Is myelin a mitochondrion?

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 1, 2013, Pages 33-36

  Harris, Julia J ^a   Attwell, David ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

ATP synthase; energy; oligodendrocyte; oxidative phosphorylation

Indexed keywords

ADENOSINE TRIPHOSPHATE; MYELIN; PROTON; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ARTICLE; ENERGY YIELD; HYDROLYSIS KINETICS; MATHEMATICAL COMPUTING; MEMBRANE POTENTIAL; MITOCHONDRION; MYELIN SHEATH; OLIGODENDROGLIA; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN SECRETION;

ADENOSINE TRIPHOSPHATE; ENERGY METABOLISM; EXTRACELLULAR SPACE; HYDROGEN-ION CONCENTRATION; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MODELS, BIOLOGICAL; MYELIN SHEATH; OLIGODENDROGLIA; PROTONS;

EID: 84871923469     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.148     Document Type: Article

References (21)

1. Ravera S, Panfoli I, Calzia D, Aluigi MG, Bianchini P, Diaspro A et al. Evidence foraerobic ATP synthesis in isolated myelin vesicles. Int J Biochem Cell Biol 2009; 41:1581-1591.
2. Porcelli AM, Ghelli A, Zanna C, Pinton P, Rizzuto R, Rugolo M. pH difference acrossthe outer mitochondrial membrane measured with a green fluorescent proteinmutant. Biochem Biophys Res Commun 2005; 326: 799-804. (Pubitemid 39655990)
3. Nicholls DG, Ferguson SJ (eds).Bioenergetics. 3rd ed. (Academic Press: London,2002.
4. Watt IN, Montgomery MG, Runswick MJ, Leslie AG, Walker JE. Bioenergetic cost ofmaking an adenosine triphosphate molecule in animal mitochondria. Proc NatlAcad Sci USA 2010; 107: 16823-16827.
5. Ravera S, Panfoli I, Aluigi MG, Calzia D, Morelli A. Characterization of MyelinSheath F(o)F(1)-ATP synthase and its regulation by IF(1). Cell Biochem Biophys2011; 59: 63-70.
6. Morelli A, Ravera S, Panfoli I. Hypothesis of an energetic function for myelin. CellBiochem Biophys 2011; 61: 179-187.
7. Jiang X, Wang X. Cytochrome C-mediated apoptosis. Annu Rev Biochem 2004; 73:87-106. (Pubitemid 39050364)
8. Nave KA. Myelination and the trophic support of long axons. Nat Rev Neurosci2010; 11: 275-283.
9. Funfschilling U, Supplie LM, Mahad D, Boretius S, Saab AS, Edgar J et al. Glycolyticoligodendrocytes maintain myelin and long-term axonal integrity. Nature 2012;485: 517-521.
10. Harris JJ, Attwell D. The energetics of CNS white matter. J Neurosci 2012; 32: 356-371.
11. Taylor CM, Marta CB, Claycomb RJ, Han DK, Rasband MN, Coetzee T et al. Proteomicmapping provides powerful insights into functional myelin biology. ProcNatl Acad Sci USA 2004; 101: 4643-4648. (Pubitemid 38437464)
12. Roth AD, Ivanova A, Colman DR. New observations on the compact myelin proteome.Neuron Glia Biol 2006; 2: 15-21. (Pubitemid 43248060)
13. Boussouf A, Gaillard S. Intracellular pH changes during oligodendrocyte differentiationin primary culture. J Neurosci Res 2000; 59: 731-739.
14. Bakiri Y, Karadottir R, Cossell L, Attwell D. Morphological and electrical propertiesof oligodendrocytes in the white matter of the corpus callosum and cerebellum.J Physiol 2011; 589: 559-573.
15. Champagne E, Martinez LO, Collet X, Barbaras R. Ecto-F1Fo ATP synthase/F1ATPase: metabolic and immunological functions. Curr Opin Lipidol 2006; 17: 279-284. (Pubitemid 43786062)
16. Panfoli I, Ravera S, Bruschi M, Candiano G, Morelli A. Proteomics unravels theexportability of mitochondrial respiratory chains. Expert Rev Proteomics 2011; 8:231-239.
17. Chi SL, Pizzo SV. Cell surface F1Fo ATP synthase: a new paradigm? Ann Med 2006;38: 429-438. (Pubitemid 44484880)
18. Mangiullo R, Gnoni A, Leone A, Gnoni GV, Papa S, Zanotti F. Structural andfunctional characterization of F(o)F(1)-ATP synthase on the extracellular surface ofrat hepatocytes. Biochim Biophys Acta 2008; 1777: 1326-1335.
19. Corriden R, Insel PA. Basal release of ATP: an autocrine-paracrine mechanism forcell regulation. Sci Signal 2010; 3: 3re1.
20. Moser TL, Kenan DJ, Ashley TA, Roy JA, Goodman MD, Misra UK et al. Endothelialcell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited byangiostatin. Proc Natl Acad Sci USA 2001; 98: 6656-6661. (Pubitemid 32538272)
21. Martinez LO, Jacquet S, Esteve JP, Rolland C, Cabezon E, Champagne E et al.Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepaticHDL endocytosis. Nature 2003; 421: 75-79. (Pubitemid 36077087)