Combinatorial synthesis of linearly condensed polycyclic compounds, including anthracyclinones, through tandem diels-alder additions

Topics in Current Chemistry

Volumn 282, Issue , 2008, Pages 187-214

  Vogel, Pierre ^a  

^a EPFL   (Switzerland)

Author keywords

2,3,5,6 Tetramethylidene 7 oxabicyclo 2.2.1 heptane; Anthracyclines; Desymmetrization; Diels Alder reactions; DNA strand religation; Furans; Topoisomerase inhibitors

Indexed keywords

EID: 84871671906     PISSN: 03401022     EISSN: None     Source Type: Book Series    
DOI: 10.1007/128-2007-148     Document Type: Article

References (256)

1. Grein A, Spalla C, Canevazzi G, Dimarco A (1963) Giorn Microbiol 11:109
2. Dubost M, Pinnert S, Maral R, Ganter P, Preudhomme J, Werner GH, Ninet L (1963) CR Acad Sci Paris 257:1813
3. Arcarmone F (1981) Doxorubicin: anticancer antibiotics. Academic, New York, p 369
4. Neidle S (1977) Nature 268:195
5. Lown JW (1993) Chem Soc Rev 22:165
6. Maral R, Ponsinet G, Jolles G (1972) CR Acad Sci Ser D 275:301
7. Zunino F, Gambetta R, Dimarco A, Luoni G, Zaccara A (1976) Biochem Biophys Res Commun 69:744
8. Arcamone F, Bernardi L, Giardino P, Patelli B, Dimarco A, Casazza AM, Pratesi G, Reggiani P (1976) Cancer Treat Rep 60:829
9. Gabbay EJ, Grier D, Fingerle RE, Reimer R, Levy R, Pearce SW, Wilson WD (1976) Biochemistry 15:2062
10. Penco S, Angelucci F, Vigevani A, Arlandini E, Arcamone F (1977) J Antibiot 30:764
11. Dimarco A, Casazza AM, Giuliani F, Pratesi G, Arcamone F, Bernardi L, Franchi G, Giardino P, Patelli B, Penco S (1978) Cancer Treat Rep 62:375
12. Arcamone F, Bernardi L, Patelli B, Giardino P, Dimarco A, Casazza AM, Soranzo C, Pratesi G (1978) Experientia 34:1255
13. Smith TH, Fujiwara AN, Henry DW (1978) J Med Chem 21:280
14. Ducep J, Farge D, Ponsinet G, Reisdorf D (1978) US Patent 4075328
15. Bernardi L, Masi P, Sapini O, Suarato A, Arcamone F (1979) Farmaco Ed Sci 34:884
16. Lown JW, Chen HH, Plambeck JA, Acton EM (1979) Biochem Pharmacol 28:2563
17. Plumbridge TW, Brown JR (1979) Biochem Biophys Acta 563:181
18. Arlandini E, Vigevani A, Arcamone F (1980) Farmaco Ed Sci 35:65
19. Acton EM, Tong GL (1981) J Med Chem 24:669
20. Yoshimoto A, Fujii S, Johdo O, Kubo K, Ishikura T, Naganawa H, Sawa T, Takeuchi T, Umezawa H (1986) J Antibiot 39:902
21. Swenton J, Morrow G, Priebe W (1987) US Patent 4697005
22. Ishizumi K, Ohashi N, Tanno N (1987) J Org Chem 52:4477
23. Caruso M, Suaroto A, Angelucci F, Arcamone F (1988) Eur Pat Appl EP 288268
24. Matsuda F, Matsumoto T, Ohsaki M, Terashima S (1989) Tetrahedron Lett 30:4259
25. Adams N, Blake C, Broadhurst MJ, Bushnell DJ, Hassall CH, Hartmann HR, Keech E, Stratton AR, Thomas GJ (1990) J Med Chem 33:2380
26. Giolitti A, Guidi A, Pasqui F, Pestellini V, Arcamone F (1991) Can Pat Appl CA 2029715
27. Barr KE, Russell RA, Warrener RN, Collins JG (1993) FEBS Lett 322:173
28. Canfarini F, Giolitti A, Guidi A, Pasqui F, Pestellini V, Arcamone F (1993) Tetrahedron Lett 34:4697
29. Lown JW (1993) Chem Soc Rev 22:165
30. Priebe W (1995) Curr Pharm Des 1:51
31. Priebe W (1995) Anthracycline antibiotics: new analogs, methods of delivery, and mechanisms of action. Am Chem Soc, Washington DC, p 332
32. Israel M, Modest EJ, Frei E (1975) Cancer Res 35:1365
33. Arcamone F, Penco S, Redaelli S, Hanessian S (1976) J Med Chem 19:1424
34. Penco S, Franchi G, Arcamone F (1978) DE 751395
35. Cassinelli G, Ruggieri D, Arcamone F (1979) J Med Chem 22:122
36. Horton D, Priebe W, Varela O (1984) J Antibiot 37:1635
37. Cassinelli G, BallabioM, Arcamone F, Casazza AM, Podesta A (1985) J Antibiot 38:856
38. Florent JC, Genot A, Monneret C (1989) J Antibiot 42:1823
39. Kunimoto S, Komuro K, Nosaka C, Tsuchiya T, Fukatsu S, Takeuchi T (1990) J Antibiot 43:556
40. Priebe W, Neamati N, Perez-Soler R (1992) J Antibiot 45:386
41. Florent JC, Gaudel G, Monneret C, Hoffmann D, Kraemer HP (1993) J Med Chem 36:1364
42. Zhang G, Fang L, Wang PG, Sun D (2006) PIXXD2 WO 2006/124720 A1 2006/1123
43. Zhang G, Fang L, Zhu L, Zhong Y, Wang PG, Sun D (2006) J Med Chem 49:1792
44. Al-Ismail SAD, Parry DH, Whittaker JA (1977) Brit Med J 1:815
45. Mcguire WP (1978) Cancer Treat Rep 62:855
46. Villani F, Meazza R, Materazzo C (2006) Anticancer Res 26:797
47. Menna P, Minotti G, Salvatorelli E (2007) Cell Biol Toxicol 23:49
48. Wiseman LR, Spencer CM (1998) Drugs 56:385
49. Cvetkokic RS, Scott LJ (2005) Drugs 65:1005
50. Hasinoff B (2006) Future Oncol 2:15
51. Kaufman PA (1999) Semin Oncol 26:39
52. Danesi R, Conte PF, Del Tacca M (1999) Clin Pharmacokinet 37:195
53. Bakker M, Van der Graaf W, Groen H, De Vries E (1995) Curr Pharm Des 1:133
54. Lenaz L, Page JA (1976) Cancer Treat Rev 3:111
55. Von Hoff DD, Layard M, Rozencweig M, Muggia FM (1977) Cancer Treat Rep 61:1411
56. Beck WT (1987) Biochem Pharmacol 36:2879
57. Keizer HG, Pinedo HM, Schuurhuis GJ, Joenje H (1990) Pharmacol Ther 47:219
58. Mazue G, Iatropoulos M, Imondi A, Castellino S, Brughera M, Podesta A, Dellatorre P, Moneta D (1995) Int J Oncol 7:713
59. Ravdin PM (1995) Eur J Cancer 31A:S11
60. Cersosimo RJ (1992) Clin Pharm 11:152
61. Goebel M (1993) Ann Hematol 66:33
62. Buckley MM, Lamb HM (1997) Drugs Aging 11:61
63. Krohn K (1990) Tetrahedron 46:291
64. Krohn K (1986) Angew Chem Int Ed Engl 25:790
65. Krohn K (1989) Prog Chem Org Nat Prod 55:37
66. Broadhurst MJ, Hassall CH, Thomas GJ (1985) Chem Ind 106
67. Kawasaki M, Matsuda F, Terashima S (1988) Tetrahedron Lett 29:791
68. Cameron DW, Feutrill GI, Griffiths PG (1988) Tetrahedron Lett 29:4629
69. Adams N, Blake C, Broadhurst MJ, Bushnell DJ, Hassall CH, Hartmann HR, Keech E, Stratton AR, Thomas GJ (1990) J Med Chem 33:2375
70. Farquhar D, Newman RA, Zuckerman JE, Andersson BS (1991) J Med Chem 34:561
71. Bertounesque E, Florent JC, Monneret C (1991) Synthesis, p 270
72. Cherif A, Farquhar D (1992) J Med Chem 35:3208
73. Laugraud S, Guingant A, Dangelo J (1992) Tetrahedron Lett 33:1289
74. Giolitti A, Guidi A, Pasqui F, Pestellini V, Arcamone FM (1992) Tetrahedron Lett 33:1637
75. Deguin B, Bertounesque E, Gaudel G, Florent JC, Monneret C (1992) Tetrahedron 48:4885
76. Terashima S (1992) Synlett, p 691
77. Cousson A, Legouadec G, Monneret C, Florent JC (1993) J Chem Soc, Chem Commun, p 388
78. Kita Y, Maeda H, Takahashi F, Fukui S (1993) J Chem Soc, Chem Commun, p 410
79. Florent JC, Gaudel G, Monneret C, Hoffmann D, Kraemer HP (1993) J Med Chem 36:1364
80. Lavallee JF, Rej R, Courchesne M, Nguyen D, Attardo G (1993) Tetrahedron Lett 34:3519
81. Welch SC, Levine JA, Arimilli MN (1993) Synth Commun 23:131
82. Krohn K, Roemer E, Top M, Wagner C (1993) Angew Chem Int Ed Engl 32:1151
83. Farina F, Paredes MC, Valderrama JA (1993) Tetrahedron 49:10715
84. Canfarini F, Giolitti A, Guidi A, Pasqui F, Pestellini V, Arcamone F (1993) Tetrahedron Lett 34:4697
85. Cameron DW, Griffiths PG (1993) Tetrahedron Lett 34:4685
86. Monneret C, Florent JC (1994) Synlett, p 305
87. Guidi A, Canfarini F, Giolitti A, Pasqui F, Pestellini F, Pestellini V, Arcamone F (1994) Pure Appl Chem 66:2319
88. Tanaka H, Yoshioka T (1994) Chem Lett 953
89. Gesson JP, Jacquesy JC, Renoux B (1994) Tetrahedron 50:1165
90. Guidi A, Arcamone F (1996) Tetrahedron Lett 37:1123
91. Takagi Y, Nakai K, Tsuchiya T, Takeuchi T (1996) J Med Chem 39:1582
92. Asenjo P, Farina F, Martin MV, Paredes MC, Soto JJ (1997) Tetrahedron 53:1823
93. TheurillatMoritz V, Guidi A, Vogel P (1997) Tetrahedron: Asymmetry 8:3497
94. Wong CM, Popien D, Schwenk R, Teraa J (1971) Can J Chem 49:2712
95. Kende AS, Belletire J, Bentley TJ, Hume E, Airey J (1975) J Am Chem Soc 97:4425
96. Suzuki F, Trenbeath S, Gleim RD, Sih CJ (1978) J Org Chem 43:4159
97. Morris MJ, Brown JR (1978) Tetrahedron Lett 19:2937
98. Hauser FM, Hewawasam P (1988) J Org Chem 53:4515
99. Gupta RC, Harland PA, Stoodley RJ (1983) J Chem Soc, Chem Commun, p 754
100. Tamariz J, Vogel P (1984) Tetrahedron 40:4549
101. Kende AS, Rizzi J, Riemer J (1979) Tetrahedron Lett 20:1201
102. Chenard BL, Dolson MG, Sercel AD, Swenton JS (1984) J Org Chem 49:318
103. Watanabe M, Maenosono H, Furukawa S (1983) Chem Pharm Bull 31:2662
104. Acton EM, Fujiwara AN, Henry DW (1974) J Med Chem 17:659
105. Kimura Y, Suzuki M, Matsumoto T, Abe R, Terashima S (1986) Bull Chem Soc Jpn 59:423
106. Vogel P, Carrupt PA (1979) CH Patent 4060/100
107. Carrupt PA, Vogel P (1979) Tetrahedron Lett 20:4533
108. Bertz SH (1982) J Am Chem Soc 104:5801
109. Diels O, Alder K (1928) Liebigs Ann Chem 460:98
110. Wollweber H (1970) Houben-Weyl, Methoden der Organischen Chemie, 4th edn. Thieme, Stuttgart
111. Wollweber H (1972) Diels-Alder Reaktion. Thieme, Stuttgart
112. Carruthers W (1978) Some modern methods of organic synthesis, 2nd edn. Cambridge University Press, Cambridge
113. Oppolzer W (1978) Synthesis, p 793
114. Brieger G, Bennett JN (1980) Chem Rev 80:63
115. Petrzilka M, Grayson JI (1981) Synthesis, p 753
116. Weinreb SM, Staib RR (1982) Tetrahedron 38:3087
117. Welzel P (1983) Nachr Chem Tech Lab 31:979
118. Fallis AG (1984) Can J Chem 62:183
119. Oppolzer W (1984) Angew Chem Int Ed Engl 23:876
120. Matsumoto K, Sera A (1985) Synthesis, p 999
121. Carruthers W (1990) Cycloaddition reactions in organic synthesis. Pergamon, Oxford
122. Fringuelli F, Taticchi A (1990) Dienes in the Diels-Alder reaction. Wiley, New York, p 348
123. Boger DL,Weinreb SM (1987) Hetero Diels-Alder methodology in organic synthesis. Academic, San Diego, p 366
124. Mahaim C, Vogel P (1982) Helv Chim Acta 65:866
125. Pilet O, Vogel P (1981) Helv Chim Acta 64:2563
126. Pilet O, Birbaum JL, Vogel P (1983) Helv Chim Acta 66:19
127. Vogel P (1989) In: Thummel R (ed)Advances in theoretically interesting molecules. JAI, Greenwich, CT, p 201
128. Dewar MJS, Dougherty R (1975) The PMO theory of organic chemistry. Plenum, New York
129. Whangbo MH, Schlegel HB, Wolfe S (1977) J Am Chem Soc 99:1296
130. Borden W (1975) Modern molecular orbital theory for organic chemists. Prentice-Hall, Englewood Cliffs, NJ
131. Fukui K (1966) Bull Chem Soc Jpn 39:498
132. Klopman G (1968) J Am Chem Soc 90:223
133. Salem L (1968) J Am Chem Soc 90:543
134. Salem L (1968) J Am Chem Soc 90:553
135. Fukui K (1971) Acc Chem Res 4:57
136. Sustmann R, Schubert R (1972) Angew Chem Int Ed 11:840
137. Epiotis N (1978) Theory of organic reactions. Springer, Berlin Heidelberg New York
138. Epiotis ND (1979) Pure Appl Chem 51:203
139. Sauer J, Sustmann R (1980) Angew Chem Int Ed Engl 19:779
140. Rucker C, Lang D, Sauer J, Friege H, Sustmann R (1980) Chem Ber Rec 113:1663
141. Houk KN (1977) Pericyclic reactions. Academic, New York
142. Scharf HD, Plum H, Fleischhauer J, Schleker W (1979) Chem Ber Rec 112:862
143. Sustmann R, Bohm M, Sauer J (1979) Chem Ber Rec 112:883
144. Dimroth O (1933) Angew Chem 46:571
145. Evans MG, Polanyi M (1938) Trans Faraday Soc 34:0011
146. Bell R (1936) Proc R Soc Lond A 154:414
147. Dewar MJS (1984) J Am Chem Soc 106:209
148. Hoffmann R (1971) Acc Chem Res 4:1
149. Hoffmann R, Imamura A, Hehre WJ (1968) J Am Chem Soc 90:1499
150. Gleiter R (1974) Angew Chem 86:770
151. Heilbronner E, Schmelzer A (1975) Helv Chim Acta 58:936
152. Roth WR, Lennartz HW, Vogel E, Leiendecker M, Oda M (1986) Chem Ber Rec 119:837
153. Hemmersbach P, Klessinger M, Bruckmann P (1978) J Am Chem Soc 100:6344
154. Heilbronner E, Gleiter R, Hopf H, Hornung V, de Meijere A (1971) Helv Chim Acta 54:783
155. Bally T, Buser U, Haselbach E (1978) Helv Chim Acta 61:38
156. Gabioud R, Vogel P (1984) Tetrahedron Lett 25:1729
157. Turner RB, Meador WR, Winkler RE (1957) J Am Chem Soc 79:4116
158. Turner RB (1964) J Am Chem Soc 86:3586
159. Wong SWS, Westrum EF (1971) J Am Chem Soc 93:5317
160. Schulman JM, Miller MA, Disch RL (1989) Pure Appl Chem 61:2103
161. Schmitz LR, Allinger NL, Flurchick KM (1988) J Comput Chem 9:281
162. Roulet JM, Vogel P, Wiesemann F, Pinkerton AA (1995) Tetrahedron 51:1685
163. Pinkerton AA, Schwarzenbach D, Stibbard JHA, Carrupt PA, Vogel P (1981) J Am Chem Soc 103:2095
164. Pinkerton AA, Schwarzenbach D, Birbaum JL, Carrupt PA, Schwager L, Vogel P (1984) Helv Chim Acta 67:1136
165. Ermer O, Bell P, Mason SA (1989) Angew Chem Int Ed Engl 28:1239
166. Houk KN, Rondan NG, Brown FK, Jorgensen WL, Madura JD, Spellmeyer DC (1983) J Am Chem Soc 105:5980
167. Carrupt PA, Vogel P (1985) J Mol Struct-Theochem 25:9
168. Bartlett PD, Roof AAM, Winter WJ (1981) J Am Chem Soc 103:6520
169. Mahaim C, Carrupt PA, Hagenbuch JP, Florey A, Vogel P (1980) Helv Chim Acta 63:1149
170. De Picciotto L, Carrupt PA, Vogel P (1982) J Org Chem 47:3796
171. Msayib KJ, Watt CIF (1992) Chem Soc Rev 21:237
172. Juaristi E, Beck AK, Hansen J, Matt T, Mukhopadhyay T, Simson M, Seebach D (1993) Synthesis, p 1271
173. Sustmann R, Binsch G (1971) Mol Phys 20:9
174. Sustmann R (1974) Pure Appl Chem 40:569
175. Houk KN (1975) Acc Chem Res 8:361
176. Vogel P (1983) Methods in stereochemical analysis. In: Watson W (ed)Stereochemistry and reactivity of systems containing π electrons. Verlag Chemie International, FL, p 147
177. Burnier G, Schwager L, Vogel P (1986) Helv Chim Acta 69:1310
178. Avenati M, Carrupt PA, Quarroz D, Vogel P (1982) Helv Chim Acta 65:188
179. Woodward RB, Katz TJ (1959) Tetrahedron 5:70
180. Firestone RA (1968) J Org Chem 33:2285
181. Firestone RA (1977) Tetrahedron 33:3009
182. Epiotis ND (1978) Theory of organic reactions, Chap 6. Springer, Berlin Heidelberg, New York
183. Dewar MJS, Pierini AB (1984) J Am Chem Soc 106:203
184. Dewar MJS, Olivella S, Stewart JJP (1986) J Am Chem Soc 108:5771
185. Wassermann A (1942) J Chem Soc, p 623
186. Rodgman A, Wright GF (1953) J Org Chem 18:465
187. Yates P, Eaton P (1960) J Am Chem Soc 82:4436
188. Olah GA, Meidar D, Fung AP (1979) Synthesis, p 270
189. Fringuelli F, Pizzo F, Taticchi A, Halls TDJ, Wenkert E (1982) J Org Chem 47:5056
190. Sonney JM, Vogel P, Burger U (1980) Helv Chim Acta 63:1016
191. Broadhurst MJ, Hassall CH (1982) J Chem Soc, Perkin Trans, p 12227
192. Oppolzer W (1977) Angew Chem Int Ed Engl 16:10
193. Smith MB (1990) Org Prep Proced Int 22:315
194. Tamariz J, Vogel P (1984) Angew Chem Int Ed Engl 23:74
195. Corey EJ, Petrzilka M (1975) Tetrahedron Lett 16:2537
196. Bailey SJ, Thomas EJ, Turner WB, Jarvis JAJ (1978) J Chem Soc, Chem Commun, p 474
197. Stork G, Nakahara Y, Nakahara Y, Greenlee WJ (1978) J Am Chem Soc 100:7775
198. Bailey SJ, Thomas EJ, Vather SM, Wallis J (1983) J Chem Soc, Perkin Trans, p 1851
199. Stork G, Nakamura E (1983) J Am Chem Soc 105:5510
200. Thomas EJ (1991) Acc Chem Res 24:229
201. Tornare JM, Vogel P (1984) J Org Chem 49:2510
202. Alder K, Stein G (1937) Angew Chem 50:510
203. Hoffmann R, Woodward RB (1968) Acc Chem Res 1:17
204. Gleiter R, Bohm MC (1983) Pure Appl Chem 55:237
205. Cohen T, Ruffner RJ, Shull DW, Daniewski WM, Ottenbrite RM, Alston PV (1978) J Org Chem 43:4052
206. Brown FK, Houk KN (1985) J Am Chem Soc 107:1971
207. Brown FK, Houk KN (1984) Tetrahedron Lett 25:4609
208. Carrupt PA, Berchier F, Vogel P (1985) Helv Chim Acta 68:1716
209. Arcamone F, Cassinelli G, Dimatteo F, Forenza S, Ripamonti MC, Rivola G, Vigevani A, Clardy J, Mccabe T (1980) J Am Chem Soc 102:1462
210. Gesson JP, Jacquesy JC, Mondon M (1980) Tetrahedron Lett 21:3351
211. Bauman JG, Barber RB, Gless RD, Rapoport H (1980) Tetrahedron Lett 21:4777
212. Kende AS, Boettger SD (1981) J Org Chem 46:2799
213. Krohn K (1981) Angew Chem Int Ed Engl 20:576
214. Alexander J, Flynn DL, Mitscher LA, Veysoglu T (1981) Tetrahedron Lett 22:3711
215. Kende AS, Rizzi JP (1981) Tetrahedron Lett 22:1779
216. Yadav J, Corey P, Hsu CT, Perlman K, Sih CJ (1981) Tetrahedron Lett 22:811
217. Kimball SD, Walt DR, Johnson F (1981) J Am Chem Soc 103:1561
218. Gesson JP, Mondon M (1982) J Chem Soc, Chem Commun, p 421
219. Rao AVR, Deshpande VH, Reddy NL (1982) Tetrahedron Lett 23:775
220. Rao AVR, Mehendale AR, Reddy KB (1982) Tetrahedron Lett 23:2415
221. Jung ME, Node M, Pfluger RW, Lyster MA, Lowe JA (1982) J Org Chem 47:1150
222. Sekizaki H, Jung M, Mcnamara JM, Kishi Y (1982) J Am Chem Soc 104:7372
223. Gesson JP, Jacquesy JC, Renoux B (1983) Tetrahedron Lett 24:2757
224. Rao AVR, Reddy KB, Mehendale AR (1983) J Chem Soc, Chem Commun, p 564
225. Gesson JP, Jacquesy JC, Mondon M (1983) New J Chem 7:205
226. Hauser FM, Mal D (1983) J Am Chem Soc 105:5688
227. Hauser FM, Prasanna S, Combs DW (1983) J Org Chem 48:1328
228. Vedejs E, Miller WH, Pribish JR (1983) J Org Chem 48:3611
229. Gesson JP, Jacquesy JC, Renoux B (1984) Tetrahedron 40:4743
230. Jung ME, Lowe JA, Lyster MA, Node M, Pfluger RW, Brown RW (1984) Tetrahedron 40:4751
231. Hauser FM, Baghdanov VM (1984) Tetrahedron 40:4719
232. Tamura Y, Akai S, Sasho M, Kita Y (1984) Tetrahedron Lett 25:1167
233. Uemura M, Minami T, Hayashi Y (1984) J Chem Soc, Chem Commun, p 1193
234. Parker KA, Tallman EA (1984) Tetrahedron 40:4781
235. Bessiere Y, Vogel P (1980) Helv Chim Acta 63:232
236. Metral JL, Lauterwein J, Vogel P (1986) Helv Chim Acta 69:1287
237. Tamariz J, Vogel P (1981) Helv Chim Acta 64:188
238. Aguilar R, Reyes A, Tamariz J, Birbaum JL (1987) Tetrahedron Lett 28:865
239. Antonsson T, Vogel P (1990) Tetrahedron Lett 31:89
240. Tamoto K, Sugimori M, Terashima S (1984) Tetrahedron 40:4617
241. Suzuki M, Kimura Y, Terashima S (1985) Chem Lett, p 367
242. Reymond JL, Vogel P (1990) Tetrahedron: Asymmetry 1:729
243. Warm A, Vogel P (1986) J Org Chem 51:5348
244. Durgnat JM, Warm A, Vogel P (1992) Synth Commun 22:1883
245. Murdock KC, Child RG, Fabio PF, Angier RB, Wallace RE, Durr FE, Citarella RV (1979) J Med Chem 22:1024
246. Showalter HDH, Johnson JL, Hoftiezer JM, Turner WR, Werbel LM, Leopold WR, Shillis JL, Jackson RC, Elslager EF (1987) J Med Chem 30:121
247. Showalter HDH, Johnson JL, Werbel LM, Leopold WR, Jackson RC, Elslager EF (1984) J Med Chem 27:253
248. Leopold WR, Nelson JM, Plowman J, Jackson RC (1985) Cancer Res 45:5532
249. Showalter HDH, Johnson JL, Hoftiezer JM (1986) J Heterocycl Chem 23:1491
250. Zhang LH, Meier WE, Watson EJ, Gibson EP (1994) Tetrahedron Lett 35:3675
251. Tabor CW, Tabor H (1984) Ann Rev Biochem 53:749
252. Porter CW, Cavanaugh PF, Stolowich N, Ganis B, Kelly E, Bergeron RJ (1985) Cancer Res 45:2050
253. Bergeron RJ, Mcmanis JS, Liu CZ, Feng Y, Weimar WR, Luchetta GR, Wu QH, Ortizocasio J, Vinson JRT, Kramer D, Porter C (1994) J Med Chem 37:3464
254. Bergeron RJ, Mcmanis JS, Weimar WR, Schreier KM, Gao FL, Wu QH, Ortizocasio J, Luchetta GR, Porter C, Vinson JRT (1995) J Med Chem 38:2278
255. Dienes Z, Vogel P (1996) J Org Chem 61:6958
256. Mosimann H, Dienes Z, Vogel P (1995) Tetrahedron 51:6495