The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway

Developmental Biology

Volumn 373, Issue 2, 2013, Pages 258-266

  Eisa Beygi, Shahram ^a   Hatch, Gary ^a   Noble, Sandra ^a   Ekker, Marc ^a   Moon, Thomas W ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Cdc42; HMGCR; Prenylation; Statin; Vasculature; Zebrafish

Indexed keywords

GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEMBRANE PROTEIN; PROTEIN CDC42; PROTEIN GGTASE I; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; BLOOD VESSEL RUPTURE; BRAIN BLOOD VESSEL; BRAIN HEMORRHAGE; CARBOXY TERMINAL SEQUENCE; CAVERNOUS HEMANGIOMA; CONTROLLED STUDY; DOWNSTREAM PROCESSING; EMBRYO; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME SUBUNIT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PRENYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; VASODILATATION; ZEBRA FISH;

DANIO RERIO; MURINAE; MUS;

EID: 84871676124     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2012.11.024     Document Type: Article

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