Virus vector-mediated rapid protein production in Nicotiana benthamianw. Effects of temperature and photosynthetic photon flux density on hemagglutinin accumulation

Environmental Control in Biology

Volumn 50, Issue 4, 2012, Pages 375-381

  Matsuda, Ryo ^a   Tahara, Aki ^a   Matoba, Nobuyuki ^b,c   Fujiwara, Kazuhiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Owensboro Cancer Research Program   (United States)

^c University of Louisville School of Medicine   (United States)

Author keywords

Influenza; MagnlCON vector; Plant made pharmaceutical (PMP); Total soluble protein (TSP); Transient expression; Vaccine antigen

Indexed keywords

EID: 84871751119     PISSN: 1880554X     EISSN: 18830986     Source Type: Journal    
DOI: 10.2525/ecb.50.375     Document Type: Article

References (28)

1. Boehm, R. 2007. Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platforms. Ann. N.Y. Acad. Sci. 1102: 121-134.
2. D'Aoust, M. A., Couture, M. M. J., Charland, N., Trépanier, S., Landry, N., Ors, F., Vézina, L. P. 2010. The production of hemagglutinin-based virus-like particles in plants: A rapid, efficient and safe response to pan-demic influenza. Plant Biotechnol. J. 8: 607-619.
3. D'Aoust, M. A., Lavoie, P. O., Couture, M. M. J., Trépanier, S., Guay, J. M., Dargis, M., Mongrand, S., Landry, N., Ward, B. J., Vézina, L. P. 2008. Influenza virus-like particles produced by transient expression in Nicotiana benthamiana induce a protective immune response against a lethal viral challenge in mice. Plant Biotechnol. J. 6: 930-940.
4. De Muynck, B., Navarre, C, Boutry, M. 2010. Production of antibodies in plants: Status after twenty years. Plant Biotechnol. J. 8: 1-35.
5. Gleba, Y, Klimyuk, V., Marillonnet, S. 2005. Magnifection - A new platform for expressing recombinant vaccines in plants. Vaccine 23: 2042-048.
6. Gleba, Y., Klimyuk, V., Marillonnet, S. 2007. Viral vectors for the expression of proteins in plants. Curr. Opin. Biotechnol. 18: 134-141.
7. Holsters, M., de Waele, D., Depicker, A., Messens, E., van Montagu, M., Schell, J. 1978. Transfection and transformation of Agrobacterium tumefaciens. Mol. Gen. Genet. 163: 181-187.
8. L -DNA gene 5 controls the tissue-specific expression of chimaeric genes carried by a novel type of Agrobacterium binary vector. Md. Gen. Genet. 204: 383-396.
9. Lamb, R. A., Choppin, P. W. 1983. The gene structure and replication of influenza virus. Ann. Rev. Biochem. 52: 467-506.
10. Liénard, D., Sourrouille, C., Gomord, V., Faye, L. 2007. Pharming and transgenic platsn. Biotechnol. Ann. Rev. 13: 115-147.
11. Ma, J. K. C., Chikwamba, R., Sparrow, P., Fischer, R., Mahoney, R., Twyman, R. M. 2005. Plant-derived pharmaceuticals - The road forward. Trends Plant Sci. 10: 580-585.
12. Makino, A., Mae, T., Ohira, K. 1984. Relation between nitrogen and ribulose-1,5-bisphosphate carboxylase in rice leaves from emergence through senescence. Plant Cell Physiol. 25: 429-437.
13. Marillonnet, S., Giritch, A., Gils, M., Kandzia, R, Klimyuk, V, Gleba, Y. 2004. In plant engineering of viral RNA replicons: Efficient assembly by recombination of DNA modules delivered by Agrobacterium. Proc. Natl. Acad. Sci. USA 101: 6852-6857.
14. Marillonnet, S., Thoeringer, C., Kandzia, R., Klimyuk, V., Gleba, Y. 2005. Systemic Agrobacterium tumefaciens-mediated transfection of viral replicons for efficient transient expression in plants. Nat. Biotechnol. 23: 718-723.
15. Matoba, N, Davis, K. R, Palmer, K. E. 2011. Recombinant protein expression in Nicotiana. Methods Mol. Biol. 701: 199-219.
16. Matoba, N, Husk, A. S., Barnett, B. W, Pickel, M. M., Arntzen, C. J., Montefiori, D. C, Takahashi, A., Tanno, K, Omura, S., Cao, H., Mooney, J. P., Hanson, C. V., Tanaka, H. 2010. HIV-1 neutralization profile and plant based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic activity. PLoS One 5: e11143.
17. Matsuda, R, Kubota, C. 2010. Variation of total soluble protein content in fruit among six greenhouse to-mato cultivars. Hort Science 45: 1645-1648.
18. Matsuda, R., Kubota, C., Alvaez, M. L., Cardneau, G. A. 2009. Biopharmaceutical protein poduction under controlled environments: Growth, development, and vaccine productivity of transgenic tomato plants grown hydroponically in a greenhouse. Hort Science 44: 1594-1599.
19. Matsuda, R., Kubota, C., Alvarez, M. L., Cardineau, G. A. 2010. Determining the optimal timing of fruit harvest in transgenic tomato expressing Fl-V, a candidate subunit vaccine against plague. Hort Science 45: 347-351.
20. Matsuda, R., Kubota, C, Alvarez, M. L., Cardineau, G. A. 2012. Effect of high electrical conductivity of hydroponic nutrient solution on vaccine protein content in transgenic tomato. Hort Technology 22: 362-367.
21. McCormick, A. A., Reddy, S., Reinl, S. J., Cameron, T. I., Czerwinkski, D. K., Vojdani, F, Hanley, K. M., Garger, S. J., White, E. L., Novak, J., Barrett, J., Holtz, R. B., Tusé, D., Levy, R. 2008. Plant-produced idiotype vaccines for the treatment of non- Hodgkin's lymphoma: Safety and immunogenicity in a phase I dinical study. Proc. Natl. Acad. Sci. USA 105: 10131-10136.
22. Mett, V., Farrance, C. E., Green, B. J., Yusibov, V. 2008. Plants as biofactories. Biologicals 36: 354-358.
23. Pogue, G. P., Vojdani, F., Palmer, K. E., Hiatt, E., Hume, S., Phelps, J., Long, L., Bohorova, N., Kim, D., Pauly, M., Velasco, J., Whaley, K, Zeitlin, L., Garger, S. J., White, E., Bai, Y., Haydon, H., Bratcher, B. 2010. Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant-based transient expression systems. Plant Biotechnol. J. 8: 638-654.
24. Rybicki, E. P. 2010. Plant-made vaccines for humans and anirnals. Plant Biotechnol J. 8: 620-637.
25. Santi, L., Giritch, A., Roy, C. J., Marillonnet, S., Klimyuk, V., Gleba, Y., Webb, R., Arntzen, C. J., Mason, H. S. 2006. Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system. Proc. Natl. Acad. Sci. USA 103: 861-866.
26. Stevens, L. H., Stoopen, G. M., Elbers, W., Molthoff, J. W., Bakker, H. A. C., Lommen, A., Bosch, D., Jordi, W. 2000. Effect of climate conditions and pant developmental stage on the stability of antibodes expressed in transgenic tobacco. Plant Physiol. 124: 173-182.
27. Sudo, E., Makino, A., Mae, T. 2003. Differences between rice and wheat in ribulose-1,5-bisphosphate regen-eration capacity per unit of leaf-N content. Plant Cell Environ. 26: 255-263.
28. Yussibov, V., Streatfield, S. J., Kushnir, N. 2011. Clinical development of plant-produced recombinant pharmaceuticals: Vaccines, antibodies and beyond. Hum. Vaccines 7: 313-321.