Risk factors for graft loss and mortality after renal transplantation according to recipient age: A prospective multicentre study

Nephrology Dialysis Transplantation

Volumn 27, Issue SUPPL.4, 2012, Pages

  Morales, Jose Maria ^a   Marcén, Roberto ^b   Del Castillo, Domingo ^c   Andres, Amado ^a   Gonzalez Molina, Miguel ^d   Oppenheimer, Federico ^e   Serón, Daniel ^f   Gil Vernet, Salvador ^g   Lampreave, Ildefonso ^h   Gainza, Francisco Javier ^h   Valdés, Francisco ⁱ   Cabello, Mercedes ^d   Anaya, Fernando ^j   Escuin, Fernando ^k   Arias, Manuel ^l   Pallardó, Luis ^m   Bustamante, Jesus ⁿ  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^d HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^e HOSPITAL CLÍNIC   (Spain)

^f HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^g HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^h HOSPITAL DE CRUCES   (Spain)

ⁱ HOSPITAL JUAN CANALEJO   (Spain)

^j HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^k HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^l HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^m HOSPITAL UNIVERSITARIO DR PESET   (Spain)

ⁿ HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

more..

Author keywords

cardiovascular mortality; graft survival; patient survival; renal function; renal transplantation

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; AZATHIOPRINE; CREATININE; CYCLOSPORIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 2 RECEPTOR ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; AGE; ARTICLE; CADAVER KIDNEY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAUSE OF DEATH; CHRONIC ALLOGRAFT NEPHROPATHY; DATA BASE; DEATH; FEMALE; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; GROUPS BY AGE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PATIENT CODING; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEINURIA; RISK FACTOR; RISK MANAGEMENT; SPAIN; SURGICAL MORTALITY; SURVIVAL; SURVIVAL TIME;

ADULT; AGE DISTRIBUTION; FEMALE; GRAFT REJECTION; HUMANS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; TIME FACTORS;

EID: 84871849256     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfs544     Document Type: Article

References (26)

1. Pascual M, Theruvath T, Kawai T et al. Strategies to improve longterm outcomes after renal transplantation. N Engl J Med 2002; 346: 580
2. Woodroffe R, Yao GL, Meads C et al. Clinical and cost-effectiveness of newer immunosuppressive regimens in renal transplantation. A systematic review and modelling study. Health Technol Assess 2005; 9: 1
3. Hariharan S, Johnson CP, Bresnahan BA et al. Improved graft survival after renal transplantation in the United States, 1998 to 1996. N Engl J Med 2000; 342: 605
4. Meier-Kriesche HU, Schold JD, Srinivas TR et al. Lack of improvement in renal allograft survival despite a marked decrease of acute rejection rates over the most recent era. Am J Transplant 2004; 4: 378
5. Foley RN, Parfrey PS, Samak MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 1998; 32 (Suppl 3):112-119
6. Morales JM, Marcen R, Andres A et al. Renal transplantation in the modern immunosuppressive era in Spain: four-year results from a multicenter database focus on post-transplant cardiovascular disease. Kidney Int 2008; 74 (Suppl 111): S94-S99
7. Moreso F, Alonso A, Gentil MA et al. for the Spanish Late Allograft Dysfunction Study Group. Improvement in late real allograft survival between 1990 and 2002 in Spain: results from a multicentre case-control study. Transplant Int 2010; 23: 907-913
8. Cecka JM. The OPTN/UNOS renal transplant registry. Clin Transpl 2005: 1-16
9. Teraoka S, Nomoto K, Kikuchi K et al. Outcomes of kidney transplants from non-heart-beating deceased donors as reported to the Japan Organ Transplant Network from April 1995-December 2003: a multi-center report. Clin Transpl 2004: 91-102
10. Fabrizii V, Kovarik J, Bodingbauer M et al. Long-term patient and graft survival in the Eurotransplant senior program: a single-center experience. Transplantation 2005; 80: 582-9
11. Ojo AO, Morales JM, González-Molina M et al. Comparison of the long-term outcomes of kidney transplantation: USA versus Spain. Nephrol Dial Transplant 2012; doi:10.1093/ndt/gfs287
12. Seron D, Arias M, Campistol JM et al. for the Spanish Chronic Allograft Study Group. Late renal allograft failure between 1990 and 1998 in Spain: a changing scenario. Transplantation 2003; 76: 1588-1594
13. de Fijter JW, Mallat MJ, Doxiadis II et al. Increased immunogenicity and cause of graft loss of old donor kidneys. J Am Soc Nephrol 2001; 12: 1538
14. Morales JM, Dominguez-Gil B. Impact of Tacrolimus and Mycophenolate Mofetil combination on cardiovascular risk profile after kidney transplantation. J Am Soc Nephrol 2006; 17(Suppl 3): s296-s303
15. Roodnat JI, Mulder PGH, Van Riemsdijk IC et al. Ischemia times and donor serum creatinine in relation to renal graft failure. Transplantation 2003; 75: 799-804
16. Ibis A, Altunoglu A, Akgüll A et al. Early onset proteinuria after renal transplantation: a marker for allograft dysfunction. Trasplant Proc 2007; 39: 938-940
17. Sancho A, Gavela E, Avila A et al. Risk factors and prognosis for proteinuria in renal transplant recipients. Transplant Proc 2007; 39: 2145-2147
18. Fernandez G, Plaza JJ, Sanchez-Plumed J et al. Proteinuria: a new marker of long-term graft and patient survival in kidney transplantation. Nephrol Dial Transplant 2004; 19(Suppl 3): 47-51
19. Yildiz A, Erkoç R, Sever MS et al. The prognostic importance of severity and type of post-transplant proteinuria. Clin Transpl 1999; 13: 241-244
20. Cherukuri A, Welberry-Smith MP, Tattersall JE et al. The clinical significance of early proteinuria after renal transplantation. Transplantation 2010; 89: 200-207
21. Rayhill SC, D'Alessandro AM, Odorico JS et al. Simultaneous pancreas-kidney transplantation and living related donor renal transplantation in patients with diabetes: is there a difference in survival? Ann Surg 2000; 231: 417-423
22. Hariharan S, McBride MA, Cherikh WS et al. Post-transplant renal function in the first year predicts long-term kidney transplant survival. Kidney Int 2002; 62: 311-318
23. Vincenti F, Jensik SC, Filo RS et al. A long-term comparison of tacrolimus (FK506) and cyclosporine in kidney transplantation: evidence for improved allograft survival at five years. Transplantation 2002; 73: 775-782
24. Kim SJ, Schaubel DE, Fenton SA et al. Mortality after kidney transplantation: a comparison between the United States and Canada. Am J Transplant 2006; 6: 109-114
25. Lindholm A, Albrechtsen D, Frodin L et al. Ischemic heart disease: major cause of death and graft loss alter renal transplantation. Transplantation 1995; 60: 451-457
26. Briggs D. Causes of death after renal transplantation. Nephrol Dial Transplant 2001; 16: 1545-1549