Mass spectrometric characterization of gentamicin components separated by the new European Pharmacopoeia method

Journal of Pharmaceutical and Biomedical Analysis

Volumn 55, Issue 1, 2011, Pages 78-84

  Li, B ^a   Van Schepdael, A ^a   Hoogmartens, J ^a   Adams, E ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Aminoglycoside antibiotics; Gentamicin; LC PED; MS; Related substances

Indexed keywords

ACETONITRILE; GENTAMICIN; PENTAFLUOROPROPIONIC ACID; PROPIONIC ACID DERIVATIVE; SODIUM HYDROXIDE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG IMPURITY; DRUG STRUCTURE; FRAGMENTATION REACTION; LIQUID CHROMATOGRAPHY COMBINED WITH PULSED ELECTROCHEMICAL DETECTION; MASS SPECTROMETRY; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY;

ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; ELECTROCHEMICAL TECHNIQUES; EUROPE; FLUOROCARBONS; GENTAMICINS; LIMIT OF DETECTION; MOLECULAR STRUCTURE; PHARMACOPOEIAS AS TOPIC; SOLVENTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TECHNOLOGY, PHARMACEUTICAL; TRIFLUOROACETIC ACID;

EID: 79951768178     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.01.017     Document Type: Article

References (22)

1. Nagabhushan T.L., Miller G.H., Weinstein M.J. The Aminoglycosides: Microbiology, Clinical Use & Toxicology 1982, 3-27. Marcel Dekker, New York. A. Whelton, H.C. Neu (Eds.).
2. European Pharmacopoeia, 7th ed., European Department for the Quality of Medicines, Council of Europe, Strasbourg, France, 2008, pp. 2091-2092.
3. Berdy J., Pauncz J.K., Vajna Z.M., Horvat G., Gyimesi J., Koczka I. Metabolites of gentamicin-producing Micromonospora species. I. Isolation and identification of metabolites. J. Antibiot. (Tokyo) 1977, 30:945-954.
4. Berdy J., Jarai M. Micromonospora produced aminoglycoside antibiotics: chemistry and microbiology. Process Biochem. 1986, 21:93-100.
5. Berdy J., Jarai M. Micromonospora produced aminoglyoside antibiotics: chemistry and microbiology. II. Process Biochem. A 1986, 21:103-106.
6. Li B., Adams E., Van Schepdael A., Hoogmartens J. Analysis of unknown compounds in gentamicin bulk samples with liquid chromatography coupled with ion trap mass spectrometry. Rapid Commun. Mass Spectrom. 2006, 20:393-402.
7. Grahek R., Zupančič-Kralj L. Identification of gentamicin impurities by liquid chromatography tandem mass spectrometry. J. Pharm. Biomed. Anal. 2009, 50:1037-1043.
8. Heller D.N., Peggins J.O., Nochetto C.B., Smith M.L., Chiesa O.A., Moulton K. LC/MS/MS measurement of gentamicin in bovine plasma, urine, milk, and biopsy samples taken from kidneys of standing animals. J. Chromatogr. B 2005, 821:22-30.
9. Bogialli S., Curini R., Corcia A.D., Laganà A., Mele M., Nazzari M. Simple confirmatory assay for analyzing residues of aminoglycoside antibiotics in bovine milk: hot water extraction followed by liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2005, 1067:93-100.
10. Cherlet M., De Baere S., Croubels S., De Backer P. Determination of gentamicin in swine and calf tissues by high-performance liquid chromatography combined with electrospray ionization mass spectrometry. J. Mass Spectrom. 2000, 35:1342-1350.
11. McLaughlin L.G., Henion J.D., Kijak P.J. Multi-residue confirmation of aminoglycoside antibiotics and bovine kidney by ion spray high-performance liquid chromatography/tandem mass spectrometry. Biol. Mass Spectrom. 1994, 23:417-429.
12. Heller D.N., Clark S.B., Righter H.F. Confirmation of gentamicin and neomycin in milk by weak cation-exchange extraction and electrospray ionization/ion trap tandem mass spectrometry. J. Mass Spectrom. 2000, 35:39-49.
13. Löffler D., Ternes T.A. Analytical method for the determination of the aminoglycoside gentamicin in hospital wastewater via liquid chromatography-electrospray-tandem mass spectrometry. J. Chromatogr. A 2003, 1000:583-588.
14. Megoulas N.C., Koupparis M.A. Development and validation of a novel LC/ELSD method for the quantitation of gentamicin sulfate components in pharmaceuticals. J. Pharm. Biomed. Anal. 2004, 36:73-79.
15. Clarot I., Chaimbault P., Hasdenteufel F., Netter P., Nicolas A. Determination of gentamicin sulfate and related compounds by high-performance liquid chromatography with evaporative light scattering detection. J. Chromatogr. A 2004, 1031:281-287.
16. Arul J., Abu R. Development and validation of a RP-HPLC method for the determination of gentamicin sulfate and its related substances in a pharmaceutical cream using a short pentafluorophenyl column and a Charged Aerosol Detector. J. Pharm. Biomed. Anal. 2010, 51:521-531.
17. Adams E., Roelants W., De Paepe R., Roets E., Hoogmartens J. Analysis of gentamicin by liquid chromatography with pulsed electrochemical detection. J. Pharm. Biomed. Anal. 1998, 18:689-698.
18. Cai Y., Cai Y., Cheng J., Mou S., Yiqiang L. Comparative study on the analytical performance of three waveforms for the determination of several aminoglycoside antibiotics with high performance liquid chromatography using amperometric detection. J. Chromatogr. A 2005, 1085:124-130.
19. Manyanga V., Grishina O., Yun Z., Hoogmartens J., Adams E. Comparison of liquid chromatographic methods with direct detection for the analysis of gentamicin. J. Pharm. Biomed. Anal. 2007, 45:257-262.
20. Manyanga V., Kreft K., Divjak B., Hoogmartens J., Adams E. Improved liquid chromatographic method with pulsed electrochemical detection for the analysis of gentamicin. J. Chromatogr. A 2008, 1189:347-354.
21. Kotretsou S.I., Constantinou-Kokotou V. Mass spectrometric studies on the fragmentation and structural characterization of aminoacyl derivatives of kanamycin A. Carbohydr. Res. 1998, 310:121-127.
22. Hu P., Chess E.K., Brynjelsen S., Jakubowski G., Melchert J., Hammond R.B., Wilson T.D. Collisionally activated dissociations of aminocyclitol-aminoglycoside antibiotics and their application in the identification of a new compound in tobramycin samples. J. Am. Soc. Mass Spectrom. 2000, 11:200-209.