Melatonin effects in methylphenidate treated children with attention deficit hyperactivity disorder: A randomized double blind clinical trial

Iranian Journal of Psychiatry

Volumn 7, Issue 2, 2012, Pages 87-92

  Mohammadi, Mohammad Reza ^a   Mostafavi, Seyed Ali ^a   Keshavarz, Seyed Ali ^a   Eshraghian, Mohammad Reza ^a   Hosseinzadeh, Payam ^a   Hosseinzadeh Attar, Mohammad Javad ^a   Kooshesh, Seyed Mohammad Ali ^a   Chamari, Maryam ^a   Akhondzadeh, Shahin ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Attention deficit disorder with hyperactivity disorder; Child; Melatonin; Methylphenidate; Sleep

Indexed keywords

EID: 84871666165     PISSN: 17354587     EISSN: 20082215     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Corkum P, Davidson F, Macpherson M. A framework for the assessment and treatment of sleep problems in children with attention-deficit/hyperactivity disorder. Pediatr Clin North Am 2011; 58: 667-683.
2. Weiss MD, Salpekar J. Sleep problems in the child with attention-deficit hyperactivity disorder: defining aetiology and appropriate treatments. CNS Drugs 2010; 24: 811-828.
3. Owens JA. Sleep disorders and attention-deficit/hyperactivity disorder. Curr Psychiatry Rep 2008; 10: 439-444.
4. Stein MA. Unravelling sleep problems in treated and untreated children with ADHD. J Child Adolesc Psychopharmacol 1999; 9: 157-168.
5. Mohammadi MR, Kashani L, Akhondzadeh S, Izadian ES, Ohadinia S. Efficacy of theophylline compared to methylphenidate for the treatment of attention-deficit hyperactivity disorder in children and adolescents: a pilot double-blind randomized trial. J Clin Pharm Ther 2004; 29: 139-144.
6. Amiri S, Mohammadi MR, Mohammadi M, Nouroozinejad GH, Kahbazi M, Akhondzadeh S. Modafinil as a treatment for Attention-Deficit/Hyperactivity Disorder in children and adolescents: a double blind, randomized clinical trial. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 145-149.
7. Akhondzadeh SH, Mohammadi MR, Momeni F. Passiflora incarnata in the treatment of attention- deficithyperactivity disorder in children and adolescents. Future Medicine. 2005; 2: 609-614.
8. Galland BC, Tripp EG, Taylor BJ. The sleep of children with attention deficit hyperactivity disorder on and off methylphenidate: a matched case-control study. J Sleep Res 2010; 19: 366-373.
9. Wurtman RJ, Larin F, Axelrod J, Shein HM and Rosasco K. Formation of melatonin and 5-hydroxyindole acetic acid from 14C-tryptophan by rat pineal glands in organ culture. Nature 1968; 217: 953-954.
10. Sielaff T, Demisch L, Gebhart P, Blumhofer A, Khazai A, Lemmer B. Chronobiological effects of L-tryptophan in humans: influence on melatonin secretion. Adv Exp Med Biol 1991; 294: 489-491.
11. Reiter RJ, Tan DX, Cabrera J, D'Arpa D. Melatonin and tryptophan derivatives as free radical scavengers and antioxidants. Adv Exp Med Biol 1999; 467: 379-387
12. Hardeland R, Pandi-Perumal SR Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug. Nutr Metab (Lond) 2005; 2: 22.
13. Paredes SD, Barriga C, Rodriguez AB. Melatonin and tryptophan as therapeutic agents against the impairment of the sleep-wake cycle and immunosenescence due to aging in Streptopelia risoria. Neuro Endocrinol Lett 2007; 28: 757-760.
14. Shamseer L, Vohra S. Complementary, holistic, and integrative medicine: melatonin. Pediatr Rev 2009; 30: 223-228.
15. Rao ML, Gross G, Strebel B, Halaris A, Huber G, Braunig P, et al. Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophrenia. Biol Psychiatry 1994; 35: 151-163.
16. Van der Heijden KB, Smits MG, Van Someren EJ, Ridderinkhof KR, Gunning WB. Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia. J Am Acad Child Adolesc Psychiatry 2007; 46: 233-241.
17. Spitzer RL, Davies M, Barkley RA. The DSM-III-R field trial of disruptive behavior disorders. J Am Acad Child Adolesc Psychiatry 1990; 29: 690-697.
18. Barkley RA. Attention-deficit hyperactivity disorder. Sci Am 1998; 279: 66-71.
19. Bruni O, Ottaviano S, Guidetti V, Romoli M, Innocenzi M, Cortesi F, et al. The Sleep Disturbance Scale for Children (SDSC). Construction and validation of an instrument to evaluate sleep disturbances in childhood and adolescence. J Sleep Res 1996; 5: 251-261.
20. Vaughan BS, March JS, Kratochvil CJ. The evidence-based pharmacological treatment of paediatric ADHD. Int J Neuropsychopharmacol 2011: 1-13.
21. Mohammadi MR, Akhondzadeh S. Pharmacotherapy of attention-deficit/hyperactivity disorder: nonstimulant medication approaches. Expert Rev Neurother 2007; 7: 195-201.
22. Huang YS, Tsai MH, Guilleminault C. Pharmacological treatment of ADHD and the short and long term effects on sleep. Curr Pharm Des 2011; 17: 1450-1458.
23. Mohammadi MR, Ghanizadeh A, Alaghband-Rad J, Tehranidoost M, Mesgarpour B, Soori H. Selegiline in comparison with methylphenidate in attention deficit hyperactivity disorder children and adolescents in a double-blind, randomized clinical trial. J Child Adolesc Psychopharmacol 2004; 14: 418-425.
24. Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 2011; 306: 613-619.
25. Pallier PN, Morton AJ. Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease. Brain Res 2009; 1279: 90-98.
26. Weiss MD, Wasdell MB, Bomben MM, Rea KJ, Freeman RD. Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia. J Am Acad Child Adolesc Psychiatry 2006; 45: 512-519.
27. Prince J. Catecholamine dysfunction in attention-deficit/hyperactivity disorder: an update. J Clin Psychopharmacol 2008; 28: S39-45.
28. Dunn DW, Kronenberger WG. Childhood epilepsy, attention problems, and ADHD: review and practical considerations. Semin Pediatr Neurol 2005; 12: 222-228.
29. Niederhofer H, Pittschieler K. A preliminary investigation of ADHD symptoms in persons with celiac disease. J Atten Disord 2006; 10: 200-204.