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Volumn 1, Issue 1-2, 2012, Pages 86-93

Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism

Author keywords

Dopamine; Food intake; Hypothalamus; Leptin; Melanocortin system; Mesolimbic dopamine system

Indexed keywords

DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; LEPTIN; MELANOCORTIN;

EID: 84871876745     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2012.07.003     Document Type: Article
Times cited : (47)

References (55)
  • 1
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • Cowley M.A., et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001, 411(6836):480-484.
    • (2001) Nature , vol.411 , Issue.6836 , pp. 480-484
    • Cowley, M.A.1
  • 2
    • 0029739970 scopus 로고    scopus 로고
    • Identification of targets of leptin action in rat hypothalamus
    • Schwartz M.W., et al. Identification of targets of leptin action in rat hypothalamus. The Journal of Clinical Investigation 1996, 98(5):1101-1106.
    • (1996) The Journal of Clinical Investigation , vol.98 , Issue.5 , pp. 1101-1106
    • Schwartz, M.W.1
  • 3
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    • Schwartz M.W., et al. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 1997, 46(12):2119-2123.
    • (1997) Diabetes , vol.46 , Issue.12 , pp. 2119-2123
    • Schwartz, M.W.1
  • 4
    • 0032436307 scopus 로고    scopus 로고
    • Leptin activates hypothalamic CART neurons projecting to the spinal cord
    • Elias C.F., et al. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 1998, 21(6):1375-1385.
    • (1998) Neuron , vol.21 , Issue.6 , pp. 1375-1385
    • Elias, C.F.1
  • 5
    • 0029098589 scopus 로고
    • The role of neuropeptide Y in the antiobesity action of the obese gene product
    • Stephens T.W., et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995, 377(6549):530-532.
    • (1995) Nature , vol.377 , Issue.6549 , pp. 530-532
    • Stephens, T.W.1
  • 6
    • 33748541108 scopus 로고    scopus 로고
    • Leptin regulation of the mesoaccumbens dopamine pathway
    • Fulton S., et al. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 2006, 51(6):811-822.
    • (2006) Neuron , vol.51 , Issue.6 , pp. 811-822
    • Fulton, S.1
  • 7
    • 33748540764 scopus 로고    scopus 로고
    • Leptin receptor signaling in midbrain dopamine neurons regulates feeding
    • Hommel J.D., et al. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 2006, 51(6):801-810.
    • (2006) Neuron , vol.51 , Issue.6 , pp. 801-810
    • Hommel, J.D.1
  • 8
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine 1995, 1(11):1155-1161.
    • (1995) Nature Medicine , vol.1 , Issue.11 , pp. 1155-1161
    • Maffei, M.1
  • 9
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y., et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372(6505):425-432.
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1
  • 10
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas J.L., et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science (New York, NY) 1995, 269(5223):543-546.
    • (1995) Science (New York, NY) , vol.269 , Issue.5223 , pp. 543-546
    • Halaas, J.L.1
  • 11
    • 0037458468 scopus 로고    scopus 로고
    • Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat
    • Figlewicz D.P., et al. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain Research 2003, 964(1):107-115.
    • (2003) Brain Research , vol.964 , Issue.1 , pp. 107-115
    • Figlewicz, D.P.1
  • 12
    • 34548675339 scopus 로고    scopus 로고
    • Leptin regulates striatal regions and human eating behavior
    • Farooqi I.S., et al. Leptin regulates striatal regions and human eating behavior. Science (New York, NY) 2007, 317(5843):1355.
    • (2007) Science (New York, NY) , vol.317 , Issue.5843 , pp. 1355
    • Farooqi, I.S.1
  • 13
    • 6844250767 scopus 로고    scopus 로고
    • Dopamine receptors: from structure to function
    • Missale C., et al. Dopamine receptors: from structure to function. Physiological Reviews 1998, 78(1):189-225.
    • (1998) Physiological Reviews , vol.78 , Issue.1 , pp. 189-225
    • Missale, C.1
  • 14
    • 0030838736 scopus 로고    scopus 로고
    • Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice
    • Kelly M.A., et al. Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron 1997, 19(1):103-113.
    • (1997) Neuron , vol.19 , Issue.1 , pp. 103-113
    • Kelly, M.A.1
  • 15
    • 78649903233 scopus 로고    scopus 로고
    • New insights into the endocrine and metabolic roles of dopamine D2 receptors gained from the Drd2 mouse
    • Garcia-Tornadu I., et al. New insights into the endocrine and metabolic roles of dopamine D2 receptors gained from the Drd2 mouse. Neuroendocrinology 2010, 92(4):207-214.
    • (2010) Neuroendocrinology , vol.92 , Issue.4 , pp. 207-214
    • Garcia-Tornadu, I.1
  • 16
    • 18844378345 scopus 로고    scopus 로고
    • Blockade of melanocortin transmission inhibits cocaine reward
    • Hsu R., et al. Blockade of melanocortin transmission inhibits cocaine reward. The European Journal of Neuroscience 2005, 21(8):2233-2242.
    • (2005) The European Journal of Neuroscience , vol.21 , Issue.8 , pp. 2233-2242
    • Hsu, R.1
  • 18
    • 40849083517 scopus 로고    scopus 로고
    • Food reward in the absence of taste receptor signaling
    • de Araujo I.E., et al. Food reward in the absence of taste receptor signaling. Neuron 2008, 57(6):930-941.
    • (2008) Neuron , vol.57 , Issue.6 , pp. 930-941
    • de Araujo, I.E.1
  • 19
    • 33748560432 scopus 로고    scopus 로고
    • Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    • Abizaid A., et al. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. The Journal of Clinical Investigation 2006, 116(12):3229-3239.
    • (2006) The Journal of Clinical Investigation , vol.116 , Issue.12 , pp. 3229-3239
    • Abizaid, A.1
  • 20
    • 33748423509 scopus 로고    scopus 로고
    • Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasis
    • Pardini A.W., et al. Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasis. Brain Research 2006, 1112(1):169-178.
    • (2006) Brain Research , vol.1112 , Issue.1 , pp. 169-178
    • Pardini, A.W.1
  • 21
    • 66149141484 scopus 로고    scopus 로고
    • Leptin targets in the mouse brain
    • Scott M.M., et al. Leptin targets in the mouse brain. The Journal of Comparative Neurology 2009, 514(5):518-532.
    • (2009) The Journal of Comparative Neurology , vol.514 , Issue.5 , pp. 518-532
    • Scott, M.M.1
  • 22
    • 0030762351 scopus 로고    scopus 로고
    • Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
    • Guan X.M., et al. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Research Molecular Brain Research 1997, 48(1):23-29.
    • (1997) Brain Research Molecular Brain Research , vol.48 , Issue.1 , pp. 23-29
    • Guan, X.M.1
  • 23
    • 42649116436 scopus 로고    scopus 로고
    • Ghrelin modulates brain activity in areas that control appetitive behavior
    • Malik S., et al. Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metabolism 2008, 7(5):400-409.
    • (2008) Cell Metabolism , vol.7 , Issue.5 , pp. 400-409
    • Malik, S.1
  • 24
    • 36749097922 scopus 로고    scopus 로고
    • Leptin replacement alters brain response to food cues in genetically leptin-deficient adults
    • Baicy K., et al. Leptin replacement alters brain response to food cues in genetically leptin-deficient adults. Proceedings of the National Academy of Sciences of the United States of America 2007, 104(46):18276-18279.
    • (2007) Proceedings of the National Academy of Sciences of the United States of America , vol.104 , Issue.46 , pp. 18276-18279
    • Baicy, K.1
  • 25
    • 79952572475 scopus 로고    scopus 로고
    • Leptin regulates energy balance and motivation through action at distinct neural circuits
    • Davis J.F., et al. Leptin regulates energy balance and motivation through action at distinct neural circuits. Biological Psychiatry 2011, 69(7):668-674.
    • (2011) Biological Psychiatry , vol.69 , Issue.7 , pp. 668-674
    • Davis, J.F.1
  • 26
    • 0037057802 scopus 로고    scopus 로고
    • The need to feed: homeostatic and hedonic control of eating
    • Saper C.B., Chou T.C., Elmquist J.K. The need to feed: homeostatic and hedonic control of eating. Neuron 2002, 36(2):199-211.
    • (2002) Neuron , vol.36 , Issue.2 , pp. 199-211
    • Saper, C.B.1    Chou, T.C.2    Elmquist, J.K.3
  • 27
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • Cone R.D. Anatomy and regulation of the central melanocortin system. Nature Neuroscience 2005, 8(5):571-578.
    • (2005) Nature Neuroscience , vol.8 , Issue.5 , pp. 571-578
    • Cone, R.D.1
  • 28
    • 0032900284 scopus 로고    scopus 로고
    • Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
    • Marsh D.J., et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nature Genetics 1999, 21(1):119-122.
    • (1999) Nature Genetics , vol.21 , Issue.1 , pp. 119-122
    • Marsh, D.J.1
  • 29
    • 41549111593 scopus 로고    scopus 로고
    • Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
    • van de Wall E., et al. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 2008, 149(4):1773-1785.
    • (2008) Endocrinology , vol.149 , Issue.4 , pp. 1773-1785
    • van de Wall, E.1
  • 30
    • 84863267488 scopus 로고    scopus 로고
    • Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice
    • Berglund E.D., et al. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. The Journal of Clinical Investigation 2012, 122(3):1000-1009.
    • (2012) The Journal of Clinical Investigation , vol.122 , Issue.3 , pp. 1000-1009
    • Berglund, E.D.1
  • 31
    • 0242499401 scopus 로고    scopus 로고
    • Reduced dopaminergic tone in hypothalamic neural circuits: expression of a thrifty genotype underlying the metabolic syndrome?
    • Pijl H. Reduced dopaminergic tone in hypothalamic neural circuits: expression of a thrifty genotype underlying the metabolic syndrome?. European Journal of Pharmacology 2003, 480(1-3):125-131.
    • (2003) European Journal of Pharmacology , vol.480 , Issue.1-3 , pp. 125-131
    • Pijl, H.1
  • 32
    • 77953865230 scopus 로고    scopus 로고
    • Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice
    • Pfaffly J., et al. Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice. Synapse (New York, NY) 2010, 64(7):503-510.
    • (2010) Synapse (New York, NY) , vol.64 , Issue.7 , pp. 503-510
    • Pfaffly, J.1
  • 33
    • 77950574396 scopus 로고    scopus 로고
    • Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors
    • Kim K.S., et al. Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors. The Journal of Biological Chemistry 2010, 285(12):8905-8917.
    • (2010) The Journal of Biological Chemistry , vol.285 , Issue.12 , pp. 8905-8917
    • Kim, K.S.1
  • 34
    • 77449101244 scopus 로고    scopus 로고
    • A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes
    • Butler A.A., Kozak L.P. A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes 2010, 59(2):323-329.
    • (2010) Diabetes , vol.59 , Issue.2 , pp. 323-329
    • Butler, A.A.1    Kozak, L.P.2
  • 35
    • 0025921566 scopus 로고
    • Effects of dopamine D1 and dopamine D2 antagonists on the free feeding and drinking patterns of rats
    • Clifton P.G., Rusk I.N., Cooper S.J. Effects of dopamine D1 and dopamine D2 antagonists on the free feeding and drinking patterns of rats. Behavioral Neuroscience 1991, 105(2):272-281.
    • (1991) Behavioral Neuroscience , vol.105 , Issue.2 , pp. 272-281
    • Clifton, P.G.1    Rusk, I.N.2    Cooper, S.J.3
  • 36
    • 0028043808 scopus 로고
    • Parametric studies of selective D1 or D2 antagonists: effects on appetitive and feeding behaviour
    • Rusk I.N., Cooper S.J. Parametric studies of selective D1 or D2 antagonists: effects on appetitive and feeding behaviour. Behavioural Pharmacology 1994, 5(6):615-622.
    • (1994) Behavioural Pharmacology , vol.5 , Issue.6 , pp. 615-622
    • Rusk, I.N.1    Cooper, S.J.2
  • 37
    • 2542475178 scopus 로고    scopus 로고
    • Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
    • Chen H.Y., et al. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 2004, 145(6):2607-2612.
    • (2004) Endocrinology , vol.145 , Issue.6 , pp. 2607-2612
    • Chen, H.Y.1
  • 38
    • 33846975815 scopus 로고    scopus 로고
    • Metabolic considerations in the use of antipsychotic medications: a review of recent evidence
    • Newcomer J.W. Metabolic considerations in the use of antipsychotic medications: a review of recent evidence. The Journal of Clinical Psychiatry 2007, 68(Suppl 1):20-27.
    • (2007) The Journal of Clinical Psychiatry , vol.68 , Issue.SUPPL 1 , pp. 20-27
    • Newcomer, J.W.1
  • 39
    • 4344622156 scopus 로고    scopus 로고
    • Pharmacogenetics of antipsychotic-induced weight gain
    • Correll C.U., Malhotra A.K. Pharmacogenetics of antipsychotic-induced weight gain. Psychopharmacology (Berl) 2004, 174(4):477-489.
    • (2004) Psychopharmacology (Berl) , vol.174 , Issue.4 , pp. 477-489
    • Correll, C.U.1    Malhotra, A.K.2
  • 41
    • 33751169810 scopus 로고    scopus 로고
    • Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women
    • Kok P., et al. Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women. American Journal of Physiology, Endocrinology and metabolism 2006, 291(5):E1038-E1043.
    • (2006) American Journal of Physiology, Endocrinology and metabolism , vol.291 , Issue.5
    • Kok, P.1
  • 42
    • 33747744740 scopus 로고    scopus 로고
    • Activation of dopamine D2 receptors lowers circadian leptin concentrations in obese women
    • Kok P., et al. Activation of dopamine D2 receptors lowers circadian leptin concentrations in obese women. The Journal of Clinical Endocrinology and Metabolism 2006, 91(8):3236-3240.
    • (2006) The Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.8 , pp. 3236-3240
    • Kok, P.1
  • 43
    • 0030807442 scopus 로고    scopus 로고
    • Bilateral hypothalamic dopamine infusion in male Zucker rat suppresses feeding due to reduced meal size
    • Yang Z.J., et al. Bilateral hypothalamic dopamine infusion in male Zucker rat suppresses feeding due to reduced meal size. Pharmacology, Biochemistry and Behavior 1997, 58(3):631-635.
    • (1997) Pharmacology, Biochemistry and Behavior , vol.58 , Issue.3 , pp. 631-635
    • Yang, Z.J.1
  • 44
    • 67849092898 scopus 로고    scopus 로고
    • Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
    • Leinninger G.M., et al. Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metabolism 2009, 10(2):89-98.
    • (2009) Cell Metabolism , vol.10 , Issue.2 , pp. 89-98
    • Leinninger, G.M.1
  • 46
    • 62749183678 scopus 로고    scopus 로고
    • Sugar and fat bingeing have notable differences in addictive-like behavior
    • Avena N.M., Rada P., Hoebel B.G. Sugar and fat bingeing have notable differences in addictive-like behavior. The Journal of Nutrition 2009, 139(3):623-628.
    • (2009) The Journal of Nutrition , vol.139 , Issue.3 , pp. 623-628
    • Avena, N.M.1    Rada, P.2    Hoebel, B.G.3
  • 47
    • 0032423613 scopus 로고    scopus 로고
    • What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
    • Berridge K.C., Robinson T.E. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?. Brain Research Brain Research Reviews 1998, 28(3):309-369.
    • (1998) Brain Research Brain Research Reviews , vol.28 , Issue.3 , pp. 309-369
    • Berridge, K.C.1    Robinson, T.E.2
  • 49
    • 36348992560 scopus 로고    scopus 로고
    • Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography
    • Thanos P.K., et al. Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography. Synapse (New York, NY) 2008, 62(1):50-61.
    • (2008) Synapse (New York, NY) , vol.62 , Issue.1 , pp. 50-61
    • Thanos, P.K.1
  • 50
    • 0035798931 scopus 로고    scopus 로고
    • Brain dopamine and obesity
    • Wang G.J., et al. Brain dopamine and obesity. Lancet 2001, 357(9253):354-357.
    • (2001) Lancet , vol.357 , Issue.9253 , pp. 354-357
    • Wang, G.J.1
  • 51
    • 54249084372 scopus 로고    scopus 로고
    • Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors
    • Volkow N.D., et al. Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors. Neuroimage 2008, 42(4):1537-1543.
    • (2008) Neuroimage , vol.42 , Issue.4 , pp. 1537-1543
    • Volkow, N.D.1
  • 52
    • 77957274035 scopus 로고    scopus 로고
    • Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons
    • Briggs D.I., et al. Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons. Endocrinology 2010, 151(10):4745-4755.
    • (2010) Endocrinology , vol.151 , Issue.10 , pp. 4745-4755
    • Briggs, D.I.1
  • 53
    • 33847319765 scopus 로고    scopus 로고
    • Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons
    • Enriori P.J., et al. Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metabolism 2007, 5(3):181-194.
    • (2007) Cell Metabolism , vol.5 , Issue.3 , pp. 181-194
    • Enriori, P.J.1
  • 54
    • 80052156758 scopus 로고    scopus 로고
    • Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance
    • Enriori P.J., et al. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 2011, 31(34):12189-12197.
    • (2011) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience , vol.31 , Issue.34 , pp. 12189-12197
    • Enriori, P.J.1
  • 55
    • 34547828083 scopus 로고    scopus 로고
    • Interactions between the cognitive and metabolic brain in the control of food intake
    • Berthoud H.R. Interactions between the cognitive and metabolic brain in the control of food intake. Physiology and Behavior 2007, 91(5):486-498.
    • (2007) Physiology and Behavior , vol.91 , Issue.5 , pp. 486-498
    • Berthoud, H.R.1


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