메뉴 건너뛰기




Volumn 30, Issue 1, 2013, Pages

Expression of Bcl2L12 in chronic lymphocytic leukemia patients: Association with clinical and molecular prognostic markers

Author keywords

Bcl2L12; CD38; Chronic lymphocytic leukemia; Expression analysis; IGHV mutational status; LPL

Indexed keywords

CD38 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; LIPOPROTEIN LIPASE; PROTEIN BCL 2; PROTEIN BCL 2 LIKE 12; UNCLASSIFIED DRUG;

EID: 84871720560     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-012-0405-7     Document Type: Article
Times cited : (15)

References (29)
  • 1
    • 4344704897 scopus 로고    scopus 로고
    • Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
    • 15314077 10.1084/jem.20040544 1:CAS:528:DC%2BD2cXmvFeht74%3D
    • Messmer BT, Albesiano E, Efremov DG, et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med. 2004;200(4):519-25.
    • (2004) J Exp Med. , vol.200 , Issue.4 , pp. 519-525
    • Messmer, B.T.1    Albesiano, E.2    Efremov, D.G.3
  • 2
    • 57749113071 scopus 로고    scopus 로고
    • In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow
    • 19074880 10.1158/0008-5472.CAN-08-2325
    • van Gent R, Kater AP, Otto SA, et al. In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow. Cancer Res. 2008;68(24):10137-44.
    • (2008) Cancer Res. , vol.68 , Issue.24 , pp. 10137-10144
    • Van Gent, R.1    Kater, A.P.2    Otto, S.A.3
  • 3
    • 0242298176 scopus 로고    scopus 로고
    • Role of the microenvironment in chronic lymphocytic leukaemia
    • 14616995 10.1046/j.1365-2141.2003.04679.x
    • Caligaris-Cappio F. Role of the microenvironment in chronic lymphocytic leukaemia. Br J Haematol. 2003;123(3):380-8.
    • (2003) Br J Haematol. , vol.123 , Issue.3 , pp. 380-388
    • Caligaris-Cappio, F.1
  • 4
    • 0032941221 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia: A bird of a different feather
    • 10458259 1:STN:280:DyaK1MzosFCnsw%3D%3D
    • Caligaris-Cappio F, Hamblin TJ. B-cell chronic lymphocytic leukemia: a bird of a different feather. J Clin Oncol. 1999;17:399-408.
    • (1999) J Clin Oncol. , vol.17 , pp. 399-408
    • Caligaris-Cappio, F.1    Hamblin, T.J.2
  • 5
    • 0037097598 scopus 로고    scopus 로고
    • Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes
    • 12036888 10.1182/blood.V99.12.4554 1:CAS:528:DC%2BD38XksFGksLo%3D
    • Korz C, Pscherer A, Benner A, et al. Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes. Blood. 2002;99(12):4554-61.
    • (2002) Blood. , vol.99 , Issue.12 , pp. 4554-4561
    • Korz, C.1    Pscherer, A.2    Benner, A.3
  • 6
    • 47649116872 scopus 로고    scopus 로고
    • SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL
    • 18434611 10.1182/blood-2007-11-124065 1:CAS:528:DC%2BD1cXos1Cit7g%3D
    • Proto-Siqueira R, Panepucci RA, Careta FP, et al. SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL. Blood. 2008;112(2):394-7.
    • (2008) Blood. , vol.112 , Issue.2 , pp. 394-397
    • Proto-Siqueira, R.1    Panepucci, R.A.2    Careta, F.P.3
  • 7
    • 73949119120 scopus 로고    scopus 로고
    • Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: The therapeutic potential of Akt inhibition
    • 19713228 10.3324/haematol.2009.010272 1:CAS:528:DC%2BC3cXitlals7k%3D
    • Zhuang J, Hawkins SF, Glenn MA, et al. Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition. Haematologica. 2010;95(1):110-8.
    • (2010) Haematologica. , vol.95 , Issue.1 , pp. 110-118
    • Zhuang, J.1    Hawkins, S.F.2    Glenn, M.A.3
  • 8
    • 16444375702 scopus 로고    scopus 로고
    • Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia
    • 15804279 10.1111/j.1365-2567.2005.02117.x 1:CAS:528:DC%2BD2MXjtFeqtL0%3D
    • Packham G, Stevenson FK. Bodyguards and assassins: bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia. Immunology. 2005;114(4):441-9.
    • (2005) Immunology. , vol.114 , Issue.4 , pp. 441-449
    • Packham, G.1    Stevenson, F.K.2
  • 9
    • 0347416908 scopus 로고    scopus 로고
    • Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia
    • 14695629 10.1002/ajh.10453 1:CAS:528:DC%2BD2cXhtVOntb4%3D
    • Saxena A, Viswanathan S, Moshynska O, et al. Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia. Am J Hematol. 2004;75(1):22-33.
    • (2004) Am J Hematol. , vol.75 , Issue.1 , pp. 22-33
    • Saxena, A.1    Viswanathan, S.2    Moshynska, O.3
  • 10
    • 0029970093 scopus 로고    scopus 로고
    • Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression
    • 8608978 10.1002/(SICI)1097-0215(19960422)69:2<114: AID-IJC8>3.0.CO;2-3 1:CAS:528:DyaK28XjtVyrtLg%3D
    • Aguilar-Santelises M, Rottenberg ME, Lewin N, Mellstedt H, Jondal M. Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression. Int J Cancer. 1996;69(2):114-9.
    • (1996) Int J Cancer. , vol.69 , Issue.2 , pp. 114-119
    • Aguilar-Santelises, M.1    Rottenberg, M.E.2    Lewin, N.3    Mellstedt, H.4    Jondal, M.5
  • 11
    • 0030752756 scopus 로고    scopus 로고
    • Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance
    • 9328155 10.1038/bjc.1997.487 1:CAS:528:DyaK2sXmvVGqur0%3D
    • Pepper C, Hoy T, Bentley DP. Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance. Br J Cancer. 1997;76(7):935-8.
    • (1997) Br J Cancer. , vol.76 , Issue.7 , pp. 935-938
    • Pepper, C.1    Hoy, T.2    Bentley, D.P.3
  • 12
    • 0032079746 scopus 로고    scopus 로고
    • Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses
    • 9558396 1:CAS:528:DyaK1cXislCnsL4%3D
    • Kitada S, Andersen J, Akar S, et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood. 1998;91(9):3379-89.
    • (1998) Blood. , vol.91 , Issue.9 , pp. 3379-3389
    • Kitada, S.1    Andersen, J.2    Akar, S.3
  • 13
    • 0035280247 scopus 로고    scopus 로고
    • Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family
    • 11401436 10.1006/geno.2000.6455 1:CAS:528:DC%2BD3MXitlagsb8%3D
    • Scorilas A, Kyriakopoulou L, Yousef GM, et al. Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family. Genomics. 2001;72(2):217-21.
    • (2001) Genomics. , vol.72 , Issue.2 , pp. 217-221
    • Scorilas, A.1    Kyriakopoulou, L.2    Yousef, G.M.3
  • 14
    • 0038827160 scopus 로고    scopus 로고
    • Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors
    • 12783122 1:CAS:528:DC%2BD3sXlt1Kqtb8%3D
    • Talieri M, Diamandis EP, Katsaros N, Gourgiotis D, Scorilas A. Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors. Thromb Haemost. 2003;89(6):1081-8.
    • (2003) Thromb Haemost. , vol.89 , Issue.6 , pp. 1081-1088
    • Talieri, M.1    Diamandis, E.P.2    Katsaros, N.3    Gourgiotis, D.4    Scorilas, A.5
  • 15
    • 57649131064 scopus 로고    scopus 로고
    • Quantitative expression analysis and prognostic significance of the novel apoptosis-related gene BCL2L12 in colon cancer
    • 18844453 10.1515/BC.2008.173 1:CAS:528:DC%2BD1cXhsVOjtL7J
    • Kontos CK, Papadopoulos IN, Scorilas A. Quantitative expression analysis and prognostic significance of the novel apoptosis-related gene BCL2L12 in colon cancer. Biol Chem. 2008;389(12):1467-75.
    • (2008) Biol Chem. , vol.389 , Issue.12 , pp. 1467-1475
    • Kontos, C.K.1    Papadopoulos, I.N.2    Scorilas, A.3
  • 16
    • 72949113841 scopus 로고    scopus 로고
    • Molecular analysis and prognostic impact of the novel apoptotic gene Bcl2L12 in gastric cancer
    • 10.1016/j.bbrc.2009.11.034
    • Floro D, Papadopoulos IN, Scorilas A. Molecular analysis and prognostic impact of the novel apoptotic gene Bcl2L12 in gastric cancer. Biochem Biophys Res Commun. 2010;391:214-8.
    • (2010) Biochem Biophys Res Commun. , vol.391 , pp. 214-218
    • Floro, D.1    Papadopoulos, I.N.2    Scorilas, A.3
  • 17
    • 33846120996 scopus 로고    scopus 로고
    • Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma
    • 17210792 10.1101/gad.1480007 1:CAS:528:DC%2BD2sXmsFyksg%3D%3D
    • Stegh AH, Kim H, Bachoo RM, et al. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev. 2007;21(1):98-111.
    • (2007) Genes Dev. , vol.21 , Issue.1 , pp. 98-111
    • Stegh, A.H.1    Kim, H.2    Bachoo, R.M.3
  • 18
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • 10477713 1:CAS:528:DyaK1MXlvFCnuro%3D
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6):1848-54.
    • (1999) Blood. , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 19
    • 0037441762 scopus 로고    scopus 로고
    • The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression
    • 12406914 10.1182/blood-2002-06-1801 1:CAS:528:DC%2BD3sXht1agtLo%3D
    • Ghia P, Guida G, Stella S, et al. The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood. 2003;101(4):1262-9.
    • (2003) Blood. , vol.101 , Issue.4 , pp. 1262-1269
    • Ghia, P.1    Guida, G.2    Stella, S.3
  • 20
    • 33746304485 scopus 로고    scopus 로고
    • Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia
    • 16840197 10.1080/10428190500464161
    • Nuckel H, Huttmann A, Klein-Hitpass L, et al. Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia. Leuk Lymphoma. 2006;47(6):1053-61.
    • (2006) Leuk Lymphoma. , vol.47 , Issue.6 , pp. 1053-1061
    • Nuckel, H.1    Huttmann, A.2    Klein-Hitpass, L.3
  • 21
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the international workshop on chronic lymphocytic leukemia updating the national cancer institute-working group 1996 guidelines
    • 18216293 10.1182/blood-2007-06-093906 1:CAS:528:DC%2BD1cXnsVOktrk%3D
    • Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the international workshop on chronic lymphocytic leukemia updating the national cancer institute-working group 1996 guidelines. Blood. 2008;111(12):5446-56.
    • (2008) Blood. , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 22
    • 80053196884 scopus 로고    scopus 로고
    • The novel member of the BCL2 gene family, BCL2L12, is substantially elevated in chronic lymphocytic leukemia patients, supporting its value as a significant biomarker
    • 21737576 10.1634/theoncologist.2010-0349 1:CAS:528:DC%2BC3MXhs1emt7nP
    • Papageorgiou SG, Kontos CK, Pappa V, et al. The novel member of the BCL2 gene family, BCL2L12, is substantially elevated in chronic lymphocytic leukemia patients, supporting its value as a significant biomarker. Oncologist. 2011;16(9):1280-91.
    • (2011) Oncologist. , vol.16 , Issue.9 , pp. 1280-1291
    • Papageorgiou, S.G.1    Kontos, C.K.2    Pappa, V.3
  • 23
    • 33847378042 scopus 로고    scopus 로고
    • Lipoprotein lipase mRNA expression in whole blood is a prognostic marker in B cell chronic lymphocytic leukemia
    • 17158192 10.1373/clinchem.2006.076331
    • Van Bockstaele F, Pede V, Janssens A, et al. Lipoprotein lipase mRNA expression in whole blood is a prognostic marker in B cell chronic lymphocytic leukemia. Clin Chem. 2007;53(2):204-12.
    • (2007) Clin Chem. , vol.53 , Issue.2 , pp. 204-212
    • Van Bockstaele, F.1    Pede, V.2    Janssens, A.3
  • 24
    • 33846108722 scopus 로고    scopus 로고
    • Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations
    • 16985177 10.1182/blood-2006-03-012948 1:CAS:528:DC%2BD2sXivVyrurk%3D
    • Stamatopoulos K, Belessi C, Moreno C, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood. 2007;109(1):259-70.
    • (2007) Blood. , vol.109 , Issue.1 , pp. 259-270
    • Stamatopoulos, K.1    Belessi, C.2    Moreno, C.3
  • 25
    • 58149263841 scopus 로고    scopus 로고
    • Analysis of CD23 antigen expression in B-chronic lymphocytic leukaemia and its correlation with clinical parameters
    • 18183502 10.1007/s12032-007-9038-7
    • Jurisic V, Colovic N, Kraguljac N, Atkinson HD, Colovic M. Analysis of CD23 antigen expression in B-chronic lymphocytic leukaemia and its correlation with clinical parameters. Med Oncol. 2008;25(3):315-22.
    • (2008) Med Oncol. , vol.25 , Issue.3 , pp. 315-322
    • Jurisic, V.1    Colovic, N.2    Kraguljac, N.3    Atkinson, H.D.4    Colovic, M.5
  • 26
    • 0037103212 scopus 로고    scopus 로고
    • V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia
    • 12149225 1:CAS:528:DC%2BD38Xmt12iur0%3D
    • Krober A, Seiler T, Benner A, et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood. 2002;100(4):1410-6.
    • (2002) Blood. , vol.100 , Issue.4 , pp. 1410-1416
    • Krober, A.1    Seiler, T.2    Benner, A.3
  • 27
    • 85009914892 scopus 로고    scopus 로고
    • CD38 expression is an important prognostic marker in chronic lymphocytic leukaemia
    • 11840260 10.1038/sj.leu.2402339
    • Dürig J, Naschar M, Schmücker U, et al. CD38 expression is an important prognostic marker in chronic lymphocytic leukaemia. Leukemia. 2002;16(1):30-5.
    • (2002) Leukemia. , vol.16 , Issue.1 , pp. 30-35
    • Dürig, J.1    Naschar, M.2    Schmücker, U.3
  • 28
    • 0033567968 scopus 로고    scopus 로고
    • Ig v gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • 10477712 1:CAS:528:DyaK1MXlvFCnur0%3D
    • Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94(6):1840-7.
    • (1999) Blood. , vol.94 , Issue.6 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 29
    • 32544451164 scopus 로고    scopus 로고
    • The predictive value of lipoprotein lipase for survival in chronic lymphocytic leukemia
    • 16434371
    • van't Veer MB, Brooijmans AM, Langerak AW, et al. The predictive value of lipoprotein lipase for survival in chronic lymphocytic leukemia. Haematologica. 2006;91(1):56-63.
    • (2006) Haematologica. , vol.91 , Issue.1 , pp. 56-63
    • Van'T Veer, M.B.1    Brooijmans, A.M.2    Langerak, A.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.