Silexan, an essential oil from flowers of Lavandula angustifolia, is not recognized as benzodiazepine-like in rats trained to discriminate a diazepam cue

Phytomedicine

Volumn 20, Issue 2, 2013, Pages 172-177

  Silenieks, Leo B ^a   Koch, Egon ^b   Higgins, Guy A ^a,c  

^a InterVivo Solutions Inc   (Canada)

^b DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Abuse; Addiction; Drug dependence; GABAA receptor; Lavender oil; Withdrawal symptoms

Indexed keywords

DIAZEPAM; LAVENDER OIL; PLANT EXTRACT; SILEXAN; UNCLASSIFIED DRUG; WS 1265;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABUSE; DRUG ACTIVITY; DRUG DEPENDENCE; DRUG DISCRIMINATION; DRUG DOSE INCREASE; DRUG TOLERABILITY; FLOWER; LAVANDULA ANGUSTIFOLIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CONDITIONING, OPERANT; CUES; DIAZEPAM; DISCRIMINATION (PSYCHOLOGY); DRUG EVALUATION, PRECLINICAL; FLOWERS; HYPNOTICS AND SEDATIVES; LAVANDULA; MALE; OILS, VOLATILE; PLANT OILS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; LAVANDULA; LAVANDULA ANGUSTIFOLIA; RATTUS;

EID: 84871721832     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.10.004     Document Type: Article

References (16)

1. Anonymous, 2006. Guideline on the non-clinical investigation of the dependence potential of medicinal products. EMEA/CHMP/SWP/94227/2004.
2. Anonymous Guide for the care and use of laboratory animals eight ed. 2011 The National Academies Press Washington, DC
3. A receptors expressed in Xenopus oocytes by perfume and phytocid Bioscience, Biotechnology, and Biochemistry 63 1999 743 748
4. L.P. Carter, and R.R. Griffiths Principles of laboratory assessment of drug abuse liability and implications for clinical development Drug and Alcohol Dependence 105 Suppl. 1 2009 S14 S25
5. T. Haug, and K.G. Götestam The diazepam stimulus complex: specificity in a rat model European Journal of Pharmacology 80 1982 225 230
6. L. Huang, S. Abuhamdah, M.J. Howes, C.L. Dixon, M.S. Elliot, C. Ballard, C. Holmes, A. Burns, E.K. Perry, P.T. Francis, G. Lees, and P.L. Chazot Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels Journal of Pharmacy and Pharmacology 60 2008 1515 1522
7. N. Joharchi, E.M. Sellers, and G.A. Higgins Effect of 5-HT3 receptor antagonists on the discriminative stimulus properties of morphine in rats Psychopharmacology 112 1993 111 115
8. S. Kasper, M. Gastpar, W.E. Mueller, H.P. Volz, H.J. Moeller, A. Dienel, and S. Schlaefke Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder-evidence from clinical trials Wiener Medizinische Wochenschrift 160 2010 547 556
9. S. Kasper, M. Gastpar, W.E. Mueller, H.P. Volz, H.J. Moeller, S. Schlaefke, and A. Dienel No withdrawal symptoms after discontinuation of Silexan Poster 015-005 Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN), 23.11.2011-26.11.2011 2011
10. A receptor agonist, gaboxadol, and allosteric modulators of the benzodiazepine binding site in the rat drug discrimination procedure Psychopharmacology 193 2007 151 157
11. P. Moser, T. Wolinsky, M. Duxon, and R.D. Porsolt How good are current approaches to nonclinical evaluation of abuse and dependence? Journal of Pharmacology and Experimental Therapeutics 336 2011 588 595
12. M.D. Recker, and G.A. Higgins The opioid receptor like-1 receptor agonist Ro 64-6198 (1S,3aS-8-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl-1-phenyl-1,3,8- triaza-spiro[4.5]decan-4-one) produces a discriminative stimulus in rats distinct from that of a mu, kappa, and delta opioid receptor agonist cue Journal of Pharmacology and Experimental Therapeutics 311 2004 652 658
13. P. Sasannejad, M. Saeedi, A. Shoeibi, A. Gorji, M. Abbasi, and M. Foroughipour Lavender essential oil in the treatment of migraine headache: a placebo-controlled clinical trail European Neurology 67 2012 288 291
14. A receptor subtypes Advances in Pharmacology 54 2006 231 263
15. A receptor subtypes and addiction Trends in Neurosciences 34 2011 188 197
16. H. Woelk, and S. Schlaefke A multi-center, double-blind, randomised study of the lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder Phytomedicine 17 2010 94 99