Common variation in the LRRK2 gene is a risk factor for Parkinson's disease

Movement Disorders

Volumn 27, Issue 14, 2012, Pages 1823-1826

  Mata, Ignacio F ^a,b   Checkoway, Harvey ^c   Hutter, Carolyn M ^c,d   Samii, Ali ^a,b   Roberts, John W ^e   Kim, Hojoong M ^a,b   Agarwal, Pinky ^f   Alvarez, Victoria ^g   Ribacoba, Renee ^g   Pastor, Pau ^h,i,j   Lorenzo Betancor, Oswaldo ^h,i,j   Infante, Jon ^j,k   Sierra, María ^k   Gómez Garre, Pilar ^j,l   Mir, Pablo ^j,l   Ritz, Beate ^m,n   Rhodes, Shannon L ^m   Colcher, Amy ^o   Van Deerlin, Vivianna ^o   Chung, Kathryn A ^p,q   Quinn, Joseph F ^p,q   Yearout, Dora ^a,b   Martinez, Erica ^a,b   Farin, Federico M ^c   Wan, Jia Y ^c   Edwards, Karen L ^c   Zabetian, Cyrus P ^a,b   more..

^a VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

^e VIRGINIA MASON MEDICAL CENTER   (United States)

^f Evergreen Hospital Medical Center   (United States)

^g HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^h UNIVERSITY OF NAVARRA   (Spain)

ⁱ UNIVERSITY CLINIC OF NAVARRA   (Spain)

^j CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^k HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^l UNIVERSITY OF SEVILLE   (Spain)

^m UNIVERSITY OF CALIFORNIA   (United States)

ⁿ UNIVERSITY OF CALIFORNIA   (United States)

^o UNIVERSITY OF PENNSYLVANIA   (United States)

^p OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^q PORTLAND VA MEDICAL CENTER   (United States)

more..

Author keywords

LRRK2; Parkinson's disease; SNP

Indexed keywords

LEUCINE RICH REPEAT KINASE 2;

AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE REPLICATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HUMAN; MAJOR CLINICAL STUDY; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84871801859     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.25226     Document Type: Article

References (20)

1. Tan EK, Peng R, Teo YY, et al. Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study. Hum Mutat. 2010; 31: 561-568.
2. Wu X, Tang KF, Li Y, et al. Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: a meta-analysis. Parkinsonism Relat Disord. 2012; 18: 722-730.
3. Zabetian CP, Yamamoto M, Lopez AN, et al. LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease. Mov Disord. 2009; 24: 1034-1041.
4. Di Fonzo A, Wu-Chou YH, Lu CS, et al. A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan. Neurogenetics. 2006; 7: 133-138.
5. Ross OA, Wu YR, Lee MC, et al. Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Ann Neurol. 2008; 64: 88-92.
6. Biskup S, Mueller JC, Sharma M, et al. Common variants of LRRK2 are not associated with sporadic Parkinson's disease. Ann Neurol. 2005; 58: 905-908.
7. Paisan-Ruiz C, Nath P, Washecka N, Gibbs JR, Singleton AB. Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls. Hum Mutat. 2008; 29: 485-490.
8. Edwards TL, Scott WK, Almonte C, et al. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Ann Hum Genet. 2010; 74: 97-109.
9. Simon-Sanchez J, van Hilten JJ, van de Warrenburg B, et al. Genome-wide association study confirms extant PD risk loci among the Dutch. Eur J Hum Genet. 2011; 19: 655-661.
10. Spencer CC, Plagnol V, Strange A, et al. Dissection of the genetics of Parkinson's disease identifies an additional association 5′ of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet. 2011; 20: 345-353.
11. Hamza TH, Zabetian CP, Tenesa A, et al. Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. Nat Genet. 2010; 42: 781-785.
12. Do CB, Tung JY, Dorfman E, et al. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet. 2011; 7: e1002141.
13. Simon-Sanchez J, Schulte C, Bras JM, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 2009; 41: 1308-1312.
14. Nalls MA, Plagnol V, Hernandez DG, et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet. 2011; 377: 641-649.
15. Lill CM, Roehr JT, McQueen MB, et al. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: the PDGene database. PLoS Genet. 2012; 8: e1002548.
16. Zabetian CP, Samii A, Mosley AD, et al. A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations. Neurology. 2005; 65: 741-744.
17. Checkoway H, Powers K, Smith-Weller T, Franklin GM, Longstreth WT Jr, Swanson PD. Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake. Am J Epidemiol. 2002; 155: 732-738.
18. Kang GA, Bronstein JM, Masterman DL, Redelings M, Crum JA, Ritz B. Clinical characteristics in early Parkinson's disease in a central California population-based study. Mov Disord. 2005; 20: 1133-1142.
19. Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry. 1988; 51: 745-752.
20. Ross OA, Soto-Ortolaza AI, Heckman MG, et al. Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study. Lancet Neurol. 2011; 10: 898-908.