Fourth European conference on infections in leukaemia (ECIL-4): Guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus

Clinical Infectious Diseases

Volumn 56, Issue 2, 2013, Pages 258-266

  Hirsch, Hans H ^a,b   Martino, Rodrigo ^c   Ward, Katherine N ^d   Boeckh, Michael ^e   Einsele, Hermann ^f   Ljungman, Per ^g,h  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e Fred Hutchinson Cancer Research Center   (United States)

^f UNIVERSITY OF WÜRZBURG   (Germany)

^g KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^h KAROLINSKA INSTITUTE   (Sweden)

Author keywords

bone marrow transplantation; hematopoietic; leukemia; respiratory virus; transplantation

Indexed keywords

CORTICOSTEROID; IMMUNOGLOBULIN; PALIVIZUMAB; RIBAVIRIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANTIVIRAL THERAPY; CANCER PATIENT; CHEMOPROPHYLAXIS; CHILDHOOD LEUKEMIA; CLINICAL FEATURE; COMMUNITY ACQUIRED RESPIRATORY VIRUS INFECTION; CORONAVIRUS INFECTION; CORTICOSTEROID THERAPY; DISEASE CLASSIFICATION; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN METAPNEUMOVIRUS; HUMAN METAPNEUMOVIRUS INFECTION; HUMAN RHINOVIRUS; IMMUNOGLOBULIN DEFICIENCY; INFECTION COMPLICATION; INFECTION PREVENTION; INFECTION RISK; LEUKEMIA; LOWER RESPIRATORY TRACT INFECTION; PARAINFLUENZA VIRUS 1; PARAINFLUENZA VIRUS 2; PARAINFLUENZA VIRUS 3; PARAINFLUENZA VIRUS 4; PARAINFLUENZA VIRUS INFECTION; PRACTICE GUIDELINE; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY SYNCYTIAL VIRUS INFECTION; REVIEW; RHINOVIRUS INFECTION; SCREENING TEST; VIRAL RESPIRATORY TRACT INFECTION; VIRAL UPPER RESPIRATORY TRACT INFECTION;

COMMUNITY-ACQUIRED INFECTIONS; CORONAVIRUS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA; METAPNEUMOVIRUS; PARAMYXOVIRINAE; PRACTICE GUIDELINES AS TOPIC; RESPIRATORY SYNCYTIAL VIRUSES; RESPIRATORY TRACT INFECTIONS; RHINOVIRUS; VIRUS DISEASES;

EID: 84871760253     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cis844     Document Type: Review

References (89)

1. Turner RB. Upper respiratory tract infections section B. In: Mandell DaBs, ed. Principles and practice of infectious diseases. 7th ed. Philadelphia: Elsevier, 2010:809-13.
2. Ruuskanen O, Lahti E, Jennings LC, Murdoch DR. Viral pneumonia. Lancet 2011; 377:1264-75.
3. Hall CB. Respiratory syncytial virus and parainfluenza virus. N Engl J Med 2001; 344:1917-28. (Pubitemid 32553362)
4. Couch RB, Englund JA, Whimbey E. Respiratory viral infections in immunocompetent and immunocompromised persons. Am J Med 1997; 102:2-9; discussion 25-6.
5. Whimbey E, Englund JA, Couch RB. Community respiratory virus infections in immunocompromised patients with cancer. Am J Med 1997; 102:10-8; discussion 25-6.
6. Boeckh M. The challenge of respiratory virus infections in hematopoi-etic cell transplant recipients. Br J Haematol 2008; 143:455-67.
7. Ison MG. Respiratory syncytial virus and other respiratory viruses in the setting of bone marrow transplantation. Curr Opin Oncol 2009; 21:171-6.
8. Chemaly RF, Ghosh S, Bodey GP, et al. Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center. Medicine (Baltimore) 2006; 85:278-87. (Pubitemid 44401460)
9. Ljungman P, Ward KN, Crooks BN, et al. Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 2001; 28:479-84. (Pubitemid 33069626)
10. European Group for Blood and Marrow Transplantation. 2011 Updates of ECIL. http://www.ebmt.org/Contents/Resources/Library/ECIL/-layouts/mobile/view. aspx?List=9c1d8b11-2538-4794-a3d1-0320e97 fe76c&View=f8038554-db71-45ae- ba17-5439cb906493). Accessed 8 October 2012.
11. Weigt SS, Gregson AL, Deng JC, Lynch JP 3rd, Belperio JA. Respiratory viral infections in hematopoietic stem cell and solid organ transplant recipients. Semin Respir Crit Care Med 2011; 32:471-93.
12. Bredius RG, Templeton KE, Scheltinga SA, Claas EC, Kroes AC, Vossen JM. Prospective study of respiratory viral infections in pediat-ric hemopoietic stem cell transplantation patients. Pediatr Infect Dis J 2004; 23:518-22. (Pubitemid 38802296)
13. Kuypers J, Campbell AP, Cent A, Corey L, Boeckh M. Comparison of conventional and molecular detection of respiratory viruses in hema-topoietic cell transplant recipients. Transpl Infect Dis 2009; 11:298-303.
14. Khanna N, Widmer AF, Decker M, et al. Respiratory syncytial virus infection in patients with hematological diseases: single-center study and review of the literature. Clin Infect Dis 2008; 46:402-12. (Pubitemid 351263523)
15. Kassis C, Champlin RE, Hachem RY, et al. Detection and control of a nosocomial respiratory syncytial virus outbreak in a stem cell transplantation unit: the role of palivizumab. Biol Blood Marrow Transplant 2010; 16:1265-71.
16. van Kraaij MG, van Elden LJ, van Loon AM, et al. Frequent detection of respiratory viruses in adult recipients of stem cell transplants with the use of real-time polymerase chain reaction, compared with viral culture. Clin Infect Dis 2005; 40:662-9. (Pubitemid 40381338)
17. van Elden LJ, van Kraaij MG, Nijhuis M, et al. Polymerase chain reaction is more sensitive than viral culture and antigen testing for the detection of respiratory viruses in adults with hematological cancer and pneumonia. Clin Infect Dis 2002; 34:177-83. (Pubitemid 34028349)
18. Piralla A, Percivalle E, Di Cesare-Merlone A, Locatelli F, Gerna G. Multicluster nosocomial outbreak of parainfluenza virus type 3 infection in a pediatric oncohematology unit: a phylogenetic study. Haema-tologica 2009; 94:833-9.
19. Campbell AP, Chien JW, Kuypers J, et al. Respiratory virus pneumonia after hematopoietic cell transplantation (HCT): associations between viral load in bronchoalveolar lavage samples, viral RNA detection in serum samples, and clinical outcomes of HCT. J Infect Dis 2010; 201:1404-13.
20. Lee JH, Jang JH, Lee SH, et al. Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients [published online ahead of print 4 March 2012]. Clin Transplant 2012; doi:10.1111/j.1399-0012.2012.01607.x.
21. Milano F, Campbell AP, Guthrie KA, et al. Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients. Blood 2010; 115:2088-94.
22. Peck AJ, Corey L, Boeckh M. Pretransplantation respiratory syncytial virus infection: impact of a strategy to delay transplantation. Clin Infect Dis 2004; 39:673-80. (Pubitemid 39180440)
23. Relman DA, Falkow S. Microbial pathogenesis section A. In: Mandell DaBs, ed. Principles and practice of infectious diseases. 7th ed. Philadelphia: Elsevier, 2010:3-13.
24. Nair H, Nokes DJ, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010; 375:1545-55.
25. Abdallah A, Rowland KE, Schepetiuk SK, To LB, Bardy P. An outbreak of respiratory syncytial virus infection in a bone marrow transplant unit: effect on engraftment and outcome of pneumonia without specific antiviral treatment. Bone Marrow Transplant 2003; 32:195-203. (Pubitemid 36903444)
26. Machado AF, Sallum MA, Vilas Boas LS, Tateno AF, Machado CM. Molecular characterization of strains of respiratory syncytial virus identified in a hematopoietic stem cell transplant outpatient unit over 2 years: community or nosocomial infection?. Biol Blood Marrow Transplant 2008; 14:1348-55.
27. Lavergne V, Ghannoum M, Weiss K, Roy J, Beliveau C. Successful prevention of respiratory syncytial virus nosocomial transmission following an enhanced seasonal infection control program. Bone Marrow Transplant 2011; 46:137-42.
28. Kuypers J, Wright N, Ferrenberg J, et al. Comparison of realtime PCR assays with fluorescent-antibody assays for diagnosis of respiratory virus infections in children. J Clin Microbiol 2006; 44:2382-8. (Pubitemid 44109661)
29. Sung L, Alonzo TA, Gerbing RB, et al. Respiratory syncytial virus infections in children with acute myeloid leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer 2008; 51:784-6.
30. Torres HA, Aguilera EA, Mattiuzzi GN, et al. Characteristics and outcome of respiratory syncytial virus infection in patients with leukemia. Haematologica 2007; 92:1216-23. (Pubitemid 350144180)
31. Nichols WG, Gooley T, Boeckh M. Community-acquired respiratory syncytial virus and parainfluenza virus infections after hematopoietic stem cell transplantation: the Fred Hutchinson Cancer Research Center experience. Biol Blood Marrow Transplant 2001; 7(suppl):11S-5S. (Pubitemid 33734763)
32. Martino R, Porras RP, Rabella N, et al. Prospective study of the incidence, clinical features, and outcome of symptomatic upper and lower respiratory tract infections by respiratory viruses in adult recipients of hematopoietic stem cell transplants for hematologic malignancies. Biol Blood Marrow Transplant 2005; 11:781-96. (Pubitemid 41403760)
33. Avetisyan G, Mattsson J, Sparrelid E, Ljungman P. Respiratory syncy-tial virus infection in recipients of allogeneic stem-cell transplantation: a retrospective study of the incidence, clinical features, and outcome. Transplantation 2009; 88:1222-6.
34. Hassan IA, Chopra R, Swindell R, Mutton KJ. Respiratory viral infections after bone marrow/peripheral stem-cell transplantation: the Christie hospital experience. Bone Marrow Transplant 2003; 32:73-7. (Pubitemid 36850283)
35. McCarthy AJ, Kingman HM, Kelly C, et al. The outcome of 26 patients with respiratory syncytial virus infection following allogeneic stem cell transplantation. Bone Marrow Transplant 1999; 24:1315-22. (Pubitemid 30052788)
36. Peck AJ, Englund JA, Kuypers J, et al. Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection. Blood 2007; 110:1681-8. (Pubitemid 47443987)
37. Erard V, Chien JW, Kim HW, et al. Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses. J Infect Dis 2006; 193:1619-25. (Pubitemid 43839464)
38. Shah JN, Chemaly RF. Management of RSV infections in adult recipients of hematopoietic stem cell transplantation. Blood 2011; 117:2755-63.
39. Khanna N, Hirsch HH. Respiratory syncytial virus infection in immu-nocompromised patients revisited. Clin Infect Dis 2008; 46:1934-5.
40. Buckingham SC, Jafri HS, Bush AJ, et al. A randomized, double-blind, placebo-controlled trial of dexamethasone in severe respiratory syncy-tial virus (RSV) infection: effects on RSV quantity and clinical outcome. J Infect Dis 2002; 185:1222-8. (Pubitemid 34439128)
41. Liu V, Dhillon GS, Weill D. A multi-drug regimen for respiratory syn-cytial virus and parainfluenza virus infections in adult lung and heart-lung transplant recipients. Transpl Infect Dis 2010; 12:38-44.
42. Hynicka LM, Ensor CR. Prophylaxis and treatment of respiratory syn-cytial virus in adult immunocompromised patients. Ann Pharmac-other 2012; 46:558-66.
43. Boeckh M, Englund J, Li Y, et al. Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients. Clin Infect Dis 2007; 44:245-9. (Pubitemid 46079989)
44. Laurichesse H, Dedman D, Watson JM, Zambon MC. Epidemiological features of parainfluenza virus infections: laboratory surveillance in England and Wales, 1975-1997. Eur J Epidemiol 1999; 15:475-84. (Pubitemid 29320925)
45. Chemaly RF, Hanmod SS, Rathod DB, et al. The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation. Blood 2012; 119:2738-45; quiz 969.
46. Srinivasan A, Wang C, Yang J, et al. Parainfluenza virus infections in children with hematologic malignancies. Pediatr Infect Dis J 2011; 30:855-9.
47. Srinivasan A, Wang C, Yang J, Shenep JL, Leung WH, Hayden RT. Symptomatic parainfluenza virus infections in children undergoing hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2011; 17:1520-7.
48. Ustun C, Slaby J, Shanley RM, et al. Human parainfluenza virus infection after hematopoietic stem cell transplantation: risk factors, management, mortality, and changes over time. Biol Blood Marrow Transplant 2012; 18:1580-8.
49. Lewis VA, Champlin R, Englund J, et al. Respiratory disease due to parainfluenza virus in adult bone marrow transplant recipients. Clin Infect Dis 1996; 23:1033-7. (Pubitemid 26367489)
50. Lessler J, Reich NG, Brookmeyer R, Perl TM, Nelson KE, Cummings DA. Incubation periods of acute respiratory viral infections: a systematic review. Lancet Infect Dis 2009; 9:291-300.
51. McCann S, Byrne JL, Rovira M, et al. Outbreaks of infectious diseases in stem cell transplant units: a silent cause of death for patients and transplant programmes. Bone Marrow Transplant 2004; 33:519-29. (Pubitemid 38425783)
52. Cortez KJ, Erdman DD, Peret TC, et al. Outbreak of human parainflu-enza virus 3 infections in a hematopoietic stem cell transplant population. J Infect Dis 2001; 184:1093-7. (Pubitemid 33010460)
53. Hohenthal U, Nikoskelainen J, Vainionpaa R, et al. Parainfluenza virus type 3 infections in a hematology unit. Bone Marrow Transplant 2001; 27:295-300. (Pubitemid 32177930)
54. Sydnor ER, Greer A, Budd AP, et al. An outbreak of human parainflu-enza virus 3 infection in an outpatient hematopoietic stem cell transplantation clinic. Am J Infect Control 2012; 40:601-5.
55. Maziarz RT, Sridharan P, Slater S, et al. Control of an outbreak of human parainfluenza virus 3 in hematopoietic stem cell transplant recipients. Biol Blood Marrow Transplant 2010; 16:192-8.
56. Zambon M, Bull T, Sadler CJ, Goldman JM, Ward KN. Molecular epidemiology of two consecutive outbreaks of parainfluenza 3 in a bone marrow transplant unit. J Clin Microbiol 1998; 36:2289-93. (Pubitemid 28324082)
57. Nichols WG, Corey L, Gooley T, Davis C, Boeckh M. Parainfluenza virus infections after hematopoietic stem cell transplantation: risk factors, response to antiviral therapy, and effect on transplant outcome. Blood 2001; 98:573-8.
58. Marcolini JA, Malik S, Suki D, Whimbey E, Bodey GP. Respiratory disease due to parainfluenza virus in adult leukemia patients. Eur J Clin Microbiol Infect Dis 2003; 22:79-84. (Pubitemid 36349968)
59. Schiffer JT, Kirby K, Sandmaier B, Storb R, Corey L, Boeckh M. Timing and severity of community acquired respiratory virus infections after myeloablative versus non-myeloablative hematopoietic stem cell transplantation. Haematologica 2009; 94:1101-8.
60. Hodson A, Kasliwal M, Streetly M, Macmahon E, Raj K. A parainflu-enza-3 outbreak in a SCT unit: sepsis with multi-organ failure and multiple co-pathogens are associated with increased mortality. Bone Marrow Transplant 2011; 46:1545-50.
61. Chakrabarti S, Collingham KE, Holder K, Oyaide S, Pillay D, Milligan DW. Parainfluenza virus type 3 infections in hematopoietic stem cell transplant recipients: response to ribavirin therapy. Clin Infect Dis 2000; 31:1516-8.
62. Shima T, Yoshimoto G, Nonami A, et al. Successful treatment of para-influenza virus 3 pneumonia with oral ribavirin and methylpredniso-lone in a bone marrow transplant recipient. Int J Hematol 2008; 88:336-40.
63. Stankova J, Carret AS, Moore D, et al. Long-term therapy with aerosolized ribavirin for parainfluenza 3 virus respiratory tract infection in an infant with severe combined immunodeficiency. Pediatr Transplant 2007; 11:209-13. (Pubitemid 46174995)
64. Sparrelid E, Ljungman P, Ekelof-Andstrom E, et al. Ribavirin therapy in bone marrow transplant recipients with viral respiratory tract infections. Bone Marrow Transplant 1997; 19:905-8. (Pubitemid 27217657)
65. Versluys AB, Rossen JW, van Ewijk B, Schuurman R, Bierings MB, Boelens JJ. Strong association between respiratory viral infection early after hematopoietic stem cell transplantation and the development of life-threatening acute and chronic alloimmune lung syndromes. Biol Blood Marrow Transplant 2010; 16:782-91.
66. Debur MC, Vidal LR, Stroparo E, et al. Human metapneumovirus infection in hematopoietic stem cell transplant recipients. Transpl Infect Dis 2010; 12:173-9.
67. Williams JV, Martino R, Rabella N, et al. A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections. J Infect Dis 2005; 192:1061-5. (Pubitemid 41266804)
68. Oliveira R, Machado A, Tateno A, Boas LV, Pannuti C, Machado C. Frequency of human metapneumovirus infection in hematopoietic SCT recipients during 3 consecutive years. Bone Marrow Transplant 2008; 42:265-9.
69. Debiaggi M, Canducci F, Sampaolo M, et al. Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients. J Infect Dis 2006; 194:474-8. (Pubitemid 44162658)
70. Debiaggi M, Canducci F, Terulla C, et al. Long-term study on symp-tomless human metapneumovirus infection in hematopoietic stem cell transplant recipients. New Microbiol 2007; 30:255-8. (Pubitemid 47264884)
71. Raza K, Ismailjee SB, Crespo M, et al. Successful outcome of human metapneumovirus (hMPV) pneumonia in a lung transplant recipient treated with intravenous ribavirin. J Heart Lung Transplant 2007; 26:862-4. (Pubitemid 47199078)
72. Englund JA, Boeckh M, Kuypers J, et al. Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients. Ann Intern Med 2006; 144:344-9. (Pubitemid 46768189)
73. Gerna G, Campanini G, Rovida F, et al. Genetic variability of human coronavirus OC43-, 229E-, and NL63-like strains and their association with lower respiratory tract infections of hospitalized infants and im-munocompromised patients. J Med Virol 2006; 78:938-49. (Pubitemid 43856703)
74. Folz RJ, Elkordy MA. Coronavirus pneumonia following autologous bone marrow transplantation for breast cancer. Chest 1999; 115:901-5. (Pubitemid 29129985)
75. Pene F, Merlat A, Vabret A, et al. Coronavirus 229E-related pneumonia in immunocompromised patients. Clin Infect Dis 2003; 37:929-32. (Pubitemid 37267207)
76. Uhlenhaut C, Cohen JI, Pavletic S, et al. Use of a novel virus detection assay to identify coronavirus HKU1 in the lungs of a hematopoietic stem cell transplant recipient with fatal pneumonia. Transpl Infect Dis 2011; 14:79-85.
77. Gerna G, Campanini G, Rognoni V, et al. Correlation of viral load as determined by real-time RT-PCR and clinical characteristics of respiratory syncytial virus lower respiratory tract infections in early infancy. J Clin Virol 2008; 41:45-8. (Pubitemid 50015624)
78. Oosterhof L, Christensen CB, Sengelov H. Fatal lower respiratory tract disease with human corona virus NL63 in an adult haematopoietic cell transplant recipient. Bone Marrow Transplant 2010; 45:1115-6.
79. Parody R, Rabella N, Martino R, et al. Upper and lower respiratory tract infections by human enterovirus and rhinovirus in adult patients with hematological malignancies. Am J Hematol 2007; 82:807-11. (Pubitemid 350194510)
80. Gerna G, Piralla A, Rovida F, et al. Correlation of rhinovirus load in the respiratory tract and clinical symptoms in hospitalized immuno-competent and immunocompromised patients. J Med Virol 2009; 81:1498-507.
81. Gutman JA, Peck AJ, Kuypers J, Boeckh M. Rhinovirus as a cause of fatal lower respiratory tract infection in adult stem cell transplantation patients: a report of two cases. Bone Marrow Transplant 2007; 40:809-11. (Pubitemid 47521544)
82. Schenk T, Strahm B, Kontny U, Hufnagel M, Neumann-Haefelin D, Falcone V. Disseminated bocavirus infection after stem cell transplant. Emerg Infect Dis 2007; 13:1425-7. (Pubitemid 47510320)
83. Gerna G, Piralla A, Campanini G, Marchi A, Stronati M, Rovida F. The human bocavirus role in acute respiratory tract infections of pedi-atric patients as defined by viral load quantification. New Microbiol 2007; 30:383-92. (Pubitemid 350183837)
84. Schenk T, Maier B, Hufnagel M, et al. Persistence of human bocavirus DNA in immunocompromised children. Pediatr Infect Dis J 2010; 30:82-4.
85. Debiaggi M, Canducci F, Brerra R, et al. Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients. J Med Virol 2010; 82:153-6.
86. Mourez T, Bergeron A, Ribaud P, et al. Polyomaviruses KI and WU in immunocompromised patients with respiratory disease. Emerg Infect Dis 2009; 15:107-9.
87. Rao S, Garcea RL, Robinson CC, Simoes EA. WU and KI polyomavi-rus infections in pediatric hematology/oncology patients with acute respiratory tract illness. J Clin Virol 2011; 52:28-32.
88. Kuypers J, Campbell AP, Guthrie KA, et al. WU and KI polyomavi-ruses in respiratory samples from allogeneic hematopoietic cell transplantation receipients. Emerg Infect Dis 2012; 18:1580-8.
89. Zamora MR, Budev M, Rolfe M, et al. RNA interference therapy in lung transplant patients infected with respiratory syncytial virus. Am J Respir Crit Care Med 2011; 183:531-8.