Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis

Fertility and Sterility

Volumn 99, Issue 1, 2013, Pages 231-240

  Guo, Sun Wei ^a   Mao, Xiaoyan ^a   Ma, Qingliang ^b   Liu, Xishi ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Adenomyosis; amplitude; dysmenorrhea; oxytocin receptor; severity; uterine contractility

Indexed keywords

ANDROGRAPHOLIDE; OXYTOCIN RECEPTOR; TRICHOSTATIN A;

ADENOMYOSIS; ADULT; CLINICAL ARTICLE; CLINICAL EVALUATION; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DOSE RESPONSE; DYSMENORRHEA; ENDOMETRIOSIS; FEMALE; GENE OVEREXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYSTERECTOMY; MYOMETRIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; UNIVERSITY HOSPITAL; UTERINE CERVIX DYSPLASIA; UTERUS CANCER; UTERUS CONTRACTILITY; UTERUS MYOMA; VISUAL ANALOG SCALE; WESTERN BLOTTING;

ADENOMYOSIS; ADULT; CASE-CONTROL STUDIES; CELLS, CULTURED; CROSS-SECTIONAL STUDIES; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DYSMENORRHEA; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYDROXAMIC ACIDS; LEIOMYOMA; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; MYOMETRIUM; RECEPTORS, OXYTOCIN; SEVERITY OF ILLNESS INDEX; UTERINE CERVICAL DYSPLASIA; UTERINE CONTRACTION; UTERINE NEOPLASMS;

EID: 84871923948     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2012.08.038     Document Type: Conference Paper

References (69)

1. C. Bergeron, F. Amant, and A. Ferenczy Pathology and physiopathology of adenomyosis Best Pract Res Clin Obstet Gynaecol 20 2006 511 521 (Pubitemid 44688626)
2. C. Farquhar, and I. Brosens Medical and surgical management of adenomyosis Best Pract Res Clin Obstet Gynaecol 20 2006 603 616 (Pubitemid 44688625)
3. I.M. Matalliotakis, A.I. Kourtis, and D.K. Panidis Adenomyosis Obstet Gynecol Clin North Am 30 2003 63 82 viii (Pubitemid 36356713)
4. X. Zhang, B. Lu, X. Huang, H. Xu, C. Zhou, and J. Lin Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine fibroids Fertil Steril 92 2009 1799 1801
5. X. Zhang, B. Lu, X. Huang, H. Xu, C. Zhou, and J. Lin Innervation of endometrium and myometrium in women with painful adenomyosis and uterine fibroids Fertil Steril 94 2010 730 737
6. G. Wang, N. Tokushige, and I.S. Fraser Nerve fibers and menstrual cycle in peritoneal endometriosis Fertil Steril 95 2011 2772 2774
7. D. de Ziegler, C. Bulletti, R. Fanchin, M. Epiney, and P.A. Brioschi Contractility of thenonpregnant uterus: the follicular phase Ann N Y Acad Sci 943 2001 172 184 (Pubitemid 32928313)
8. M.M. Ijland, J.L. Evers, G.A. Dunselman, C. van Katwijk, C.R. Lo, and H.J. Hoogland Endometrial wavelike movements during the menstrual cycle Fertil Steril 65 1996 746 749 (Pubitemid 26096912)
9. G. Leyendecker, G. Kunz, L. Wildt, D. Beil, and H. Deininger Uterine hyperperistalsis and dysperistalsis as dysfunctions of the mechanism of rapid sperm transport in patients with endometriosis and infertility Hum Reprod 11 1996 1542 1551 (Pubitemid 26335111)
10. R.A. Woodbury, R. Torpin, G.P. Child, H. Watson, and M. Jarboe Myometrial physiology and its relation to pelvic pain J Am Med Assoc 134 1947 1081 1085
11. G. Kunz, and G. Leyendecker Uterine peristaltic activity during the menstrual cycle: characterization, regulation, function and dysfunction Reprod Biomed Online 4 Suppl 3 2002 5 9
12. G. Kunz, M. Noe, M. Herbertz, and G. Leyendecker Uterine peristalsis during the follicular phase of the menstrual cycle: effects of oestrogen, antioestrogen and oxytocin Hum Reprod Update 4 1998 647 654 (Pubitemid 29041478)
13. Y.P. Vedernikov, J.R. Hartke, M.A. de Long, G.R. Saade, and R.E. Garfield Sex hormone effects in non-pregnant rat and human myometrium Eur J Obstet Gynecol Reprod Biol 108 2003 59 66 (Pubitemid 36411851)
14. U. Roth-Brandel, M. Bygdeman, and N. Wiqvist Effect of intravenous administration of prostaglandin E1, and F2 on the contractility of the non-pregnant human uterus in vivo Acta Obstet Gynecol Scand Suppl 5 1970 19 25
15. G. Gimpl, and F. Fahrenholz The oxytocin receptor system: structure, function, and regulation Physiol Rev 81 2001 629 683 (Pubitemid 32267075)
16. M. Akerlund, P. Melin, and M. Maggi Potential use of oxytocin and vasopressin V1a antagonists in the treatment of preterm labour and primary dysmenorrhoea Adv Exp Med Biol 395 1995 595 600
17. F.M. Abdalla, E. Marostica, Z.P. Picarelli, L.C. Abreu, M.C. Avellar, and C.S. Porto Effect of estrogen on muscarinic acetylcholine receptor expression in rat myometrium Mol Cell Endocrinol 213 2004 139 148 (Pubitemid 38213142)
18. S. Adachi, and M. Oku The regulation of oxytocin receptor expression in human myometrial monolayer culture J Smooth Muscle Res 31 1995 175 187 (Pubitemid 26035589)
19. O.N. Richter, K. Kubler, J. Schmolling, M. Kupka, J. Reinsberg, and U. Ulrich Oxytocin receptor gene expression of estrogen-stimulated human myometrium in extracorporeally perfused non-pregnant uteri Mol Hum Reprod 10 2004 339 346 (Pubitemid 38714365)
20. O.N. Richter, K. Tschubel, J. Schmolling, M. Kupka, U. Ulrich, and E. Wardelmann Immunohistochemical reactivity of myometrial oxytocin receptor in extracorporeally perfused nonpregnant human uteri Arch Gynecol Obstet 269 2003 16 24 (Pubitemid 37408837)
21. J.G. Fleming, T.E. Spencer, S.H. Safe, and F.W. Bazer Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements Endocrinology 147 2006 899 911 (Pubitemid 43113008)
22. V. Terzidou, Y. Lee, T. Lindstrom, M. Johnson, S. Thornton, and P.R. Bennett Regulation of the human oxytocin receptor by nuclear factor-kappaB and CCAAT/enhancer-binding protein-beta J Clin Endocrinol Metab 91 2006 2317 2326 (Pubitemid 43855023)
23. J. Nie, X. Liu, and S.W. Guo Immunoreactivity of oxytocin receptor and transient receptor potential vanilloid type 1 and its correlation with dysmenorrhea in adenomyosis Am J Obstet Gynecol 202 2010 346.e1 346.e8
24. S. Mechsner, B. Grum, C. Gericke, C. Loddenkemper, J.W. Dudenhausen, and A.D. Ebert Possible roles of oxytocin receptor and vasopressin-1alpha receptor in the pathomechanism of dysperistalsis and dysmenorrhea in patients with adenomyosis uteri Fertil Steril 94 2010 2541 2546
25. J. Nie, Y. Lu, X. Liu, and S.W. Guo Immunoreactivity of progesterone receptor isoform B, nuclear factor kappaB, and IkappaBalpha in adenomyosis Fertil Steril 92 2009 886 889
26. J. Kitawaki Adenomyosis: the pathophysiology of an oestrogen-dependent disease Best Pract Res Clin Obstet Gynaecol 20 2006 493 502 (Pubitemid 44688624)
27. N. Jichan, L. Xishi, and S.W. Guo Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent Reprod Sci 17 2010 995 1005
28. X. Liu, J. Nie, and S.W. Guo Elevated immunoreactivity against Class I histone deacetylases (HDACs) in adenomyosis Gynecol Obstet Invest 74 2012 50 55
29. X. Liu, and S.W. Guo A pilot study on the off-label use of valproic acid to treat adenomyosis Fertil Steril 89 2008 246 250
30. X. Liu, and S.W. Guo Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis J Obstet Gynaecol Res 37 2011 696 708
31. L. Xishi, Y. Lei, and S.W. Guo Valproic acid as a therapy for adenomyosis: a comparative case series Reprod Sci 17 2010 904 912
32. X. Mao, Y. Wang, A.V. Carter, X. Zhen, and S.W. Guo The retardation of myometrial infiltration, reduction of uterine contractility, and alleviation of generalized hyperalgesia in mice with induced adenomyosis by levo-tetrahydropalmatine (L-THP) and andrographolide Reprod Sci 18 2011 1025 1037
33. Y.F. Xia, B.Q. Ye, Y.D. Li, J.G. Wang, X.J. He, and X. Lin Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50 J Immunol 173 2004 4207 4217 (Pubitemid 39280787)
34. H. Ota, S. Igarashi, N. Sato, H. Tanaka, and T. Tanaka Involvement of catalase in the endometrium of patients with endometriosis and adenomyosis Fertil Steril 78 2002 804 809
35. L. Fedele, S. Bianchi, M. Dorta, L. Arcaini, F. Zanotti, and S. Carinelli Transvaginal ultrasonography in the diagnosis of diffuse adenomyosis Fertil Steril 58 1992 94 97
36. M. Bazot, E. Darai, J. Rouger, R. Detchev, A. Cortez, and S. Uzan Limitations of transvaginal sonography for the diagnosis of adenomyosis, with histopathological correlation Ultrasound Obstet Gynecol 20 2002 605 611 (Pubitemid 36002621)
37. S.M. Meredith, L. Sanchez-Ramos, and A.M. Kaunitz Diagnostic accuracy of transvaginal sonography for the diagnosis of adenomyosis: systematic review and metaanalysis Am J Obstet Gynecol 201 2009 107.e1 107.e6
38. K. Sakhel, and A. Abuhamad Sonography of adenomyosis J Ultrasound Med 31 2012 805 808
39. M. Akerlund, K.E. Andersson, and I. Ingemarsson Effects of terbutaline on myometrial activity, uterine blood flow, and lower abdominal pain in women with primary dysmenorrhoea Br J Obstet Gynaecol 83 1976 673 678
40. R Development Core Team R: a language and environment for statistical computing 2011 R Foundation for Statistical Computing Vienna, Austria
41. M. Akerlund Targeting the oxytocin receptor to relax the myometrium Expert Opin Ther Targets 10 2006 423 427 (Pubitemid 43949956)
42. S. Mechsner, J. Bartley, C. Loddenkemper, D.S. Salomon, A. Starzinski-Powitz, and A.D. Ebert Oxytocin receptor expression in smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts Fertil Steril 83 Suppl 1 2005 1220 1231 (Pubitemid 40543507)
43. C. Bulletti, D. De Ziegler, V. Polli, E. Del Ferro, S. Palini, and C. Flamigni Characteristics of uterine contractility during menses in women with mild to moderate endometriosis Fertil Steril 77 2002 1156 1161 (Pubitemid 34626322)
44. C. Bulletti, S. Rossi, A. Albonetti, V.V. Polli, D. De Ziegler, and M. Massoneau Uterine contractility in patients with endometriosis J Am Assoc Gynecol Laparosc 3 4 Suppl 1996 S5
45. A. Salamanca, and E. Beltran Subendometrial contractility in menstrual phase visualized by transvaginal sonography in patients with endometriosis Fertil Steril 64 1995 193 195
46. A. Kido, K. Togashi, M. Nishino, K. Miyake, T. Koyama, and R. Fujimoto Cine MR imaging of uterine peristalsis in patients with endometriosis Eur Radiol 17 2007 1813 1819 (Pubitemid 46909670)
47. A. Kitlas, E. Oczeretko, J. Swiatecka, M. Borowska, and T. Laudanski Uterine contraction signals - application of the linear synchronization measures Eur J Obstet Gynecol Reprod Biol 144 Suppl 1 2009 S61 S64
48. T. Wilson, G.C. Liggins, and D.J. Whittaker Oxytocin stimulates the release of arachidonic acid and prostaglandin F2 alpha from human decidual cells Prostaglandins 35 1988 771 780
49. P.D. Burns, J.O. Mendes Jr., R.S. Yemm, C.M. Clay, S.E. Nelson, and S.H. Hayes Cellular mechanisms by which oxytocin mediates ovine endometrial prostaglandin F2alpha synthesis: role of G(i) proteins and mitogen-activated protein kinases Biol Reprod 65 2001 1150 1155 (Pubitemid 32927581)
50. K.J. Sales, and H.N. Jabbour Cyclooxygenase enzymes and prostaglandins in pathology of the endometrium Reproduction 126 2003 559 567 (Pubitemid 37540615)
51. K.J. Sales, V. Grant, and H.N. Jabbour Prostaglandin E2 and F2alpha activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element Mol Cell Endocrinol 285 2008 51 61
52. B. Schmid, S. Wong, and B.F. Mitchell Transcriptional regulation of oxytocin receptor by interleukin-1beta and interleukin-6 Endocrinology 142 2001 1380 1385 (Pubitemid 32299664)
53. G.C. Weston, I. Haviv, and P.A. Rogers Microarray analysis of VEGF-responsive genes in myometrial endothelial cells Mol Hum Reprod 8 2002 855 863 (Pubitemid 35012474)
54. J. Nie, Y. Lu, X.S. Liu, and S.W. Guo Immunoreactivity of progesterone receptor isoform B (PR-B), nuclear factor-κB (NF-κB) and IκBα in adenomyosis Fertil Steril 92 2009 886 889
55. A.T. Moynihan, M.P. Hehir, A.M. Sharkey, S.C. Robson, G.N. Europe-Finner, and J.J. Morrison Histone deacetylase inhibitors and a functional potent inhibitory effect on human uterine contractility Am J Obstet Gynecol 199 2008 167.e1 167.e7
56. T.M. Lindstrom, A.R. Mohan, M.R. Johnson, and P.R. Bennett Histone deacetylase inhibitors exert time-dependent effects on nuclear factor-kappaB but consistently suppress the expression of proinflammatory genes in human myometrial cells Mol Pharmacol 74 2008 109 121 (Pubitemid 351877001)
57. Y. Wu, and S.W. Guo Suppression of IL-1beta-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells Eur J Obstet Gynecol Reprod Biol 135 2007 88 93 (Pubitemid 350026147)
58. Y. Wu, and S.W. Guo Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780 Gynecol Obstet Invest 62 2006 193 205 (Pubitemid 44763186)
59. Y. Wu, A. Starzinski-Powitz, and S.W. Guo Constitutive and tumor necrosis factor-alpha-stimulated activation of nuclear factor-kappaB in immortalized endometriotic cells and their suppression by trichostatin A Gynecol Obstet Invest 70 2010 23 33
60. A.A. Abu-Ghefreh, H. Canatan, and C.I. Ezeamuzie In vitro and in vivo anti-inflammatory effects of andrographolide Int Immunopharmacol 9 2009 313 318
61. M.A. Hidalgo, A. Romero, J. Figueroa, P. Cortes, I.I. Concha, and J.L. Hancke Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells Br J Pharmacol 144 2005 680 686 (Pubitemid 40445616)
62. A. Varma, H. Padh, and N. Shrivastava Andrographolide: a new plant-derived antineoplastic entity on horizon Evid Based Complement Alternat Med 2011 2011 815390
63. Y.J. Wang, J.T. Wang, Q.X. Fan, and J.G. Geng Andrographolide inhibits NF-kappaBeta activation and attenuates neointimal hyperplasia in arterial restenosis Cell Res 17 2007 933 941
64. H. Ota, S. Igarashi, M. Sasaki, and T. Tanaka Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis Hum Reprod 16 2001 561 566 (Pubitemid 32218810)
65. G. Krikun, F. Schatz, H. Taylor, and C.J. Lockwood Endometriosis and tissue factor Ann N Y Acad Sci 1127 2008 101 105 (Pubitemid 351563101)
66. F.L. Lin, S.J. Wu, S.C. Lee, and L.T. Ng Antioxidant, antioedema and analgesic activities of Andrographis paniculata extracts and their active constituent andrographolide Phytother Res 23 2009 958 964
67. M.R. Sulaiman, Z.A. Zakaria, A. Abdul Rahman, A.S. Mohamad, M.N. Desa, and J. Stanslas Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models Biol Res Nurs 11 2010 293 301
68. R.A. Burgos, J.L. Hancke, J.C. Bertoglio, V. Aguirre, S. Arriagada, and M. Calvo Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial Clin Rheumatol 28 2009 931 946
69. M. Jane, and C.W. Minkin What every woman needs to know about menopause 1997 Yale University Press New Haven, CT