The clinical significance of early proteinuria after renal transplantation

Transplantation

Volumn 89, Issue 2, 2010, Pages 200-207

  Cherukuri, Aravind ^a   Welberry Smith, Matthew P ^a   Tattersall, James E ^a   Ahmad, Niaz ^a   Newstead, Chas G ^a   Lewington, Andrew J P ^a   Baker, Richard J ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Graft outcomes; Proteinuria; Renal transplantation

Indexed keywords

AZATHIOPRINE; BASILIXIMAB; CREATININE; CYCLOSPORIN; METHYLPREDNISOLONE; PREDNISOLONE;

ADULT; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; EARLY DIAGNOSIS; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; GRAFT SURVIVAL; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; KIDNEY ALLOGRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PROTEINURIA; RENAL GRAFT DYSFUNCTION; SYSTOLIC BLOOD PRESSURE;

ADULT; CREATININE; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMERASE CHAIN REACTION; POSTOPERATIVE COMPLICATIONS; PROTEINURIA; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 76649135820     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181c352c5     Document Type: Article

References (41)

1. Chapman JR, O'Connell PJ, Nankivell BJ. Chronic renal allograft dysfunction. J Am Soc Nephrol 2005; 16: 3015.
2. Rush D, Arlen D, Boucher A, et al. Lack of benefit of early protocol biopsies in renal transplant patients receiving TAC and MMF: A randomized study. Am J Transplant 2007; 7: 2538.
3. Schaub S, Wilkins JA, Nickerson P. Proteomics and renal transplantation: Searching for novel biomarkers and therapeutic targets. Contrib Nephrol 2008; 160: 65.
4. Bright R. Cases and observations illustrative of renal disease accompanied with the secretion of albuminous urine. Guys Hosp Rep 1836; 1: 338.
5. Burton C, Harris KP. The role of proteinuria in the progression of chronic renal failure. Am J Kidney Dis 1996; 27: 765.
6. Cattran DC, Pei Y, Greenwood C. Predicting progression in membranous glomerulonephritis. Nephrol Dial Transplant 1992; 7(suppl 1): 48.
7. Iseki K, Ikemiya Y, Iseki C et al. Proteinuria and the risk of developing end-stage renal disease. Kidney Int 2003; 63: 1468.
8. Grimm RH Jr, Svendsen KH, Kasiske B, et al. Proteinuriais a risk factor for mortality over10 years of follow-up. MRFIT Research Group. Multiple Risk Factor Intervention Trial. Kidney Int Suppl 1997; 63: S10.
9. Abbate M, Zoja C, Remuzzi G. How does proteinuria cause progressive renal damage? J Am Soc Nephrol 2006; 17: 2974.
10. Stam F, van Guldener C, Becker A, et al. Endothelial dysfunction contributes to renal function-associated cardiovascular mortality in a population with mild renal insufficiency: The Hoorn Study. J Am Soc Nephrol 2006; 17: 537.
11. Bakris GL. Slowing nephropathy progression: Focus on proteinuria reduction. Clin J Am Soc Nephrol 2008; 3(suppl 1): S3.
12. First MR, Vaidya PN, Maryniak RK, et al. Proteinuria following transplantation. Correlation with histopathology and outcome. Transplantation 1984; 38: 607.
13. AmerH, Fidler ME, MyslakM, et al. Proteinuria after kidney transplantation, relationship to allograft histology and survival. Am J Transplant 2007; 7: 2748.
14. Fellstrom B, Holdaas H, Jardine AG, et al. Risk factors for reaching renal endpoints in the assessment of Lescol in renal transplantation (ALERT) trial. Transplantation 2005; 79: 205.
15. Halimi JM, Buchler M, Al-Najjar A, et al. Urinary albumin excretion and the risk of graft loss and death in proteinuric and non-proteinuric renal transplant recipients. Am J Transplant 2007; 7: 618.
16. Halimi JM, Laouad I, Buchler M, et al. Early low-grade proteinuria: Causes, short-term evolution and long-term consequences in renal transplantation. Am J Transplant 2005; 5: 2281.
17. Roodnat JI, Mulder PG, Rischen-Vos J, et al. Proteinuria after renal transplantation affects not only graft survival but also patient survival. Transplantation 2001; 72: 438.
18. Yildiz A, Erkoc R, Sever MS, et al. The prognostic importance of severity and type of post-transplant proteinuria. Clin Transplant 1999; 13: 241.
19. Fernandez-Fresnedo G, Plaza JJ, Sanchez-Plumed J, et al. Proteinuria: A new marker of long-term graft and patient survival in kidney transplantation. Nephrol Dial Transplant 2004; 19(suppl 3): iii47.
20. Dyson EH, Will EJ, Davison AM, et al. Use of the urinary protein creatinine index to assess proteinuria in renal transplant patients. Nephrol Dial Transplant 1992; 7: 450.
21. Hariharan S, McBride MA, Cherikh WS, et al. Post-transplant renal function in the first year predicts long-term kidney transplant survival. Kidney Int 2002; 62: 311.
22. KaplanB, Schold J, Meier-Kriesche HU. Poor predictive valueof serum creatinine for renal allograft loss. Am J Transplant 2003; 3: 1560.
23. Rush D, Nickerson P, Gough J, et al. Beneficial effects of treatment of early subclinical rejection: Arandomized study. J Am Soc Nephrol 1998; 9: 2129.
24. Shaw AB, Risdon, P, Lewis-Jackson JD. Protein creatinine index and Albustix in assessment of proteinuria. BMJ (Clin Res Ed) 1983; 287: 929.
25. Letavernier E, Pe'raldi MN, Pariente A, et al. Proteinuria following a switch from calcineurin inhibitors to sirolimus. Transplantation 2005; 80: 1198.
26. Halimi JM, Matthias B, Al-Najjar A, et al. Respective predictive role of urinary albumin excretion and nonalbumin proteinuria on graft loss and death in renal transplant recipients. Am J Transplant 2007; 7: 2775.
27. D'Cunha PT, Parasuraman R, Venkat KK. Rapid resolution of protein-uria of native kidney origin following live donor renal transplantation. Am J Transplant 2005; 5: 351.
28. Myslak M, Amer H, Morales P, et al. Interpreting post-transplant pro-teinuria in patients with proteinuria pre-transplant. Am J Transplant 2006; 6: 1660.
29. Russo LM, Sandoval RM, McKee M, et al. The normal kidney filters nephrotic levelsofalbumin retrievedbyproximal tubule cells: Retrieval is disrupted in nephrotic states. Kidney Int 2007; 71: 504.
30. Straathof-Galema L, Wetzels JF, Dijkman HB, et al. Sirolimus-associ-ated heavy proteinuria in a renal transplant recipient: Evidence for a tubular mechanism. Am J Transplant 2006; 6: 429.
31. Nankivell BJ, Borrows RJ, Fung CL, et al. The natural history of chronic allograft nephropathy. N Engl J Med 2003; 349: 2326.
32. Satchell SC, Tooke JE. What is the mechanism of microalbuminuria in diabetes: A role for the glomerular endothelium? Diabetologia 2008; 51: 714.
33. Cosio FG, Gloor JM, Sethi S, et al. Transplant glomerulopathy. Am J Transplant 2008; 8: 492.
34. Schaub S, Mayr M, Honger G, et al. Detection of subclinical tubular injury after renal transplantation: Comparison of urine protein analysis with allograft histopathology. Transplantation 2007; 84: 104.
35. Teppo AM, Honkanen E, Finne P, et al. Increased urinary excretion of alpha1-microglobulin at 6 months after transplantation is associated with urinary excretion of transforming growth factor-beta1 and indicates poor long-term renal outcome. Transplantation 2004; 78: 719.
36. Van Timmeren MM, Vaidya VS, van Ree RM, et al. High urinary excretion ofkidney injury molecule-1isanindependent predictorofgraft loss in renal transplant recipients. Transplantation 2007; 84: 1625.
37. Perkins BA, Ficociello LH, Ostrander BE, et al. Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes. J Am Soc Nephrol 2007; 18: 1353.
38. Kannel WB, Stampfer MJ, Castelli WP, et al. The prognostic significance of proteinuria: The Framingham Study. Am Heart J 1984; 108: 1347.
39. Kasiske BL, Guijarro C, Massy ZA, et al. Cardiovascular disease after renal transplantation. J Am Soc Nephrol 1996; 7: 158.
40. Keane WF, Eknoyan G. Proteinuria, albuminuria, risk, assessment, detection, elimination (PARADE): A position paper of the National Kidney Foundation. Am J Kidney Dis 1999; 33: 1004.
41. Ritz E. Albuminuria and vascular damage-The vicious twins. N Engl J Med 2003; 348: 2349.