Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of salvianolic acid A

Drug Metabolism and Pharmacokinetics

Volumn 27, Issue 6, 2012, Pages 579-585

  Han, De En ^a,b   Zheng, Yi ^a   Chen, Xijing ^a   He, Jiake ^a   Zhao, Di ^a   Yang, Shuoye ^a   Zhang, Chunfeng ^a   Yang, Zhonglin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b HENAN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Human liver microsomes; Salvianolic acid A; UDP glucuronosyltransferanses; UGT1A1; UGT1A9

Indexed keywords

GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A9; MEFENAMIC ACID; PHENYLBUTAZONE; PLANT MEDICINAL PRODUCT; PROPOFOL; RECOMBINANT ENZYME; SALVIANOLIC ACID A; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INTESTINE; INTESTINE MICROSOME; LIVER MICROSOME; MASS SPECTROMETRY; MICROSOME; PROTEIN HYDROLYSIS;

EID: 84871693145     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-12-RG-023     Document Type: Article

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