All-Trans Retinoic Acid in Combination with Primaquine Clears Pneumocystis Infection

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Lei, Guang Sheng ^a   Zhang, Chen ^a   Shao, Shoujin ^a   Jung, Hsin Wei ^a,b   Durant, Pamela J ^a   Lee, Chao Hung ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; PRIMAQUINE; RETINOIC ACID; RIBOSOME RNA; SULFAMETHOXAZOLE; TRIMETHOPRIM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNOMODULATION; LUNG LAVAGE; NONHUMAN; PNEUMOCYSTIS PNEUMONIA; POLYMERASE CHAIN REACTION; RAT; SUPPRESSOR CELL; SURVIVAL;

ANIMALS; CELL DIFFERENTIATION; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IMMUNOCOMPROMISED HOST; LUNG; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED BALB C; PNEUMOCYSTIS; PNEUMONIA, PNEUMOCYSTIS; PRIMAQUINE; RATS; RATS, SPRAGUE-DAWLEY; SURVIVAL ANALYSIS; TRETINOIN; TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION;

ANIMALIA; MUS; PNEUMOCYSTIS; RATTUS; RODENTIA;

EID: 84871902011     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053479     Document Type: Article

References (49)

1. Morris A, Lundgren JD, Masur H, Walzer PD, Hanson DL, et al. (2004) Current epidemiology of Pneumocystis pneumonia. Emerg Infect Dis 10: 1713-1720.
2. Kovacs JA, Masur H, (2009) Evolving health effects of Pneumocystis: one hundred years of progress in diagnosis and treatment. JAMA 301: 2578-2585.
3. Miller RF, (1999) Pneumocystis carinii infection in non-AIDS patients. Curr Opin Infect Dis 12: 371-377.
4. Martin SI, Fishman JA, (2009) Pneumocystis pneumonia in solid organ transplant recipients. Am J Transplant 9Suppl 4: S227-233.
5. Komano Y, Harigai M, Koike R, Sugiyama H, Ogawa J, et al. (2009) Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab: a retrospective review and case-control study of 21 patients. Arthritis Rheum 61: 305-312.
6. Kalyoncu U, Karadag O, Akdogan A, Kisacik B, Erman M, et al. (2007) Pneumocystis carinii pneumonia in a rheumatoid arthritis patient treated with adalimumab. Scand J Infect Dis 39: 475-478.
7. Helweg-Larsen J, Benfield T, Atzori C, Miller RF, (2009) Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort study. J Antimicrob Chemother 64: 1282-1290.
8. Gordin FM, Simon GL, Wofsy CB, Mills J, (1984) Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med 100: 495-499.
9. Wright TW, Gigliotti F, Finkelstein JN, McBride JT, An CL, et al. (1999) Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia. J Clin Invest 104: 1307-1317.
10. Swain SD, Meissner NN, Harmsen AG, (2006) CD8 T cells modulate CD4 T-cell and eosinophil-mediated pulmonary pathology in pneumocystis pneumonia in B-cell-deficient mice. Am J Pathol 168: 466-475.
11. Gigliotti F, Crow EL, Bhagwat SP, Wright TW, (2006) Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia. Infect Immun 74: 6310-6316.
12. Wang J, Gigliotti F, Bhagwat SP, George TC, Wright TW, (2010) Immune modulation with sulfasalazine attenuates immunopathogenesis but enhances macrophage-mediated fungal clearance during Pneumocystis pneumonia. PLoS Pathog 6: e1001058.
13. Lasbury ME, Lin P, Tschang D, Durant PJ, Lee CH, (2004) Effect of bronchoalveolar lavage fluid from Pneumocystis carinii-infected hosts on phagocytic activity of alveolar macrophages. Infect Immun 72: 2140-2147.
14. Chen W, Mills JW, Harmsen AG, (1992) Development and resolution of Pneumocystis carinii pneumonia in severe combined immunodeficient mice: a morphological study of host inflammatory responses. Int J Exp Pathol 73: 709-720.
15. Koziel H, Eichbaum Q, Kruskal BA, Pinkston P, Rogers RA, et al. (1998) Reduced binding and phagocytosis of Pneumocystis carinii by alveolar macrophages from persons infected with HIV-1 correlates with mannose receptor downregulation. J Clin Invest 102: 1332-1344.
16. Liao CP, Lasbury ME, Wang SH, Zhang C, Durant PJ, et al. (2009) Pneumocystis mediates overexpression of antizyme inhibitor resulting in increased polyamine levels and apoptosis in alveolar macrophages. J Biol Chem 284: 8174-8184.
17. Lasbury ME, Merali S, Durant PJ, Tschang D, Ray CA, et al. (2007) Polyamine-mediated apoptosis of alveolar macrophages during Pneumocystis pneumonia. J Biol Chem 282: 11009-11020.
18. Lasbury ME, Liao CP, Hage CA, Durant PJ, Tschang D, et al. (2011) Defective nitric oxide production by alveolar macrophages during Pneumocystis pneumonia. Am J Respir Cell Mol Biol 44: 540-547.
19. Zhang C, Wang SH, Liao CP, Shao S, Lasbury ME, et al. (2010) Downregulation of PU.1 leads to decreased expression of Dectin-1 in alveolar macrophages during Pneumocystis pneumonia. Infect Immun 78: 1058-1065.
20. Eichbaum Q, Heney D, Raveh D, Chung M, Davidson M, et al. (1997) Murine macrophage mannose receptor promoter is regulated by the transcription factors PU.1 and SP1. Blood 90: 4135-4143.
21. Eichbaum QG, Iyer R, Raveh DP, Mathieu C, Ezekowitz RA, (1994) Restriction of interferon gamma responsiveness and basal expression of the myeloid human Fc gamma R1b gene is mediated by a functional PU.1 site and a transcription initiator consensus. J Exp Med 179: 1985-1996.
22. Moulton KS, Semple K, Wu H, Glass CK, (1994) Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif. Mol Cell Biol 14: 4408-4418.
23. Panopoulos AD, Bartos D, Zhang L, Watowich SS, (2002) Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1. J Biol Chem 277: 19001-19007.
24. Zhang C, Lei GS, Shao S, Jung HW, Durant PJ, et al. (2012) Accumulation of Myeloid-Derived Suppressor Cells in the Lungs during Pneumocystis Pneumonia. Infect Immun.
25. Gabrilovich DI, Nagaraj S, (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9: 162-174.
26. Nefedova Y, Fishman M, Sherman S, Wang X, Beg AA, et al. (2007) Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells. Cancer Res 67: 11021-11028.
27. Lee JM, Seo JH, Kim YJ, Kim YS, Ko HJ, et al. (2012) The restoration of myeloid-derived suppressor cells as functional antigen-presenting cells by NKT cell help and all-trans-retinoic acid treatment. Int J Cancer 131: 741-751.
28. Kusmartsev S, Cheng F, Yu B, Nefedova Y, Sotomayor E, et al. (2003) All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. Cancer Res 63: 4441-4449.
29. Mirza N, Fishman M, Fricke I, Dunn M, Neuger AM, et al. (2006) All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients. Cancer Res 66: 9299-9307.
30. Lasbury ME, Durant PJ, Bartlett MS, Smith JW, Lee CH, (2003) Correlation of organism burden and alveolar macrophage counts during infection with Pneumocystis carinii and recovery. Clin Diagn Lab Immunol 10: 293-302.
31. Center for Drug Evaluation and Research FaDA, U.S. Department of Health and Human Services (2005) Guidance for industry: Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers.
32. Zhang C, Wang SH, Lasbury ME, Tschang D, Liao CP, et al. (2006) Toll-like receptor 2 mediates alveolar macrophage response to Pneumocystis murina. Infect Immun 74: 1857-1864.
33. Jakubzick C, Tacke F, Llodra J, van Rooijen N, Randolph GJ, (2006) Modulation of dendritic cell trafficking to and from the airways. J Immunol 176: 3578-3584.
34. Lu JJ, Chen CH, Bartlett MS, Smith JW, Lee CH, (1995) Comparison of six different PCR methods for detection of Pneumocystis carinii. J Clin Microbiol 33: 2785-2788.
35. Wakefield AE, Pixley FJ, Banerji S, Sinclair K, Miller RF, et al. (1990) Detection of Pneumocystis carinii with DNA amplification. Lancet 336: 451-453.
36. Queener SF, Bartlett MS, Richardson JD, Durkin MM, Jay MA, et al. (1988) Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo. Antimicrob Agents Chemother 32: 807-813.
37. Youn JI, Collazo M, Shalova IN, Biswas SK, Gabrilovich DI (2011) Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J Leukoc Biol.
38. Vale N, Moreira R, Gomes P, (2009) Primaquine revisited six decades after its discovery. Eur J Med Chem 44: 937-953.
39. Lee JS, Newman RA, Lippman SM, Huber MH, Minor T, et al. (1993) Phase I evaluation of all-trans-retinoic acid in adults with solid tumors. J Clin Oncol 11: 959-966.
40. Patatanian E, Thompson DF, (2008) Retinoic acid syndrome: a review. J Clin Pharm Ther 33: 331-338.
41. Lathers DM, Clark JI, Achille NJ, Young MR, (2004) Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3. Cancer Immunol Immunother 53: 422-430.
42. Shiohira H, Kitaoka A, Shirasawa H, Enjoji M, Nakashima M, (2010) Am80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line. Int J Mol Med 26: 393-399.
43. Bhagwat SP, Wright TW, Gigliotti F, (2010) Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia. J Immunol 184: 497-502.
44. Voisin MB, Buzoni-Gatel D, Bout D, Velge-Roussel F, (2004) Both expansion of regulatory GR1+ CD11b+ myeloid cells and anergy of T lymphocytes participate in hyporesponsiveness of the lung-associated immune system during acute toxoplasmosis. Infect Immun 72: 5487-5492.
45. Sunderkotter C, Nikolic T, Dillon MJ, Van Rooijen N, Stehling M, et al. (2004) Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol 172: 4410-4417.
46. Mencacci A, Montagnoli C, Bacci A, Cenci E, Pitzurra L, et al. (2002) CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. J Immunol 169: 3180-3190.
47. Terrazas LI, Walsh KL, Piskorska D, McGuire E, Harn DA Jr, (2001) The schistosome oligosaccharide lacto-N-neotetraose expands Gr1(+) cells that secrete anti-inflammatory cytokines and inhibit proliferation of naive CD4(+) cells: a potential mechanism for immune polarization in helminth infections. J Immunol 167: 5294-5303.
48. Gomez-Garcia L, Lopez-Marin LM, Saavedra R, Reyes JL, Rodriguez-Sosa M, et al. (2005) Intact glycans from cestode antigens are involved in innate activation of myeloid suppressor cells. Parasite Immunol 27: 395-405.
49. Slatore CG, Tilles SA, (2004) Sulfonamide hypersensitivity. Immunol Allergy Clin North Am 24: 477-490.