobilized HSC and other cells from third party donors. Br J Haematol 2009, 147:161-176.
15. Sebrango A., Vicuña I., De Laiglesia A., et al. Haematopoietic transplants combining a single unrelated cord blood unit and mobilized haematopoietic stem cells from an adult HLA-mismatched third-party donor: comparable results to transplants from HLA-identical related donors in adults with acute leukaemia and myelodysplastic syndromes. Best Pract Res Clin Haematol 2010, 23:259-274.
16. Cheson D.B., Bennett J.M., Kopecky K.J., et al. Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia. J Clin Oncol 2003, 21:4642-4649.
17. Sorror M.L., Maris M.B., Storb R., et al. Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood 2005, 106:2912-2919.
18. Buño I., Nava P., Simón A., et al. A comparison of fluorescent in situ hybridization and multiplex short tandem repeat polymerase chain reaction for quantifying chimerism after stem cell transplantation. Haematologica 2005, 90:1373-1379.
19. Przepiorka D., Weisdorf D., Martin P., et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant 1995, 15:825-828.
20. Filipovich A.H., Weisdorf D., Pavletic S., et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease, I: Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant 2005, 11:945-956.
21. Gooley T.A., Leisenring W., Crowley J.A., et al. Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med 1999, 18:665-706.
22. Klein J.P., Rizzo J.D., Zhang M.J., et al. Statistical methods for the analysis and presentation of the results of bone marrow transplants, I: unadjusted analysis. Bone Marrow Transplant 2001, 28:909-915.
23. + cells improved transplant outcome for patients with severe aplastic anemia undergoing cord blood transplantation (ASH Annual Meeting Abstracts). Blood 2011, 118:654.
24. Liu H., Rich E.S., Godley L., et al. Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions. Blood 2011, 118:6438-6445.
25. Anasetti C., Logan B.R., Lee S.J., et al. Increased incidence of chronic graft-versus-host disease (GVHD) and no survival advantage with filgrastim-mobilized peripheral blood stem cells (PBSC) compared to bone marrow (BM) transplants from unrelated donors: results of Blood and Marrow Transplant Clinical Trials Network (BMT CTN) protocol 0201, a Phase III prospective randomized trial (ASH Annual Meeting Abstracts). Blood 2011, 118:1.
26. Ringdén O., Labopin M., Beelen D.W., et al. Bone marrow or peripheral blood stem cell transplantation from unrelated donors in adult patients with acute myeloid leukemia: an Acute Leukaemia Working Party analysis in 2262 patients. J Intern Med 2012, [Epub ahead of print]. 10.1111/j.1365-2796.2012.02547.x.
27. Chan K.W., Grimley M.S., Taylor C., et al. Early identification and management of graft failure after unrelated cord blood transplantation. Bone Marrow Transplant 2008, 42:35-41.
28. Barker J.N., Scaradavou A., Stevens C.E. Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies. Blood 2010, 115:1843-1849.
29. Wagner J.E., Barker J.N., DeFor T.E., et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002, 100:1611-1618.
30. Rodrigues C.A., Sanz G., Brunstein C.G., et al. Analysis of risk factors for outcomes after unrelated cord blood transplantation in adults with lymphoid malignancies: a study by the Eurocord-Netcord and Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol 2009, 27:256-263.
31. Takanashi M., Atsuta Y., Fujiwara K., et al. The impact of anti-HLA antibodies on unrelated cord blood transplantations. Blood 2010, 116:2839-2846.
32. Page K.M., Zhang L., Mendizabal A. Total colony-forming units are a strong, independent predictor of neutrophil and platelet engraftment after unrelated umbilical cord blood transplantation: a single-center analysis of 435 cord blood transplants. Biol Bone Marrow Transplant 2011, 17:1362-1374.
33. Barker J.N., Byam C., Scaradavou A. How I treat: the selection and acquisition of unrelated cord blood grafts. Blood 2011, 117:2332-2339.
34. Lee S.J., Vogelsang G., Flowers M.E. Chronic graft-versus-host disease. Biol Blood Marrow Transplant 2003, 9:215-233.
35. Pidala J., Kurland B., Chai X., et al. Patient-reported quality of life is associated with severity of chronic graft-versus-host disease as measured by NIH criteria: report on baseline data from the Chronic GVHD Consortium. Blood 2011, 117:4651-4657.
36. Martín-Donaire T., Rico M., Bautista G., et al. Immune reconstitution after cord blood transplants supported by coinfusion of mobilized hematopoietic stem cells from a third-party donor. Bone Marrow Transplant 2009, 44:213-225.
37. Ruggeri L., Mancusi A., Perruccio K., et al. Natural killer cell alloreactivity for leukemia therapy. J Immunother 2005, 28:175-182.
38. Brunstein C.G., Fuchs E.J., Carter S.L., et al. Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts. Blood 2011, 118:282-288.
39. Ballen K.K., Koreth J., Chen Y.B., et al. Selection of optimal alternative graft source: mismatched unrelated donor, umbilical cord blood, or haploidentical transplant. Blood 2012, 119:1972-1980.