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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 2, 2013, Pages 503-506

2′-Fluoro-6′-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action

(10) Rawal, Ravindra K a Singh, Uma S a Chavre, Satish N a Wang, Jianing a Sugiyama, Masaya b Hung, Wai a Govindarajan, Rajgopal a Korba, Brent c Tanaka, Yasuhito b Chu, Chung K a

a UNIVERSITY OF GEORGIA (United States)

b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES (Japan)

c GEORGETOWN UNIVERSITY MEDICAL CENTER (United States)

Author keywords

Anti HBV activity; Carbocyclic nucleos(t)ide; Drug resistant mutants; Lamivudine entecavir triple mutant; Wild type

Indexed keywords

2' FLUORO 6' METHYLENE CARBOCYCLIC ADENOSINE; 2' FLUORO 6' METHYLENE CARBOCYCLIC ADENOSINE MONOPHOSPHATE; ANTIVIRUS AGENT; ENTECAVIR; LAMIVUDINE; PHOSPHORAMIDIC ACID DERIVATIVE; UNCLASSIFIED DRUG; 2' FLUORO 6' METHYLENE CARBOCYCLIC ADENOSINE PHOSPHORAMIDATE; 2'-FLUORO-6'-METHYLENE-CARBOCYCLIC ADENOSINE; 2'-FLUORO-6'-METHYLENE-CARBOCYCLIC ADENOSINE PHOSPHORAMIDATE; ADENOSINE; DRUG DERIVATIVE; GUANINE; PRODRUG;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CHEMICAL REACTION; CYTOTOXICITY; DRUG BINDING; DRUG SYNTHESIS; HEPATITIS B; HEPATITIS B VIRUS; HYDROGEN BOND; NONHUMAN; VAN DER WAALS INTERACTION; BINDING SITE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GENETICS; HUMAN; IC 50; MUTATION; SYNTHESIS; THERMODYNAMICS;

HEPATITIS B VIRUS;

ADENOSINE; ANTIVIRAL AGENTS; BINDING SITES; CELLS, CULTURED; DRUG RESISTANCE, VIRAL; GUANINE; HEPATITIS B VIRUS; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; LAMIVUDINE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PRODRUGS; THERMODYNAMICS;

EID: 84871717179 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.11.027 Document Type: Article

Times cited : (17)

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