Quercetin impairs the reproductive potential of male mice

Andrologia

Volumn 45, Issue 1, 2013, Pages 56-65

  Ranawat, P ^a   Kaushik, G ^a   Saikia, U N ^a   Pathak, C M ^a   Khanduja, K L ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Infertility; Quercetin; Reproductive potential; Sperm motility; Testis

Indexed keywords

CATALASE; GLUTATHIONE; MALONALDEHYDE; QUERCETIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GERM CELL; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; REPRODUCTION; SEMINIFEROUS TUBULE EPITHELIUM; SERTOLI CELL; SPERMATOZOON MOTILITY; TESTIS; TESTOSTERONE BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; CATALASE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; LIPID PEROXIDATION; MALE; MICE; OXIDATIVE STRESS; QUERCETIN; REACTIVE OXYGEN SPECIES; REPRODUCTION; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; SUPEROXIDE DISMUTASE; TESTIS;

EID: 84871766725     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2012.01311.x     Document Type: Article

References (50)

1. Agarwal A, Prabakaran S, Allamaneni S (2006a) What an andrologist/urologist should know about free radicals and why. Urology 67:2-8.
2. Agarwal A, Sharma RK, Nallella KP, Thomas AJ Jr, Alvarez JG, Sikka SC (2006b) Reactive oxygen species as an independent marker of male factor infertility. Fertil Steril 86:878-885.
3. Allamaneni SS, Agarwal A, Nallella KP, Sharma RK, Thomas AJ Jr, Sikka SC (2005) Characterization of oxidative stress status by evaluation of reactive oxygen species levels in whole semen and isolated spermatozoa. Fertil Steril 83:800-803.
4. 2+- ATPase in maintaining motility in ram spermatozoa. J Biol Chem 260:11548-11553.
5. Bu T, Mi Y, Zeng W, Zhang C (2011) Protective effect of quercetin on cadmium-induced oxidative toxicity on germ cells in male mice. Anat Rec 294:520-526.
6. Chen YT, Zheng RL, Jia ZJ, Ju Y (1990) Flavonoids as superoxide scavengers and antioxidants. Free Radic Biol Med 9:19-21.
7. Creasy DM, Flynn JC, Gray TJB, Butler WH (1985) A quantitative study of stage-specific spermatocyte damage following administration of ethylene glycol monomethyl ether in the rat. Exp Mol Pathol 43:321-336.
8. Driver AS, Rao P, Kodavanti S, Mundy WR (2000) Age-related changes in the reactive oxygen species production in rat brain homogenates. Neurotoxicol Teratol 22:175-181.
9. Dunson DB, Baird DD, Colombo B (2004) Increased infertility with age in men and women. Obstet Gynecol 103:51-56.
10. Elias H, Hyde DM (1980) An elementary introduction to stereology (quantitative microscopy). Am J Anat 159:412-446.
11. Formica JV, Regelson W (1995) Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 33:1061-1080.
12. Garrett SD, Lee HA, Morgan MRA (1999) A nonisotopic estrogen receptor-based assay to detect estrogenic compounds. Nat Biotechnol 17:1219-1222.
13. Ghosh D, Das UB, Ghosh S, Mallick M, Debnath J (2002) Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat; a correlative study with testicular oxidative stress. Drug Chem Toxicol 25:281-292.
14. Girotti AW (1990) Photodynamic lipid peroxidation in biological systems. Photochem Photobiol 51:497-509.
15. Griswold MD (1998) The central role of sertoli cells in spermatogenesis. Semin Cell Dev Biol 9:411-416.
16. Hew KW, Ericson WA, Michael JW (1993) A single low cadmium dose causes failure of spermiation in the rat. Toxicol Appl Pharmacol 121:15-21.
17. Hissin PJ, Hilf R (1976) A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74:214-226.
18. Holstein AF, Eckmann C (1986) Multinucleated spermatocytes and spermatids in human seminiferous tubules. Andrologia 18:5-16.
19. Kandaswami C, Middleton E (1994) Free radical scavenging and antioxidant activity of plant flavonoids. In: Free Radicals in Diagnostic Medicine. Armstrong D (ed.). Plenum Press, New York, pp 351-376.
20. Katiyar SK (2006) Oxidative stress and photocarcinogenesis: strategies for prevention. In: Oxidative Stress, Disease and Cancer. Singh KK (ed.). Imperial College Press, London, pp 933-964.
21. Khaki A, Fathiazad F, Nouri M, Khaki A, Maleki NA, Khamnei HJ, Ahmadi P (2010) Beneficial effects of quercetin on sperm parameters in streptozotocin-induced diabetic male rats. Phytother Res 24:1285-1291.
22. Khanduja KL, Bhardwaj A (2003) Stable free radical scavenging and antiperoxidative properties of resveratrol compared in vitro with some other bioflavonoids. Indian J Biochem Biophys 40:416-422.
23. Khanduja KL, Verma A, Bhardwaj A (2001) Impairment of human sperm motility and viability by quercetin is independent of lipid peroxidation. Andrologia 33:277-281.
24. Kono Y (1978) Generation of superoxide radical during auto oxidation of hydroxylamine and as assay for superoxide dismutase. Arch Biochem Biophys 186:189-195.
25. Kris-Etherton PM, Lefevre M, Beecher GR, Gross MD, Keen CL, Etherton TD (2004) Bioactive compounds in nutrition and health-research methodologies for establishing biological function: the antioxidant and anti-inflammatory effects of flavonoids on atherosclerosis. Annu Rev Nutr 24:511-538.
26. Laughton MJ, Halliwell B, Evans PJ, Hoult JRS (1989) Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin: effects on lipid peroxidation, hydroxyl radical generation and bleomycin dependent damage to DNA. Biochem Pharmacol 38:2859-2863.
27. LeBlond CP, Clermont Y (1952) Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann N Y Acad Sci 55:548-573.
28. Lee KP, Frame SR, Sykes GP, Valentine R (1993) Testicular degeneration and spermatid retention in young rats. Toxicol Pathol 21:292-302.
29. Lenzi A, Gandini L, Picardo M, Tramer F, Sandri G, Panfili E (2000) Lipoperoxidation damage of spermatozoa polyunsaturated fatty acids (PUFA): scavenger mechanism and possible scavenger therapies. Front Biosci 5:E1-E15.
30. Li G, Ma A, Shi W, Zhong XH (2010) Quercetin protects hamster spermatogenic cells from oxidative damage induced by diethylstilboestrol. Andrologia 42:285-290.
31. Linder RE, Strader LF, Slott VL, Suarez JD (1992) Endpoints of spermatotoxicity in the rat after short duration exposures to 14 reproductive toxicants. Reprod Toxicol 6:491-505.
32. Liu CM, Zheng YL, Lu J, Zhang ZF, Fan SH, Wu DM, Ma JQ (2010) Quercetin protects rat liver against lead-induced oxidative stress and apoptosis. Environ Toxicol Pharmacol 29:158-166.
33. Lowry OH, Rosebrough NJ, Farr AL, Randell RJ (1951) Protein measurement with folin-phenol reagent. J Biol Chem 193:265-275.
34. Luck H (1963) Catalase. In: Methods of Enzymatic Analysis. Bergmeyer HW (ed.). Academic Press, New York, pp 885-894.
35. Ma YH, Hu JH, Zhou XG, Mei ZT, Fei J, Guo LH (2000) Gamma-aminobutyric acid transporter (GAT1) overexpression in mouse affects the testicular morphology. Cell Res 10:59-69.
36. Matsui H, Mitsumori K, Yasuhara K, Onodera H, Shimo T, Takahashi M (1995) Morphological evaluation of cyclophosphamide testicular toxicity in rats using quantitative morphometry of spermatogenic cycle stages. J Toxicol Sci 20:407-414.
37. Mclean DJ, Friel PJ, Pouchnik D, Griswold MD (2002) Oligonucleotide microarray analysis of gene expression in follicle-stimulating hormone-treated rat sertoli cells. Mol Endocrinol 16:2780-2792.
38. Metodiewa D, Dunford HB (1993) Medical aspects and techniques for peroxidases and catalases. In: Atmospheric Oxidation and Antioxidants, Vol. 111. Scott G (ed.). Elsevier, Amsterdam, pp 287-332.
39. Metodiewa D, Jaiswal AK, Cenas N, Dickancaite E, Segura-Aguilar J (1999) Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic Biol Med 26:107-116.
40. Mi Y, Zhang C, Li C, Taneda S, Watanabe G, Suzuki AK, Taya K (2010) Quercetin attenuates oxidative damage induced by treatment of embryonic chicken spermatogonial cells with 4-nitro-3-phenylphenol in diesel exhaust particles. Biosci Biotechnol Biochem 74:934-938.
41. Nass-Arden L, Breitbart H (1990) Modulation of mammalian sperm motility by quercetin. Mol Reprod Dev 25:369-373.
42. Ranawat P, Bansal MP (2010) Modulatory effects of selenium on spermatogenesis: involvement of transcription factors CREB and CREM. Am J Biomed Sci 2:329-341.
43. Russell LD, Etllin RA, Hikim APS, Clegg ED (1990) Histological and Histopathological Evaluation of the Testis. Cache River Press, Florida.
44. Stavric B, Matula TI (1988) Biological Significance of Flavonoids in Foods: A Review of Some Recent Issues and Problems. INRA Publications, Universite Brock, St. Catherines, ON, Canada, pp 95-104.
45. Taepongsorat L, Tangpraprutgul P, Kitana N, Malaivijitnond D (2008) Stimulating effects of quercetin on sperm quality and reproductive organs in adult male rats. Asian J Androl 10:249-258.
46. Tapanainen JS, Tilly JL, Vihko KK, Hsueh AJW (1993) Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors. Mol Endocrinol 7:643-650.
47. Ulbrich B, Palmer AK (1995) Detection of effects on male reproduction - a literature survey. J Am Coll Toxicol 14:2293-3327.
48. Williams RJ, Spencer JP, Rice-Evans C (2004) Flavonoids: antioxidants or signaling molecules? Free Radic Biol Med 36:838-849.
49. Wills ED (1966) Mechanisms of lipid peroxide formation in animal tissues. Biochem J 99:667-676.
50. Zeinick H, Clegg ED (1989) Assessment of male reproductive toxicity: a risk assessment approach. In: Principles and Methods of Toxicology. Hayes AW (ed.). Raven Press, New York, pp 275-309.