Endomysial antibodies predict celiac disease irrespective of the titers or clinical presentation

World Journal of Gastroenterology

Volumn 18, Issue 20, 2012, Pages 2511-2516

  Kurppa, Kalle ^a   Räsänen, Tiia ^a   Collin, Pekka ^b   Iltanen, Sari ^a   Huhtala, Heini ^c   Ashorn, Merja ^a   Saavalainen, Päivi ^d   Haimila, Katri ^e   Partanen, Jukka ^e   Mäki, Markku ^a   Kaukinen, Katri ^b  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF TAMPERE   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e FINNISH RED CROSS BLOOD SERVICE   (Finland)

Author keywords

Celiac disease; Clinical presentations; Diagnosis; Endomysial antibodies; Transglutaminase 2 antibodies

Indexed keywords

ANTIBODY; ENDOMYSIUM ANTIBODY; GLUTEN; TRANSGLUTAMINASE 2 ANTIBODY; UNCLASSIFIED DRUG; AUTOANTIBODY; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN A; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2;

ADOLESCENT; ADULT; AGED; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; CELIAC DISEASE; CHILD; CLINICAL EVALUATION; CLINICAL FEATURE; COHORT ANALYSIS; DIET; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HISTOLOGY; HUMAN; HUMAN TISSUE; INTESTINE MUCOSA; INTESTINE VILLUS; INTESTINE VILLUS ATROPHY; MAJOR CLINICAL STUDY; MALE; POPULATION RISK; PREDICTION; PREDICTOR VARIABLE; SEROLOGY; BLOOD; CONNECTIVE TISSUE; IMMUNOLOGY; INFANT; MIDDLE AGED; PATHOLOGY; PRESCHOOL CHILD; SMALL INTESTINE; SMOOTH MUSCLE;

ADOLESCENT; ADULT; AGED; AUTOANTIBODIES; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; CONNECTIVE TISSUE; FEMALE; GTP-BINDING PROTEINS; HUMANS; IMMUNOGLOBULIN A; INFANT; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MIDDLE AGED; MUSCLE, SMOOTH; TRANSGLUTAMINASES; YOUNG ADULT;

EID: 84871905390     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v18.i20.2511     Document Type: Article

References (30)

1. Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, Elitsur Y, Green PH, Guandalini S, Hill ID, Pietzak M, Ventura A, Thorpe M, Kryszak D, Fornaroli F, Wasserman SS, Murray JA, Horvath K. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003; 163: 286-292
2. Lohi S, Mustalahti K, Kaukinen K, Laurila K, Collin P, Rissanen H, Lohi O, Bravi E, Gasparin M, Reunanen A, Mäki M. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther 2007; 26: 1217-1225
3. Green PH, Cellier C. Celiac disease. N Engl J Med 2007; 357: 1731-1743
4. Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child 1990; 65: 909-911
5. Collin P, Kaukinen K, Vogelsang H, Korponay-Szabó I, Sommer R, Schreier E, Volta U, Granito A, Veronesi L, Mascart F, Ocmant A, Ivarsson A, Lagerqvist C, Bürgin-Wolff A, Hadziselimovic F, Furlano RI, Sidler MA, Mulder CJ, Goerres MS, Mearin ML, Ninaber MK, Gudmand-Høyer E, Fabiani E, Catassi C, Tidlund H, Alainentalo L, Mäki M. Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease: a biopsy-proven European multicentre study. Eur J Gastroenterol Hepatol 2005; 17: 85-91
6. Scott BB, Losowsky MS. Patchiness and duodenal-jejunal variation of the mucosal abnormality in coeliac disease and dermatitis herpetiformis. Gut 1976; 17: 984-992
7. Gonzalez S, Gupta A, Cheng J, Tennyson C, Lewis SK, Bhagat G, Green PH. Prospective study of the role of duodenal bulb biopsies in the diagnosis of celiac disease. Gastrointest Endosc 2010; 72: 758-765
8. Valdimarsson T, Franzen L, Grodzinsky E, Skogh T, Ström M. Is small bowel biopsy necessary in adults with suspected celiac disease and IgA anti-endomysium antibodies? 100% positive predictive value for celiac disease in adults. Dig Dis Sci 1996; 41: 83-87
9. Scoglio R, Di Pasquale G, Pagano G, Lucanto MC, Magazzù G, Sferlazzas C. Is intestinal biopsy always needed for diagnosis of celiac disease? Am J Gastroenterol 2003; 98: 1325-1331
10. Barker CC, Mitton C, Jevon G, Mock T. Can tissue transglutaminase antibody titers replace small-bowel biopsy to diagnose celiac disease in select pediatric populations? Pediatrics 2005; 115: 1341-1346
11. Donaldson MR, Firth SD, Wimpee H, Leiferman KM, Zone JJ, Horsley W, O'Gorman MA, Jackson WD, Neuhausen SL, Hull CM, Book LS. Correlation of duodenal histology with tissue transglutaminase and endomysial antibody levels in pediatric celiac disease. Clin Gastroenterol Hepatol 2007; 5: 567-573
12. Donaldson MR, Book LS, Leiferman KM, Zone JJ, Neuhausen SL. Strongly positive tissue transglutaminase antibodies are associated with Marsh 3 histopathology in adult and pediatric celiac disease. J Clin Gastroenterol 2008; 42: 256-260
13. Hill PG, Holmes GK. Coeliac disease: a biopsy is not always necessary for diagnosis. Aliment Pharmacol Ther 2008; 27: 572-577
14. Vivas S, Ruiz de Morales JG, Riestra S, Arias L, Fuentes D, Alvarez N, Calleja S, Hernando M, Herrero B, Casqueiro J, Rodrigo L. Duodenal biopsy may be avoided when high transglutaminase antibody titers are present. World J Gastroenterol 2009; 15: 4775-4780
15. Sugai E, Moreno ML, Hwang HJ, Cabanne A, Crivelli A, Nachman F, Vázquez H, Niveloni S, Argonz J, Mazure R, La Motta G, Caniggia ME, Smecuol E, Chopita N, Gómez JC, Mauriño E, Bai JC. Celiac disease serology in patients with different pretest probabilities: is biopsy avoidable? World J Gastroenterol 2010; 16: 3144-3152
16. Collin P, Huhtala H, Virta L, Kekkonen L, Reunala T. Diagnosis of celiac disease in clinical practice: physician's alertness to the condition essential. J Clin Gastroenterol 2007; 41: 152-156
17. Kurppa K, Collin P, Viljamaa M, Haimila K, Saavalainen P, Partanen J, Laurila K, Huhtala H, Paasikivi K, Mäki M, Kaukinen K. Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study. Gastroenterology 2009; 136: 816-823
18. Tosco A, Salvati VM, Auricchio R, Maglio M, Borrelli M, Coruzzo A, Paparo F, Boffardi M, Esposito A, D'Adamo G, Malamisura B, Greco L, Troncone R. Natural history of potential celiac disease in children. Clin Gastroenterol Hepatol 2011; 9: 320-335; quiz e336
19. Ladinser B, Rossipal E, Pittschieler K. Endomysium antibodies in coeliac disease: an improved method. Gut 1994; 35: 776-778
20. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ("celiac sprue"). Gastroenterology 1992; 102: 330-354
21. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999; 11: 1185-1194
22. Mäki M, Holm K, Koskimies S, Hällström O, Visakorpi JK. Normal small bowel biopsy followed by coeliac disease. Arch Dis Child 1990; 65: 1137-1141
23. Troncone R. Latent coeliac disease in Italy. The SIGEP Working Group on Latent Coeliac Disease. Italian Society for Paediatric Gastroenterology and Hepatology. Acta Paediatr 1995; 84: 1252-1257
24. Kaukinen K, Mäki M, Partanen J, Sievänen H, Collin P. Celiac disease without villous atrophy: revision of criteria called for. Dig Dis Sci 2001; 46: 879-887
25. Paparo F, Petrone E, Tosco A, Maglio M, Borrelli M, Salvati VM, Miele E, Greco L, Auricchio S, Troncone R. Clinical, HLA, and small bowel immunohistochemical features of children with positive serum antiendomysium antibodies and architecturally normal small intestinal mucosa. Am J Gastroenterol 2005; 100: 2294-2298
26. Kurppa K, Ashorn M, Iltanen S, Koskinen LL, Saavalainen P, Koskinen O, Mäki M, Kaukinen K. Celiac disease without villous atrophy in children: a prospective study. J Pediatr 2010; 157: 373-380, 380.e1
27. van Koppen EJ, Schweizer JJ, Csizmadia CG, Krom Y, Hylkema HB, van Geel AM, Koopman HM, Verloove-Vanhorick SP, Mearin ML. Long-term health and qualityof-life consequences of mass screening for childhood celiac disease: a 10-year follow-up study. Pediatrics 2009; 123: e582-e588
28. Hill ID, Dirks MH, Liptak GS, Colletti RB, Fasano A, Guandalini S, Hoffenberg EJ, Horvath K, Murray JA, Pivor M, Seidman EG. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005; 40: 1-19
29. Hopper AD, Cross SS, Hurlstone DP, McAlindon ME, Lobo AJ, Hadjivassiliou M, Sloan ME, Dixon S, Sanders DS. Preendoscopy serological testing for coeliac disease: evaluation of a clinical decision tool. BMJ 2007; 334: 729
30. Villalta D, Crovatto M, Stella S, Tonutti E, Tozzoli R, Bizzaro N. False positive reactions for IgA and IgG anti-tissue transglutaminase antibodies in liver cirrhosis are common and method-dependent. Clin Chim Acta 2005; 356: 102-109