Accurate nanoliter liquid characterization up to 40 GHz for biomedical applications: Toward noninvasive living cells monitoring

IEEE Transactions on Microwave Theory and Techniques

Volumn 60, Issue 12, 2012, Pages 4171-4177

  Chen, Tong ^a   Dubuc, David ^a   Poupot, Mary ^b   Fournie, Jean Jacques ^b   Grenier, Katia ^a  

^a LAAS CNRS   (France)

^b CANCER RESEARCH CENTER OF TOULOUSE   (France)

Author keywords

Biology; biomedical transducers; human cells; interdigitated capacitor (IDC); microwave spectroscopy

Indexed keywords

BIOLOGICAL MEDIUM; BIOMEDICAL APPLICATIONS; BIOMEDICAL TRANSDUCERS; CONTACT LESS; CULTURE MEDIUM; FETAL BOVINE SERUM; FULLY COMPATIBLE; HUMAN CELLS; INTERDIGITATED CAPACITORS; LIVING CELL; LOW COSTS; LYMPHOMA CELLS; MICRO TECHNOLOGY; MICROFLUIDIC CHANNEL; NANOLITERS; PARALLELIZATIONS; PROLIFERATION MONITORING; SENSING TECHNIQUES; SENSOR RESPONSE;

ANIMAL CELL CULTURE; BIOLOGY; BIOSENSORS; CAPACITANCE; CAPACITORS; CELLS; CYTOLOGY; ETHANOL; MEDICAL APPLICATIONS; MICROWAVE SPECTROSCOPY; SOLUTIONS;

SENSORS;

EID: 84871808488     PISSN: 00189480     EISSN: None     Source Type: Journal    
DOI: 10.1109/TMTT.2012.2222660     Document Type: Article

References (15)

1. R. Baw and J. Finkelsetein, "Lab on chip, " Nature, vol. 442, no. 7101, pp. 367-418, Jul. 2006.
2. R. Bashir, "BioMEMS: State-of-the-art in detection, opportunities and prospects, " Adv. Drug Del. Rev., vol. 56, pp. 1565-1586, 2004. (Pubitemid 39177689)
3. J. S. Daniels and N. Pourmand, "Label-free impedance biosensors: Opportunities and challenges, " Electroanalysis, vol. 19, no. 12, pp. 1239-1257, 2007.
4. S. Gabriel, R. W. Lau, and C. Gabriel, "The dielectric properties of biological tissues, " Phys. Med. Biol., vol. 41, no. 11, pp. 2231-2293, 1996.
5. H. P. Schwan, "Electrical properties of blood and its constituents: Alternating current spectroscopy, " Blut, vol. 46, pp. 185-197, 1983. (Pubitemid 13112795)
6. F. Kremer, "Dielectric spectroscopy-Yesterday, today and tomorrow, " J. Non-Cryst. Solids, vol. 305, no. 1-3, pp. 1-9, Jul. 2002.
7. F. Duhamel, I. Huynen, and A. Vander Vorst, "Measurement of complex permittivity of biological and organic liquids up to 110 GHz, " in IEEE MTT-S Int. Microw. Symp. Dig., 1997, vol. 1, pp. 107-110.
8. G. M. Whitesides, "The origins and the future of microfluidics, " Nature, vol. 442, pp. 368-373, Jul. 2006. (Pubitemid 44264779)
9. T. Chen, D. Dubuc, andK. Grenier, "Accurate nanoliter liquid complex admittance characterization up to 40 GHz for biomedical applications, " in IEEE MTT-S Int. Microw. Symp. Dig., Montréal, QC, Canada, Jun. 2012, pp. 1-3.
10. K. Grenier and D. Dubuc et al., "Integrated broadband microwave and microfluidic sensor dedicated to bioengineering, " IEEE Trans. Microw. Theory Tech., vol. 57, no. 12, pp. 3246-3253, Dec. 2009.
11. G. R. Facer et al., "Dielectric spectroscopy for bio-analysis: From 40 Hz to 26, 5 GHz in microfabricated waveguide, " Appl. Phys. Lett., vol. 78, no. 7, pp. 996-998, Feb. 2001. (Pubitemid 33662087)
12. J. C. Booth et al., "Quantitative permittivity measurements of nanoliter liquid in microfluidic channels to 40 GHz, " IEEE Trans. Instrum. Meas., vol. 59, no. 12, pp. 3279-3288, Dec. 2010.
13. S. S. Stuchly and C. E. Bassey, "Microwave coplanar sensors for dielectric measurements, " Meas. Sci. Technol., no. 9, pp. 1324-1329, 1998. (Pubitemid 128725083)
14. A. Raj, W. S. Holmes, and S. R. Judah, "Wide bandwidth measurement of complex permittivity of liquids using coplanar lines, " IEEE Trans. Instrum. Meas., vol. 50, no. 4, pp. 905-909, Apr. 2001. (Pubitemid 32945748)
15. S. Seo, T. Stintzing, I. Block, D. Pavlidis, M. Rieke, and P. G. Layer, "High frequency wideband permittivity measurements of biological substances using coplanar waveguides and application to cell suspensions, " in IEEE MTT-S Int. Microw. Symp. Dig., 2008, pp. 915-918.