Computational Modeling of Glucose Transport in Pancreatic β-Cells Identifies Metabolic Thresholds and Therapeutic Targets in Diabetes

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Luni, Camilla ^a,b   Marth, Jamey D ^c   Doyle III, Francis J ^a,b  

^a University of California   (United States)

^b SANSUM DIABETES RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE; GLUCOSE 6 PHOSPHATE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; LECTIN;

ANIMAL CELL; ARTICLE; CELL HETEROGENEITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORT; GLUCOSE TRANSPORTER 1 GENE; GLUCOSE TRANSPORTER 2 GENE; GLUCOSE UTILIZATION; GLYCOLYSIS; HEPATOCYTE NUCLEAR FACTOR 1ALPHA GENE; HEPATOCYTE NUCLEAR FACTOR 3BETA GENE; HUMAN; HUMAN CELL; INSULIN RELEASE; MATHEMATICAL MODEL; MICHAELIS MENTEN KINETICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET DISEASE; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; STEADY STATE; TRANSCRIPTION REGULATION;

ANIMALS; BIOLOGICAL TRANSPORT; DIABETES MELLITUS, TYPE 2; GLUCOSE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MODELS, BIOLOGICAL;

ANIMALIA;

EID: 84871660541     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053130     Document Type: Article

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