Myo-inositol treatment and GABA-A receptor subunit changes after kainate-induced status epilepticus

Cellular and Molecular Neurobiology

Volumn 33, Issue 1, 2013, Pages 119-127

  Solomonia, Revaz ^a,b   Gogichaishvili, Nana ^a   Nozadze, Maia ^a,b   Lepsveridze, Eka ^a   Dzneladze, David ^b   Kiguradze, Tamar ^b  

^a ILIA STATE UNIVERSITY   (Georgia)

^b Georgia   (Georgia)

Author keywords

Aminobutyric acid receptor subunits; Epilepsy; Epileptogenesis; Kainic acid; Myo Inositol

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA4; 4 AMINOBUTYRIC ACID A RECEPTOR DELTA; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; 4 AMINOBUTYRIC ACID RECEPTOR; INOSITOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EPILEPTIC STATE; EPILEPTOGENESIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; NEOCORTEX; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; INOSITOL; KAINIC ACID; MALE; PROTEIN SUBUNITS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; STATUS EPILEPTICUS; TREATMENT OUTCOME;

ANIMALIA; RATTUS;

EID: 84871738500     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-012-9877-4     Document Type: Article

References (39)

1. Alldred MJ, Mulder-Rosi J, Lingenfelter SE, Chen G, Luscher B (2005) Distinct gamma2 subunit domains mediateclustering and synaptic function of postsynaptic GABA-A receptors and gephyrin. J Neurosci 25:594-603
2. Bencsits E, Ebert V, Tretter V, Sieghart W (1999) A significant part of native gamma-aminobutyric acid A receptors containing alpha4 subunits do not contain gamma or delta subunits. J Biol Chem 274:19613-19616
3. Brooks-Kayal AR, Raol YH, Russek SL (2009) Alteration of epileptogenesis genes. Neurotherapeutics 6:312-318
4. Browne TR, Holmes GL (2001) Epilepsy. N Engl J Med 344:1145-1151
5. Choi DW (1987) Ionic dependence of glutamate neurotoxicity. J Neurosci 7:369-379
6. Clement AB, Hawkins A, Lichtman AH, Cravatt BF (2003) Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. J Neurosci 23:3916-3923
7. De Blas AL (1996) Brain GABAA receptors studied with subunit specific antibodies. Mol Neurobiol 12:55-71
8. - concentration in relation to changes in the size of the extracellular space. Exp Br Res 46:73-84
9. Dittmer A, Dittmer J (2006) Beta-actin is not a reliable loading control in western blot analysis. Electrophoresis 27:2844-2845
10. Dudek FE, Obenaus A, Tasker JG (1990) Osmolality induced changes in extracellular volume after epileptiform burst independent of chemical synapses in the rat: importance of non-synaptic mechanisms in hippocampal epileptogenesis. Neurosci Lett 120:267-270
11. Essrich C, Lorez M, Benson JA, Fritschy JM, Luscher B (1998) Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin. Nat Neurosci 1:563-571
12. Fisher KS, Novak JE, Agranoff BW (2002) Inositol and higher inositol phosphates in neuronal tissues: homeostasis, metabolism and functional significance. J Neurochem 82:736-754
13. Friedman LK, Pellegrini-Giampietro DE, Sperber EF, Bennett MVL, Moshe SL, Zukin RS (1994) Kainate-induced status epilepticus alters glutamate and GABA-A receptor gene expression in adult rat hippocampus:an in situ hybridization study. J Neurosci 14:2697-2707
14. Gonzalez MI, Brooks-Kayal A (2011) Altered GABA-A receptor expression during epileptogenesis. Neurosci Lett 497:218-222
15. Jia F, Pignataro S, Schofield CM, Yue M, Harrison NL, Goldstein PA (2005) An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons. J Neurophysiol 94:4491-4501
16. Joshi S, Kapur J (2009) Slow intracellular accumulation of GABA(A) receptor delta subunit is modulated by brain-derived neurotrophic factor. Neuroscience 164:507-519
17. Kharlamov EA, Lepsveridze E, Meparishvili M, Solomonia RO, Lu B, Miller ER, Kelly KM, Mtchedlishvili Z (2011) Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy. Epilepsy Res 95:20-34
18. Loescher W, Gernert M, Heinemann U (2008) Cell and gene therapies in epilepsy-promising avenues or blind alleys? Trends Neurosci 31:62-73
19. Macdonald RL, Kang JQ, Gallagher MJ (2010) Mutations in GABAA receptor subunits associated with genetic epilepsies. J Physiol 588:1861-1869
20. Majores M, Schoch S, Lie A, Becker AJ (2007) Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue. Epilepsia 48:4-12
21. Mangan PS, Sun C, Carpenter M, Goodkin HP, Sieghart HP, Kapur J (2005) Cultured hippocampal pyramidal neurons express two kinds of GABAA receptors. Mol Pharmacol 67:775-788
22. McNamara JO, Huang YZ, Leonard AS (2006) Molecular signaling mechanisms underlying epileptogenesis. Sci STKE. doi: 10.1126/stke.3562006re12
23. Nozadze M, Mikautadze M, Lepsveridze E, Mikeladze E, Kuchiashvili N, Kiguradze T, Kikvidze M, Solomonia R (2011) Anticonvulsant activities of myo-Inositol and scyllo-Inositol on pentylenetetrazol induced seizures. Seizure: European. J Epilepsy 20:173-176
24. Nusser Z, Mody I (2002) Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. J Neurophysiol 87:2624-2628
25. Olsen RW, Sieghart W (2009) GABAA receptors: subtypes provide diversity of function and pharmacology. Neuropharmacology 56:141-148
26. Pavlov I, Huusko N, Drexel M, Kirchmair E, Sperk G, Pitkanen A, Walker MC (2011) Progressive loss of phasic, but not tonic GABA-A receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats. Neuroscience 194:208-219
27. Racine RJ (1972) Modification of seizure activity by electrical stimulation II. Motor seizure: Electroencephalogram. Clin Neurophysiol 32:281-294
28. Rothman SM (1985) The neurotoxicity of excitatory amino acid is produced by passive chloride influx. J Neurosci 5:1483-1489
29. Rowley NM, Smith MD, Lamb JG, Schousboe A, White S (2011) Hippocampal betaine/GABA transporter mRNA is not regulated by inflammation or dehydrations post-statues epilepticus. J Neurochem 117:82-90
30. Schwartzkoin PA, Baraban SC, Hochmann DW (1998) Osmolarity, ionic flux and changes in brain excitability. Epilepsy Res 32:275-285
31. Solomonia R, Kuchiashvili N, Berulava A, Pkhakadze V, Trapaidze N, Zhvania M, Abesadze I, Kojima H, Dalakishvili N (2004) Purification and identification of components of the Aquilegia vulgaris extract fraction exhibiting anti-epileptic activity. J Biol Phys Chem 4:187-192
32. Solomonia R, Nozadze M, Kuchiashvili N, Bolkvadze T, Kiladze M, Zhvania M, Kiguradze T, Pkhakadze V (2007) Study of effects of myo-Inositol on pentylentetrazol and kainic acid induced convulsions in rats. Bull Exp Biol Med 143:58-60
33. Solomonia R, Mikautadze E, Nozadze M, Kuchiashvili N, Lepsveridze E, Kiguradze T (2010) Myo-Inositol treatment prevents biochemical changes triggered by kainate-induced status epilepticus. Neurosci Lett 468:277-281
34. Sperk G, Schwarzer K, Tsunashima K, Kandlhofer S (1998) Expression of GABA-A receptor subunits in the hippocampus of the rat after kainic acid-induced seizures. Epilepsy Res 32:129-139
35. Tretter V, Ehya N, Fuch K, Sieghart W (1997) Stoichiometry and assembly of a recombinant GABAA receptor subtype. J Neurosci 17:2728-2737
36. Wei W, Zhang N, Peng Z, Houser CR, Mody I (2003) Perisynaptic localization of delta subunit-containing GABA-A receptors and their activation by GABA spillover in the mouse dentate gyrus. J Neurosci 23:10650-10661
37. Williams PA, White AM, Clark S, Ferraro SJ, Swiercz W, Staley KJ, Dudek FE (2009) Development of spontaneous recurrent seizures after kainate-induced status epilepticus. J Neurosci 29:2103-2112
38. Zhang N, Wei W, Mody I, Houser CR (2007) Altered localization of GABA-A receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. J Neurosci 27:7520-7531
39. Zhvaniia MG, Solomonia RO, Bikashvili TZ, Kotaria NT, TsG Chkhikvishvili, Kiladze MT, Nozadze MB, Dzhaparidze ND (2007) The influence of myo-inositol on the ultrastructure of hippocampal CA1 area in kainate treated rats. Tsitologia 49:939-943