-
1
-
-
79957586330
-
Milestones in Parkinson's disease-Clinical and pathologic features
-
2-s2.0-79957586330 10.1002/mds.23669
-
Halliday G., Lees A., Stern M., Milestones in Parkinson's disease-Clinical and pathologic features. Movement Disorders 2011 26 6 1015 1021 2-s2.0-79957586330 10.1002/mds.23669
-
(2011)
Movement Disorders
, vol.26
, Issue.6
, pp. 1015-1021
-
-
Halliday, G.1
Lees, A.2
Stern, M.3
-
2
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
DOI 10.1016/j.neuron.2004.11.005, PII S0896627304007202
-
Zimprich A., Biskup S., Leitner P., Lichtner P., Farrer M., Lincoln S., Kachergus J., Hulihan M., Uitti R. J., Calne D. B., Stoessl A. J., Pfeiffer R. F., Patenge N., Carbajal I. C., Vieregge P., Asmus F., Müller-Myhsok B., Dickson D. W., Meitinger T., Strom T. M., Wszolek Z. K., Gasser T., Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 2004 44 4 601 607 2-s2.0-8844233579 10.1016/j.neuron.2004.11.005 (Pubitemid 39531225)
-
(2004)
Neuron
, vol.44
, Issue.4
, pp. 601-607
-
-
Zimprich, A.1
Biskup, S.2
Leitner, P.3
Lichtner, P.4
Farrer, M.5
Lincoln, S.6
Kachergus, J.7
Hulihan, M.8
Uitti, R.J.9
Calne, D.B.10
Stoessl, A.J.11
Pfeiffer, R.F.12
Patenge, N.13
Carbajal, I.C.14
Vieregge, P.15
Asmus, F.16
Muller-Myhsok, B.17
Dickson, D.W.18
Meitinger, T.19
Strom, T.M.20
Wszolek, Z.K.21
Gasser, T.22
more..
-
3
-
-
8844266996
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
-
DOI 10.1016/j.neuron.2004.10.023, PII S0896627304006890
-
Paisán-Ruíz C., Jain S., Evans E. W., Gilks W. P., Simón J., Van Der Brug M., De Munain A. L., Aparicio S., Gil A. M., Khan N., Johnson J., Martinez J. R., Nicholl D., Carrera I. M., Peňa A. S., De Silva R., Lees A., Martí-Massó J. F., Pérez-Tur J., Wood N. W., Singleton A. B., Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004 44 4 595 600 2-s2.0-8844266996 10.1016/j.neuron.2004.10.023 (Pubitemid 39531224)
-
(2004)
Neuron
, vol.44
, Issue.4
, pp. 595-600
-
-
Paisan-Ruiz, C.1
Jain, S.2
Evans, E.W.3
Gilks, W.P.4
Simon, J.5
Van Der Brug, M.6
De Munain, A.L.7
Aparicio, S.8
Gil, A.M.9
Khan, N.10
Johnson, J.11
Martinez, J.R.12
Nicholl, D.13
Carrera, I.M.14
Pena, A.S.15
De Silva, R.16
Lees, A.17
Marti-Masso, J.F.18
Perez-Tur, J.19
Wood, N.W.20
Singleton, A.B.21
more..
-
4
-
-
33645116252
-
Genetics of Parkinson disease: Paradigm shifts and future prospects
-
2-s2.0-33645116252 10.1038/nrg1831
-
Farrer M. J., Genetics of Parkinson disease: paradigm shifts and future prospects. Nature Reviews Genetics 2006 7 4 306 318 2-s2.0-33645116252 10.1038/nrg1831
-
(2006)
Nature Reviews Genetics
, vol.7
, Issue.4
, pp. 306-318
-
-
Farrer, M.J.1
-
5
-
-
77957905690
-
Genetic analysis of pathways to parkinson disease
-
2-s2.0-77957905690 10.1016/j.neuron.2010.10.014
-
Hardy J., Genetic analysis of pathways to parkinson disease. Neuron 2010 68 2 201 206 2-s2.0-77957905690 10.1016/j.neuron.2010.10.014
-
(2010)
Neuron
, vol.68
, Issue.2
, pp. 201-206
-
-
Hardy, J.1
-
6
-
-
71849086433
-
Clinical features of LRRK2 parkinsonism
-
2-s2.0-71849086433 10.1016/S1353-8020(09)70815-6
-
Haugarvoll K., Wszolek Z. K., Clinical features of LRRK2 parkinsonism. Parkinsonism and Related Disorders 2009 15 3 S205 S208 2-s2.0-71849086433 10.1016/S1353-8020(09)70815-6
-
(2009)
Parkinsonism and Related Disorders
, vol.15
, Issue.3
-
-
Haugarvoll, K.1
Wszolek, Z.K.2
-
7
-
-
70549084415
-
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
-
2-s2.0-70549084415 10.1038/ng.485
-
Satake W., Nakabayashi Y., Mizuta I., Hirota Y., Ito C., Kubo M., Kawaguchi T., Tsunoda T., Watanabe M., Takeda A., Tomiyama H., Nakashima K., Hasegawa K., Obata F., Yoshikawa T., Kawakami H., Sakoda S., Yamamoto M., Hattori N., Murata M., Nakamura Y., Toda T., Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nature Genetics 2009 41 12 1303 1307 2-s2.0-70549084415 10.1038/ng.485
-
(2009)
Nature Genetics
, vol.41
, Issue.12
, pp. 1303-1307
-
-
Satake, W.1
Nakabayashi, Y.2
Mizuta, I.3
Hirota, Y.4
Ito, C.5
Kubo, M.6
Kawaguchi, T.7
Tsunoda, T.8
Watanabe, M.9
Takeda, A.10
Tomiyama, H.11
Nakashima, K.12
Hasegawa, K.13
Obata, F.14
Yoshikawa, T.15
Kawakami, H.16
Sakoda, S.17
Yamamoto, M.18
Hattori, N.19
Murata, M.20
Nakamura, Y.21
Toda, T.22
more..
-
8
-
-
70549088602
-
Genome-wide association study reveals genetic risk underlying Parkinson's disease
-
2-s2.0-70549088602 10.1038/ng.487
-
Simón-Sánchez J., Schulte C., Bras J. M., Sharma M., Gibbs J. R., Berg D., Paisan-Ruiz C., Lichtner P., Scholz S. W., Hernandez D. G., Krüger R., Federoff M., Klein C., Goate A., Perlmutter J., Bonin M., Nalls M. A., Illig T., Gieger C., Houlden H., Steffens M., Okun M. S., Racette B. A., Cookson M. R., Foote K. D., Fernandez H. H., Traynor B. J., Schreiber S., Arepalli S., Zonozi R., Gwinn K., Van Der Brug M., Lopez G., Chanock S. J., Schatzkin A., Park Y., Hollenbeck A., Gao J., Huang X., Wood N. W., Lorenz D., Deuschl G., Chen H., Riess O., Hardy J. A., Singleton A. B., Gasser T., Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nature Genetics 2009 41 12 1308 1312 2-s2.0-70549088602 10.1038/ng.487
-
(2009)
Nature Genetics
, vol.41
, Issue.12
, pp. 1308-1312
-
-
Simón-Sánchez, J.1
Schulte, C.2
Bras, J.M.3
Sharma, M.4
Gibbs, J.R.5
Berg, D.6
Paisan-Ruiz, C.7
Lichtner, P.8
Scholz, S.W.9
Hernandez, D.G.10
Krüger, R.11
Federoff, M.12
Klein, C.13
Goate, A.14
Perlmutter, J.15
Bonin, M.16
Nalls, M.A.17
Illig, T.18
Gieger, C.19
Houlden, H.20
Steffens, M.21
Okun, M.S.22
Racette, B.A.23
Cookson, M.R.24
Foote, K.D.25
Fernandez, H.H.26
Traynor, B.J.27
Schreiber, S.28
Arepalli, S.29
Zonozi, R.30
Gwinn, K.31
Van Der Brug, M.32
Lopez, G.33
Chanock, S.J.34
Schatzkin, A.35
Park, Y.36
Hollenbeck, A.37
Gao, J.38
Huang, X.39
Wood, N.W.40
Lorenz, D.41
Deuschl, G.42
Chen, H.43
Riess, O.44
Hardy, J.A.45
Singleton, A.B.46
Gasser, T.47
more..
-
9
-
-
79951811351
-
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: A meta-analysis of genome-wide association studies
-
2-s2.0-79951811351 10.1016/S0140-6736(10)62345-8
-
Nalls M. A., Plagnol V., Hernandez D. G., Sharma M., Sheerin U. M., Saad M., Simón-Sánchez J., Schulte C., Lesage S., Sveinbjö rnsdóttir S., Stefánsson K., Martinez M., Hardy J., Heutink P., Brice A., Gasser T., Singleton A. B., Wood N. W., Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. The Lancet 2011 377 9766 641 649 2-s2.0-79951811351 10.1016/S0140-6736(10)62345-8
-
(2011)
The Lancet
, vol.377
, Issue.9766
, pp. 641-649
-
-
Nalls, M.A.1
Plagnol, V.2
Hernandez, D.G.3
Sharma, M.4
Sheerin, U.M.5
Saad, M.6
Simón-Sánchez, J.7
Schulte, C.8
Lesage, S.9
Sveinbjörnsdó ttir, S.10
Stefánsson, K.11
Martinez, M.12
Hardy, J.13
Heutink, P.14
Brice, A.15
Gasser, T.16
Singleton, A.B.17
Wood, N.W.18
-
10
-
-
35948952469
-
The roles of kinases in familial Parkinson's disease
-
DOI 10.1523/JNEUROSCI.3695-07.2007
-
Cookson M. R., Dauer W., Dawson T., Fon E. A., Guo M., Shen J., The roles of kinases in familial Parkinson's disease. Journal of Neuroscience 2007 27 44 11865 11868 2-s2.0-35948952469 10.1523/JNEUROSCI.3695-07.2007 (Pubitemid 350072099)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.44
, pp. 11865-11868
-
-
Cookson, M.R.1
Dauer, W.2
Dawson, T.3
Fon, E.A.4
Guo, M.5
Shen, J.6
-
11
-
-
84857285604
-
Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?
-
Rudenko I. N., Chia R., Cookson M. R., Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease? BMC Medicine 2012 10, article 20
-
(2012)
BMC Medicine
, vol.1020
-
-
Rudenko, I.N.1
Chia, R.2
Cookson, M.R.3
-
13
-
-
68949125734
-
Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease
-
2-s2.0-68949125734 10.1016/j.bbadis.2008.09.015
-
Biskup S., West A. B., Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease. Biochimica et Biophysica Acta 2009 1792 7 625 633 2-s2.0-68949125734 10.1016/j.bbadis.2008.09.015
-
(2009)
Biochimica et Biophysica Acta
, vol.1792
, Issue.7
, pp. 625-633
-
-
Biskup, S.1
West, A.B.2
-
14
-
-
77953395313
-
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: Three questions
-
2-s2.0-77953395313 10.1042/AN20090007 e00002
-
Greggio E., Cookson M. R., Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions. ASN Neuro 2009 1 1 2-s2.0-77953395313 10.1042/AN20090007 e00002
-
(2009)
ASN Neuro
, vol.1
, Issue.1
-
-
Greggio, E.1
Cookson, M.R.2
-
15
-
-
84864743687
-
The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation
-
Rudenko I. N., Kaganovich A., Hauser D. N., The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation. Biochemical Journal 2012 446 1 99 111
-
(2012)
Biochemical Journal
, vol.446
, Issue.1
, pp. 99-111
-
-
Rudenko, I.N.1
Kaganovich, A.2
Hauser, D.N.3
-
16
-
-
34548604567
-
The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase thatstimulates kinase activity
-
DOI 10.1016/j.yexcr.2007.07.007, PII S0014482707003345
-
Guo L., Gandhi P. N., Wang W., Petersen R. B., Wilson-Delfosse A. L., Chen S. G., The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase thatstimulates kinase activity. Experimental Cell Research 2007 313 16 3658 3670 2-s2.0-34548604567 10.1016/j.yexcr.2007.07.007 (Pubitemid 47404550)
-
(2007)
Experimental Cell Research
, vol.313
, Issue.16
, pp. 3658-3670
-
-
Guo, L.1
Gandhi, P.N.2
Wang, W.3
Petersen, R.B.4
Wilson-Delfosse, A.L.5
Chen, S.G.6
-
17
-
-
34247468302
-
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
-
DOI 10.1016/j.bbrc.2007.04.006, PII S0006291X07006894
-
Lewis P. A., Greggio E., Beilina A., Jain S., Baker A., Cookson M. R., The R1441C mutation of LRRK2 disrupts GTP hydrolysis. Biochemical and Biophysical Research Communications 2007 357 3 668 671 2-s2.0-34247468302 10.1016/j.bbrc.2007.04.006 (Pubitemid 46653831)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.357
, Issue.3
, pp. 668-671
-
-
Lewis, P.A.1
Greggio, E.2
Beilina, A.3
Jain, S.4
Baker, A.5
Cookson, M.R.6
-
18
-
-
79955548865
-
LRRK2 signaling pathways: The key to unlocking neurodegeneration?
-
2-s2.0-79955548865 10.1016/j.tcb.2011.01.001
-
Berwick D. C., Harvey K., LRRK2 signaling pathways: the key to unlocking neurodegeneration? Trends in Cell Biology 2011 21 5 257 265 2-s2.0-79955548865 10.1016/j.tcb.2011.01.001
-
(2011)
Trends in Cell Biology
, vol.21
, Issue.5
, pp. 257-265
-
-
Berwick, D.C.1
Harvey, K.2
-
19
-
-
84856070973
-
LRRK2 and human disease: A complicated question or a question of complexes?
-
ARTICLE 2
-
Lewis P. A., Manzoni C., LRRK2 and human disease: a complicated question or a question of complexes? Science Signaling 2012 5 207, article 2
-
(2012)
Science Signaling
, vol.5
, Issue.207
-
-
Lewis, P.A.1
Manzoni, C.2
-
20
-
-
47749114984
-
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
-
2-s2.0-47749114984 10.1074/jbc.M708718200
-
Greggio E., Zambrano I., Kaganovich A., Beilina A., Taymans J. M., Daniëls V., Lewis P., Jain S., Ding J., Syed A., Thomas K. J., Baekelandt V., Cookson M. R., The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. Journal of Biological Chemistry 2008 283 24 16906 16914 2-s2.0-47749114984 10.1074/jbc.M708718200
-
(2008)
Journal of Biological Chemistry
, vol.283
, Issue.24
, pp. 16906-16914
-
-
Greggio, E.1
Zambrano, I.2
Kaganovich, A.3
Beilina, A.4
Taymans, J.M.5
Daniëls, V.6
Lewis, P.7
Jain, S.8
Ding, J.9
Syed, A.10
Thomas, K.J.11
Baekelandt, V.12
Cookson, M.R.13
-
21
-
-
40349101849
-
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
-
DOI 10.1073/pnas.0709098105
-
Deng J., Lewis P. A., Greggio E., Sluch E., Beilina A., Cookson M. R., Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proceedings of the National Academy of Sciences of the United States of America 2008 105 5 1499 1504 2-s2.0-40349101849 10.1073/pnas.0709098105 (Pubitemid 351346543)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.5
, pp. 1499-1504
-
-
Deng, J.1
Lewis, P.A.2
Greggio, E.3
Sluch, E.4
Beilina, A.5
Cookson, M.R.6
-
22
-
-
73649120624
-
Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization
-
2-s2.0-73649120624 10.1074/jbc.M109.025437
-
Sen S., Webber P. J., West A. B., Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization. Journal of Biological Chemistry 2009 284 52 36346 36356 2-s2.0-73649120624 10.1074/jbc.M109.025437
-
(2009)
Journal of Biological Chemistry
, vol.284
, Issue.52
, pp. 36346-36356
-
-
Sen, S.1
Webber, P.J.2
West, A.B.3
|