Impurity profiling of micronomicin sulfate injection by liquid chromatography-ion trap mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 75, Issue , 2013, Pages 94-104

  Yuan, Yao Zuo ^a,c   Zhao, Xun ^a   Zhang, Mei ^a   Fan, Xia Lei ^a   Hu, Chang Qin ^b   Jin, Shao Hong ^b   Van Schepdael, Ann ^c   Hoogmartens, Jos ^c   Adams, Erwin ^c  

^a Jiangsu Institute for Food and Drug Control   (China)

^b NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Aminoglycoside antibiotics; Impurity profiling; LC MS; Micronomicin sulfate

Indexed keywords

ALKALINE EARTH METAL; ANTIBIOTIC AGENT; ETIMICIN; FUNCTIONAL GROUP; GENTAMICIN; MICRONOMICIN; NETILMICIN; SISOMICIN; UNCLASSIFIED DRUG; VERDAMYCIN; VERTILMICIN;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG IMPURITY; DRUG MANUFACTURE; DRUG SOLUBILITY; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; FRAGMENTATION REACTION; INJECTION; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; PH; PHASE TRANSITION; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CHINA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DRUG CONTAMINATION; INJECTIONS; MOLECULAR STRUCTURE; QUALITY CONTROL; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFURIC ACID ESTERS; TANDEM MASS SPECTROMETRY;

EID: 84871802143     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.11.029     Document Type: Article

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