Perceiving threat in the face of safety: Excitation and inhibition of conditioned fear in human visual cortex

Journal of Neuroscience

Volumn 33, Issue 1, 2013, Pages 72-78

  Miskovic, Vladimir ^a   Keil, Andreas ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CONDITIONED REFLEX; CONDITIONING; ELECTROENCEPHALOGRAPHY; EVOKED VISUAL RESPONSE; FEAR; FEMALE; HABITUATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; REINFORCEMENT; THREAT; VISUAL CORTEX; VISUAL STIMULATION;

ADOLESCENT; CONDITIONING, CLASSICAL; DISCRIMINATION LEARNING; EVOKED POTENTIALS, VISUAL; FEAR; FEMALE; HUMANS; INHIBITION (PSYCHOLOGY); MALE; PHOTIC STIMULATION; VISUAL CORTEX; VISUAL PERCEPTION; YOUNG ADULT;

EID: 84871800396     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3692-12.2013     Document Type: Article

References (33)

1. Andersen SK, Müller MM (2010) Behavioral performance follows the time course of neural facilitation and suppression during cued shifts of featureselective attention. Proc Natl Acad Sci U S A 107:13878-13882. CrossRef Medline
2. Armony JL, Dolan RJ (2002) Modulation of spatial attention by fear conditioned stimuli: an event-related fMRI study. Neuropsychologia 40:817-826. CrossRef Medline
3. Brainard DH (1997) The psychophysics toolbox. Spat Vis 10:433-436. CrossRef Medline
4. Damaraju E, Huang YM, Barret LF, Pessoa L (2009) Affective learning enhances activity and functional connectivity in early visual cortex. Neuropsychologia 47:2480-2487. CrossRef Medline
5. Jovanovic T, Keyes M, Fiallos A, Myers KM, Davis M, Duncan EJ (2005) Fear potentiation and fear inhibition in a human fear-potentiated startle paradigm. Biol Psychiatry 57:1559-1564. CrossRef Medline
6. Junghöfer M, Elbert T, Tucker DM, Rockstroh B (2000) Statistical control of artifacts in dense array EEG/MEG studies. Psychophysiology 37:523-532. CrossRef Medline
7. Keil A, Gruber T, Müller MM, Moratti S, Stolarova M, Bradley MM, Lang PJ (2003) Early modulation of visual perception by emotional arousal: Evidence from steady-state visual evoked brain potentials. Cogn Affect Behav Neurosci 3:195-206. CrossRef Medline
8. Keil A, Stolarova M, Moratti S, Ray WJ (2007) Adaptation in human visual cortex as a mechanism for rapid discrimination of aversive stimuli. Neuroimage 36:472-479. CrossRef Medline
9. Kluge C, Bauer M, Leff AP, Heinze HJ, Dolan RJ, Driver J (2011) Plasticity of human auditory-evoked fields induced by shock conditioning and contingency reversal. Proc Natl Acad Sci U S A 108:12545-12550. CrossRef Medline
10. Lang PJ, Bradley MM (2010) Emotion and the motivational brain. Biol Psychol 84:437-450. CrossRef Medline
11. Lang PJ, Bradley MM, Cuthbert BN (1997) Motivated attention: affect, activation, and action. In: Attention and orienting: sensory and motivational processes (Lang PJ, Simons RF, Balaban MT, eds), pp 97-135. Hillsdale, NJ: Erlbaum.
12. Lohr JM, Olatunji BO, Sawchuk CN (2007) A functional analysis of danger and safety signals in anxiety disorders. Clin Psychol Rev 27:114-126. CrossRef Medline
13. Mineka S, Oehlberg K (2008) The relevance of recent developments in classical conditioning to understanding the etiology and maintenance of anxiety disorders. Acta Psychol (Amst) 127:567-580. CrossRef Medline
14. Moratti S, Keil A (2005) Cortical activation during Pavlovian fear conditioning depends on heart rate response patterns: anMEGstudy. Brain Res Cogn Brain Res 25:459-471. CrossRef Medline
15. Moratti S, Keil A (2009) Not what you expect: experience but not expectancy predicts conditioned responses in human visual and supplementary cortex. Cereb Cortex 19:2803-2809. CrossRef Medline
16. Moratti S, Keil A, Miller GA (2006) Fear but not awareness predicts enhanced sensory processing in fear conditioning. Psychophysiology 43: 216-226. CrossRef Medline
17. Morris JS, Friston KJ, Dolan RJ (1998) Experience-dependent modulation of tonotopic neural responses in human auditory cortex. Proc Biol Sci 265:649-657. CrossRef Medline
18. Müller MM, Teder-Sälejärvi W, Hillyard SA (1998) The time course of cortical facilitation during cued shifts of spatial attention. Nat Neurosci 1:631-634. CrossRef Medline
19. Müller MM, Malinowski P, Gruber T, Hillyard SA (2003) Sustained division of the attentional spotlight. Nature 424:309-312. CrossRef Medline
20. Myers KM, Davis M (2004) AX+, BX- discrimination learning in the fearpotentiated startle paradigm: possible relevance to inhibitory fear learning in extinction. Learn Mem 11:464-475. CrossRef Medline
21. Myers KM, Toufexis DJ, Winslow JT, Jovanovic T, Norrholm SD, Duncan E, Davis M (2009) Measurement of fear inhibition in rats, monkeys, and humans with and without posttraumatic stress disorder, using the AX+, BX-paradigm. In: The human amygdala (Whalen PJ, Phelps EA, eds), pp 61-81. New York: Guildford.
22. Padmala S, Pessoa L (2008) Affective learning enhances visual detection and responses in primary visual cortex. J Neurosci 28:6202-6210. CrossRef Medline
23. Pelli DG (1997) The VideoToolbox software for visual psychophysics: transforming numbers into movies. Spat Vis 10:437-442. CrossRef Medline
24. Peyk P, De Cesarei A, Junghöfer M (2011) ElectroMagnetoEncephalography software: overview and integration with other EEG/MEG toolboxes. Comput Intell Neurosci 2011:861705. CrossRef Medline
25. Schiller D, Levy I, Niv Y, LeDoux JE, Phelps EA (2008) From fear to safety and back: reversal of fear in the human brain. J Neurosci 28:11517-11525. CrossRef Medline
26. Stolarova M, Keil A, Moratti S (2006) Modulation of the C1 visual eventrelated component by conditioned stimuli: evidence for sensory plasticity in early affective perception. Cereb Cortex 16:876-887. CrossRef Medline
27. Vialatte FB, Maurice M, Dauwels J, Cichocki A (2010) Steady-state visually evoked potentials: focus on essential paradigms and future perspectives. Prog Neurobiol 90:418-438. CrossRef Medline
28. Wang J, Clementz BA, Keil A (2007) The neural correlates of feature-based selective attention when viewing spatially and temporally overlapping images. Neuropsychologia 45:1393-1399. CrossRef Medline
29. Weike AI, Schupp HT, Hamm AO (2008) In dubio pro defensio: initial activation of conditioned fear is not cue specific. Behav Neurosci 122: 685-696. CrossRef Medline
30. Weinberger NM (2007) Associative representational plasticity in the auditory cortex: a synthesis of two disciplines. Learn Mem 14:1-16. CrossRef Medline
31. Weisz N, Kostadinov B, Dohrmann K, Hartmann T, Schlee W (2007) Tracking short-term auditory cortical plasticity during classical conditioning using frequency-tagged stimuli. Cereb Cortex 17:1867-1876. CrossRef Medline
32. Wieser MJ, McTeague LM, Keil A (2011) Sustained preferential processing of social threat cues: bias without competition? J Cogn Neurosci 23:1973-1986. CrossRef Medline
33. Winslow JT, Noble PL, Davis M (2008) AX+/BX- discrimination learning in the fear-potentiated startle paradigm in monkeys. Learn Mem 15:63-66. CrossRef Medline