Oxytocin receptor gene expression of estrogen-stimulated human myometrium in extracorporeally perfused non-pregnant uteri

Molecular Human Reproduction

Volumn 10, Issue 5, 2004, Pages 339-346

  Richter, Oliver N ^a   Kubler K ^a   Schmolling, J ^a   Kupka, J ^a   Reinsberg, J ^a   Ulrich, U ^a   van der Ven, H ^a   Wardelmann, E ^a   van der Ven, K ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Estradiol; Oxytocin; Oxytocin receptor; Oxytocin receptor gene expression; Reverse transcriptase triple primer polymerase chain reaction

Indexed keywords

ESTRADIOL; ESTROGEN; OXYTOCIN; OXYTOCIN RECEPTOR;

ADULT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; EXPERIMENTAL MODEL; EXTRACORPOREAL CIRCULATION; FEMALE; GENE EXPRESSION; HORMONAL REGULATION; HUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; THIRD TRIMESTER PREGNANCY; UTERUS CONTRACTION;

ADULT; ESTROGENS; FEMALE; GENE EXPRESSION; HUMANS; MIDDLE AGED; MYOMETRIUM; OXYTOCIN; PERFUSION; PREGNANCY; RECEPTORS, OXYTOCIN; UTERUS;

EID: 2642548886     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/gah039     Document Type: Article

References (64)

1. Adachi S and Oku M (1995) The regulation of oxytocin receptor expression in human myometrial monolayer culture. J Smooth Muscle Res 31,175-187.
2. Akerlund M (1994) Vascularization of human endometrium uterine blood flow in healthy condition and in primary dysmenorrhoea. Ann NY Acad Sci 30,47-56.
3. Akerlund M, Melin P and Maggi M (1995) Potential use of oxytocin and vasopressin V1a antagonists in the treatment of preterm labour and primary dysmenorrhoea. Adv Exp Med Biol 395,595-600.
4. Bossmar T, Akerlund M, Fantoni G, Szamatowicz J, Melin P and Maggi M (1994) Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human pregnancy: effects of the oxytocin antagonist atosiban. Am J Obstet Gynecol 171,1634-1642.
5. Bossmar T, Akerlund M, Szamatowicz J, Laudanski T, Fantoni G and Maggi M (1995) Receptor-mediated uterine effects of vasopressin and oxytocin in nonpregnant women. Br J Obstet Gynecol 102,907-912.
6. Bulletti C, Jasonni VM, Lubicz S, Flamigni C and Gurpide E (1986) Extracorporeal perfusion of the human uterus. Am J Obstet Gynecol 154,683-688.
7. Bulletti C, Jasonni VM, Ciotti PM, Tabanelli S, Naldi S and Flamigni C (1988) Extraction of estrogens by human perfused uterus: effects of membrane permeability and binding by serum proteins on differential influx into endometrium and myometrium. Am J Obstet Gynecol 159,509-515.
8. Bulletti C, Prefetto RA, Bazzocchi G et al. (1993) Electromechanical activities of human uteri during extra-corporeal perfusion with ovarian steroids. Hum Reprod 8,1558-1563.
9. Caldeyro-Barcia R and Sereno JA (1961) The response of the human uterus to oxytocin throughout pregnancy In Caldeyro-Barcia R and Heller H (eds), Oxytocin Pergamon Press, New York, p. 177.
10. Dorn C, Reinsberg J, Schlebusch H, Prietl G, van der Ven H and Krebs D (1999) Serum oxytocin concentration during embryo transfer procedure. Eur J Obstet Gynecol Reprod Biol 87,77-80.
11. Einspanier A, Bielefeld A and Kopp JH (1998) Expression of the oxytocin receptor in relation to steroid receptors in the uterus of a primate model, the marmoset monkey. Hum Reprod Update 4,634-646.
12. Ekström P, Akerlund M, Forsling M, Kindahl H, Laudanski T and Mrugacz G (1992) Stimulation of vasopression release in women with primary dysmenorrhoea and after oral contraceptive treatment-effect on uterine contractility. Br J Obstet Gynecol 99,680-684.
13. Englund K, Blanck A, Gustavsson I, Lundkvist U, Sjoblom P, Norgren A and Lindblom B (1998) Sex steroid receptors in human myometrium and fibroids: changes during menstrual cycle and gonadotropin-releasing hormone treatment. J Clin Endocrinol Metab 83,4092-4096.
14. Engstrom T, Atke A and Vilhardt H (1988) Receptor-binding characteristics and contractile responsiveness of the myometrium following prolonged infusion of bradikinin and oxytocin in rats. J Endocrinol 118,81-85.
15. Engstrom T, Atke A and Vilhardt H (1992) Oxytocin receptors and contractile response of the myometrium after long term infusion of prostaglandin F2 alpha, indomethacin, oxytocin and an oxytocin antagonist in rats. Regul Pept 20,65-72.
16. Engstrom T, Bratholm P, Vilhardt H and Christensen NJ (1998) Beta-2-adrenoceptor desensitization in non-pregnant estrogen-primed rat myometrium involves modulation of oxytocin receptor gene expression. J Mol Endocrinol 20,261-270.
17. Feng HC, Bhave M and Fairclough RJ (2000) Regulation of oxytocin receptor gene expression in sheep: tissue specifity, multiple transcripts and mRNA editing. J Reprod Fertil 120,187-200.
18. Fuchs AR, Fuchs F, Husslein P, Soloff MS and Fernström MJ (1982) Oxytocin and human parturition: a dual role for oxytocin in the initiation of labor. Science 251,1396-1398.
19. 2α in spontaneous and oxytocin-induced labor at term. Am J Obstet Gynecol 147,497-502.
20. Fuchs AR, Fuchs F, Husslein P and Soloff MS (1984) Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol 150,734-741.
21. Fuchs AR, Fuchs F and Soloff MS (1985) Oxytocin receptors in nonpregnant human uterus. J Clin Endocrinol Metab 60,37-41.
22. Fuchs AR, Behrens O, Maschek H, Kupsch E and Einspanier A (1998) Oxytocin and vasopressin receptors in human and uterine myomas during menstrual cycle and early pregnancy. Hum Reprod Update 4,594-604.
23. Garfield RE, Sims S and Daniel EE (1977) Gap junctions: their presence ans necessity in myometrium during parturition. Science 198,958-959.
24. Gimpl G and Fahrenholz F (2001) The oxytocin receptor system: structure, function, and regulation. Physiol Rev 81,629-683.
25. Grazini E, Guillon G, Mouillac B and Zingg HH (1998) Inhibition of oxytocin receptor by direct binding of progesterone. Nature 392,509-512.
26. Guyton AC (1991) Rhythmic excitation of the heart In Textbook of Medical Physiology. 8th edn, WB Saunders, Philadelphia, pp. 111-117.
27. Helmer H, Dobianer K, Koukal T and Husslein P (1995) Quantitative polymerase chain reaction for determination of different oxytocin receptor mRNA expression in non-pregnant uterine tissue. In Ivell R and Russell JA (eds) Oxytocin. Plenum Press, New York, vol 395, pp. 487-488.
28. Ing NH and Tornesi MB (1997) Estradiol up-regulates estrogen receptor and progesterone gene expression in specific ovine uterine cells. Biol Reprod 56,1205-1215.
29. Ivell R, Bathgate T, Kimura T and Parry L (1997) Molecular biology of the oxytocin receptor: a comparative approach. Biochem Soc Trans 25,1058-1066.
30. Kano T (1982) Effects of estrogen and progesterone on adrenoceptors and cyclic nucleotides in rat uterus. Jpn J Pharmacol 32,535-543.
31. Kimura T (1998) Regulation of the human oxytocin receptor in the uterus: a molecular approach. Hum Reprod Update 4,615-624.
32. Kimura T, Azuma C, Saji F et al. (1992a) Estimation by an electrophysiological method of the expression of oxytocin receptor mRNA in human myometrium during pregnancy. J Steroid Biochem Mol Biol 42,253-258.
33. Kimura T, Tanizawa O, Mori K, Brownstein M and Okayama H (1992b) Structure and expression of a human oxytocin receptor. Nature 356,526-529.
34. Kimura T, Azuma C and Takemura M (1993) Molecular cloning of a human oxytocin receptor. Regul Pept 45,73-77.
35. Kimura T, Takemura M, Nomura S et al. (1996) Expression of oxytocin receptor in human pregnant myometrium. Endocrinology 137,780-785.
36. Kitazawa T, Kajiwara T, Kiuchi A, Hatakejama H and Taneike T (2001) Muscle layer- and region-dependent distributions of oxytocin receptors in the porcine myometrium. Peptides 22,963-974.
37. Kunz G, Noe M, Herbertz M and Leyendecker G (1998) Uterine peristalsis during the follicular phase of the menstrual cycle: effects of estrogen, antioestrogen and oxytocin. Hum Reprod Update 4,647-654.
38. Larcher A, Neculcea J, Breton C, Arslan A, Rozen F, Russo C and Zingg H (1995) Oxytocin receptor gene expression in the rat uterus during pregnancy, during the estrus cycle and in response to gonadal steroid treatment. Endocrinology 136,5350-5356.
39. Lee KH, Khan-Dawood FS and Dawood MY (1998) Oxytocin receptor and its messenger ribonucleic acid in human leiomyoma and myometrium. Am J Obstet Gynecol 179,620-627.
40. Lessey BA, Killiam ASP, Metzger DA, Haney AF, Greene GL and McCarty Jr KS (1988) Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle. J Clin Endocrinol Metab 67,334-339.
41. Leygue E, Murphy L, Kuttenn F and Watson P (1996) Triple primer polymerase chain reaction a new way to quantify truncated mRNA expression. Am J Pathol 148,1097-1103.
42. Maggi M, Magini A, Fiscella A et al (1992) Sex steroid modulation of neurohypophysial hormone receptors in human nonpregnant myometrium. J Clin Endocrinol Metab 74,385-392.
43. Muller PK, Stubbs TM and Laurent SL (1992) A prospective randomized clinical trial comparing two oxytocin protocols. Am J Obstet Gynecol, 167,373-381.
44. Noe M, Kunz G, Herbertz M, Mall G and Leyendecker G (1999) The cyclic pattern of the immunohistochemical expression of oestrogen and progesterone receptors in human myometrial and endometrial layers: characterization of the endometrial-subendometrial unit. Hum Reprod 14,190-197.
45. Phaneuf S, Asbóth G, Carrasco MP et al. (1997) The desensitization of oxytocin receptors in human myometrial cells is accompanied by down-regulation of the oxytocin receptor messenger RNA. J Endocrinol 154, 7-18.
46. Phaneuf S, Rodriguez Linares B, Tamby Raja RL, MacKenzie IZ and Lopez Bernal A (2000) Loss of myometrial oxytocin receptors during oxytocin-induced and oxytocin-augmented labour. J Reprod Fertil 120,91-97.
47. Quinones-Jenab V, Jenab S, Ogawa S, Adan RA, Burbach JP and Pfaff DW (1997) Effects of estrogen on oxytocin receptor messenger ribonuclic acid expression in the uterus, pituitary, and forebrain of the female rat. Neuroendocrinology 65,9-17.
48. Rezapour M, Backstrom T and Ulmsten U (1996) Myometrial steroid concentration and oxytocin receptor density in parturient women at term. Steroids 61,338-344.
49. Richter O, Kiel R, Schmolling J, Schneider C, Pakos E, Krebs D and van der Ven H (1998) Extracorporeal perfusion of the human uterus: A physiological model in experimental gynecology and reproductive medicine. J Soc Gynecol Invest 5(Suppl),178a (Abstr).
50. Richter O, Wardelmann E, Dombrowski F et al (2000) Extracorporeal perfusion of the human uterus as an experimental model in gynaecology and reproductive medicine. Hum Reprod 15,1235-1240.
51. Roberts JS, McCracken JA, Gavagan JE and Soloff MS (1976) Oxytocin-stimulated release of prostaglandin F2α from ovine endometrium in vitro: correlation with estrous cycle and oxytocin-receptor binding. Endocrinology 99,1107-1114.
52. Robinson RS, Mann GE, Lamming GE and Wathes DC (1999) The effect of pregnancy on the expression of uterine oxytocin, oestrogen and progesterone receptors during early pregnancy in the cow. J Endocrinol 160,21-33.
53. Robinson RS, Mann GE, Lamming GE and Wathes DC (2001) Expression of oxytocin, oestrogen and progesterone receptors in uterine biopsy samples throughout the oestrous cycle and early pregnancy in cows. Reproduction 122,965-979.
54. Severino MF, Murray MJ, Brandon DD, Clinton GM, Burry KA and Novy MJ (1996) Rapid loss of oestrogen and progesterone receptors in human leiomyoma and myometrial explant cultures. Mol Hum Reprod 2,823-828.
55. Sheldrick EL and Flint APF (1985) Endocrine control of uterine oxytocin receptors in the ewe. J Endocrinol 106,249-258.
56. Sheldrick EL, Flick-Smith HC and Dos Santos Cruz GJ (1993) Oxytocin receptor binding activity in ovine cultured endometrium. J Reprod Fertil 98,521-528.
57. Soloff MS (1975) Uterine receptor for oxytocin: effects of estrogen. Biochem Biophys Res Commun 65,205-212.
58. Soloff MS, Fernstrom MA, Periyasami S, Soloff S, Baldwin S and Wieder M (1983) Regulation of oxytocin receptor concentration in rat uterine explants by estrogen and progesterone. Can J Biochem Cell Biol 61,625-630.
59. Starbuck GR, Stout TA, Lamming GE, Allen WR and Flint AP (1998) Endometrial oxytocin receptor and uterine prostaglandin secretion in mares during the oestrous cycle and early pregnancy. J Reprod Fertil 113,173-179.
60. Tahara A, Tsukada J, Tomura Y et al. (2000) Pharmacologic characterization of the oxytocin receptor in human uterine smooth muscle cells. Br J Pharmacol 129,131-139.
61. Wada J, Dobashi Y, Saito Y, Takeo T, Nakano K, Kamimura N and Wakui M (1995) Repetition of oxytocin stimuli increases the sensitivity of oxytocin receptors in the dissected myometrium. J Smooth Muscle Res 31,522-524.
62. Wathes DC and Hamon M (1993) Localisation of oestradiol, progesterone and oxytocin receptors in the uterus during the oestrous cycle and early pregnancy of the ewe. J Endocrinol 138,479-491.
63. Wathes DC, Mann GE, Payne JH, Riley PR, Stevenson KR and Lamming GE (1996) Regulation of oxytocin, estradiol and progesterone receptor concentrations in different uterine regions by estradiol, progesterone and oxytocin in ovariectomized ewes. J Endocrinol 151,375-393.
64. Zingg HH, Rosen F, Chu K et al (1995) Oxytocin and oxytocin receptor gene expression in the uterus. Recent Prog Horm Res 50,255-273.